Iimbalasane
I-DIM okanye i-diindolylmethane, isongezelelo esisetyenziswa ngokuxhaphakileyo, yimetabolite ye-I3C (indole-3-carbinol), efumaneka kakhulu kwimifuno enempilo efana ne-broccoli, ikhaphetshu, icauliflower kunye ne-kale. Izigulana ezinomhlaza zihlala zizama ukubandakanya izongezo zokutya ngokungacwangciswanga kunye nonyango lwabo oluqhubekayo lomhlaza ukuphucula umgangatho wobomi babo okanye unyango olusebenzayo, ngokucinga ukuba ukuthatha nasiphi na isongezelelo sendalo okanye isityalo esisekwe kunye nonyango lwabo oluqhubekayo kuhlala kukhuselekile kwaye kunokubangela ukwenzakala. Oku akusoloko kuyinyani. Ngokusekwe kuhlobo lomhlaza kunye nonyango, iimpembelelo zezi zongezelelo zinokwahluka kwaye zinokuphazamisa unyango oluthile lomhlaza. Kule bhlog, sixoxa ngesinye sezifundo zeklinikhi ezifumanise ukuba i-DIM (diindolylmethane) inokuphazamisa iTamoxifen, unyango oluqhelekileyo lomhlaza wamabele, kunye nokunciphisa amanqanaba e-metabolite esebenzayo yeTamoxifen. Unxibelelwano lwe-DIM-tamoxifen lunokuthi luchaphazele ukusebenza kweTamoxifen kwaye kungoko kungcono ukuba ungabandakanyi izongezo ze-DIM njengenxalenye yebele Ukutya kwabaguli abanomhlaza ngelixa ufumana unyango lweTamoxifen. Oku kuqaqambisa imfuneko yesicwangciso sesondlo somntu esinokutya okufanelekileyo kunye nezongezo ukuxhasa okuthe ngqo umhlaza unyango kwaye ufumane izibonelelo kwaye uhlale ukhuselekile.
Ukusetyenziswa kwe-DIM (diindolylmethane) kuMhlaza webele
Kukho inani elikhulu labasindileyo kumhlaza wamabele abazichaza ngokwabo isityalo sokutya esine-bio-active sezongezo ngenjongo yokuthintela. umhlaza ukuphindaphinda kwaye ufumane izibonelelo zokusinda. Ukhetho lwezongezelelo abaluthathayo alukhethi olusekwe kudluliselo oluvela kubahlobo kunye nosapho, okanye ngokusekelwe kukhangelo lwabo lwewebhu kunye nolwazi kwi-intanethi.
Isongezelelo esisetyenziswa ngokuxhaphakileyo yi-DIM (diindolylmethane), imetabolite ye-I3C (indole-3-carbinol), efumaneka kwimifuno enqatyisiweyo efana ne-broccoli, icauliflower, i-kale, ikhaphetshu, nehlumelo laseBrussels. Ukusetyenziswa okuxhaphakileyo kwe-DIM phakathi kwezigulana ezinomhlaza wamabele kunokuba kusekwe kwiziphumo ezivela kwizifundo zeklinikhi eziqwalaselweyo kubandakanya isifundo seWomen's Healthy Eating and Living (WHEL) kwizigulana ezingaphezulu kwe-3000 zomhlaza wamabele ezifumene umbutho wokuncipha komngcipheko wokuphindaphinda komhlaza webele kubafazi abathatha Unyango lweTamoxifen, ekwa yitya imifuno enqatyisiweyo njengenxalenye yokutya kwabo. Lo mbutho njengabaphandi unokunxulunyaniswa nomsebenzi wee-phytochemicals ezinje nge-DIM kule mifuno iphambili ine-anti-cancer kunye nepropathi ezichasayo (I-Thomson CA, Unyango lweCancer Breast., 2011). Olunye uphononongo lwe-meta lwakutshanje lwe-13 lokulawulwa kwamatyala kunye nolwazelelo lwezifundo zeqela kwakhona liphakamise ukuba ukusetyenziswa okuphezulu kwemifuno ye-cruciferous (etyebileyo kwi-indole-3-carbinol) enjenge-broccoli, i-kale, iklabishi, icauliflower kunye nesipinatshi kwindawo yokutya yayihambelana kakhulu ngomngcipheko ophantsi we-15% womhlaza webele (Liu X okqhubekayo, Isifuba, 2013).
