Iimbalasane
I-Cisplatin, i-chemotherapy edla ngokusetyenziswa kwizibilini eziqinileyo inokubangela iziphumo ebezingalindelekanga zokulahleka kweendlebe kwizigulana, ezinokuthi zibe sisigxina. Uphononongo lwakutsha nje luvavanye ukusebenzisana kwe-Cisplatin chemotherapy kunye nokusetyenziswa kwe-caffeine kwimodeli yegundane kwaye yafumanisa ukuba ukusetyenziswa kwe-caffeine ngexesha lonyango lwe-Cisplatin kwandisa i-Cisplatin ebangela ukulahlekelwa kwindlebe. Cancer izigulana kwiCisplatin chemotherapy kufuneka zilunyukiswe ngokuchasene nokusetyenziswa kwecaffeine.
ICisplatin Chemotherapy
I-Cisplatin yeyona chemotherapy isebenzayo, edla ngokusetyenziswa ukunyanga amathumba aqinileyo. Nangona kunjalo, i-Cisplatin chemotherapy ngelishwa ikwakhokelela kwiziphumo ebezingalindelekanga ezimandundu kubandakanya ukungeva kunye netyhefu yezintso. Ngokungafaniyo nezinye iziphumo ebezingalindelekanga ezithi zijike emva kokuba unyango luyekiwe, ukungeva kakuhle kunokuba sisigxina kwaye kunokuba nempembelelo enkulu kumgangatho wobomi bomntu. umhlaza ixhoba. Ngaphambi kokuba siqonde indlela iCisplatin ebangela ngayo ukulahlekelwa kwindlebe (i-ototoxicity), kufuneka siqonde i-anatomy yendlebe.
Iindawo zendlebe abantu abaninzi abaziqhelileyo yindlebe yangaphandle nendlebe kodwa ezinye iindawo eziphambili zibandakanya ii-ossicles eziphakathi kwendlebe, i-cochlea, kunye ne-basilar membrane, eyinxalenye yendlebe yangaphakathi. Ngokusisiseko, isandi siveliswa nje kukungcangcazela kwezinto kwaye ezi nyikima zihanjiswa ngumgqomo wendlebe ovela emoyeni uye kwii-ossicles kunye ne-cochlea ngaphakathi kwendlebe. I-cochlea inoxanduva lokwahlula zonke iindawo ezahlukeneyo ezenza isandi kwaye ikwenza oko nge-basilar membrane ebekwe ngaphakathi kwi-cochlea. Ke xa izandi ezitsha zigqithiselwa kwigubu lendlebe, iiseli zeenwele ezikwimbonakalo ye-basilar ziya kujikeleza ngokujonga kumaza afanelekileyo aza kukhokelela ekusebenziseni imiqondiso ye-neural ekhokelela kwingqondo. Yiyo loo nto abantu abanxibe izixhobo zokuva bandisa isandi esiya endlebeni kodwa abakwazi ukubuyisela iiseli ezonakeleyo ngaphakathi kwi-cochlea.
I-Cisplatin inokungena kwiiseli kwi-cochlea kwaye igcinwe apho iinyanga kunye neminyaka. I-Cisplatin inokubangela umonakalo kwiiseli kwi-membrane ye-basilar kwaye ibangele ukuvuvukala nokufa kweeseli zeenwele, ngaloo ndlela kubangele ukulahlekelwa kwindlebe ngokusisigxina. (Rybak LP et al, Semin Hear., 2019) Iiseli ze-Cochlea zine-adenosine receptors ezinokuthi xa zisebenza, zinokukhusela umonakalo kula maseli kunye nokulahlekelwa kwindlebe okuhambelanayo. Kuphononongo olupapashwe kutshanje ngo-2019, izazinzulu ziye zafumanisa ukuba izinto ezisetyenziswa ngokuqhelekileyo njengecaffeine, ezifumaneka kofu kunye neentlobo ezahlukeneyo zamandla kunye neziselo ze-carbonated, ezinokunqanda ezi receptor ze-adenosine, xa zidliwe ngexesha lonyango lwe-chemotherapy ye-Cisplatin, lunamandla okuba mbi ngakumbi i-side effect side-effect.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-Caffeine kunye neCisplatin chemotherapy-ebangelwa yilahleko yokuva
Kolu phando lwenziwe ngabaphandi abavela kwiYunivesithi yase-Illinois eseMelika eUnited States, kuvavanywe ingcinga yokuba icaffeine inokwandisa iziphumo zeCisplatin kwizigulana ebeziqala ukuphulukana nokuva kwazo ngenxa yonyango. Le hypothesis bavavanye kwimodeli ye-rat ye-cisplatin ototoxicity elawulwa nge-caffeine ngomlomo. Bafumanise ukuba idosi enye ye-cafeine eyenze mandundu ilahleko ye-cisplatin-induction ngaphandle kokonakala kwiiseli zangaphandle zeenwele kodwa yonyusa ukudumba kwendlebe ngaphakathi. Kodwa iidosi ezininzi zecaffeine zikwabangele ukonakala kwiiseli zeenwele ezikwi-cochlea ngaphandle kokubangela ukudumba. Isenzo se-caffeine esinqumle kungenxa yokuthintela i-adenosine receptors kwiiseli ze-cochlea. (U-Sheth S okqhubekayo, uSci Rep. 2019)
isiphelo
Ukuqukumbela, iziphumo zolu phononongo zibonisa ukusebenzisana okunokwenzeka kweziyobisi phakathi kwe-caffeine kunye ne-cisplatin-induced hearing loss. Ngoko ke, umhlaza izigulane kwi-cisplatin equkethe i-chemotherapy regimens kufuneka zixwayiswe malunga nokusetyenziswa kwekhofi kunye nezinye iziphuzo ze-caffeinated. Ukuphepha i-caffeine ngexesha lonyango lwe-chemotherapy ye-Cisplatin inokungayeki okanye ibuyisele umva ukulahleka kokuva okuzayo, kodwa ubuncinci akuyi kuba mbi ngakumbi kwaye kukhawulezise inkqubo nokuba. Izigulana ezikunyango lweCisplatin eziqala ukungeva kakuhle kufuneka zazise oogqirha babo ngoko nangoko malunga nezicwangciso ezinokwenzeka zokunciphisa idosi kwaye bazikhwebule kuzo zonke iintlobo zecaffeine..
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukuphepha ukuqagela kunye nokukhetha okungakhethiyo) lolona nyango lulungileyo lwendalo umhlaza kunye neziphumo ebezingalindelekanga ezinxulumene nonyango.