Iimbalasane
Ukudinwa okunxulumene nomhlaza okanye i-cachexia yimeko eqhubekayo, nexhalabisayo ebonwa kwizigulana ezinomhlaza nakwabasindileyo nkqu nakwiminyaka emva konyango. Izifundo ezahlukeneyo zibonisa ukuba ungenelelo olufanelekileyo lwesondlo kubandakanya ukusetyenziswa kwezongezo ze-zinc, iVitamin C, i-omega-3 fatty acids, guarana izicatshulwa, Ubusi be-tualang okanye ubusi obenziwe kunye nejeli yasebukhosini kunokuba negalelo elibonakalayo ekunciphiseni iimpawu ezinxulumene nokudinwa okanye i-cachexia kwiintlobo ezithile zomhlaza kunye nonyango. Ukunqongophala kukaVitamin D kwizigulana ezinomhlaza ezichaza ukudinwa kukwacebisa ukuba ukongezwa kweVitamin D kunokunceda ekunciphiseni iimpawu zecachexia.
Ukudinwa okungapheliyo okanye ubuthathaka obugqithisileyo obuhlala buqwalaselwa kwizigulana ezinomhlaza kubizwa ngokuba 'kukudinwa okunxulumene nomhlaza' okanye 'iCachexia'. Kwahlukile kubuthathaka obuqhelekileyo obuhlala buhamba emva kokuthatha ukutya okufanelekileyo kunye nokuphumla. I-Cachexia okanye ukudinwa kunokubangelwa sisifo somhlaza okanye iziphumo ebezingalindelekanga zonyango olusetyenziselwe ukunyanga umhlaza. Ubuthathaka ngokwasemzimbeni, ngokweemvakalelo nangokuqonda obonwa kwizigulana ngenxa yomhlaza okanye unyango lomhlaza okanye zombini ziyabandezeleka kwaye zihlala ziphazamisa ukusebenza kwesiqhelo kwabaguli.
Iimpawu zomhlaza onxulumene ne-cachexia:
- ukuncipha kakhulu
- ukulahleka kwesidlo
- i-anemia
- ubuthathaka / ukudinwa.
Ukudinwa okunxulumene nomhlaza okanye i-cachexia bekusoloko kuyingxaki ebonwa kwizigulana ezinomhlaza ngexesha nasemva kokuba unyango lomhlaza luphele ekulahlekeni kobunzima obukhulu. Ubungakanani bokudinwa kunye neempawu ezinxulumene nokukhathala okunxulumene nomhlaza zinokwahluka ngokusekwe kwizinto ezahlukeneyo kubandakanya:
- uhlobo lomhlaza
- unyango lomhlaza
- isondlo kunye nokutya
- Impilo yangaphambi konyango yesigulana
Ukuthatha ukutya okufanelekileyo kunye nezongezo njengenxalenye yesondlo somhlaza kubalulekile ukujongana neempawu zecachexia. Kule bhlog, siza kubonelela ngemizekelo yezifundo ezahlukeneyo ezenziwa ngabaphandi kwihlabathi liphela ukuvavanya ifuthe longenelelo lokutya okunesondlo kubandakanya izongezo / ukutya okwahlukeneyo ekunciphiseni ukudinwa okanye i-cachexia kwizigulana ezinomhlaza.
