Muchidimbu
Mukaka Thistle Extract/Silymarin uye chikamu chayo chakakosha Silibinin ine akawanda anokatyamadza hutano mabhenefiti nekuda kweiyo antioxidant, anti-kuzvimba uye anti-gomarara zvivakwa. Yakasiyana in vitro/in vivo uye zvidzidzo zvemhuka zvakaongorora hutano hwemukaka mbijana inotorwa uye kugona kwayo kuvharidzira akasiyana siyana kenza uye yakawana mhedzisiro inovimbisa. Miedzo mishoma yevanhu yakaratidzawo kuti mukaka rukato uye zvimisikidzo zvawo zvinoshanda zvinogona kubatsira mukudzikisa mamwe enjodzi-mhedzisiro yechemotherapy uye radiotherapy senge cardiotoxicity, hepatotoxicity uye brain edema mune dzimwe nguva. kenza mhando dzinorapwa nechaiyo chemo.
Chii chinonzi Milk Thistle?
Mukaka rukato chirimwa chinotumbuka icho chashandiswa kwemazana emakore semushonga wepanyama wekurapa chiropa uye bile kusagadzikana zvakanyanya munyika dzeEurope. Mukaka rukato runowanikwawo sekuwedzera kwekudya. Rukato rwemukaka rwakawana zita raro kubva kune mukaka wemukaka unobuda mumashizha kana atyoka.
Makiyi Akakosha Anoshanda eiyo Milk Thistle
Iwo makiyi anoshanda anoumba emukaka wakaomeswa mhodzi mbeu ndeye flavonolignans (zvakasikwa phenols zvinoumbwa nechikamu che flavonoid uye chikamu lignan) izvo zvinosanganisira:
- Silibinin (silybin)
- Isosilybin
- Silychristin
- Silydianin.
Musanganiswa weaya flavonolignans anotorwa kubva mumukaka rukato mbeu iri pamwe inozivikanwa seSilymarin. Silibinin iyo inozivikanwawo sekuti silybin, ndiyo inonyanya kushanda silymarin. Silymarin ine antioxidant, antiviral uye anti-kupisa zvinhu. Mukaka Thistle / Silymarin inowanikwa sekuwedzera kwekudya uye inowanzo shandiswa pazvinhu zvayo zvinobatsira pakurapa kusagadzikana kwechiropa. Mazhinji ekuwedzera anoverengerwa akavakirwa pane yavo silibinin zvemukati. Iko kune zvakare akakosha mafomati e silymarin kana silibinin anowanikwa ayo anogona kuwedzera kwavo bioavailability nekubatana ne phosphatidylcholine.
General Hutano Kubatsirwa kweMukaka Thistle
Dzidzo zhinji dzemhuka uye mashoma emakiriniki akaitwa kuti aongorore zvakanakira mukaka rukato. Zvimwe zvehutano hwakarongedzwa hwemukaka munga ndeizvi:
- Inogona kubatsira mumatambudziko eropa anosanganisira cirrhosis, jaundice, hepatitis
- Inogona kubatsira kuGall bladder kusagadzikana
- Kana ikatorwa pamwe chete nemishonga yakajairika, inogona kusimudzira chirwere cheshuga
- Inogona kubatsira kuvandudza cholesterol mazinga mune vane chirwere cheshuga varwere
- Inogona kubatsira nekurwadziwa pamoyo uye kuzvimba
- Inogona kubatsira nekenza inodzivirira
Zvakanakira Mukaka Thistle muCancer
Kwemakumi maviri emakore apfuura, kwave kuwedzera kufarira mukunzwisisa mabhenefiti ekiriniki emukaka thistle mugomarara. Zvimwe zve in vitro/in vivo/mhuka/zvidzidzo zvevanhu zvakaongorora mashandisirwo/zvakaita zvemukaka thistle mu kenza zvakapfupikiswa pazasi:
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
MuVitro / MuVivo / Zvidzidzo Zvezvipfuyo
1.May Inodzivisa Pancreatic Cancer Kukura & Kuderedza Pancreatic Cancer-Inoita Cachexia / Kushaya simba
In vitro zvidzidzo zvakaratidza kuti mukaka rukato runoshanda silibinin rine mukana wekudzivirira pancreatic cancer cancer kukura mune yedosi-inoenderana nenzira. Zvimwe muzvidzidzo zve vivo zvinoratidza zvakare kuti silibinin inoderedza kukura kwechirwere uye kuwanda kwekenza yepancreatic uye inogona kubatsira kudzivirira kurasikirwa kwehuremu hwemuviri uye mhasuru. (Shukla SK et al, Oncotarget., 2015)
Muchidimbu, in vitro uye mhuka zvidzidzo zvinoratidza kuti mukaka rukato / silibinin inogona kubatsirwa mukuderedza pancreatic cancer kukura uye pancreatic cancer-Inoitwa cachexia / kushaya simba. Zvemakiriniki miedzo inodiwa kumisikidza zvakafanana muvanhu.
