o ka Naauao
ʻO ka bioactive Silymarin mai ka herb- Milk Thistle, he antioxidant a ua hōʻike ʻia i kekahi mau pono i Ka maʻi 'aʻai nā maʻi e like me nā hopena pale cardio ma o ka hōʻemi ʻana i ke kaumaha oxidative. ʻO ka hoʻohana ʻana i ka Milk Thistle active Silymarin me Doxorubicin e hoʻopōmaikaʻi i nā keiki me ka maʻi leukemia ma o ka hoʻohaʻahaʻa ʻana i ka cardiotoxicity i hoʻokomo ʻia e Doxorubicin e like me ka hōʻike ʻana ma kahi noiʻi lapaʻau me nā keiki me ka leukemia lymphoblastic acute.
ʻO Doxorubicin Chemotherapy & Cardiotoxicity ma Leukemia
ʻO Doxorubicin kahi lāʻau lapaʻau chemotherapy i ʻae ʻia no ka hoʻohana ʻana ma ke ʻano o ka mālama mālama ʻana i nā hōʻailona maʻi maʻi e pili ana i ka leukemia lymphoblastic acute (ALL), acute myeloblastic leukemia (AML), neuroblastoma, sarcomas, umauma, ovarian, bladder, thyroid, gastric a me nā mea he nui. nā maʻi maʻi ʻē aʻe. Hiki iā Doxorubicin ke pepehi i ka ulu wikiwiki ʻana Ka maʻi 'aʻai nā pūnaewele ma o ka hoʻonui ʻana i ka pōʻino DNA a me ka hoʻonui ʻana i ke koʻikoʻi oxidative e hoʻoulu ai i ka make cell. Eia nō naʻe, ʻo kēia hopena o Doxorubicin ka hopena i ka pōʻino koʻikoʻi koʻikoʻi i nā cell olakino, me ka cardiotoxicity ʻo ia kekahi o nā hopena ʻaoʻao koʻikoʻi loa i loaʻa ka hopena o ka hōʻeha ʻana o ka naʻau congestive, hiki ke hiki i ka wā o ka mālama ʻana a i ʻole mau mahina a i ʻole mau makahiki ma hope o ka lāʻau. . Hoʻonui ʻia ka nui o ka cardiotoxicity, e like me ka loiloi ʻia e nā hōʻailona like ʻole a me nā hōʻailona e like me ka emi ʻana o ka hana o ka naʻau a i ʻole ka hoʻololi ʻana i nā pae o nā mea hōʻailona enzyme nui o ka cardiotoxicity, e hoʻonui me ka hoʻonui ʻana i ka huina kumulative dose o Doxorubicin.
ʻO kēia conundrum o ka hoʻopau ʻana i ka maʻi ʻaʻai a me ka hana pū ʻana me nā hopena ʻeha a koʻikoʻi i kekahi manawa he pilikia nui ia i ke kaiāulu maʻi maʻi. No laila, ke hoʻomau nei nā hana e ʻike i nā ala e hiki ke kōkua i ka hoʻopau ʻana a pale ʻana i ka mea maʻi mai nā hopena ʻino loa. Ua aʻo nā kānaka noiʻi i ka hopena o nā mea kanu maoli i loaʻa mai i nā mea hoʻopihapiha ke lawe pū ʻia me Doxorubicin ma nā hopena cardiotoxicity i nā pūnaeho maʻi ʻaʻai a me nā ʻano maʻi maʻi holoholona, nā mea like e like me ka hoʻohana ʻana i ka hana hoʻomohala lāʻau no nā lāʻau ʻae ʻia. ʻO kahi ʻano o nā mea kanu i loaʻa mai iā Silymarin mai ka mea kanu Milk thistle ua hoʻāʻo ʻia i loko o nā hoʻokolohua hoʻokolohua he nui a ua hōʻike ʻia i nā hopena pale ma ka puʻuwai.
ʻO Milk Thistle a me kāna Silymarin hana
Kākoʻo waiū he mea kanu i hoʻohana ʻia no nā kenekulia ma ke ʻano he lapaʻau no nā maʻi hepa a me nā bile ma ʻEulopa. Loaʻa iā ia ma ke ʻano he papaʻai meaʻai. Ua loaʻa ka inoa ʻo ka waiū waiū mai ka waiū waiu i hoʻokuʻu ʻia ke haki nā lau. ʻO nā mea ola bioactive o nā hua Milk Thistle me Silibinin (silybin), Isosilybin, Silychristin a me Silydianin i ʻike ʻia ʻo Silymarin.