Uphononongo lweklinikhi olwenziwe ngabaphandi baseBrazil bavavanya idatha kwizigulana ezingama-24 kwi-chemotherapy ye-colorectal adenocarcinoma kwisibhedlele sikarhulumente esikhathalelo esiphakamileyo, ukuvavanya iimpembelelo zokuncedwa ngomlomo kwe-zinc kukhathala okunxulumene nomhlaza okanye i-cachexia. Izigulana zifumene iipilisi ze-zinc ngomlomo i-35mg kabini yonke imihla kwiiveki ze-16 kwangoko emva kotyando kude kube ngumjikelo wesine wekhemotherapy. (USofia Miranda de Figueiredo Ribeiro okqhubekayo, Einstein (Sao Paulo), Jan-Mar 2017)
Uphononongo lufumanise ukuba abaguli abangakhange bafumane iicapsule ze-zinc baxele ukonakala komgangatho wobomi kunye nokudinwa okwandileyo phakathi komjikelo wokuqala nowesine wekhemotherapy. Nangona kunjalo, abaguli abanomhlaza abebelawulwa ngee-capsules zeZinc khange baxele naluphi na uhlobo lobomi okanye imiba yokudinwa. Ngokusekwe kuphononongo, abaphandi bagqiba kwelokuba ukuxhaswa kwe-zinc kunokuba luncedo ekuthinteleni ukudinwa okanye i-cachexia kunye nokugcina umgangatho wobomi bezigulana ezinomhlaza ongalunganga kwi-chemotherapy.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Ukusetyenziswa kweVitamin C yoNyango oluDibeneyo lokuNyanga umhlaza
Kuphononongo lweklinikhi olupapashwe ngo-2019, abaphandi bavavanya ukhuseleko kunye nefuthe lokusebenzisa i-ascorbate (Vitamin C) kunye nonyango olusemgangathweni kwizigulana zomhlaza wobuchopho / i-glioblastoma. Uphononongo luhlalutye idatha evela kwi-11 ingqondo umhlaza izigulana kunye neziphumo ebezingalindelekanga zonyango zokudinwa, isicaphucaphu kunye neziganeko ezimbi ze-hematological ezinxulumene nomgangatho wonyango. (UAllen BG okqhubekayo, uMhlaza kwiCancer Res., 2019)
Abaphandi bafumanise ukuba umthamo ophakamileyo we-Vitamin C / ascorbate infusions uphucule ukusinda kwezigulana ze-glioblastoma ukusuka kwiinyanga ezili-12.7 ukuya kwiinyanga ezingama-23 kwaye kuncitshiswe neziphumo ebezingalindelekanga zokudinwa, isicaphucaphu kunye neziganeko ezigwenxa zehematological ezinxulumene nonyango lomhlaza wobuchopho. Iziphumo ezingalunganga kuphela ezinxulunyaniswa nokufakwa kweVitamin C abaguli abanamava kuyo yayingumlomo owomileyo kunye nokubanda.
Iziphumo zeVitamin C kuMgangatho woBomi beZigulana ezinomhlaza
Kwisifundo sokujonga esineziko elininzi, abaphandi bavavanye iziphumo zedosi ephezulu yokufakwa kweVitamin C kumgangatho wobomi bezigulana ezinomhlaza. Kolu phando, abaphandi bavavanya idatha yezigulana ezinomhlaza ezisandula ukufunyanwa ezifumene idosi ephezulu ye-Vitamin C njengonyango olunyangayo. Idatha evela kwizigulana ezinomhlaza ezingama-60 yafunyanwa kumaziko athatha inxaxheba eJapan phakathi kukaJuni noDisemba 2010. Uvavanyo lomgangatho wobomi lwenziwa kusetyenziswa idatha esekwe kwimibuzo efunyenwe ngaphambili, nakwiiveki ezi-2 ukuya kwezi-4 emva kwethamo eliphezulu leyeza elinethamo le-Vitamin C.
Uphononongo lubonise ukuba idosi ephezulu yolawulo lwe-Vitamin C inokuphucula impilo yezempilo kunye nomgangatho wobomi babaguli abanomhlaza. Isifundo sikwafumanise ukuphucuka komzimba, iimvakalelo, ukuqonda, kunye nokusebenza ekuhlaleni kwiiveki ezi-4 zolawulo lweVitamin C. Iziphumo zibonise ukunciphisa okukhulu kwiimpawu kubandakanya ukudinwa, iintlungu, ukuqaqanjelwa sisisu kunye nokuqhinwa. (UHidenori Takahashi okqhubekayo, ubuGcisa boLuntu obuCwangcisiweyo, 2012).