2.May Inodzivisa Kukura Kwekenza Yemuzamu
In vitro zvidzidzo zvakaratidza kuti silibinin inhibited kenza yemazamu maseru kukura uye yakakonzera apoptosis / kufa sero mumasero emukenza wemazamu. Zviwanikwa kubva kuongororo dzakasiyana zvinoratidza kuti silibinin ine inoshanda anti-kenza yemazamu zvinhu. (Tiwari P et al, Cancer Invest., 2011)
3. Inogona Kudzivirira Prostate Cancer Kukura
Mune kumwe kuongorora, iyo anti-cancer mhedzisiro yeSilibinin yakaongororwa musanganiswa musanganiswa pamwe neDOX / Adriamycin. Muchidzidzo ichi, maseru eprostate carcinoma akarapwa ne silibinin uye DOX mukubatana.Zvakawanikwa zvakaratidza kuti silibinin-DOX mubatanidzwa zvakakonzera 62-69% yekudzivirira kwekukura mumasero akarapwa. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
4. Inogona Kutadzisa Kenza yeGanda
Zvidzidzo zvakawanda zvakaitwawo kuti zviongorore zvinoitika zveMukaka Thistle anoshanda Silibinin pagomarara reganda. Zviwanikwa kubva kune izvi mu vitro zvidzidzo zvakaratidza kuti kurapwa kweSilibinin kunogona kuve nemhedzisiro yekudzivirira mumasero egomarara eganda remunhu. An in vivo kudzidza yakawana kuti Silibinin inogona zvakare kudzivirira UVB radiation-inokonzerwa neganda reganda uye inogona kubatsira mukugadzirisa UV-inokonzeresa kukuvara kweDNA muganda regonzo. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
Zvidzidzo izvi zvinovimbisa uye zvinoratidza kuti mukaka thistle/silibinin inogona kunge yakachengeteka uye inobatsira ganda kenza.
5. Inogona Kutadzisa Colorectal Cancer
Dzimwe dzedzidzo in vitro dzakaratidza kuti Silibinin inogona kukonzera kufa kwesero mumasero macancer emunhu. Zvidzidzo zve in vitro zvakare zvakawana kuti kurapwa kweSilibinin kwe24h kunogona kudzora kukura kwemasero ekenza ne30-49%. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
Mabhenefiti eMukaka Thistle / Silibinin akaongororwawo pamwe chete nemamwe marapirwo akaita se histone-deacetylase (HDAC) inhibitors. Iko kusanganisa kwakaratidza kuenzanirana mhedzisiro mumaseru akajeka.
6. May inhibit Lung Kenza
In vitro zvidzidzo zvakaratidza kuti Silibinin inogona kuve neanodzivirira mhedzisiro mune yemunhu kenza yemapapu maseru mitsara. Zvidzidzo zvakare zvakaratidza kuti Silibinin pamwe chete neDOX inhibited cancer cancer yemapapu kukura mu vitro. Silibinin pamwe neine indole-3-carbinol yakakonzerawo yakasimba antiproliferative mhedzisiro kupfuura yeavo vamiririri. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
Izvi zvakawanikwa zvinoratidza kuti Mukaka Thistle anoshanda Silibinin anogona zvakare kuve nehutano hwekubatsira pakurwisa kenza yemapapu.
