Iimbalasane
Umhlaza we-genome / ulungelelwaniso lwe-DNA lunokunceda ekuchongeni umhlaza ngokuchanekileyo, ukuxela kwangaphambili okungcono kunye nokuchongwa kweendlela zonyango ezizezakho ezisekwe kwiimpawu zomhlaza womhlaza. Nangona kunjalo, ngaphandle kokukhula kokuthandwa kunye ne-hype malunga nezibonelelo kunye nokusetyenziswa kokulandelelana komhlaza we-genomic, kukho kuphela iqhezu lezigulana ezixhamlayo ngoku.
Kumntu osandula kufunyaniswa ukuba unalo umhlaza kunye nokujongana nokothuka kolu kuxilongwa, kukho imibuzo emininzi yokuba njani, yintoni, kutheni kunye namanyathelo alandelayo. Bonganyelwe ngamagama amaninzi kunye nejargon, enye yazo lulandelelwano lwegenomic yomhlaza kunye nonyango lomntu.
Yintoni ukuLandelelana kweTumor Genomic?
Ulandelelwano lwesisu somzimba bubuchule bokufumana uhlobo lwe-molecular scan ye-DNA ekhutshwe kwiiseli zethumba ezifunyenwe kumzekelo we-biopsy okanye kwigazi okanye umongo wethambo lesigulana. Olu lwazi lubonelela ngeenkcukacha malunga nokuba yeyiphi imimandla ye-DNA ye-tumor yahluke kwi-non-tumor cell DNA kunye nokutolikwa kwedatha yolandelelwano lwe-genomic inika ingqiqo kwiijezi eziphambili kunye nabaqhubi umhlaza. Kubekho ukuqhubela phambili okumangalisayo kubuchwephesha bokulandelelana okwenze ukuba ufumane ulwazi lwe-genomic ye-tumor ngexabiso eliphantsi kwaye ifikeleleke ngakumbi kusetyenziso lwezonyango. Iiprojekthi zophando ezininzi ezixhaswa ngoorhulumente abohlukeneyo kwihlabathi liphela zidibanisa idatha kwi-tumor genomic ulandelelwano lwamanani amakhulu abaguli abanomhlaza, kunye nembali yabo yezonyango, iinkcukacha zonyango kunye neziphumo zonyango, eziye zenziwa zafumaneka ukuze zihlalutywe kwindawo yoluntu kwiiprojekthi. ezifana: ICancer Genome Atlas (TCGA), Genomic England, cBIOPortal kunye nabanye abaninzi. Uhlalutyo oluqhubekayo lwezi datha zikhulu zomhlaza zinike umbono ophambili otshintsha imeko yemigaqo yonyango lomhlaza kwihlabathi liphela:
- Umhlaza wemvelaphi ethile yethishu njengayo yonke imihlaza yomhlaza wamabele okanye yonke imihlaza yemiphunga, ebikade icingelwa ukuba inembali efanayo kwaye inyangwa ngokufanayo, namhlanje iyabonwa njengokwahluka kakhulu kwaye yahlulwa yangamacandelwana eemolekyuli ezizodwa ekufuneka ziphathwe ngokwahlukileyo.
- Nokuba ngaphakathi kwe-molekyuli subclass yomqondiso othile womhlaza, iprofayili nganye yesifo somntu eyahlukileyo yahlukile kwaye yahlukile.
- Uhlalutyo lwe-genomic lomhlaza we-DNA lubonelela ngolwazi malunga nokuphazamiseka kofuzo oluphambili (uguquko) olunoxanduva lokuqhuba isifo kwaye uninzi lwezi ziyobisi zenzelwe ukuthintela isenzo sabo.
- Ukungaqheleki komhlaza kwi-DNA kunceda ekuqondeni ngcono iindlela ezisebenza ngayo iseli yomhlaza ekukhuleni kwayo okuqhubekekayo nokukhawulezayo kunye nokusasazeka, kwaye oku kuyanceda ekufumaneni amachiza amatsha nala kujoliswe kuwo ngakumbi.
Ke ngoko, xa kuziwa kwisifo esifana nomhlaza, esidibaniswa neziphumo ezibi kunye nokubulala, lonke ulwazi olunceda ekuqondeni iimpawu zomhlaza womntu luluncedo.
Kutheni izigulana ezinomhlaza kufuneka ziqwalasele ukuLandelelana kweTumomic Genomic Sequicing?