Ulawulo lweVitamin C kwizigulana ezinomhlaza wamabele
Kuphononongo lwamaziko amaninzi eJamani, idatha evela kwi-125 Stage IIa kunye ne-IIIb yezigulane zomhlaza wamabele zavavanywa ukuze kufundwe impembelelo yolawulo lwe-Vitamin C kumgangatho wobomi bezigulana zomhlaza wamabele. Kwezi, izigulana ezingama-53 zanikwa ivithamin C emithanjeni kunye nonyango lwazo lomhlaza ubuncinci kangangeeveki ezi-4 kwaye izigulana ezingama-72 azizange zinikwe iVithamin C. umhlaza unyango. (Claudia Vollbracht et al, KwiVivo., Nov-Dec 2011)
Uphononongo lufumanise ukuba xa kuthelekiswa nezigulana ezingakhange zifumane Vitamin C, kukho ukuncitshiswa okukhulu kwezikhalazo ezibangelwa sisifo kunye ne-chemotherapy / i-radiotherapy kubandakanya ukudinwa / i-cachexia, isicaphucaphu, ukuphelelwa ngumdla, ukudakumba, ukuphazamiseka ebuthongweni, isiyezi kunye ne-diemhesis yesifo kwezo zigulana zifumene iVithamin C. efakwa emithanjeni
Iziphumo ezifumaneka kwizigulana ezinomhlaza esekwe kwiProjekthi yeCachexia yeProjekthi yaseYurophu yokuNyamekela abantu
Ukuphononongwa ngokuchanekileyo kwenziwa ngabaphandi beSibhedlele saseYunivesithi yaseBonn eJamani, iYunivesithi yaseDiponegoro / iSibhedlele saseKariadi e-Indonesia kunye neYunivesithi yaseNorway yeSayensi kunye neThekhnoloji eNorway, ukuvavanya impembelelo yamavithamini, amaminerali, iiprotheni kunye nezinye izongezo kwi-cachexia kumhlaza. Uphando olucwangcisiweyo loncwadi kwiCENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov kunye nokukhethwa kwamaphephancwadi omhlaza de kube li-15 ku-Epreli 2016 kuveliswe iimpapasho ezingama-4214, apho ezingama-21 zazibandakanyiwe kufundo. (UMochamat okqhubekayo, J Cachexia Sarcopenia Muscle., 2017)
Uphononongo lufumanise ukuba ukongezwa kweevithamini C kukhokelele kuphuculo lwemiba eyahlukeneyo yobomi kwisampulu enezinto ezahlukeneyo zokufumanisa isifo somhlaza.
Impembelelo ye-β-hydroxy-β-methylbutyrate (HMB), iArginine kunye neGlutamine yokudibanisa kuMzimba oLinganisiweyo kwiZigulana eziQinisekileyo zeTumor
Kwisifundo esinye esichazwe apha ngasentla ebesiphantsi kweProjeki yasePalliative yoPhando lweZiko laseCachexia, abaphandi bafumanise ukuba unyango oludibeneyo lwe-β-hydroxy-β-methylbutyrate (HMB), i-arginine, kunye ne-glutamine ibonise ukwanda kobunzima bomzimba emva Kwiiveki ezi-4 kuphononongo lwezigulana ezomeleleyo eziqinileyo. Nangona kunjalo, bakwafumanise ukuba olu manyano alunasibonelelo kubunzima bomzimba ocekeceke kwisampulu enkulu yemiphunga ephambili kunye nezinye izigulana ezinomhlaza emva kweeveki ezisi-8. (UMochamat okqhubekayo, J Cachexia Sarcopenia Muscle., 2017)
Iprojekthi yeCachexia yeCandelo loPhando loNonophelo lwaseYurophu
I-European Palliative Care Research Centre Cachexia Project nayo yafumanisa ukuba vitamin D ukuxhaswa kunamandla okuphucula ubuthathaka bemisipha kwizigulane ezinomdlavuza we-prostate. (Mochamat et al, J Cachexia Sarcopenia Muscle., 2017)
Ukongeza, kwa isifundo esinye sikwafumanise ukuba i-L-carnitine inokukhokelela ekwandeni kobunzima bomzimba kunye nokonyuka kokusinda ngokubanzi kwizigulana ezinomhlaza wepancreatic.
