Izinzuzo Zomtholampilo zeLycopene Ezigulini Zomdlavuza

Amaphuzu avelele

Ukudla ukudla okunothile ngotamatisi, umthombo we-antioxidant red pigment carotenoid, i-lycopene, kunezinzuzo eziningi zezempilo kubandakanya ukusebenza okuthuthukile kwe-docetaxel kumdlavuza we-prostate ongazweli emthanjeni. Olunye ucwaningo lomtholampilo lukhombisile ukuthi i-lycopene (etholakala kutamatisi nakokunye ukudla) isengezo singanciphisa ukulimala kwezinso okubangelwa i-cisplatin (umthelela we-chemotherapy ohambisana nokusetshenziswa kwe-Cisplatin) - ikhambi lemvelo elingaba khona lokwelashwa komdlavuza okubangelwe yimiphumela emibi. Kubandakanya utamatisi nokudla okunothe nge-lycopene njengengxenye ye-prostate Ukudla kweziguli ezinomdlavuza kungazuzisa.

I-Lycopene

Ukudla okunempilo ngokudla izithelo nemifino eminingi ngokusobala kubalulekile ekugcineni impilo enhle, kodwa ucwaningo lomtholampilo luye lwahlola ngokucacile ukuthi ukudla okuthile kungasiza yini ekwehliseni ingozi yomdlavuza noma ukuthuthukisa umphumela wemithi ethile yokwelapha ngamakhemikhali kumdlavuza othile. Ucwaningo lwenziwe ukuhlola izinzuzo zomtholampilo ze I-Lycopene kumdlavuza. I-Lycopene i-pigment yemvelo ebomvu, i-carotenoid, eyingxenye yezithelo nemifino, iningi lethu elingazi okuningi ngayo naphezu kokuyidla cishe nsuku zonke. Sonke sidla utamatisi njengengxenye yokudla kwethu futhi utamatisi uthola umbala wabo obomvu ngenxa yokuba umthombo ocebile we-lycopene.

Izinzuzo Ezijwayelekile Zezempilo zeLycopene

I-Lycopene iyi-antioxidant enamandla enezinzuzo eziningi zezempilo. Okulandelayo ngezinye zezinzuzo zezempilo zeLycopene:

• Kungasiza ukukhuthaza impilo yenhliziyo (UPaul F Jacques et al, Br J Nutriti., 2013; ULars Müller et al, uCrit Rev Ukudla iSci Nutriti., 2016)
• Kwangathi kungasiza ukunciphisa izinhlungu (UFang Fang Zhang et al, Life Sci., 2016)
• Kungasiza ukunciphisa amazinga e-cholesterol (UP Palozza et al, Ann Nutr Metab., 2012)
• Kungasiza ukunciphisa ukushiswa yilanga (U-Andreia Ascenso et al, i-Oxid Med Cell Longev., 2016)
• Kunganciphisa ukufa phakathi kwabantu abane-metabolic syndrome (UGuang-Ming Han et al, iNutr Res., 2016)

Ngokwengeziwe, i-lycopene inezinzuzo ezigulini zomdlavuza wesibeletho ezichazwe ngokuhamba kwesikhathi kule bhulogi.

Umthamo wamaphilisi weLycopene Supplement uhla kusuka ku-10-30 mg kabili ngosuku ngomlomo.

Ukudla ngokweqile izithasiselo ze-lycopene kungaholela emiphumeleni ethile emibi efana nokushintshwa umbala kwesikhumba, isicanucanu, ukuqunjelwa nohudo. Abesifazane abakhulelwe kufanele bagweme ukuthatha izithasiselo ze-lycopene.

