Amaphuzu avelele
Imikhiqizo yemvelo/izithako zokudla uma zikhethwa ngokwesayensi zingazuza futhi zigcwalise izimpendulo ze-chemo kumdlavuza othile ngezindlela eziningi ezihlanganisa: ukuthuthukisa izindlela ezizwelayo emishanguzweni, ukuvimbela izindlela zokumelana nomuthi kanye nokwenza ngcono i-bioavailability yomuthi. Ukwengeza, umuntu kufanele agweme ukuthatha noma yimiphi imikhiqizo Yemvelo/izithako zokudla ezisebenzisana ne-chemotherapy (i-chemo) ngenkathi elashelwa ukulwa nomdlavuza. Ngakho-ke, imikhiqizo yemvelo ekhethwe ngokwesayensi/izithako zokudla zingazuza impendulo ye-chemo ngaphandle kokwandisa umthwalo wobuthi umdlavuza. Gwema ukusetshenziswa okungahleliwe kwemikhiqizo yemvelo ene-chemo ukuze uqhelelane nokusebenzisana okungafuneki.
Imikhiqizo Yemvelo / Izithasiselo kanye neChemo
Ingabe izitshalo eziningi zezidakamizwa azitholakalanga? - Ngokuya ngokubuyekezwa kuka-2016, kusukela ngeminyaka yo-1940 kuya kowezi-2014, emithini yomdlavuza engu-175 evunyelwe kulesi sikhathi, ama-85 (49%) kwakuyimikhiqizo yemvelo noma etholakala ngqo ezitshalweni (UNewman noCragg, uJ Nat. Ukukhiqiza., 2016).
Ngemiphumela emibi eyaziwayo ye-chemotherapy, umdlavuza iziguli zihlale zifuna izindlela ezengeziwe zokwenza ngcono impilo yazo kanye nokuthatha imithi yokwelapha ngamakhemikhali. Kunentshisekelo evuselelwe ekusetshenzisweni kokwelapha kwemikhiqizo ethathwe ezitshalweni njengenye indlela, ephephile futhi engenabo ubuthi kanye nokwelashwa ngamakhemikhali okuvamile (ikhambi lemvelo lomdlavuza). Futhi naphezu kweqiniso lokuthi kunenani elikhulu lezifundo zokuhlolwa nokwelashwa kwemikhiqizo ehlukahlukene yemvelo/izithako zokudla kanye nokusetshenziswa kwazo kabanzi emithini yesintu, yesintu kanye neminye, kukhona ukungakholwa okuvamile phakathi kodokotela nodokotela mayelana nokusetshenziswa kwabo kanye nezinzuzo. Imibono isukela ekungabazeni okuphelele futhi lokhu kungqubuzana nesayensi kanye nesigaba sikawoyela wenyoka, kuya emiphumeleni yabo yokuba yi-placebo noma engasho lutho ukuncoma ukusetshenziswa kwayo.
Kodwa-ke, ucwaningo lucubungule imininingwane yokuhlola yokwelashwa okusebenzayo kwemikhiqizo ye-anticancer yemvelo engama-650 uma kuqhathaniswa nemithi evunyelwe umdlavuza engama-88 futhi kutholakale ukuthi ama-25% wemikhiqizo yemvelo inomthelela wokwelapha ofana nezinga lamandla ezidakamizwa nomunye u-33% wemikhiqizo yemvelo zazingaphakathi kwebanga eliphindwe kalishumi leleveli yamandla ezidakamizwa (UQin C et al, PLoS One., 2012). Le datha ikhombisa ukuthi imikhiqizo / izithasiselo zemvelo eziningi ngezindlela zazo zokusabalalisa ngokusebenzisa imigomo nezindlela eziningi zinempumelelo efanayo yokwelapha kumuthi wokulwa nomdlavuza ocwaningwe kakhulu futhi wahlolwa ngezindlela ezithile ezicacisiwe nezibhekiwe. Izidakamizwa ezivunyelwe zinomthwalo ophakeme wobuthi okungenzeka ukuthi imikhiqizo yemvelo ayinayo ngenxa yokusebenza kwazo okubanzi nokusakazeka okwengeziwe, ngakho-ke kungaba gcwalisa i-chemotherapy uma ikhethwe ngokwesayensi.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ingabe Imikhiqizo Yemvelo noma Izithasiselo Zokudla zizizuzisa kanjani Izimpendulo zeChemo kuCancer?
Ukuhlonza imikhiqizo engcono kakhulu yemvelo noma izithako zokudla okufanele uzithathe ngesikhathi se-chemotherapy (chemo) kubaluleke kakhulu. Izindlela ezine eziphezulu lapho imikhiqizo yemvelo noma izengezo zokudla ezikhethwe ngokwesayensi zingazuza futhi zihambisane nekhemotherapy yilezi:
- Ngokwandisa ukutholakala kwamakhemikhali esitokisini, endaweni yokusebenza: Imithi eminingi ithuthelwa ngaphakathi futhi ingakhishwa ngenkuthalo ngaphandle kweseli ngamaphrotheni athile okuthutha izidakamizwa. Imikhiqizo yemvelo uma ikhethwe kahle ingasiza ekuvimbeleni ukuthekelisa kwezidakamizwa kanye nokwandisa ukungenisa kwezidakamizwa engqamuzaneni yomdlavuza, ngaleyo ndlela yenze i-chemotherapy ibe ngaphakathi umdlavuza iseli isikhathi eside, ukwenza umsebenzi walo wokubulala ingqamuzana lomdlavuza.