Izifundo ezahlukeneyo zenziwe ukuqonda ubudlelwane phakathi kokusilela kweVitamin D kunye nokudinwa okanye i-cachexia kwizigulana ezinomhlaza.
Kwisifundo esapapashwa ngo-2015, abaphandi baseSpain bavavanya umbutho we-Vitamin D kunye nomgangatho wemicimbi yobomi, ukukhathala / i-cachexia kunye nokusebenza ngokomzimba kwizigulana ezinomhlaza okanye zemastatic okanye ezingasebenziyo ezinomhlaza. Phakathi kwezigulana ezingama-30 ezinomhlaza oqinileyo oqhubele phambili owayephantsi kokhathalelo lokunyanga, iipesenti ezingama-90 zazinesiphene seVitamin D. Uhlalutyo lweziphumo zolu phononongo lufumanise ukuba ukusilela kweVitamin D kunokunxulunyaniswa nokudinwa / i-cachexia enxulumene nomhlaza, iphakamisa ukuba ukongezwa kweevithamini D kunokunciphisa imeko yokudinwa kunye nokuphucula impilo yomzimba kunye nokusebenza kakuhle kwezigulana ezinomhlaza. (UMontserrat Martínez-Alonso okqhubekayo, uPalliat Med., 2016)
Nangona kunjalo, njengoko oku kucetyiswa kuphela ngokusekwe kwikhonkco phakathi kokusilela kweVitamin D kunye nokukhathala okunxulumene nomhlaza / i-cachexia, ukuqinisekiswa koku kutolikwa kwisifundo esilawulwayo kuyafuneka.
I-Omega-3 Fatty Acid Supplementation kwizigulana ezineBile Duct okanye iPancreatic Cancer ephantsi kweChemotherapy
Kwisifundo esenziwe ngabaphandi beJikei University School of Medicine, eTokyo eJapan, into yokutya (ukutya ukutya ngephecana lesisu (GI)) isondlo esenziwe nge-omega-3 fatty acids, yanikwa i-27 pancreatic kunye ne-bile duct izigulana ezinomhlaza. Ulwazi malunga nobunzima bemisipha kunye novavanyo lwegazi lwafunyanwa ngaphambi kokunika i-omega-3-fatty acid supplement kwizigulana nakwiiveki ezi-4 ukuya kwezi-8 emva kokuba beqalisile ukuthatha izongezo. (UKyohei Abe okqhubekayo, iAnticancer Res., 2018)
Uphononongo lufumanise ukuba kuzo zonke izigulana ezingama-27, ubukhulu bamathambo buye bonyuka kakhulu kuzo zombini iiveki ezi-4 nezisi-8 emva kokuqaliswa kwe-omega-3-fatty acids xa kuthelekiswa nobunzima bemisipha ngaphambi kolawulo lwe-omega-3-fatty acids. Iziphumo zophononongo zicebise ukuba i-omega-3 fatty acid supplementation kwizigulana ezinomhlaza ongafunekiyo womhlaza wepancreatic kunye ne-bile duct inokuba luncedo ekuphuculeni umhlaza weempawu zomhlaza.
