Amaphuzu avelele
I-Vitamin E iyisakhi se-antioxidant esisithola ngemithombo yokudla noma izithasiselo. Kodwa-ke, ukwengezwa kwe-Vitamin E kubonise umthelela ohlukile ezinhlobonhlobo zomdlavuza. I-Vitamin E ibonise ubungozi obukhulayo be-prostate kanye nomdlavuza wobuchopho, akukho mthelela kumdlavuza wamaphaphu kanye nezinzuzo kumdlavuza we-Ovarian. Lo mphumela ohlukile ungaxhunyaniswa nokuhlukahluka kofuzo kubantu ngabanye ngokusekelwe ekuhlukeni kokuthi i-Vitamin E icutshungulwa kanjani emzimbeni. Ukwengezwa kwe-Vitamin E ngokweqile kungabangela ukulimala ngenxa yokopha kakhulu kanye nesifo sohlangothi. Ngakho-ke, kungcono kakhulu ukwandisa i-Vitamin E ngemithombo yokudla njengengxenye yokudla okunempilo noma umsoco we umdlavuza, esikhundleni sokuthatha izithasiselo.
Ukuxhaswa kukaVitamin E
Abantu abaningi bakholelwa ukuthi ukuthatha amavithamini nezithasiselo kungasiza ekwehliseni ubungozi bezimo eziningi ezingalapheki futhi kuthuthukise impilo yabo yonke. Kodwa-ke, kunezifundo eziningi zemitholampilo ezibonisa ukuthi izinzuzo zamavithamini nezithasiselo ziqondene nomongo futhi ezimweni eziningi azihlinzeki nganoma iyiphi inzuzo futhi zingaba yingozi. UVitamin E ngesinye sezakhi esinjalo esidume ngezinzuzo zempilo ezahlukahlukene futhi ngaphandle kokuba yingxenye yokudla okuningi esikudlayo njengengxenye yokudla / umsoco wethu, kuthathwa njengesengezo somthamo owengeziwe nenzuzo. Sizohlola imithombo, izinzuzo nezingozi ezihambisana nokwengezwa ngokweqile kukaVitamin E ekudleni komdlavuza / ekudleni okunempilo.
UVitamin E yiqembu lezakhi ezinomsoco we-antioxidant oncibilikayo otholakala ekudleni okuningi futhi futhi uthathwe njengesengezo ngawodwana noma ingxenye yokwengezwa kwamavithamini amaningi, ngezinzuzo zawo eziningi zezempilo. UVitamin E empeleni wenziwe ngamaqembu amabili amakhemikhali: ama-tocopherols nama-tocotrienols. Izici ze-antioxidant zikaVitamin E zisiza ekuvikeleni amaseli ethu ekulimaleni okubangelwa ama-radicals wamahhala asebenzayo nokucindezeleka okwenziwe nge-oxidative. Ngakho-ke, imithombo yokudla nezithasiselo zeVitamin E zinikela ngezinzuzo eziningi zezempilo ezisukela ekunakekelweni kwesikhumba ziye ezimpilweni zenhliziyo nobuchopho.
Imithombo kaVitamin E
Imithombo yokudla ecebile ngo-Vitamin E ifaka uwoyela wommbila, uwoyela wemifino, uwoyela wesundu, ama-alimondi, ama-hazelnut, i-pinenuts, imbewu ye-sunflower, ngaphandle kwezinye izithelo nemifino esiyidlayo ekudleni kwethu. Ama-Tocopherols ayimithombo emikhulu ye-Vitamin E ekudleni kwethu nakwizithasiselo uma kuqhathaniswa ne-tocotrienols. Ukudla okune-tocotrienol ephakeme ngama-rice bran, i-oats, i-rye, ibhali namafutha esundu.
