Amaphuzu avelele
Izidakamizwa zePlatinum chemotherapy ezihlanganisa iCisplatin neCarboplatin, yize izidakamizwa zomdlavuza ezisebenzayo, ziyaziwa futhi ngokudala imiphumela emibi, enye yazo ukuncipha okukhulu kwamazinga e-Magnesium ebalulekile emzimbeni, okuholela ekulimaleni kwezinso. Ucwaningo lwezokwelapha lubike ukuthi ukusetshenziswa kwesithasiselo seMagnesium kanye nokwelashwa kwePlatinum kuyasiza ekubaleni ukuncipha kanye nokunciphisa imiphumela emibi ye-chemotherapy yobuthi bezinso umdlavuza.
Ukusetshenziswa Kwe-Platinum Therapy kuCancer
I-Platinum therapy enezidakamizwa ezifana ne-Cisplatin ne-Carboplatin iyingxenye yethuluzi lokulwa nomdlavuza ezinhlobonhlobo eziningi zomdlavuza ohlanganisa umdlavuza we-ovary, womlomo wesibeletho, wamaphaphu, esinyeni, wesende, wekhanda nowentamo neminye eminingi. I-Cisplatin yaba umuthi wokuqala weplatinamu owagunyazwa njenge-a umdlavuza ukwelashwa ngo-1978 futhi isetshenziswa ngayinye futhi ihlanganiswe nezinye izidakamizwa ze-chemotherapy. Le mithi iyakwazi ukuqeda amangqamuzana omdlavuza akhula ngokushesha ngokufaka ukucindezeleka kwe-oxidative ngokweqile kanye nokulimala kwe-DNA, okuvimbela ukuphindaphinda nokukhula kwawo. Kodwa-ke, umonakalo we-DNA obangelwa yile mithi ye-platinum nawo unomthelela kwamanye amangqamuzana avamile omzimba futhi yingakho le mithi ihlotshaniswa nokulimala okubambisene okuholela emiphumeleni emibi enzima nengathandeki.
Ukwehla kweMagnesium - Umphumela Oseceleni We-Platinum Chemotherapy
Omunye wemiphumela emibi ehambisana ne-Cisplatin noma i-Carboplatin platinum therapy kungukuncipha okukhulu emazingeni e-mineral ebalulekile iMagnesium (Mg) emzimbeni, okuholela ku-hypomagnesemia (ULajer H et al, IBritish J Cancer, 2003). Lesi simo sixhunyaniswe ne-cisplatin noma ukulimala kwezinso okubangelwa i-carboplatin. I-Hypomagnesemia ingahlotshaniswa nezimpawu eziningi ezisongela impilo zenhliziyo, zemithambo yegazi noma zokuziphatha isibalo esikhulayo sabasindile bomdlavuza ababhekene naso, ngemuva kokuphothulwa kwemithi yabo yokwelashwa ngamakhemikhali futhi besethethelelweni (UVelimirovic M. et al, Hosp. Zijwayeze. (1995), 2017).
Ukufunda ngeNhlangano phakathi kokungajwayelekile kweMagnesium eCarboplatin Chemotherapy yelaphe i-Ovarian Cancer
Ucwaningo oluvela eMd Anderson Cancer Center, e-USA, luhlaziye ukuhlangana kokungajwayelekile kwe-magnesium ne-hypomagnesemia ezigulini zomdlavuza we-ovari eziphathwe nge-carboplatin. Bahlaziye amarekhodi abalulekile okuhlolwa kwezimpawu zaselabhoratri eziguli ezingama-229 ezisezingeni eliphezulu zomdlavuza we-ovarian ezazihlinzwa kanye nokwelashwa nge-carboplatin chemotherapy phakathi kukaJanuwari 2004 kuya kuDisemba 2014 (U-Liu W et al, Oncologist, 2019). Bathola ukuthi ukuvela kaningi kwe-hypomagnesemia ezigulini ngesikhathi sokwelapha i-carboplatin kwakubikezela ngokuqinile ukusinda okufushane jikelele. Lokhu bekuzimele ekupheleleni kokuncishiswa kwesimila kulezi ziguli ezinomdlavuza we-ovarian eziphambili.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ukusetshenziswa Kwe-Magnesium Supplements ngesikhathi sePlatinum Chemotherapy
Ukusetshenziswa kwe-Magnesium supplements ngesikhathi sokwelashwa kwePlatinum ku umdlavuza yahlolwa ezifundweni zomtholampilo futhi ibonise inzuzo. Esivivinyweni somtholampilo esilawulwa ngokungahleliwe, esinelebula evulekile eyenziwe e-Iran University of Medical Science e-Tehran, i-oral magnesium oxide supplementation to the Cisplatin therapy ezigulini ezikhulile ezingama-62 ezinomdlavuza ongewona we-leukemia osanda kutholwa. Kwakukhona iziguli ze-31 eqenjini lokungenelela ezinikezwe i-Mg supplementation kanye ne-Cisplatin kanye ne-31 eqenjini lokulawula ngaphandle kokuxhaswa. Bathole ukuthi ukwehla kwamazinga e-Mg eqenjini lokulawula kwakubaluleke kakhulu. I-Hypomagnesemia ibonwe kuphela ku-10.7% weqembu lokungenelela vs. 23.1% eqenjini lokulawula (UZarif Yeganeh M et al, Iran J Impilo Yomphakathi, 2016). Olunye ucwaningo lweqembu laseJapan luye lwaqinisekisa nokuthi ukulayishwa kwangaphambili nge-Mg supplementation ngaphambi kokwelapha i-Cisplatin kunciphise kakhulu i-Cisplatin eyenze ubuthi bezinso (14.2 kuqhathaniswa ne-39.7%) ezigulini ezinomdlavuza we-thoracic. (UYoshida T. et al, waseJapan J Clin Oncol, 2014).
Isiphetho
Umdlavuza uma ungelashwa ungabulala, futhi izindlela zokwelashwa ngamakhemikhali naphezu kwezinkinga nezinselele ezihlukahlukene ezinemiphumela emibi kakhulu, kufanele zisetshenziselwe ukulawula lesi sifo. Ngakho-ke, kanye namasu okunciphisa ubungozi bemiphumela emibi ye-chemotherapy, njengokwengeza nge-Mg ngaphambi nangesikhathi sokwelashwa kweplatinamu, umdlavuza Iziguli zingadla nokudla okunothe nge-Magnesium njengembewu yethanga, ama-alimondi, i-oatmeal, i-tofu, isipinashi, ubhanana, ukwatapheya, ushokoledi omnyama nokunye ukuze kwengezelele imisoco enciphile namaminerali ngemithombo yemvelo, emuncwa kalula umzimba. Indlela edidiyelwe yokuhlanganisa ukwelapha ngamakhemikhali kanye nezithako ezihambisanayo nezihambisana ngokwesayensi, amaminerali, namavithamini, kanye nokudla okunempilo, kuyadingeka ukuthuthukisa amathuba okuphumelela ezigulini ezinomdlavuza!
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) ikhambi lemvelo elingcono kakhulu umdlavuza kanye nemiphumela engemihle ehlobene nokwelashwa.