N-3-fatty acid use in Pancreatic Cancer Izigulana zeCachexia
Olunye uvavanyo lweklinikhi lwenziwe ngabaphandi baseJamani ukuthelekisa idosi esezantsi phospholipids kunye neoyile yeentlanzi, ezazinexabiso elifanayo kunye nokwakhiwa kwe-n-3 fatty acid, kubunzima kunye nokuzinzisa ukutya, umgangatho wobomi kunye neeplasma ezinamafutha acid-iiprofayili. kwizigulana ezinomhlaza wepancreatic. Uphononongo lubandakanya abaguli abanomhlaza wepancreatic abangama-60 ababenikwe ioyile yeentlanzi okanye i-phospholipids yaselwandle. (UKristin Werner okqhubekayo, Lipids Health Dis. 2017)
Uphononongo lufumanise ukuba ungenelelo ngedosi esezantsi ye-n-3-fatty acids, nokuba yioyile yeentlanzi okanye ukuxhaswa kweMPL, kukhokelele ekuthembekeni kobunzima kunye nokutya okuzinzisayo kwizigulana ezinomhlaza wepancreatic. Uphononongo lufumanise ukuba iifomsile zaselwandle ze-phospholipids zazinganyamezelwa ngcono xa zineziphumo ebezingalindelekanga, xa kuthelekiswa nongezo lweoyile yentlanzi.
I-Omega-3-Fatty Acid Supplementation kwizigulana zesisu kunye nezigulana ezinomhlaza wemiphunga
Kuhlalutyo lweemeta olwenziwe ngabaphandi basePortugal, bavavanya isiphumo se-n-3 polyunsaturated fatty acids kwiimpawu zesondlo kunye nomgangatho wobomi kumhlaza wecachexia. Bafumene izifundo zeklinikhi zophando ezipapashwe phakathi kwe-2000 kunye ne-2015 ngophando loncwadi kwi-PubMed nakwi-B-yolwazi. Izifundo ezi-7 zisetyenziselwe uhlalutyo. (UDaryna Sergiyivna Lavriv okqhubekayo, iklinikhi yesondlo ESPEN., 2018)
Uphononongo lufumanise ukuba ubunzima bezigulana ezinomhlaza wamathumbu zonyuke kakhulu ngokusetyenziswa kwe-n-3 polyunsaturated fatty acids, nangona kunjalo, abaguli abanomhlaza wemiphunga ababonisanga mpendulo ibalulekileyo.
IGuarana (Paullinia cupana) Sebenzisa kwizigulana ezinomhlaza ophambili
Abaphandi abavela kwi-ABC Foundation Medical School eBrazil bavavanye ifuthe lokukhutshwa kwe-guarana ekwehleni komdla wokutya kunye nokwehla kwesisindo kwizigulana ezinomhlaza. Izigulana zanikwa i-50 mg yesicatshulwa esomileyo se-guarana kabini ngemini iiveki ezi-4. (UCláudia G Latorre Palma okqhubekayo, J Diet Suppl., 2016)
Ngaphandle kwezigulana ezili-18 ezigqibe umthetho olandelwayo, abaguli ababini bafumana ubunzima obungaphezulu kwe-5% kwisiseko sabo kwaye abaguli abathandathu babenokuphuculwa kwamanqaku ama-3 kwinqanaba lokutya xa kulawulwa izicatshulwa ze-guarana. Bafumanise ukuba kukho ukwehla okubonakalayo kukungabikho komdla kunye nokulala amaxesha amade ngokungaqhelekanga.
Isifundo siqwalasele ukuzinza kobunzima kunye nokwanda kokutya xa kusongezwa izicatshulwa ze-guarana ezibonisa izibonelelo zokudinwa okunxulumene nomhlaza / i-cachexia. Abaphandi bacebisa ukuqhubeka kwezifundo ze-guarana kwesi sigulana sinomhlaza.
