Amaphuzu avelele
IMannitol, umkhiqizo wemvelo, isetshenziswa njenge-diuretic ukwandisa ukukhiqizwa komchamo kubantu abanesifo esibi sezinso (imiphumela emibi ye-chemo). Ucwaningo lomtholampilo lukhombisile ukuthi ukusebenzisa i-mannitol kanye ne-Cisplatin chemotherapy kunciphisa ukulimala kwezinso okubangelwa yi-Cisplatin, umphumela ongemuhle obonwa engxenyeni yesithathu yeziguli ezelashwa nge-Cisplatin. Ukusetshenziswa kweMannitol kanye neCisplatin kungaba nephroprotective.
Imiphumela emibi yeCisplatin Chemotherapy
I-Cisplatin iyi-chemotherapy esetshenziselwa ukwelapha izimila eziningi eziqinile kanye nezinga lokunakekela umdlavuza wesinye, ikhanda nentamo, ingqamuzana elincane kanye namaphaphu amaseli angewona amancane. zomdlavuza, umdlavuza wesibeletho, womlomo wesibeletho nowesende nabanye abaningi. I-Cisplatin iyasebenza ekuqedeni amangqamuzana omdlavuza ngokubangela ukwanda kwengcindezi ye-oxidative kanye nokulimala kwe-DNA, ngaleyo ndlela idale ukufa kwamangqamuzana omdlavuza. Kodwa-ke, ukusetshenziswa kwe-Cisplatin kubuye kuxhunyaniswe nemiphumela emibi eminingi engathandeki ehlanganisa ukungezwani komzimba, ukuzivikela komzimba okwehlisiwe, ukuphazamiseka kwesisu, i-cardiotoxicity kanye nezinkinga ezinzima zezinso. Ingxenye eyodwa kwezintathu yeziguli ezelashwe nge-Cisplatin ithola ukulimala kwezinso kulandela ukwelashwa kokuqala (UYao X, et al, Am J Med. Isayensi., 2007). Ukulimala kwezinso noma i-nephrotoxicity ebangelwa i-Cisplatin kuye kwaqashelwa njengesenzakalo esibi esibalulekile (O, Gi-Su, et al. I-Electrolyte Blood Press, 2014). Esinye sezizathu ezisemqoka ze-nephrotoxicity ephakeme ne-Cisplatin kungenxa yokuthi kunokuqoqeka okukhulu komuthi ezinso ngaleyo ndlela kubangele ukulimala okukhulu ezinso.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Kuyini iMannitol?
IMannitol, eyaziwa nangokuthi ushukela utshwala, itholakala emithonjeni eminingi yemvelo njengamakhowe, ama-strawberry, isilimo esidliwayo esinamagatsha anamanzi, u-anyanisi, amathanga nolwelwe lwasolwandle. Iphinde yaziwe njengesithako esiphephile yi-FDA (Food and Drug Administration), futhi iyinto esetshenziswa kabanzi emikhiqizweni yokwelapha.
Izinzuzo / Ukusetshenziswa kweMannitol Supplements
Okulandelayo okunye ukusetshenziswa okuvamile kwe-mannitol:
- I-Mannitol ivame ukusetshenziswa njenge-diuretic yokwengeza ukukhiqizwa komchamo kubantu abanokwehluleka okukhulu kwezinso.
- IMannitol nayo iyasetshenziswa emithini kadokotela ukunciphisa ingcindezi nokuvuvukala kobuchopho.
- IMannitol ingasiza ekuthuthukiseni ukulawulwa kukashukela egazini
Imiphumela emibi Yama-Mannitol Supplements
Okulandelayo eminye yemiphumela emibi ejwayelekile yama-mannitol supplements:
- Ukuchama Njalo
- Ukwandisa izinga lenhliziyo
- Ukuphathwa yikhanda
- isiyezi
- Ukuphelelwa amanzi emzimbeni
IMannitol yeCisplatin Chemo Side Effect- Ukulimala Kwezinso
Enye indlela yokwehlisa imiphumela emibi ye-chemo njenge-nephrotoxicity, lapho yelashwa nge-Cisplatin, ehlolwe ngomtholampilo isebenzisa iMannitol kanye neCisplatin chemotherapy.
Kube nezifundo eziningi lapho behlolisise umphumela wokusetshenziswa kweMannitol kanye neCisplatin chemotherapy kuma-nephrotoxicity (chemo side-effect) izimpawu ezifana namazinga we-serum creatinine:
- Ucwaningo lwe-retrospective oluvela ohlelweni lwe-University of Minnesota Health-Fairview luhlaziye iziguli ezingama-313 ezelashwe nge-Cisplatin (95 zelashwe nge-mannitol futhi ezingama-218 ngaphandle), luthole ukuthi iqembu elisebenzisa i-Mannitol lalinokwenyuka okumaphakathi okuphansi kumazinga e-serum creatinine kuneqembu elingazange liyisebenzise. I-Mannitol. I-Nephrotoxicity yenzeka kancane ezigulini ezithole iMannitol kunalezo ezingazange ziyithole - 6-8% ngeMannitol vs. 17-23% ngaphandle kweMannitol (UWilliam RP Jr et al, J Oncol Pharm Pract., 2017).
- Olunye ucwaningo oluvela e-Emory University lubandakanya ukubuyekezwa kweshadi lokubuyisa zonke iziguli ezithola i-cisplatin enemisebe ehambisanayo ye-squamous cell carcinoma yekhanda nentamo. Ukuhlaziywa kwemininingwane evela ezigulini eziyi-139 (i-88 ene-Mannitol ne-51 ene-saline iyodwa) kukhombisile ukuthi iqembu leMannitol likhuphuke kancane ku-serum creatinine ekhombisa i-nephrotoxicity ephansi (UMcKibbin T et al, Umdlavuza Wokunakekela Ukusekela, 2016).
- Ucwaningo lwesikhungo olulodwa oluvela esibhedlela i-Rigshospitalet kanye ne-Herlev, eDenmark, luphinde lwaqinisekisa imiphumela ye-nephroprotective yokusetshenziswa kwe-Mannitol ekhanda nasentanyeni. umdlavuza iziguli ezithola ukwelashwa kwe-cisplatin eqenjini leziguli ezingama-78 (UHagerstrom E, et al, iClin Med Insights Oncol., 2019).
Isiphetho
Ubufakazi bomtholampilo obungenhla buyakweseka ukusetshenziswa kwento ephephile, yemvelo njenge-mannitol, ukunciphisa umphumela obalulekile we-nephrotoxicity owenziwe yi-cisplatin. umdlavuza iziguli.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.