7.May anogona kutadzisa Cancer Dundira Cancer
Zvidzidzo zve in vitro zvakaratidza kuti Silibinin akakurudzira apoptosis / sero kufa kwekenza yemunhu bladder maseru. Zvidzidzo zvakare zvakaratidza kuti Silibinin inogona zvakare kudzvinyirira kutama uye kupararira kwemaseru emukenza wedundira. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
8. Inogona kutadzisa Ovarian Cancer
In vitro zvidzidzo zvakaratidza kuti silibinin inogona kudzvinyirira kukura kwemasero emukenza emunhu ovarian, uye zvakare yakakonzera apoptosis / kufa kwesero. Zvidzidzo zvakare zvakawana kuti Silibinin inogona kusimudzira kunzwisisika kwemasero emukenza eovarian kune PTX (Onxal). Silibinin painoshandiswa pamwe chete ne PTX (Onxal) inogona zvakare kusimudzira apoptosis / kufa kwesero. (Prabha Tiwari naKaushala Prasad Mishra, Cancer Research Frontiers., 2015)
Izvi zvakawanikwa zvinoratidza kuti silibinin inogona kushandiswa sechikamu chemasanganiswa ekurwisa kenza yeovari.
9.Akatadzisa Cervical Cancer
Zvidzidzo zvinoratidza kuti Silibinin inogona kudzivisa kuwanda kwemasero emurume wechibereko. Uye zvakare, silibinin pamwe neMET, inozivikanwa inorwisa-chirwere cheshuga mumiriri, inoratidza kuenzanirana pamhedzisiro yekudzivirira kwecancer cancer maseru uye sero kufa. Nekudaro, silibinin inogona kushanda seye chemopreventive mumiriri kurwisa gomarara remuromo wechibereko. Zvimwe zvidzidzo zvinofanirwa kuongorora mikana yekuvandudza zvirinani nzira dzekurapa kurwisa gomarara remuromo wechibereko.
Clinical Zvidzidzo muVanhu
Ngatitarisei pazvidzidzo zvakasiyana zvemakiriniki kuti tinzwisise kana kusanganisira mukaka rukato sechikamu che kanzuru yevarwere chikafu inobatsira kana kwete.
1. Kubatsira kweMukaka Thistle mukuderedza Cardiotoxicity muAcute Lymphoblastic Leukemia Vana Vanobatwa neDXX (Adriamycin)
Silymarin, imwe yeakakosha anoshanda emukaka rukato, yakaratidzirwa kuyedza kuve neacopoprotective mhedzisiro painopihwa pamwe neDOX. Silymarin inogona kudzora kushushikana kweiyo oxidative, iyo yakakonzera cardiotoxicity. Iyo antioxidant uye inogona kudzora kukuvara kweiyo membreni nemapuroteni neanogadzirisa marudzi, ayo akagadzirwa sechikamu cheDOX mashandiro ekuita, nekudzivirira kupera kweiyo yakasikwa antioxidant michina yemasero ane hutano. (Roskovic A et al, Mamorekuru 2011)
Chidzidzo chekiriniki kubva kuYunivhesiti yeTanta kuEjipitori chakaongorora maitiro eSilymarin kubva kuMukaka Thistle muvana vane Acute Lymphoblastic Leukemia (ALL), avo vakarapwa neDOX. Chidzidzo ichi chakashandisa dhata kubva kuvana makumi masere vane VOSE, kunze kwekuti varwere makumi mana vaibatwa neDOX pamwe naSilymarin pa80 mg / zuva uye makumi mana vakasara vaingorapwa chete neDXX (placebo boka). Chidzidzo chacho chakawana kuti muboka reSilymarin, pakanga paine 'kuderera kwekutanga kweDOX-yakakonzera kuruboshwe ventricular systolic basa kukanganiswa' pamusoro peboka re placebo. Ichi kiriniki yekudzidza, kunyangwe iine vashoma nhamba yeVOSE vana, inopa kumwe kusimbiswa kweye cardioprotective mhedzisiro yaSilymarin sekuonekwa mune yekuyedza chirwere mhando. (Adel A Hagag et al, Infect Disord Zvinodhaka Zvinangwa., 40)
2. Kubatsira kweMukaka Thistle mukuderedza Chiropa Toxicity muAcute Lymphoblastic Leukemia Vana Vanorapwa neChemotherapy
Kurapa kwevana vane acute lymphoblastic leukemia (ZVESE) vachishandisa chemotherapy mishonga inowanzo kanganiswa nekuda kwehepatotoxicity / chiropa chepfu inokonzerwa nekemotherapy zvinodhaka. Iyi conundrum yekubvisa gomarara uchishandisa chemotherapy madhiragi vs. kubata neakakomba uye dzimwe nguva asingachinjiki mhedzisiro-mhedzisiro yemishonga iyi idambudziko riri kuenderera mberi munharaunda yekenza. Nekudaro, kune kuenderera mberi kwekuedza kutsvaga nzira dzinogona kubatsira kudzikamisa kana kudzivirira murwere kubva kune yakaipa mhedzisiro-mhedzisiro.