Kwisifundo seklinikhi kubandakanya abathathi-nxaxheba abangama-40, abaphakathi kweminyaka eli-18 ukuya kwengama-65, benomhlaza wentloko nentamo abagqibe ichemotherapy kunye / okanye i-radiotherapy kwisibhedlele i-USM, iKelantan Malaysia okanye iSibhedlele iTaiping, abaphandi bavavanye ifuthe lokuxhasa ubusi beTualang okanye uVitamin C ku ukudinwa kunye nomgangatho wobomi. (UVinji Ramasamy, iGulf J Oncolog., 2019)
Uphononongo lufumanise ukuba emva kweeveki ezine kunye nesibhozo zonyango kunye nobusi beTualang okanye uVitamin C, inqanaba lokudinwa kwezigulana ezanyangwa ngobusi beTualang lalibhetele kakhulu kunalezo zazinyangwe ngeVitamin C. Abaphandi bafumanisa ukuphucuka okukhulu kumgangatho wobomi. kwizigulana ezanyangwa ngobusi beTualang kwiveki 8. Nangona kunjalo, apho abafumananga mahluko mkhulu / uphuculo kubalo lweseli emhlophe kunye nenqanaba le-C-esebenzayo yeeprotheyini phakathi kwamaqela amabini ezigulana.
Kwisifundo esapapashwa ngo-2016, abaphandi abavela kwiiyunivesithi ezahlukeneyo zenzululwazi yezonyango eIran bavavanya ukusebenza kobusi obuqhubekileyo kunye nejeli yasebukhosini kwiimpawu zokudinwa okanye i-cachexia kwizigulana ezinomhlaza ezifumana unyango lwehomoni, ichemotherapy, i-chemo-radiation okanye i-radiotherapy. Olu phononongo lubandakanya abathathi-nxaxheba abangama-52 kwizigulana abatyelele iklinikhi ye-oncology yesibhedlele saseShohada-e-Tajrish eTehran (Iran) phakathi kukaMeyi 2013 no-Agasti 2014. Iminyaka yobudala yezi zigulana yayimalunga neminyaka engama-54. Kwezi, izigulana ezingama-26 zafumana ubusi obuqhubekileyo kunye nejeli yasebukhosini, ngelixa abanye befumana ubusi obusulungekileyo, kabini imihla ngemihla iiveki ezi-4. (Mohammad Esmaeil Taghavi okqhubekayo, Ugqirha we-Electron., 2016)
Uphononongo lufumanise ukuba ukusetyenziswa kobusi obuqhubekileyo kunye nejeli yasebukhosini kunciphise kakhulu ukudinwa okanye iimpawu ze-cachexia kwizigulana ezinomhlaza xa kuthelekiswa nokusetyenziswa kobusi obusulungekileyo.
isiphelo
Uninzi lwezifundo ezichazwe apha ngasentla zibonisa ukubaluleka kokuthatha ukutya okufanelekileyo kunye nezongezo zeentlobo ezithile zomhlaza ukunciphisa ukudinwa kunye ne-cachexia kwizigulana ezinomhlaza. Ukuthatha izongezo ze-zinc, i-Vitamin C, i-omega-3 fatty acids, i-guarana extracts, i-tualang honey, i-honeyed processed kunye ne-royal jelly inokuba negalelo elikhulu ekunciphiseni ukudinwa okanye i-cachexia kwiintlobo ezithile zomhlaza kunye nonyango. Ukunqongophala kukaVitamin D kwizigulana ezinomhlaza ezixela ukudinwa kunokubonisa ukuba ukongezwa kweVitamin D kunokunceda ekunciphiseni i-cachexia.
Ukungenelela kwesondlo kudlala indima enkulu ekunciphiseni ukudinwa okanye iimpawu ze-cachexia kwizigulana ezinomhlaza nakwabasindileyo. Izigulana ezinomhlaza kufuneka ke ngoko zidibane ne-oncologist kunye nesondlo sokutya ukuze ziyile isicwangciso esifanelekileyo sesondlo esenzelwe umhlaza kunye nonyango ukuphucula umgangatho wobomi.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.