Ingozi - Inhlangano ezuzisa iVitamin E neCancer
Izakhiwo ze-Antioxidant ze-Vitamin E zingasiza ekwehliseni ingcindezi eyingozi ye-oxidative kanye nomonakalo kumaseli ethu. Ukuguga kubangela ukuncipha kwamandla emvelo e-antioxidant emizimbeni yethu, ngaleyo ndlela i-Vitamin E isiza ngemiphumela yokulwa nokuguga. Kuhlotshaniswa nokunciphisa ingozi yezifo ezingelapheki nezihlobene nokuguga njengenhliziyo nemithambo yegazi, isifo sikashukela kanye nokuba nomthelela wokulwa nomdlavuza. Izifundo ku umdlavuza amaseli namamodeli ezilwane abonise umthelela onenzuzo we-Vitamin E supplementation ekuvimbeleni umdlavuza. Izivivinyo eziningi zemitholampilo zihlole ukuhlotshaniswa kokusetshenziswa kwe-Vitamin E ezigulini ezinomdlavuza futhi kubonise imiphumela eyahlukahlukene kusukela ekuzuzeni, kuya kokungabi nalutho, ukulimaza, kumdlavuza ohlukene.
Kule bhulogi sizofingqa ezinye zalezi zifundo zokwelapha ezigqamisa ukuthi ukusetshenziswa kukaVitamin E njengengxenye yokudla / ukudla kunenzuzo kweminye imidlavuza ngenkathi kuhlotshaniswa nomthelela omubi kwezinye izinhlobo zomdlavuza. Ngakho-ke, izinzuzo zihambisana nobungozi bokusetshenziswa kwemithombo kaVitamin E ekudleni komdlavuza / kokudla okunomsoco kuncike kumongo futhi kuyahluka ngohlobo lomdlavuza nokwelashwa.
Izinzuzo zikaVitamin E ku-Ovarian Cancer
Ukuxilongwa komdlavuza we-Ovarian kuvame ukwenzeka esikhathini esizayo, esithuthuke kakhulu, ngoba izigaba zokuqala zalo mdlavuza azivami ukudala izimpawu. Phakathi nezigaba zakamuva zomdlavuza we-ovari, izimpawu ezinjengokuncipha kwesisindo kanye nobuhlungu besisu, ngokuvamile okungacacisiwe, ziqala ukubonakala futhi lokhu akuvami ukuphakamisa inhlabamkhosi enkulu. Kungenxa yalezi zizathu ukuthi abesifazane bathola ukuthi banomdlavuza we-ovari ezigabeni zakamuva kakhulu, ezinesilinganiso seminyaka emihlanu sokusinda sama-47% (American Cancer Society). Iziguli ezinomdlavuza we-Ovarian ziphathwa ngemithi yokwelashwa ngamakhemikhali abaningi abangayiphenduli. Okukodwa kwe izindlela zokwelashwa ezihlosiwe kakhulu esetshenziselwa umdlavuza we-ovari isebenza ngokulambisa amaseli wesimila ngokuvimbela ukukhula kwemithambo yegazi emisha ebalulekile ekuthuthweni kwezakhamzimba kwisimila esikhula ngokushesha.
Ngokomongo womdlavuza we-ovari, i-Vitamin E eyinhlanganisela ye-tocotrienol ikhombise izinzuzo lapho isetshenziswa ngokuhlangana nomuthi ojwayelekile wokunakekelwa (SOC) (i-humanized anti-VEGF monoclonal antibody) ezigulini ezingazweli ekwelashweni ngamakhemikhali. Abaphenyi eMnyangweni we-Oncology esibhedlela iVejle, eDenmark, bafunde ngomphumela weqembu elincane le-tocotrienol likaVitamin E lihlangene nomuthi we-SOC ezigulini zomdlavuza we-ovari ezingaphendulanga ekwelashweni ngamakhemikhali. Ucwaningo lubandakanya iziguli ezingama-23. Ukuhlanganiswa kwe-tocotrienol nomuthi we-SOC kukhombise ubuthi obuphansi kakhulu ezigulini futhi kwaba nezinga lokuqiniswa kwezifo ngo-70%. Ukusinda okuphelele okuphakathi okurekhodwe kulesi silingo sesigaba II kwakuphakeme kakhulu uma kuqhathaniswa nezincwadi zamanje. (I-Thomsen CB et al, i-Pharmacol Res., 2019) Lolu cwaningo lusekela umphumela wokulwa nomdlavuza weqembu le-delta-tocotrienol likaVithamini E kumdlavuza we-ovari omningi, kepha okufanayo akusungulwanga ama-tocopherols.
