Ka makaʻu o nā ʻōkena hope loa i nā mea pakele maʻi ʻōpio

o ka Naauao

ʻO nā maʻi ʻōpio e like me leukemia e mālama ʻia me nā koina kumulative kiʻekiʻe aʻe o ka chemotherapy e like me cyclophosphamides a me antracyclines, kū i mua o ka hoʻonui ʻana i nā maʻi maʻi aʻe Maʻamau / ʻelua kekela ma nā mea ola i ka maʻi ʻaʻa kamaliʻi he mea maʻamau hopena hopena chemotherapy lōʻihi.

Nā maʻi ʻōpio

Loaʻa nā maʻi maʻi maʻi kamaliʻi i nā keiki, nā ʻōpio a me nā ʻōpio. ʻO ka maʻi maʻi maʻi maʻamau i nā keiki he leukemia, he maʻi maʻi koko. ʻO nā ʻano maʻi maʻi ʻē aʻe e like me lymphoma, lolo lolo, sarcomas a me nā maʻi maʻi paʻa ʻē aʻe e hiki mai ana. Mahalo i nā lāʻau lapaʻau i hoʻomaikaʻi ʻia, ʻoi aku ma mua o 80% o nā mea ola maʻi maʻi kamaliʻi ma US. Hoʻopili ʻia nā lāʻau lapaʻau i ke ʻano o ka maʻi maʻi maʻi akā hiki ke komo i ka ʻokiʻoki, chemotherapy, radiation therapy a me nā mea hou aku i ka immunotherapy. Eia nō naʻe, e like me ka National Pediatric Cancer Foundation, manaʻo lākou he ʻoi aku ma mua o 95% o nā mea ola maʻi maʻi ʻōpio e loaʻa kahi pilikia pili i ke olakino ma ka manawa he 45 mau makahiki, ʻo ia paha ka hopena o kā lākou mālama ʻana i ka maʻi maʻi maʻi ma mua.https://nationalpcf.org/facts-about-childhood-cancer/).

Nā maʻi maʻi ʻelua ma nā mea pakele maʻi ʻōpio

Me ke alo o kahi nui o nā mea i koe i ka maʻi ʻaʻai, ua nīnaninau nā kānaka noiʻi mai ke Kula Nui Lapaʻau o ke Kulanui o Minnesota i ka hui o nā mea ola maʻi ʻōpio i mālama ʻia me ka chemotherapy me nā hanana o ka neoplasm malignant (SMN) ma ke ʻano he haʻawina o ka poʻe i pakele i ka maʻi ʻaʻa kamaliʻi (Turcotte LM et al, J Clin Oncol., 2019). Loiloi lākou i nā SMN i nā mea ola i ʻike mua ʻia me ka maʻi ʻaʻai i ka wā ma lalo o 21 mau makahiki, ma waena o 1970-1999. ʻO nā kikoʻī nui o ka heluna noiʻi a me nā hopena o kā lākou kālailai ʻana:

• ʻO ka makahiki median ma ka hōʻailona he 7 mau makahiki a ʻo ka makahiki waena ma hope o 31.8 makahiki.
• Nānā lākou i ʻoi aku ma mua o 20,000 ka poʻe i pakele i ka wā kamaliʻi i mālama ʻia me chemotherapy wale nō, chemotherapy me radiation radiation, radiation therapy wale nō ʻaʻole paha.
• ʻO nā mea i pakele i ka wā kamaliʻi i mālama ʻia me chemotherapy wale nō i loaʻa iā 2.8 a hoʻonui i ka makaʻu o SMN.
• ʻOi aku ke kiʻekiʻe o ka hanana SMN i nā mea pakele o ka wā kamaliʻi i mālama ʻia me ka platinum therapy. Hoʻohui ʻia, no nā konohiki alkylating (Eg. Cyclophosphamide) a me nā anthracyclines (Eg. Doxorubicin), aia kahi pilina pane pane i ʻike ʻia ma waena o nā kaona kiʻekiʻe o kēia chemotherapy a me nā hanana kiʻekiʻe o ka maʻi ʻaʻai umauma.

ʻO ka makaʻu o ka maʻi ʻaʻai ʻelua ma Leukemia a i ʻole Surcomivors Sarcoma

I loko o kahi loiloi mua loa ma ke ʻano he ʻāpana o ke aʻo ʻana i ka maʻi ʻaʻa kamaliʻi i komo pū me 3,768 wahine leukemia ʻōpio a maʻi ʻaʻai sarcoma nā mea i pakele i mālama ʻia me ka hoʻonui ʻia ʻana o ka lāʻau chemotherapy e like me cyclophosphamide a i ʻole anthracyclines, ua ʻike ʻia ua pili nui lākou me ka makaʻu o ka hoʻomohala ʻana i ka maʻi ʻaʻai lua / ʻelua. Ua loaʻa he 5.3 pa a me 4.1 pā i hoʻonui i ka makaʻu o ka hoʻomohala ʻana i ka maʻi ʻelua o ka maʻi ʻelua / haumāna i ka maʻi maʻi umauma ma sarcoma a me nā mea ola leukemia. (Henderson TO et al., J Clin Oncol., 2016)

Ka makaʻu o ka maʻi ʻili ʻelua ma ke ola ʻana i nā maʻi ʻaʻai kamaliʻi i loaʻa iā Radiotherapy

Wahi a nā ʻike mai kahi noiʻi ʻē aʻe i kapa ʻia ʻo DCOG-LATER cohort study i komo pū me 5843 mau mea ola maʻi maʻi ʻōpio Dutch i loaʻa i nā ʻano like ʻole. maʻi pū ma waena o 1963 a me 2001, ʻo ka poʻe i pakele i mālama ʻia me ka radiotherapy, ua piʻi aʻe ka pilikia o nā maʻi maʻi ʻili lua. Ua pili pū kēia i ka nui o ka ʻili i ʻike ʻia i ka wā o ka mālama ʻana. (Jop C Teepen et al, J Natl Cancer Inst., 2019)

Panina

Ma ka hōʻuluʻulu manaʻo, ʻo nā mea ola maʻi maʻi ʻōpiopio i mālama ʻia me ka nui o ka nui o ka chemotherapy e like me cyclophosphamide a i ʻole anthracyclines no nā maʻi maʻi e like me ka leukemia e kū nei i ka piʻi nui o ka hoʻomohala ʻana i nā maʻi maʻi maʻi lua/kekona hope (ka hopena ʻaoʻao chemotherapy lōʻihi). No laila, pilikia-pōmaikaʻi kālailai o Ka maʻi 'aʻai ʻO ka lāʻau lapaʻau no nā keiki a me nā ʻōpio ʻōpio e makemake i ka mālama ʻana me ka hoʻopaʻa ʻana i nā kumulative doses o ka chemotherapy a me ka noʻonoʻo ʻana i nā koho lapaʻau ʻē aʻe a i ʻole ke koho ʻia e hōʻemi i ka hopena o ka hoʻomohala ʻana i nā maʻi maʻi maʻi maʻi i ka wā e hiki mai ana.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

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