Uluhlu olungezantsi zizizathu ezintathu eziphambili zokuba izigulana kufuneka ziqwalasele ngokulandelelana kwe-DNA yazo kunye neengcali zokubonisana neziphumo zazo:
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Ukulandelelana kweCarome yeCancer hi-elps ngoQeqesho oluchanekileyo
Kwiimeko ezininzi, indawo kunye nonobangela womhlaza oyintloko awucacanga kwaye ukulandelelana kwe-genome yesisu se-DNA kunokunceda ekuchongeni ngcono indawo yokuqala yethumba kunye nemfuza ephambili yomhlaza, ngaloo ndlela kubonelelwe ngokuchanekileyo isifo. Kwiimeko ezinjalo zomhlaza ezinqabileyo okanye zomhlaza eziye zafunyaniswa kade kwaye ziye zasasazeka kumalungu ahlukeneyo, ukuqonda iimpawu zomhlaza kunokunceda ekuchongeni iindlela zonyango ezifanelekileyo.
Ukulandelelana komhlaza kwiCancer hI-elps enesifo esingcono
Ukusuka kwidatha yokulandelelana enye ifumana iprofayili ye-genomic ye umhlaza DNA. Ngokusekwe kuhlalutyo lwedatha yolandelelwano lwabemi bomhlaza, iipateni zokungaqhelekanga ezahlukeneyo ziye zanxulunyaniswa nobungqongqo besifo kunye nokuphendula konyango. Umz. Ukungabikho kofuzo lwe-MGMT luqikelela impendulo engcono nge-TMZ (Temodal) kwizigulane ezinomdlavuza wengqondo i-glioblastoma multiforme. (UHegi ME okqhubekayo, u-Engl J Med omtsha, ngo-2005Ubukho bokutshintsha kwemfuza kwe-TET2 kwonyusa amathuba okuphendula kudidi oluthile lwamachiza abizwa ngokuba zii-hypomethylating agents kwizigulana ezinomhlaza. (Bejar R, Igazi, 2014) Olu lwazi ke lunika ukuqonda ngobukrakra kunye neempawu zesifo kunye noncedo ekukhetheni unyango olunamandla okanye olunamandla.
Ukulandelelana komhlaza kwiCancer helps ngokufumana uKhetho oluNyango oluKhethekileyo
Kwabaninzi umhlaza izigulana ezingaphenduliyo kumgangatho wokhathalelo lwechemotherapy unyango, ukulandelelanisa ithumba kunceda ekuchongeni ngcono izinto ezingaqhelekanga ezinokuthi emva koko zinyangwe ngamachiza ekujoliswe kuwo aphuhliswe kutshanje kwaye anokusetyenziswa kuphela kwiimeko ezithile ezifunekayo. uphawu. Kuninzi lwezomhlaza ezinenkani, ezibuyele umva kwaye zinganyangekiyo, iprofayili ye-genomic ye-tumor DNA iya kwenza kube lula ukufikelela kunye nokubhaliswa kulingo lwezonyango oluvavanya amachiza amatsha ekujoliswe kuwo okanye ukufumana enye indlela eyodwa kunye nokhetho lwamachiza omntu (unyango) ngokusekelwe kwiimpawu zomhlaza.
isiphelo
Eyona nto iphambili kukuba ulandelelwano lwe-genome luba yinto eqhelekileyo kwizigulana ezifunyaniswe zine umhlaza namhlanje. Njengomfanekiso ocacileyo weblue-prints eyenziwe ngumyili wezakhiwo ngaphambi kokuba aqalise iprojekthi yokwakha, idatha ye-genomic luphawu oluluhlaza lomhlaza wesigulana kwaye inokunceda ugqirha ukuba azenzele unyango olusekwe kwiimpawu ezithile zomhlaza kwaye ke kulindeleke ukuba ube luncedo kumhlaza. unyango. Ukujonga okwenyani malunga nobume kunye nemimangaliso yokulandelelana kwethumba kunye neprofayili yomhlaza icaciswe kakuhle kwinqaku lakutshanje nguDavid H. Freedmen 'kwiNewsweek' nge-7/16/19. Ulumkisa ngelithi ngaphandle kweempumelelo zokujolisa kwithumba elikhethekileyo lesigulana ngasinye ngokusebenzisa amayeza achanekileyo, kukho iqhezu lezigulana ezixhamlayo koku. (https://www.newsweek.com/2019/07/26/targeting-each-patients-unique-tumor-precision-medicine-crushing-once-untretable-cancers-1449287.html)
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.