Ubungozi be-Vitamin E ku-Cancer Brain
Ucwaningo olususelwe eminyangweni ehlukene ye-neuro oncology kanye neye-neurosurgery ezibhedlela zonke zase-US luhlaziye imininingwane yezingxoxo ezihlelekile ezivela ezigulini ezingama-470 ezenziwa ngemuva kokutholakala komdlavuza wobuchopho i-glioblastoma multiforme (GBM). Imiphumela ikhombise ukuthi inani elikhulu kakhulu lalezi ziguli (77%) libike ngokungahleliwe lisebenzisa uhlobo oluthile lokwelashwa okuhambisanayo njengamavithamini noma izengezo zemvelo. Ngokumangazayo, abasebenzisi bakaVitamin E babe nokufa okuphezulu uma kuqhathaniswa nalabo abangazange basebenzise izithasiselo zikaVitamin E. (UMulphur BH et al, uNeurooncol Pract., 2015)
Kwesinye isifundo esivela e-Umea University, eSweden kanye neCancer Registry yaseNorway, abacwaningi bathatha indlela ehlukile yokunquma izinto ezinobungozi zomdlavuza wobuchopho, i-glioblastoma. Bathathe amasampula we-serum kuze kube yiminyaka engama-22 ngaphambi kokuxilongwa kwe-glioblastoma futhi baqhathanisa ukugxila kwemetabolite kwamasampuli we-serum walabo abakha umdlavuza kulabo abangawutholanga. Bathola ukuhlushwa okuphezulu kakhulu kwe-serum kaVitamin E isoform alpha-tocopherol kanye ne-gamma-tocopherol ezimweni ezakha i-glioblastoma. (UBjorkblom B et al, Oncotarget, 2016)
Ubungozi be-Vitamin E ku-Cancer Prostate
I-Selenium ne-Vitamin E Cancer Prevention Trial enkulu kakhulu (KHETHA) eyenziwe ezindaweni ezingama-427 e-United States, Canada nasePuerto Rico kumadoda angaphezu kwama-35,000 ukuhlola ubungozi bokusizakala kwe-Vitamin E. Lokhu kuhlolwa kwenziwa emadodeni abeneminyaka engama-50 noma ngaphezulu futhi abenamazinga aphansi e-prostate specific antigen (PSA) ka-4.0 ng / ml noma ngaphansi. Uma kuqhathaniswa nalabo abangathathanga izithako ze-Vitamin E (i-Placebo noma iqembu lesethenjwa), ucwaningo luthole ukwanda okuphelele engozini yomdlavuza wendlala yabesilisa kulabo abathatha izithasiselo zikavithamini E. Ngakho-ke, ukwesekwa nge-Vitamin E ekudleni / kokudla okunomsoco kuhlotshaniswa nengozi eyengeziwe yomdlavuza wendlala yabesilisa phakathi kwamadoda aphilile. (UKlein EA et al, JAMA, 2011)
Awukho umthelela we-Vitamin E ku-Cancer Lung
Ku-alpha-tocopherol, ucwaningo lokuvikela umdlavuza lwe-beta-carotene olwenziwe kubantu ababhemayo besilisa abaneminyaka engaphezu kwengu-50 ubudala, abatholanga ukuncipha ezimeni zomdlavuza wamaphaphu ngemuva kweminyaka emihlanu kuya kwengu-XNUMX yokwengezelelwa ekudleni nge-alpha-tocopherol. (U-Engl J Med omusha, 1994)
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Umhlomulo / Ubungozi be-Vitamin E kuCancer buxhunyaniswe nokuhlukahluka kofuzo ngakunye
Ucwaningo lwakamuva luhlaziye imiphumela ehlukahlukene yomthelela kaVitamin E kumdlavuza ohlukile, futhi lukhombisile ukuthi imiphumela yokuvikela umdlavuza yemithombo kaVitamin E yehlukile kubantu ngenxa yokwehluka kwe-enzyme eyenza iVitamin E emzimbeni. ICatechol-o-methyltransferase (COMT) yi-enzyme ecubungula uVitamin E emzimbeni wethu. Umuntu ngamunye angaba nokuhluka okuhlukile kwe-COMT, okuhlukile okukodwa kube nomsebenzi ophakeme kakhulu we-COMT, kanti okunye okuhlukile kunomsebenzi ophansi kanti abanye bangaba nekhophi ngayinye ngakho-ke babe nomsebenzi olinganiselayo we-COMT.