Izinzuzo zokuthatha iLycopene Rich Foods / Supplements by Prostate Cancer Patients

Umdlavuza wendlala yesinye uvame kakhulu umdlavuza phakathi kwamadoda. Lolu hlobo lomdlavuza luyadlondlobala noma lubhebhezelwa i-testosterone namanye amahomoni ocansi wesilisa yingakho ukwelapha umdlavuza wendlala yowesilisa kubandakanya ukwehlisa izinga lamahomoni esigulini ngamakhemikhali noma ngezindlela zokuhlinzwa. Kodwa-ke, uma umdlavuza ukwazi ukumetastaze futhi usakazeke ezingxenyeni eziningi zomzimba, khona-ke umdlavuza ubizwa ngokuthi umdlavuza we-castrate resistant prostate (CRPC) ngoba kulokhu, ukwehlisa inani lama-hormone ocansi esiguli ngeke kube nomthelela wokulwa nomdlavuza kumdlavuza okhulayo. . Umuthi wamanje osebenza kahle kakhulu we-CRPC emakethe umuthi we-chemo obizwa ngokuthi i-Docetaxel, kodwa noma kunjalo, ukwazi ukukhulisa ubude bempilo yesiguli ngesilinganiso sezinyanga ezimbili.

Ngo-2011, kwenziwa ucwaningo ngabaphenyi base-University of California, e-Irvine, behlola ukuthi i-carotenoids efana ne-lycopene ingawukhulisa kanjani umphumela we-Docetaxel (DTX / DXL) kumdlavuza wendlala yabesilisa. Abaphenyi bathole ukuthi isengezo se-lycopene kanye ne-docetaxel kunemithelela yokukhula ebonakala kakhulu kunaleyo yokwelashwa kwe-docetaxel kuphela. I-Lycopene ithuthukise kakhulu ukusebenza kwe-antitumor kwe-docetaxel cishe ngama-38% okuphakamisa ukuthi izithasiselo ze-lycopene kanye nokudla okunothile kwe-lycopene kungasiza kwiziguli ezinomdlavuza wesinye. (UTang Y et al, Neoplasia, 2011Eminyakeni yamuva nje, izifundo ezengeziwe ziqinisekisile ukuthi imiphumela yalolu cwaningo inembile futhi ibuye ikhombise izinzuzo zengozi encishisiwe yomdlavuza wendlala esetshenziswa kakhulu nge-lycopene. (U-Chen P et al, Umuthi (Baltimore), 2015)

Umphumela weLycopene ku-Cisplatin-Induced Nephrotoxicity (Ukulimala Kwezinso)

Olunye ucwaningo olwenziwe ngo-2017 ngabaphenyi base-Shahrekord University of Medical Sciences e-Iran babheka imiphumela yokuthi i-lycopene (etholakala kutamatisi) angaba ne-cisplatin eyenze ukulimala kwezinso (nephropathy) ezigulini. I-Cisplatin yisidakamizwa esinamandla, esinobuthi se-chemotherapy esisetshenziselwa ukwelapha umdlavuza amaningi. Kodwa-ke, njengoba lo muthi uthinta womabili amangqamuzana omdlavuza nongewona umdlavuza, kufanele usetshenziswe ngemithamo elinganiselwe kungenjalo ungadala ezinye izinkinga ezinkulu zempilo emzimbeni. Omunye umphumela ohlangothini ovamile weCisplatin yi-nephropathy, ebangelwa ukulimala kwemithambo yegazi ngaphakathi kwezinso. Ngakho-ke, abacwaningi besifundo bafuna ukubona ukuthi i-lycopene ikwazile yini ukunciphisa lo mphumela onobuthi womuthi ofana ne-cisplatin. Ngemuva kokwenza ukuhlolwa okungahleliwe okungahleliwe, ngokuhlukanisa iziguli eziyi-120 zibe ngamaqembu amabili, bathole ukuthi “iLycopene (evela kutamatisi) ingasebenza ekwehliseni izinkinga ngenxa ye-cisplatin-induced nephrotoxicity (ukulimala kwezinso) ngokuthinta ezinye izimpawu zomsebenzi wezinso ”(UMahmoodnia L et al, J Nephropathol. 2017).

Isiphetho

Ekugcineni, iziguli ezine-prostate umdlavuza noma labo njengamanje abathola ukwelashwa ngamakhemikhali okubandakanya isidakamizwa i-Cisplatin kufanele bacabangele ukwandisa ukusetshenziswa kwabo kwemifino ebomvu ecebile i-lycopene, ikakhulukazi utamatisi, ukuze babasize bakwazi ukululama futhi bathuthukise amathuba abo okusinda.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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