Muchidzidzo chekiriniki, acute lymphoblastic leukemia (ALL) vana vane hepatic toxicity vaigona kurapwa nekemotherapy chete (placebo) kana mubatanidzwa wemukaka rukato capsule ine 80 mg yesilibinin pamwe nekemotherapy (MTX / 6-MP / VCR) nemuromo ( Mukaka Thistle Boka) kwemazuva makumi maviri nemasere. Vana makumi mashanu vakanyoreswa kubva muna Chivabvu 28 kusvika Nyamavhuvhu 50 yechidzidzo ichi, iine zvidzidzo makumi maviri nezvitanhatu muboka re placebo uye makumi maviri nevaviri muMilk Thistle Group. 2002 pavana makumi mashanu vakaongororwa pachidzidzo. Chiropa chepfu chakatariswa mukati menguva yekurapa. (EJ Ladas et al, Gomarara., 2010)
Zvakawanikwa kubva kutsvagurudzo zvakaratidza kuti kutora Mukaka Thistle pamwe nekemotherapy nevarwere VESE kunogona kusangana nekudzikiswa kukuru kwechiropa chepfu. Chidzidzo chacho hachina kuwana huturu husingatarisirwi, kudiwa kwekudzikisa madosi emakemotherapy, kana chero kunonoka kurapa panguva yemukaka rukato rwekuwedzera nguva. Zvidzidzo zvakare zvakaratidza kuti mukaka rukato haruna kukanganisa kushanda kwemakemikari vamiririri anoshandiswa pakurapa KWESE.
Vatsvakurudzi zvakadaro vakakurudzira zvidzidzo zvenguva yemberi kuti vawane chinonyanya kushanda cheMukaka Thistle uye mhedzisiro yayo pahepatotoxicity / chiropa chepfu uye kupona-kusina leukemia.
3. Kubatsira kweMukaka Thistle inoshanda Silibinin yekudzora huropi edema muLung Cancer Varwere vane Brain Metastasis
Zvidzidzo zvinoratidza kuti kushandiswa kwemukaka thistle inoshanda silibinin-based nutraceutical inonzi Legasil® inogona kuvandudza Brain Metastasis kubva kuNSCLC/varwere vekenza yemapapu iyo yakafambira mberi kurapwa neradiotherapy uye chemotherapy. Zvakawanikwa zvezvidzidzo izvi zvinoratidzawo kuti silibinin kutonga kunogona kuderedza zvakanyanya edema yehuropi. Nekudaro, idzi inhibitory mhedzisiro yesilibinin pahuropi metastasis inogona kusakanganisa iyo yekutanga bundu kubuda mumapapu. kenza varwere. (Bosch-Barrera J et al, Oncotarget., 2016)
4. Kubatsira kweMukaka Thistle mukuderedza Chiropa Toxicity muCreast Cancer Patient
Chidzidzo cheakaitika chakaburitswa pamurwere wekenza yemazamu uyo akarapwa ne5 dzakasiyana chemotherapy kurapwa uye akaenderera mberi nekundikana kwechiropa. Chirevo chakataura kuti mhedzisiro yekuyedzwa kwechiropa yakadzikira kusvika pamwero wekutyisidzira hupenyu mushure memakosi mana chemotherapy kurapwa. Murwere akabva awedzerwa pamwe neSilibinin-based nutraceutical inonzi Legasil® post iyo kiriniki uye nekuvandudza kwechiropa kwakacherechedzwa, izvo zvakabatsira murwere kuenderera mberi nekunyaradza chemotherapy. (Bosch-Barrera J et al, Anticancer Res., 2014)
Ichi chidzidzo chakaratidza kuti zvinokwanisika zvemakiriniki kubatsirwa nesilibinin mukuderedza huturu hwechiropa mukenza yemazamu varwere vanorapwa nekemotherapy.
