Muchidimbu
An open-label, single institution, phase I yekudzidza yakaitwa nevatsvagiri vekuJapan yakaratidza kuti zuva rega rega 12 g yeGBS-01, ine inenge 4g burdock michero inotorwa yakapfuma mu arctigenin, inogona kunge yakachengeteka mukiriniki uye inogona kuve nemabhenefiti. varwere vane advanced pancreatic kenza refractory kuGemcitabine therapy. Zvisinei, miyedzo mikuru yakanyatsotsanangurwa inodiwa kuti uwane izvi zvakawanikwa.
Burdock uye ayo Anoshanda Makomponi
Arctium lappa, inowanzozivikanwa se burdock, chirimwa chisingaperi chinowanikwa kuAsia neEurope. Burdock ikozvino inozivikanwa pasirese uye inorimwa uye inoshandiswa semuriwo munzvimbo zhinji dzepasi. Midzi, mashizha, uye mhodzi dzeichi chirimwa zvinoshandiswa mumushonga wechiChinese wechiChina semushonga wezvirwere zvakasiyana. Midzi yeBurdock yakazara nema antioxidants uye inoonekwawo seinopesana nekenza mhedzisiro.
Zvidzidzo zvakasiyana zvepamberi zvakamboratidza kuti burdock inogona kunge iine anti-kupisa, antibacterial, antidiabetic, antiulcerogenic, hepatoprotective, uye anticancer zvivakwa. Iwo akakosha makomputa ezve burdock anotora anosanganisira caffeoylquinic acid zvigadzirwa, lignans uye akasiyana flavonoids.
Mashizha e burdock anonyanya kuve nemhando mbiri dze lignans:
- Arctiin
- Arctigenin
Kunze kweizvi, phenolic acids, quercetin, quercitrin uye luteolin inogona kuwanikwa mumashizha e-burdock.
Mbeu dzeBurdock dzine phenolic acids senge Caffeic acid, Chlorogenic acid uye Cynarin.
Makiyi anokosha anoshanda muBurdock midzi ndeye Arctiin, Luteolin uye Quercetin rhamnoside iyo inogona kupa kune avo vanogona kurwisa kenza mhedzisiro.
Kunotarisirwa Kushandiswa kweBurdock Zvakatorwa
Burdock rave richishandiswa zvakanyanya muChinese Chinese Mishonga yezvinangwa zvinotevera, asi pasina humbowo hwekiriniki hwekutsigira mashandisiro ayo kune mazhinji eaya mamiriro:
- Kunatsa ropa
- Kuderedza hypertension
- Kuderedza gout
- Kuderedza hepatitis
- Kuderedza hutachiona hutachiona
- Kuderedza shuga yeropa mune varwere vane chirwere cheshuga
- Kurapa kusagadzikana kweganda senge eczema uye psoriasis
- Kuderedza kuunyana
- Kurapa kusagadzikana kusagadzikana
- Kurapa AIDS
- Kurapa Gomarara
- Sezvo diuretic
- Sezvo antipyretic tii yekurapa fever
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Ko Burdock Anoburitsa Anobatsira Pancreatic Cancer varwere vanoratidzira kuGemcitabine?
Maererano neAmerican Cancer Society, kenza yepancreatic ndiyo yepfumbamwe yakajairika kenza muvakadzi uye chegumi chegomarara rinowanzoitika muvarume uye inoverengera 7% yerufu rwekenza.
Ichowo chiri chechina chinotungamira chinokonzera kufa kwekenza muvarume nevakadzi.
Gemcitabine yakajairwa yekutanga-mutsara chemotherapeutic mumiriri wepancreatic cancer. Nekudaro, kenza yepancreatic microenvironment inozivikanwa kuti inozivikanwa neakakomba hypoxia, mamiriro umo muviri unonyimwa kukwana kwakakwana kweoksijeni padanho rezvinyama, uye kushomeka kwehutano, kunyanya glucose. Hypoxia inowedzera chemoresistance inopesana ne gemcitabine, nokudaro ichideredza mabhenefiti eiyi chemotherapy.
