Amaphuzu avelele
Umthamo ophakeme kakhulu we-Ascorbic Acid (Vitamin C) onikezwe ngemithambo kanye ne-chemotherapy ehlanganisiwe efana ne-FOLFOX ne-FOLFIRI, ezigulini ezinomdlavuza we-metastatic colorectal noma esiswini, inganikezwa ngokuphepha ngaphandle kobuthi obengeziwe. Ukuthatha umthamo ophakeme Vitamin C noma kufaka phakathi ukudla okunothile kukaVitamin C njengengxenye ye- Ukudla kweziguli ezinomdlavuza kanye nokwelashwa ngamakhemikhali kungase kuthuthukise ukusabela okuphelele futhi kunciphise imiphumela emibi ehlobene ne-chemotherapy kumdlavuza we-colorectal noma wesisu. umdlavuza.
Uvithamini C / Ascorbic Acid
I-Ascorbic Acid (I-Vitamin C) iyisikhuthazi se-antioxidant esivame ukusetshenziswa futhi esisetshenziswa kabanzi. Nokho, indima yayo ku umdlavuza ukuvimbela nokwelashwa kube nempikiswano. Nakuba ubufakazi obuthile be-anecdotal bubonisa ukuthi ukudla ukudla okucebile kwe-Vitamin C kunciphisa ingozi yomdlavuza, ubufakazi obuvela ezivivinyweni zomtholampilo ezingenele, ezingahleliwe nge-oral ascorbate azange zibonise inzuzo. Kodwa ocwaningweni lwakamuva lwe-preclinical olunethamo eliphezulu kakhulu le-ascorbic acid ukuchayeka ngokufakwa emthanjeni ngokukhetha okubulala amaseli omdlavuza, futhi kwabonisa imiphumela yokusebenzisana nemithi eyi-cytotoxic. Umthamo ophezulu kakhulu we-ascorbic acid ungafinyelelwa kuphela ngokufakwa kwe-intravenous futhi kulo mthamo, i-ascorbic acid ingaba nemiphumela ye-pro-oxidant, ibangele ukwanda kokulimala kwe-DNA, lokho kungabangela ukufa kwamangqamuzana omdlavuza. Ukwengeza, kunobufakazi bomtholampilo bokuqala obuqoqwayo obubonisa ukuthi umthamo ophezulu we-ascorbic acid unganikezwa ngokuphephile kanye nezidakamizwa ze-cytotoxic ezifana ne-gemcitabine, i-paclitaxel ne-carboplatin.UMa Y et al, uSci. Humusha. IMed., 2014; I-Welsh JL et al, iCancer Chemother Pharmacol, 2013)
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Usebenzisa i-Vitamin C / Ascorbic Acid kanye neChemotherapy kuMetastatic Colorectal and Gastric Cancer
Ukuhlola ukuphepha kanye nomthamo omkhulu obekezeleleke (MTD) we-ascorbic acid/ Vitamin C onganikezwa kanye nemithi ye-cytotoxic chemotherapy efana ne-FOLFOX ne-FOLFIRI, abacwaningi abavela e-Collaborative Innovation Center for Cancer Medicine, i-Sun Yat-sen University e-China. wenze isilingo somtholampilo esilindelekile seSigaba 1 (NCT02969681) ku-metastatic colorectal (mCRC) noma esiswini umdlavuza (mGC) iziguli. I-FOLFOX iyinhlanganisela yokwelapha ngamakhemikhali ehlanganisa izidakamizwa ezi-3: i-leucovorin (i-Folinic acid), i-Fluorouracil ne-oxaliplatin. Kuhlelo lwe-FOLFIRI, izidakamizwa ezi-4 ze-cytotoxic - i-Folinic acid, i-Fluorouracil, i-Irinotecan ne-Cetuximab isetshenziswa. (UWang F et al, Umdlavuza we-BMC, 2019)
Iziguli ezingama-36 zamaChinese zivivinywe ngomthamo wokukhuphuka kwe-ascorbic acid kusuka ku-0.2-1.5 g / kg nge-infusion yehora elingu-3, kanye ngosuku, izinsuku ezingu-1-3, kanye I-FOLFOX noma i-FOLFIRI kumjikelezo wezinsuku eziyi-14, kuze kutholakale i-MTD. Ezigulini ezingama-36 ezibhalisile, ezingama-24 (23 ezine-mCRC ne-1 ezine-mGC) zahlolwa ukuphendula isimila. Impendulo ephelele kunazo zonke ibandakanya ukuphendula okuyingxenye ezigulini eziyishumi nane (58.35%), izifo ezizinzile kweziyisishiyagalolunye (37.5%), ezinesilinganiso sokulawulwa kwezifo ezingama-95.8%. Abaphenyi babike ukuthi ayikho i-MTD efinyelelwe futhi abatholanga ubuthi obukhawulela umthamo obutholwe ekukhuleni komthamo. Imiphumela emibi ejwayelekile ebangelwe yi-ascorbic acid enomthamo omkhulu ibandakanya ikhanda, ikhanda elikhanyayo, umlomo owomile kanye nobuthi obuthile bamathumbu ngenxa yokufakwa ngaphakathi. Lolu cwaningo lukhombise nokwehla komnkantsha wamathambo omubi kanye nobuthi bamathumbu obuhambisana namakhambi we-chemotherapy lapho kunikezwa i-ascorbic acid ephezulu kanye ne-chemotherapy.
Okutholakele kulolu cwaningo kuphakamisa "ukuthi i-ascorbic acid / i-Vitamin C ku-1.5 g / kg kanye nsuku zonke izinsuku ezintathu ezilandelanayo ingalawulwa ngokuphepha ne-FOLFOX noma i-FOLFIRI chemotherapy emjikelezweni wezinsuku eziyi-14." (UWang F et al, Umdlavuza we-BMC, 2019)
Isiphetho
Umthamo omkhulu we-Vitamin C kanye/noma ukudla/ukudla okunothe ngo-Vitamin C onikezwa kanye nokwelashwa ngamakhemikhali kungase kuthuthukise ukusabela futhi kunciphise imiphumela engathandeki ehlobene nokwelashwa ngamakhemikhali kumdlavuza wesikhumba noma wesisu. umdlavuza.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) ikhambi lemvelo elingcono kakhulu umdlavuza kanye nemiphumela engemihle ehlobene nokwelashwa.