5.Mabhenefiti eMukaka Thistle mukuvandudza Kupona kweMigumisiro muBongo Metastatic Varwere Vanorapwa neRadiotherapy
Zvidzidzo zvinoratidza kuti Mukaka rukato runogona kubatsira uropi metastatic varwere vari kurapwa radiotherapy. Chidzidzo chekiriniki chaisanganisira data kubva kuvarwere vane metastases yeuropi avo vaibatwa kungave ne radiotherapy chete kana radiotherapy pamwe ne omega 3 fatty acids uye silymarin. Chidzidzo ichi chakawana kuti varwere vaitora omega 3 fatty acids uye silymarin vaive neyakareba nguva yekupona pamwe nekuderedza radionecrosis. (Gramaglia A et al, Anticancer Res., 1999)
mhedziso
Mukaka Thistle wabvisa / Silymarin uye chikamu chayo chakakosha Silibinin ine zvakawanda zvehutano zvinobatsira nekuda kweayo antioxidant, anti-kupisa uye anti-kenza zvivakwa. Misi yerukato yakaburitswa / Silymarin kazhinji haina yakawanda mhedzisiro painotorwa nemuromo muhuwandu hwakazara. Nekudaro, kune vamwe vanhu, kutora mukaka munzwa kuburitsa kunogona kukonzera manyoka, kusvotwa, ura hwemukati, kuzvimba, kuzara kana kurwadziwa, uye kurasikirwa nechido. Zvakare, sezvo mukaka rukato kuburitsa kunogona kudzikisa huwandu hweshuga yeropa kune vanhu vane chirwere cheshuga, mishonga yeshuga mishonga inogona kugadziridzwa. Mukaka mhunga inoburitswa inogona zvakare kuve neesrogenic mhedzisiro inogona kukuvadza mamiriro ane hutachiona, kusanganisira mamwe marudzi ekenza yemazamu.
Yakasiyana invitro/invivo uye zvidzidzo zvemhuka zvakaongorora hutano hwemukaka thistle extract uye kugona kwayo kuvharisa akasiyana siyana ecancer. Mhedzisiro inovimbisa yakataurwa nezvakawanda zvezvidzidzo izvi zvichiratidza kudzivirira kwemukaka rukato mune mamwe marudzi egomarara. Miedzo mishoma yevanhu inotsigirawo kuti mukaka rukato uye zvinhu zvawo zvinoshanda zvinogona kubatsira mukuderedza zvimwe zvine ngozi zvinokonzeresa chemotherapy uye radiotherapy senge cardiotoxicity, hepatotoxicity uye edema yeuropi mune dzimwe mhando dzegomarara dzinorapwa nekemo chaiyo. Nekudaro, kutora yakasikwa yekuwedzera senge mukaka thistle inobvisa zvisina tsarukano nechero chemotherapy kune chero kenza hazvikurudzirwe sezvo zvinogona kukonzera kushata kwemishonga yemishonga. Saka, munhu anofanirwa kugara achibvunza chiremba wavo asati atora chero chekuwedzera chepanyama pamwe chete nechemotherapy.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.