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
Hoʻohana o Milk Thistle hana Silymarin no ka Cardiotoxicity i hoʻokomo ʻia e Doxorubicin i Leukemia
Hōʻike ʻia ʻo Silymarin i kahi hoʻokolohua e loaʻa nā hopena cardioprotective ke hāʻawi ʻia me Doxorubicin (hoʻoliʻiliʻi Doxorubicin-i hoʻokomo ʻia cardiotoxicity). Hiki iā Silymarin ke hōʻemi i ke koʻikoʻi oxidative, ke kumu kumu o ka cardiotoxicity. He antioxidant ia a hiki ke hōʻemi i ka hōʻino ʻana i nā membrane a me nā protein e nā ʻano reactive, i hana ʻia ma ke ʻāpana o ka hana Doxorubicin o ka hana, ma ka pale ʻana i ka hoʻopau ʻana o nā mīkini antiantantent maoli o nā hunaola olakino (Roskovic A et al, Molecules 2011) .
Haʻawina Haumana ma Silymarin Hoʻohana & Doxorubicin-i hoʻokomo ʻia Cardiotoxicity
Ua hoʻāʻo kahi noiʻi lapaʻau mai ke Kulanui ʻo Tanta ma ʻAigupita i nā pono / cardio-protection effects o Silymarin mai Milk Thistle i nā keiki me ka leukemia lymphoblastic koʻikoʻi (ALL), i mālama ʻia me Doxorubicin (Hagag AA et al, Hoʻopilikia i nā Pahuhopu Lapaʻau Infect. 2019). I kēia noi ʻana ma 80 keiki me ALL, 40 o lākou i mālama ʻia me Doxorubicin me Silymarin ma 420 mg / lā (Pūʻulu I - hoʻokolohua) a ʻo nā mea i koe he 40 wale nō i mālama ʻia me Doxorubicin me ka ʻole o Silymarin (Pūʻulu 2 - placebo). ʻO ka loiloi o ka hana naʻau i kēia mau keiki i hana ʻia ma o nā ana echo-Doppler maʻamau o ka systolic puʻuwai a me ka hana diastolic. Ua ʻike lākou i loko o ka hui Silymarin, ua 'hoʻemi ʻia ʻo Doxorubicin i hoʻowalewale ʻia i nā haunaele ventricular systolic hema (cardiotoxicity)' ma luna o ka hui placebo.
Panina
Hōʻike ka haʻawina e loaʻa i ka Milk Thistle active Silymarin nā pōmaikaʻi i nā maʻi maʻi maʻi e like me ka hoʻemi ʻana i ka Cardiotoxicity i hoʻokomo ʻia i Doxorubicin i nā keiki me ka maʻi leukemia. Ke hāʻawi nei kēia haʻawina lapaʻau, ʻoiai me kahi helu liʻiliʻi o nā keiki leukemia, e hōʻoia ana i nā hopena cardioprotective (pono) o ka Milk thistle active Silymarin e like me ka mea i ʻike ʻia ma nā ʻano maʻi hoʻokolohua. ʻOiai ka hopena maikaʻi o nā mea hoʻohui kūlohelohe e pili ana i nā haʻawina hoʻokolohua a me nā haʻawina liʻiliʻi liʻiliʻi, pono nā mea maʻi maʻi maʻi e hoʻohana makaʻala i ka lawe ʻana i kēia mau mea hoʻopihapiha me kā lākou Ka maʻi 'aʻai nā lāʻau lapaʻau. ʻAʻole i hele kēia mau mea hoʻohui kūlohelohe i ka hoʻāʻo nui a me ka ʻae hoʻoponopono a ʻaʻole i manaʻo ʻia e mālama, pale a hoʻōla i ka maʻi. Eia kekahi, aia nā mea hiki ke hoʻohui i nā mea kanu a me nā pilina lāʻau e hiki ke hoʻopilikia i ka mālama ʻana a hiki ke pilikia i kekahi mau hihia. No laila, pono e kamaʻilio mau ka poʻe maʻi maʻi me kā lākou kauka ma mua o ka hoʻohana ʻana i kekahi mea hoʻohui kūlohelohe.
He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.