- Ngokwandisa izindlela zokwazisa ngamakhemikhali: Izidakamizwa zinezindlela ezithile ezicacile zokwenza ngokuvimbela noma ukwenza kusebenze ama-enzyme noma izindlela ezithile kwinethiwekhi yeseli yomdlavuza. Imikhiqizo yemvelo ekhethwe ngokufanele ingaba nomphumela ohambisanayo ngezenzo zabo eziqondiwe eziningi ukulinganisa abalawuli abaningi, ophathina kanye nabasebenza kokuhlosiwe okuyinhloko kwe-chemotherapy ethile.
- Ngokunciphisa izindlela zokuvikela noma zokumelana nezidakamizwa ngamakhemikhali: Iseli lomdlavuza lifunda ukugwema ukuhlaselwa ngamakhemikhali ngokwenza izindlela ezihambisanayo zokusinda ezivimbela i-chemotherapy ukuthi isebenze. Imikhiqizo yemvelo ingakhethwa ngokuya ngokuqonda izindlela zokumelana namakhemikhali ahlukile ukuvimbela lezi zindlela nokwenza ngcono impendulo.
- Ngokugwema noma yikuphi ukuxhumana okwengeza ukudla-chemotherapy (chemo) ngesikhathi sokwelashwaImikhiqizo yemvelo / izithasiselo zokudla ezifana neTurmeric / Curcumin, itiye eliluhlaza, okukhishwe ugarlic, iSt John's wort kuyaziwa ukuthi inekhono lokulwa nomdlavuza. Ngakho-ke, zisetshenziswa ngezikhathi ezithile ukukhulisa umphumela we-chemotherapy kanye nokunqoba umphumela wobuthi. (NCBI) Okunye okukhathazayo kakhulu ngokusetshenziswa okungahleliwe kwemikhiqizo yemvelo / isithasiselo sokudla ukuthi kungaphazamisa umphumela wokwelashwa kweChemotherapy wokulwa umdlavuza amaseli. Imikhiqizo yemvelo / isithasiselo sokudla siphazamisa umthamo we-chemotherapy ngokushintsha ukumuncwa. Isengezo singase sihlanganyele ne-chemotherapy ngokusebenzisa indlela yokusebenzisana ye-supplement-drugs (CYP). Okunye ukuhlangana okwaziwayo kwe-supplement-drugs yilezi:
- Ingxenye yetiye eluhlaza (i-Epigallocatechin gallate) ihlangana namakhemikhali afana ne-Bortezomib ne-fluorouracil. (UJinping Qiao et al, Ukudla Chem Toxicol., 2011; Ukuhlanganisa B Golden et al, Igazi., 2009)
- I-St. John's wort inciphisa ukutholakala kwe-Imatinib ne-Irinotecan. (UReginald F Frye et al, uMtholampilo Pharmacol Ther., 2004; URon HJ Mathijssen et al, J Natl Cancer Inst., 2002)
- Isengezo sokudla noma sokudla iTurmeric kufanele igwenywe ngenkathi iselashwa i-Doxorubicin kanye neCyclophosphamide njengoba inciphisa amandla abo okulwa nomdlavuza webele. (USivagurunathan Somasundaram et al, iCancer Res. 2002)
Isiphetho
Ngokwenza noma yiziphi izenzo ezihambisanayo, izenzo eziphikisana nokuphikisana noma ngokukhuphula ukutholakala kwe-intracellular ye-chemotherapy noma ukugwema noma yikuphi ukuxhumana ne-chemotherapy, imikhiqizo yemvelo ekhethwe ngokwesayensi noma izithako zokudla kungasiza ekuthuthukiseni izimpendulo ze-chemotherapy ngaphandle kokwandisa umthwalo wobuthi kumdlavuza. Ngakho-ke ukuba nolwazi lokuthi iziphi izithako okufanele uzithathe noma uzigweme ngesikhathi se-chemotherapy kubaluleke kakhulu ekwandiseni ikhono lokulwa nomdlavuza we-chemotherapy (chemo). Ukusetshenziswa okungahleliwe kwanoma yimuphi umkhiqizo wemvelo we-anticancer kufanele kugwenywe njengoba kungalimaza futhi kungaphazamisa ukwelashwa ngamakhemikhali.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha umsoco ofanele nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela kanye Ukukhetha okungahleliwe) yikhambi lemvelo elihle kakhulu lomdlavuza nemiphumela emibi ehlobene nokwelashwa.