Muchidimbu
Ongororo yekiriniki yakaratidza kuti kushandiswa (infusion) kweyepamusoro dosi ascorbate (vitamini C) ine mukana wekuvandudza kupona kwese kwekenza yehuropi (GBM) varwere vane fungidziro yakaipa. Iyo Vitamin C infusions (uye pamwe yekuwedzera) yakapihwa pamwe chete neyakajairwa radiation yekutarisira uye Temozolomide kurapwa kwehuropi. kenza inewo mukana wekudzikisa mhedzisiro, nekudaro inovandudza hupenyu hwemurwere.
Kenza yeBongo - Glioblastoma
Glioblastoma (GBM) ndiyo inonyanya kuzivikanwa gomarara repfungwa. Muitiro wekurapwa kweGBM unosanganisira musanganiswa wekuvhiya rese remota yeuropi inoteverwa neyemukati mairi radiation (RT) uye temozolomide (TMZ) kurapwa. Muzviitiko zvakawanda, izvi zvinoteverwa nemamwe macircuit eadjuvant TMZ post radiation. Kunyangwe paine kuvandudzwa kwemukenza yemanyorerwo madhiragi uye kwese kufambira mberi mukurapa, kufungidzira kwevarwere veGMM kuri kuramba kuchishungurudza, nekupona kwemwedzi gumi nemana uye kupona kwemakore mashanu zviri pasi pegumi muzana. (Stupp R et al, Iyo Lancet Oncol., 2009; Gilbert MR et al, Nyowani Engl. J Med., 2014)
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Vitamin C / Ascorbic Acid Kushandisa muBongo Kenza
Preclinical zvidzidzo uye kunyangwe miedzo yekiriniki mune imwe kenza zviratidzo zvakange zvaratidza kubatsira kwekushandisa yakakwira dose yeVitamin C infusions kuve yakachengeteka uye kuvandudza kushanda uye kuderera muchetura kana uchishandiswa pamwe nemwaranzi uye chemotherapy kurapwa.
Chekutanga muchidzidzo chekiriniki chevanhu chakaitwa pavarwere gumi nevaviri vachangobva kuongororwa GBM neDhipatimendi reRadiation Oncology paYunivhesiti yechipatara cheIowa, kuongorora kuchengetedzeka pamwe nekukanganiswa kwemushonga wezvemishonga, unopihwa pamwe neyakajairwa kurapwa kweGBM. (Allen BG et al, Kenza Cancer Res., 2019) Yakakwira dose ascorbate yakamisikidzwa katatu pasvondo panguva yeRT / TMZ yekurapa kutenderera uye kaviri pasvondo panguva yeadjuvant TMZ macircule. Panyaya gumi neimwe yezvidzidzo zviri muchidzidzo ichi, zvisere zvacho zvaive zvine fungidziro yakaipa zvichienderana nehunhu hweMGMT enzyme, chinozivikanwa chikonzero chekupindura kwakaderera kuTMZ. Nhoroondo dzekare inoratidza kuti varwere veGMM vasina MGMT vanosimudzira methylation vane hupenyu hwese hwemwedzi gumi nembiri chete apo zvidzidzo zviri muchidzidzo ichi pasina MGMT inosimudzira methylation zvine hupenyu hwese hwemwedzi makumi maviri nematatu nezvidzidzo zvitatu zvichiri kurarama. Izvo chete zvakashata zvinosangana nezvakataurwa yaive yakaoma muromo uye kutonhora kwakabatana neiyo ascorbate infusion, nepo zvimwe zvakakomba mhedzisiro mhedzisiro yekuneta, kuda kurutsa uye kunyange hematological zviitiko zvakashata zvine hukama neTMZ neRT zvakadzikira.
mhedziso
Ichi chidzidzo chinoratidza kuti kupinza yakakwira dhivhosi Vitamin C kana ascorbate mukenza yeuropi (GBM) varwere vari kurapwa neRT / TMZ kurapa macircuit ane mukana wekuvandudza kupona kwese, kunyanya muzvidzidzo zvine unmethylated MGMT mucherechedzo unozivikanwa kuva nehurombo hwekufungidzira . Chidzidzo ichi chinoratidza kuti pharmacological ascorbate infusion haigone chete kugadzirisa kurapika kushivirira kweRT uye TMZ, asi ine mukana wekuwedzera hupenyu hwevarwere uye kudzikira huturu hwemwaranzi uye chemotherapy kurapwa regimen. Yakakwira dose vhitamini C (ascorbate) infusion yakaratidzawo vimbiso mukuderedza huturu hwemakemotherapies senge gemcitabine, carboplatin uye paclitaxel mupancreatic uye ovarian cancer. (Welsh JL et al, Cancer Chemother Pharmacol., 2013; Ma Y et al, Sci. Dudziro. Med., 2014) Vatsvakurudzi vanoratidza kuti migumisiro yekudzidza kwavo pamusoro peboka diki revarwere vachiri kuvimbisa zvakakwana kuti vakwanise kuferefetwa kwekiriniki pamusoro pekukanganiswa kweVitamin C infusions uye zvinowedzera muuropi. kenza.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.