Amaphuzu avelele
I-Cisplatin, i-chemotherapy evame ukusetshenziswa yezimila eziqinile ingabangela imiphumela emibi yokulahlekelwa ukuzwa ezigulini, okungahlala unomphela. Ucwaningo lwakamuva luhlole ukusebenzisana kwe-Cisplatin chemotherapy nokusetshenziswa kwe-caffeine kumodeli yamagundane futhi lwathola ukuthi ukusetshenziswa kwe-caffeine phakathi nokwelashwa kwe-Cisplatin kwenza i-Cisplatin ibe yimbi kakhulu ekulahlekelweni kwezindlebe. Cancer iziguli ezisebenzisa i-Cisplatin chemotherapy kufanele zixwayiswe ngokusetshenziswa kwe-caffeine.
I-Cisplatin Chemotherapy
I-Cisplatin iyi-chemotherapy ephumelela kakhulu, evame ukusetshenziswa ukwelapha izimila eziqinile. Kodwa-ke, i-Cisplatin chemotherapy ngeshwa iphinde iholele emiphumeleni emibi ehlanganisa ukungezwa kanye nobuthi bezinso. Ngokungafani neminye imiphumela engemihle ehlehlayo lapho ukwelashwa sekuyekiwe, ukulahlekelwa ukuzwa kungase kube unomphela futhi kungaba nomthelela omkhulu kukhwalithi yempilo yesiguli. umdlavuza osindile. Ngaphambi kokuba siqonde ukuthi i-Cisplatin ibangela kanjani ukungezwa kwezindlebe (i-ototoxicity), sidinga ukuqonda i-anatomy yendlebe.
Izingxenye zendlebe abantu abaningi abajwayelene nazo yisigubhu sendlebe nendlebe yangaphandle kodwa ezinye izingxenye ezibalulekile zifaka ama-ossicles asendlebeni ephakathi, i-cochlea, ne-basilar membrane, ingxenye yendlebe yangaphakathi. Empeleni, umsindo ukhiqizwa nje ukudlidlizela kwezinto futhi lokhu kunyakaza kudluliswa yisigubhu sendlebe sisuka emoyeni siye kuma-ossicles nase-cochlea ngaphakathi kwendlebe. I-cochlea inesibopho sokudiliza yonke imikhakha ehlukene eyakha umsindo futhi ikwenza lokhu nge-basilar membrane etholakala ngaphakathi kwe-cochlea. Ngakho-ke lapho imisindo emisha idluliswa isuka esigubhini sendlebe, amangqamuzana ezinwele akulo ulwelwesi lwe-basilar azogudluka ngokuya ngamaza awo athile azoholela ekusebenzeni kwezimpawu ze-neural eziholela ebuchosheni. Ngakho-ke, abantu abagqoke izinsiza-kuzwa bakhulisa umsindo ongena endlebeni kuphela kepha abakwazi ukufaka amanye amangqamuzana alimele ngaphakathi kwe-cochlea.
I-Cisplatin ingangena kumaseli ku-cochlea futhi igcinwe lapho izinyanga neminyaka. I-Cisplatin ingabangela ukulimala kwamangqamuzana kulwelwesi lwe-basilar futhi ibangele ukuvuvukala nokufa kwamangqamuzana ezinwele, ngaleyo ndlela kubangele ukulahlekelwa ukuzwa unomphela. (Rybak LP et al, Semin Hear., 2019) Amaseli ku-Cochlea anama-adenosine receptors okuthi uma ecushiwe, akwazi ukuvikela emonakalweni walawa maseli kanye nokulahlekelwa ukuzwa okuhambisanayo. Ocwaningweni olusanda kushicilelwa ngo-2019, ososayensi bathole ukuthi izinto ezisetshenziswa kakhulu njenge-caffeine, ezitholakala ku- ikhofi kanye neziphuzo ezihlukahlukene zamandla ne-carbonated, ezingavimbela lawa ma-adenosine receptors, lapho zidliwe ngesikhathi sokwelashwa ngamakhemikhali e-Cisplatin, zinamandla okwenza kubi kakhulu umphumela omubi wokulahlekelwa ukuzwa.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
I-Caffeine ne-Cisplatin chemotherapy-eyenziwe Ukulahlekelwa Kokuzwa
Kulolu cwaningo olwenziwe ngabaphenyi baseSouthern Illinois University e-United States, bahlole umbono wokuthi i-caffeine ingakhuphula imiphumela iCisplatin ebinayo ezigulini ebeziqala ukulahlekelwa unomphela ngokuzwa ngenxa yokwelashwa. Le hypothesis bayivivinya kumodeli yegundane ye-cisplatin ototoxicity elawulwa nge-caffeine ngomlomo. Bathola ukuthi umthamo owodwa we-caffeine wenza ukuba ukulahleka kokuzwa kwe-cisplatin kube kubi kakhulu ngaphandle kokulimala kumaseli wezinwele ezingaphandle kepha kwanda ukuvuvukala kwendlebe kwangaphakathi. Kodwa imithamo eminingi ye-caffeine nayo idale umonakalo kumaseli ezinwele akwi-cochlea ngaphandle kokubanga ukuvuvukala. Isenzo se-caffeine abasinqumayo kungenxa yokuvinjelwa kwama-adenosine receptors kumaseli e-cochlea. (USheth S et al, uSci Rep. 2019)
Isiphetho
Sengiphetha, okutholwe kulolu cwaningo kubonisa ukusebenzisana okungenzeka kwezidakamizwa phakathi kwe-caffeine nokulahlekelwa ukuzwa okubangelwa yi-cisplatin. Ngakho-ke, umdlavuza iziguli ezisebenzisa i-cisplatin equkethe imishanguzo ye-chemotherapy kufanele zixwayiswe mayelana nokusetshenziswa kwekhofi nezinye iziphuzo ezine-caffeine. Ukugwema i-caffeine ngesikhathi sokwelashwa ngamakhemikhali e-Cisplatin kungase kungavimbi noma kukuhlehlise ukulahlekelwa ukuzwa okuzayo, kodwa okungenani ngeke kuqhubeke kubi nakakhulu futhi kusheshise inqubo. Iziguli ezithola ukwelashwa kwe-Cisplatin eziqala ukuzwa ngokungezwa kufanele zazise odokotela bazo ngokushesha ngamasu okunciphisa umthamo futhi zigweme zonke izinhlobo ze-caffeine..
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
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Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy ezithinta ikhwalithi yempilo yazo futhi zibheke ezinye izindlela zokwelapha umdlavuza ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) ikhambi lemvelo elingcono kakhulu umdlavuza kanye nemiphumela engemihle ehlobene nokwelashwa.