Ngowuphi umhlaza onokuzuza ngokubandakanya irharnati ekutyeni kwabo?

Iimbalasane

Irharnati yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kwePomegranate kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengophawu lomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Pomegranate inokunceda abo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin, kodwa isenokungabi yinto efanelekileyo kwizigulane ezifumana i-Cisplatin yeNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma. Ngaphaya koko, ngelixa irharnati inokunceda abantu abanomngcipheko wemfuza "ERBB2", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ERCC2". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwePomegranate kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuzo, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba irharnati lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / izongezo ezifana nerharnati endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iPomegranate ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iPomegranate ukuba unemfuzo enokuthanani nomhlaza onxulumene nejini ye-ERBB2? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ERCC2 gene? Ngaba kunenzuzo ukubandakanya irharnati ekutyeni kwakho ukuba ufunyaniswe unentloko eNcinci kunye neNtamo yeSquamous Cell Carcinoma, okanye ukuba uxilongo lwakho luyiPrimary Solitary Fibrous Tumor? Ngaphezu koko, kufuneka ulungelelanise ukusetyenziswa kwakho kwePomegranate ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Avastin ukuya kwi-Cisplatin? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'nerharnathi yindalo, ngoko ke isoloko iluncedo' okanye 'Irharnati yomeleza ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya irharnati kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngePomegranate kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Solitary Fibrous Tumor okanye i-Primary Head kunye neNeck Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela umngcipheko wemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana nePomegranate. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-ERBB2 unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ERCC2? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ulingana neNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo bafumana iCisplatin njengakwabo bafumana iAvastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi kubantu abasengozini eyahlukeneyo yemfuza kunye nonyango lomhlaza.

Irharnati – iSongezo seSondlo

I-Supplement Pomegranate iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Octadecanoic Acid, i-Hexadecanoic Acid, i-Betulinic Acid, i-Casuarinin kunye ne-Ursolic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-MYC Signaling, i-Epithelial ukuya kwi-Mesenchymal Transition, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Chromatin Remodeling, elawula iinkalo ezibalulekileyo zomhlaza kwinqanaba leselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengePomegranate, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa irharnati kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwePomegranate ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha ezongezelelo zerharnati

Ukuphendula umbuzo othi 'Ndingayiphepha nini irharnathi kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zePomegranate ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies, zonke zidlala indima ekunqumeni ukuba i-pomegranate ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Pomegranate Supplements iya kunceda i-Primary Head and Neck Squamous Cell Carcinoma izigulane ezifumana unyango lwe-Cisplatin?

Intloko eyiNtloko kunye neNtamo ye-Squamous Cell Carcinoma ibonakala ngokuguqulwa kofuzo oluthile, okuyi-FRG1BP, TP53 kunye ne-PCDH11X, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Epithelial kwi-Mesenchymal Transition, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kuxhomekeke kwindlela yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-pomegranate supplement, echaphazela i-Epithelial ukuya kwi-Mesenchymal Transition, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Head and Neck Squamous Cell Carcinoma xa ihamba nge-Cisplatin. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zePomegranate ziya kubazuzisa izigulana ezikwiPrimary Solitary Fibrous Tumor eziphantsi koNyango lweAvastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo sePomegranate lukhetho olunengqiqo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin. Oku kungenxa yokuba irharnathi inefuthe kwiindledlana ezifana ne-MYC yokuSayina, enokuthi ithintele izinto eziqhuba i-Primary Solitary Fibrous Tumor okanye ixhamle ukusebenza kwe-Avastin.

3. Ingaba izongezo zerharnati zikhuselekile kubantu abasempilweni abaneERCC2 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-ERCC2 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-ERCC2 kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nokulungiswa kwe-DNA, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-ERCC2 ehambelana nomngcipheko owongeziweyo woMhlaza woLusu, ingqiqo yezenzululwazi icebisa ukuphepha ukusebenzisa isongezelelo sePomegranate. Oku kungenxa yokuba isongezelelo sePomegranate sichaphazela iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, oku kunokukhokelela kwimiphumo emibi kumxholo we-ERCC2 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zerharnati zikhuselekile kubantu abasempilweni abaneERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ERBB2 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Chromatin Remodeling, i-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ERBB2 ehambelana ne-Esophageal Adenocarcinoma, cinga ukufaka izongezo zePomegranate kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela kakuhle iindlela ezifana neChromatin Remodeling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ERBB2 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana nePomegranate, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Ukungeniswa kokubanjwa komjikelo weseli kunye ne-apoptosis kumhlaza wemiphunga ongeyiyo encinci yomntu iiseli ze-A549 nge-casuarinin ukusuka kwixolo le-Terminalia arjuna Linn.
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekuchaseni unyango lwe-anti-angiogenic.