Iimbalasane
Amachiza ePlatin chemotherapy abandakanya iCisplatin kunye neCarboplatin, nangona amachiza omhlaza asebenzayo, ayaziwa ngokubangela iziphumo ebezingalindelekanga, enye yazo kukuhla okumandla kumanqanaba eeminerali ebalulekileyo yeMagnesium emzimbeni, ekhokelela kukwenzakala kwezintso. Izifundo zeklinikhi ziye zaxela ukuba ukusetyenziswa kweMagnesium yokongeza kunye nonyango lwePlatinam luluncedo ekubaleni ukuncipha kunye nokunciphisa iziphumo ebezingalindelekanga zechemotherapy yetyhefu yezintso umhlaza.
Ukusetyenziswa konyango lwePlatinum kwiCancer
Unyango lwePlatinam ngamachiza afana neCisplatin kunye neCarboplatin yinxalenye yesixhobo sokulwa nomhlaza kuninzi lomhlaza obandakanya i-ovarian, umlomo wesibeleko, imiphunga, isinyi, testicular, intloko kunye nomhlaza wentamo kunye nabanye abaninzi. ICisplatin yayilichiza lokuqala leplatinam elivunyiweyo njenge umhlaza unyango ngo-1978 kwaye lusetyenziswa ngabanye kwaye ludityaniswe namanye amachiza echemotherapy. La machiza ayakwazi ukuphelisa iiseli zomhlaza ezikhula ngokukhawuleza ngokubangela uxinzelelo olugqithisileyo lwe-oxidative kunye nomonakalo we-DNA, othintela ukuphindaphinda kunye nokukhula. Nangona kunjalo, umonakalo we-DNA owenziwe ngala machiza eplatinam nawo uchaphazela ezinye iiseli eziqhelekileyo zomzimba kwaye kungoko la machiza anxulunyaniswa nomonakalo owenzelwa isibambiso okhokelela kwiziphumo ebezingalindelekanga ezimandundu nezingafunekiyo.
Ukupheliswa kweMagnesium-Isiphumo esisecaleni sePlatinum Chemotherapy
Esinye seziphumo ebezingalindelekanga ezinxulunyaniswa neCisplatin okanye iCarboplatin unyango lweplatinam kukudinwa okukhulu kumanqanaba eeminerali ebalulekileyo iMagnesium (Mg) emzimbeni, ekhokelela kwihypomagnesemia (U-Lajer H et al, Umhlaza waseBritane J Cancer, 2003). Le meko inxulunyaniswa nomonakalo we-cisplatin okanye we-carboplatin. I-Hypomagnesemia inokunxulunyaniswa nenani lezinto ezinobungozi besifo sentliziyo, imithambo-luvo okanye isimilo esibonisa ukuba inani elikhulayo labasindileyo bomhlaza bajongene nalo, kakhulu emva kokugqitywa kweerejimeni zabo ze-chemotherapy kunye nokuxolelwa (Velimirovic M. et al, Hosp. Ziqhelise. (1995), 2017).
Isifundo soMbutho phakathi kweMagnesium Ukungaqhelekanga kwiCarboplatin Chemotherapy inyange iCancer yeOvarian
Isifundo esivela kwiziko le-MD Anderson Cancer Centre, e-USA, sihlalutye umanyano lokungaqheleki kwemagniziyam kunye ne-hypomagnesemia kwizigulana ezinomhlaza we-ovari ziphathwe nge-carboplatin. Bahlalutye imiqondiso ebalulekileyo kunye neerekhodi zovavanyo lwelabhoratri yezigulana ezingama-229 ezihambele phambili zomhlaza we-ovari ezazenziwe uqhaqho kunye nonyango lwe-carboplatin chemotherapy phakathi kukaJanuwari 2004 ukuya kuDisemba 2014 (U-Liu W okqhubekayo, Oncologist, 2019). Bafumanise ukuba ukwenzeka rhoqo kwe-hypomagnesemia kwizigulana ngexesha lonyango lwe-carboplatin kwakucacisa kwangaphambili ukusinda okufutshane. Oku kwakuzimeleyo ekupheleleni kokuncitshiswa kwethumba kwezi zigulana zinomhlaza we-ovari.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izixhobo zeMagnesium Sebenzisa ngexesha lePlatinum Chemotherapy
Ukusetyenziswa kwezongezelelo zeMagnesium ngexesha lonyango lwePlatinum umhlaza yavavanywa kwizifundo zeklinikhi kwaye ibonise inzuzo. Kuvavanyo lweklinikhi olulawulwa ngokungalindelekanga, oluvulelekileyo olwenziwe kwiYunivesithi yase-Iran yeNzululwazi yezoNyango eTehran, i-oral magnesium oxide supplementation kunyango lwe-Cisplatin kwizigulana ezingama-62 zabantu abadala ezinomhlaza we-non-leukemia osanda kufunyaniswa. Kwakukho izigulane ze-31 kwiqela lokungenelela elinikwe i-Mg supplementation kunye ne-Cisplatin kunye ne-31 kwiqela lolawulo ngaphandle kokuxhaswa. Baye bafumanisa ukuba ukuhla kwamanqanaba e-Mg kwiqela lolawulo kwakubaluleke kakhulu. I-Hypomagnesemia yabonwa kuphela kwi-10.7% yeqela lokungenelela kunye ne-23.1% kwiqela lolawulo (UZarif Yeganeh M et al, Iran J Ezempilo Zoluntu, 2016). Olunye uphononongo olwenziwe liqela laseJapan luqinisekisile ukuba ukulayishwa kwangaphambili nge-Mg supplementation ngaphambi konyango lweCisplatin kunciphise kakhulu i-Cisplatin eyenze ukuba ityhefu yezintso (14.2 kuthelekiswa ne-39.7%) kwizigulana ezinomhlaza we-thoracic. (U-Yoshida T. okqhubekayo, eJapan J Clin Oncol, 2014).
isiphelo
Umhlaza ukuba awunyangwa unokubulala, kwaye ukhetho lwechemotherapy nangona imiba yabo eyahlukeneyo kunye nemingeni eneziphumo ebezingalindelekanga ezimandundu, kufuneka zisetyenziswe ukulawula isifo. Ke ngoko, kunye nezicwangciso zokunciphisa imingcipheko yeziphumo ebezingalindelekanga zechemotherapy, njengokongeza ngeMg ngaphambi nangexesha lonyango lweplatinam, umhlaza Izigulana zinokutya ukutya okutyebileyo kwiMagnesium njengembewu yethanga, iialmonds, oatmeal, tofu, isipinatshi, ibhanana, iavokhado, itshokolethi emnyama kunye nokunye ukongeza izondlo eziphelelwe lixesha kunye neeminerali ezinemithombo yendalo, ezifunxwa lula umzimba. Indlela edibeneyo yokudibanisa unyango lwe-chemotherapy kunye nezongezelelo ezihambelanayo kunye nezesayensi, iiminerali, kunye neevithamini, kunye nokutya okunempilo, ziyafuneka ukuze kuphuculwe amathuba okuphumelela kwizigulana ezinomhlaza!
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukuphepha ukuqagela kunye nokukhetha okungakhethiyo) lolona nyango lulungileyo lwendalo umhlaza kunye neziphumo ebezingalindelekanga ezinxulumene nonyango.