Nekudaro, vaongorori kubva kuNational Cancer Center Hospital East, Meiji Pharmaceutical University, National Cancer Center, Kracie Pharma, Ltd. muToyama, uye Tokyo University yeSainzi, Japan vakaongorora makomputa akasiyana ayo anogona kudzikamisa kushivirira kwemasero ekenza kuita glucose nzara uye hypoxia, uye yakazivikanwa arctigenin, kiyi yakakosha inowanikwa muBurdock zvinyorwa, seyakanakisa mukwikwidzi muyedzo yekiriniki, nekuda kwekuita kwayo antitumor kunoonekwa mune akawanda xenograft mhando dzekenza uye zvakakwana ekuchengetedza profiles painopihwa pamadosi kusvika ku100 nguva zuva nezuva. dose inodiwa kune antitumor chiitiko mumakonzo. (Masafumi Ikeda et al, Cancer Sci., 2016)
Vatsvakurudzi vakashandisa mushonga wemuromo GBS-01, muchero weBurdock, wakapfuma mu arctigenin, muvarwere gumi nevashanu vane pancreatic pancreatic. kenza refractory kuti gemcitabine. Mukutongwa, vakaongorora huwandu hwakabvumidzwa hweGBS-01 uye vakatarisa Dose-inomisa chepfu. Dose-limiting toxicities (DLTs) inoreva kutaridzika kwegiredhi 4 hematological / ropa muchetura uye giredhi 3 kana 4 isiri-hematological / yeropa toxicity mumazuva makumi maviri nemasere ekutanga ekurapa.
Mukutsvagurudza, vakaona kuti pakange pasina zviratidzo zve grade 4 yeropa chepfu uye grade 3 kana 4 isiri yeropa chepfu mune chero yevarwere vakanyoreswa, pane chero matatu maadhi akashandiswa (mazuva ese 3.0 g, 7.5 g kana 12.0 g) . Nekudaro, huturu hwakapfava hwakaonekwa senge yakawedzera serum γ ‐ glutamyl transpeptidase, yakawedzera glucose yeropa, uye yakawedzera serum yakazara bilirubin.
Chidzidzo chakagadza chiyero chinokurudzirwa cheGBS-01, iyo mushoma yakafuma muArctigenin kubva kuBurdock, kuve 12.0 g zuva nezuva, nekuti hapana maDLTs akaonekwa pane chero matatu emazinga emazinga. Dosi rezuva nezuva re12.0 g GBS-01 raive rakaenzana ne4.0 g chibuturu chemichero.
Kunze kwevarwere vakadya iyo Burdock yakatorwa, 4 varwere vaive vakagadzikana chirwere uye 1 vakaratidza kupindura zvishoma mukati mekutarisa. Kunyatso kutaura, mwero wekupindura waive 6.7% uye chiyero chekudzivirira chirwere chaive 33.3%. Chidzidzo chacho chakawanawo kuti kufambira mberi kwepakati- kusununguka uye kupona kwevarwere kwaive mwedzi 1.1 nemwedzi 5.7, zvichiteerana.
mhedziso
Burdock zvinyorwa uye midzi inoonekwa seine anti-inflammatory, antibacterial, antidiabetic, antiulcerogenic, hepatoprotective, uye anti-cancer properties. A 2016 Phase I yekiriniki yekudzidza yakaitwa nevaongorori kubva kuJapan yakaratidza kuti zuva nezuva 12 g yeGBS-01 (ine ingangoita 4.0 g burdock michero inotorwa yakapfuma mu arctigenin) inogona kunge yakachengeteka muchipatara uye inogona kuve nemabhenefiti anogoneka kune varwere vane advanced pancreatic. kanzira refractory kuGemcitabine therapy. Nekudaro, zvakanyatsotsanangurwa miyedzo mikuru inodiwa kuti umise zvakawanikwa izvi, usati wakurudzira kushandiswa kwearctigenin muvarwere vepancreatic cancer.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.