Ucwaningo luthole ukuthi ukusebenzisa imithombo ye-Vitamin E eyeqile kubantu abanokwehluka okuphezulu komsebenzi we-COMT kubabeka kusimo esingesihle sokukhuphuka okuphezulu. umdlavuza ingozi. Kubantu abanomsebenzi ohlukile ophansi we-COMT abathathe izithako ze-Vitamin E, ukuxhaswa kwe-Vitamin E kwaba nenzuzo futhi kwehlisa ingozi yabo yomdlavuza ngo-15% uma kuqhathaniswa nozakwabo abanomsebenzi ofanayo ophansi okuhlukile kwe-COMT abangazange bathathe isithasiselo se-Vitamin E.
Ngakho-ke, ngokuya ngalokhu kuhlaziywa, ukwehluka kwemiphumela yokuvimbela umdlavuza kaVitamin E kungaxhunyaniswa kakhulu nokwakheka kofuzo kwalowo muntu ngokwendlela uVitamin E ocutshungulwa ngayo emzimbeni. (IHolo, KT et al, J National Cancer Inst., 2019) Lokhu kuhluka okubizwa nge-pharmacogenetics kwaziwa kakhulu ezimpendulweni zemithi ehlukene ngokusekelwe ekuhlukeni kofuzo kubantu ngabanye. Lokhu manje sekutholakalele ukucutshungulwa kwemithombo ye-Vitamin E futhi kungase kusebenze kweminye imithombo yezakhi ezisetshenziswa kuyo umdlavuza umsoco/ukudla kanye..
Ngakho-ke ngenkathi ukudla kukaVitamin E kungaba lusizo ekwelashweni okuthile kwi-Ovarian Cancer, kungahle kusize ekunciphiseni ubungozi bamanye umdlavuza onjengomdlavuza weProstate.
Ukuqapha ukuthathwa
Umthamo onconywayo wansuku zonke weVitamin E ngu-15 mg. Ukweqa leli nani kungaholela emiphumeleni emibi efana nengcuphe eyengeziwe yokopha nokushaywa yisifo sohlangothi, ngaphandle kwezinto eziyingozi ezingenhla ezixhunyaniswe nokwanda komdlavuza wesinye kanye neglioblastoma, njengoba kubikiwe ezifundweni zokwelashwa.
Esinye sezizathu zokuthi i-Vitamin E eningi ye-antioxidant supplementation ingaba yingozi ngoba ingaphazamisa ibhalansi enhle yokugcina izinga elifanele lokucindezeleka okwenziwe nge-oxidative endaweni yethu yeselula. Ukucindezeleka kwe-oxidative kakhulu kungabangela ukufa kwamangqamuzana nokonakala kodwa ukucindezeleka okuncane kakhulu kwe-oxidative kungase futhi kuphazamise umthamo we-antioxidant ongokwemvelo oholela kwezinye izinguquko ezibalulekile. Olunye ushintsho olunjalo ukuncipha kofuzo oluyisihluthulelo lokucindezela isimila olubizwa ngokuthi i-P53, oluthathwa njengomnakekeli we-genome, ngaleyo ndlela kwandise amathuba okukhula. umdlavuza. (USayin VI et al, iSci Transl Med., 2014)
Ngakho-ke, ukwengeza ngokweqile iVitamin E (ikakhulukazi ekudleni komdlavuza wakho) kungaba yinto enhle kakhulu! Kungcono ukwandisa i-Vitamin E yakho ngokudla imithombo yokudla ecebile ka-Vitamin E kunokusebenzisa umthamo ophakeme we-Vitamin E, ngaphandle kwalapho kunconywa udokotela wakho.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.