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-DIM (diindolylmethane) kunye nokuhlangana kweTamoxifen kuMhlaza weSifuba
Izigulana ezinomhlaza wamabele ezine-hormone eyakhayo (i-Estrogen Receptor ER +) umhlaza webele unyangwa nge-adjuvant Tamoxifen yonyango lwe-endocrine ixesha elongezelelweyo leminyaka emi-5 ukuya kweli-10 emva kotyando kunye nonyango lwe-chemo-radiation. I-Tamoxifen yindlela ekhethiweyo ye-estrogen receptor modulator (i-SERM) esebenza ngokukhuphisana nehomoni ye-estrogen yokubopha kwi-ER kwizihlunu zebele, oko ke kuthintela iziphumo zomhlaza we-estrogen. I-Tamoxifen, ichiza lomlomo, lixutywe yi-cytochrome P450 enzymes esibindini kwii-bioactive metabolites ezingabalamli abaphambili bokusebenza kwe-tamoxifen. Kukho ezinye izongezelelo zezityalo ezivela kwizityalo ezinokuthi ziphazamise imetabolism yeTamoxifen kwaye ngaloo ndlela kunciphise uxinzelelo lweziyobisi ezingaphantsi konyango lwazo. Olunye uvavanyo olungenamkhethe, oluyimfama kabini, olulawulwa yi-placebo ngokusetyenziswa kwesongezelelo se-DIM, imetabolite ye-indole-3-carbinol eyakhiwe kwimifuno ebethelelweyo, kunye neTamoxifen, kwizigulana ezinomhlaza wamabele, ibonakalisile le meko yothusayo yokuncitshiswa kwetamoxifen metabolite , ukuba abaguli abanomhlaza wamabele kwizongezo ze-DIM kufuneka bazi.
Iinkcukacha zoFundo
Iinkcukacha zolingo lweklinikhi olungahleliwe, olulawulwa yi-placebo ukuvavanya ibele elicetywayo umhlaza Umsebenzi we-chemopreventive we-DIM kwizigulane zomhlaza wesifuba ezithatha unyango lwe-Tamoxifen zishwankathelwa ngezantsi (NCT01391689) (Ref: Thomson CA, Breast Cancer Res. Treat., 2017).
- Kwakukho abafazi abali-130 ababhalelwe i-Tamoxifen, ababehlule ngokungacwangciswanga baba ngamaqela amabini: iqela elalifumene iinyanga ezili-12 nokuba li-DIM longeze kwi-150 mg, kabini ngemini, okanye kwi-placebo. Abafazi abangama-98 basigqibile isifundo (iqela le-placebo engama-51, iqela lama-47 le-DIM).
- Indawo yokugqibela yophando yayikukuvavanya utshintsho kumanqanaba okuchama kwiimetabolites zehomoni ye-estrogen 2/16-hydroxyestrone, leyo ichasene ne-tumorigenic metabolite. Ezinye iindawo zokuphela kwesibini ziye zavavanywa kubandakanya i-serum estrogens, ukuxinana kwebele kusetyenziswa i-mammography okanye i-MRI, kunye namanqanaba e-tamoxifen metabolites.
- I-DIM inyuse inqanaba le-anti-tumorigenic estrogen metabolite xa kuthelekiswa ne-placebo, esisiphumo esifanelekileyo sokuchasana nemichiza.
- Akukho lutshintsho lufumanekayo kubuninzi bebele phakathi kwala maqela mabini.
- Ukufumanisa okumangalisayo kukuba bekukho ukuncitshiswa kwamanqanaba e-plasma yeemetabolites ezisebenzayo ze-tamoxifen (endoxifen, 4-hydroxy tamoxifen, kunye ne-N-desmethyl tamoxifen). Kwiqela le-DIM, bekukho ukuncipha okubalulekileyo kumanqanaba e-plasma kwiimetabolites ezisebenzayo ze-tamoxifen, kunye neziphumo zoku kuncitshiswa okubonakalayo kwiiveki ze-6 kwaye kuzinza ngokuhamba kwexesha. Amanqanaba e-tamoxifen metabolites esebenzayo yabasetyhini kwiqela le-DIM abonwa engaphantsi komqobo wonyango wokusebenza kwe-tamoxifen.
isiphelo
Nangona ukuncipha kwamanqanaba e-tamoxifen kubonisa ukuphazamiseka okanye ukusebenzisana phakathi kwe-DIM kunye ne-Tamoxifen metabolism, abaphandi bolu phononongo bacebisa uphando olongezelelweyo ukufumanisa ukuba amanqanaba anciphayo e-tamoxifen metabolites esebenzayo aya kunciphisa kakhulu izibonelelo zekliniki ze-tamoxifen. Nangona kunjalo, kuba idatha yeklinikhi ibonisa indlela yokusebenzisana phakathi kwe-DIM (i-metabolite ye-indole-3-carbinol) kunye ne-tamoxifen, kuya kukhethwa ibele. umhlaza izigulane kunyango lwe-tamoxifen ukuba zijike kwicala lokulumkisa kwaye zigweme ukuthatha i-DIM ngelixa kunyango lwe-Tamoxifen. Ukutya okusekwe kwisityalo kubandakanya imifuno e-cruciferous equlethe i-indole-3-carbinol inokubonelela ngenzuzo efunekayo ngokuthatha isongezelelo sokutya se-DIM ngelixa kunyango lwehomoni lomhlaza wamabele.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.