Ma Ellagic Acid Supplements Amathandizira Kuyankha Kwa Radiotherapy mu Khansa ya M'mawere

Mfundo

Thandizo la radiation nthawi zambiri limagwiritsidwa ntchito pochiza khansa ya m'mawere, koma nthawi zambiri maselo a khansa amatha kusamva chithandizo cha radiation. Kudya / kugwiritsa ntchito Ellagic Acid kuchokera ku zakudya monga zipatso, makangaza ndi walnuts (olemera mu phenolic compound) kapena zowonjezera zimakhala ndi ubwino wambiri wathanzi kuphatikizapo zotsatira zotsutsana ndi khansa. Ellagic acid imathandizanso kuyankha kwa radiotherapy m'maselo a khansa ya m'mawere nthawi yomweyo kukhala chitetezo cha radio kuma cell abwinobwino: njira yachilengedwe yochizira bere. khansa.

Kodi Ellagic Acid ndi chiyani?

Ellagic Acid ndi chinthu chachilengedwe chotchedwa polyphenol chokhala ndi mphamvu ya antioxidant, yomwe imapezeka m'mitengo ndi masamba ambiri. Amagulitsidwanso pamalonda azakudya zopatsa thanzi. Ellagic acid imakhala ndi zotsatira zotsutsana ndi zotupa komanso zotsutsana ndipo imakhala ndi maubwino ambiri azaumoyo.

Zakudya Zolemera mu Ellagic Acid: Ellagic acid imapezeka kwambiri mu zakudya zosiyanasiyana kuphatikiza zipatso monga rasipiberi, strawberries, mabulosi akuda, cranberries, ndi makangaza. Zakudya zina kuphatikiza mtedza wina wamtengo monga walnuts ndi pecans zimakhalanso ndi Ellagic acid.

Ubwino Wathanzi la Ellagic Acid

Zina mwazabwino za mankhwala a Ellagic acid othandizira kuphatikiza anti-khansa, kuchepetsa zizindikilo zamatenda amadzimadzi kuphatikiza dyslipidemia, kunenepa kwambiri (pogwiritsa ntchito ellagic acid kuchokera ku makangaza) ndi zovuta zokhudzana ndi kunenepa kwambiri monga insulin kukana, mtundu 2 matenda ashuga, komanso matenda a chiwindi chamafuta. (Inhae Kang et al, Adv Nutr., 2016Zowonjezerapo zabwino zathanzi pakumwa Ellagic Acid imaphatikizaponso kusokoneza khwinya ndi kutupa komwe kumalumikizidwa ndikuwonetsedwa kwa UV kwanthawi yayitali. (Ji-Young Bae et al, Exp Dermatol., 2010)

Radiotherapy ya Khansa ya m'mawere

Khansara ya m'mimba ndiye khansa yofala kwambiri mwa azimayi padziko lonse lapansi (https://www.wcrf.org). Kuyambira Januware 2019, pali azimayi opitilira 3.1 miliyoni omwe ali ndi mbiri ya khansa ya m'mawere ku US kokha, omwe akuphatikiza azimayi omwe akupitilizidwa kapena kumaliza ntchito. (Ziwerengero za khansa ya m'mawere ku US; https://www.breastcancer.org). Chithandizo cha radiation kapena Radiotherapy ndi imodzi mwa njira zopangira khansa mankhwala kupatula opaleshoni ndi chemotherapy ndipo amagwiritsidwa ntchito nthawi zonse pochiza matenda a khansa ya m'mawere ngati chithandizo chokhazikika pambuyo pa opaleshoni, kuthandiza kuchepetsa mwayi woti khansayo ibwererenso. Chithandizo cha radiation chimagwiritsidwanso ntchito ngati khansa yayambiranso ndikufalikira ku ziwalo zina monga ubongo ndi mafupa, kuphatikizapo mankhwala ena monga chemotherapy kapena immunotherapy.

Ellagic Acid ndi Radiotherapy mu Khansa ya m'mawere

Chithandizo cha radiation chimagwira ntchito ndikuwononga DNA ya khansa maselo kudzera mkulu mphamvu ionizing particles. Komabe, zimabweretsanso kuwonongeka kwa ma cell ozungulira, omwe si a khansa, zomwe zimapangitsa kuti pakhale zovuta zina zosafunikira komanso zoyipa. Kuphatikiza apo, ndikusintha mwachangu kwa ma cell a khansa, amangosintha makina awo amkati ndikutha kupulumuka ndi radiotherapy ndikukhala osamva ma radiation. Kupititsa patsogolo mwayi wochita bwino chithandizo cha radiation pakhala kafukufuku wambiri pamagulu a radiosensitizer omwe akaphatikizidwa ndi ma radiation amatha kuthandizira kuwonongeka kwakukulu kwa chotupa pomwe nthawi yomweyo kukhala radioprotective ya maselo omwe si a khansa. Chimodzi mwazinthu zachilengedwe zomwe zawonetsa moyesera zinthu ziwiri izi kukhala radiosensitizer ku maselo a khansa ya m'mawere ndi radioprotective ku maselo abwinobwino ndi gulu la phenolic lotchedwa Ellagic Acid.

Kafukufuku m'maselo a khansa ya m'mawere MCF-7 awonetsa kuti Ellagic Acid kuphatikiza ndi radiation imawonjezera kufa kwa maselo a khansa ndi 50-62% pomwe kuphatikiza komweku kunali kuteteza m'maselo abwinobwino NIH3T3. Njira yomwe Ellagic Acid inagwirira ntchito kuti iwonjezere mphamvu ya radiation pama cell a khansa ya m'mawere inali kudzera mu kusokoneza mitochondria - mafakitale amphamvu a maselo; powonjezera kufa kwa ma cell; ndi kuchepetsa zinthu zolimbikitsa kupulumuka mu khansa selo. Kafukufukuyu akusonyeza kuti mankhwala achilengedwe monga Ellagic Acid atha kugwiritsidwa ntchito “kupititsa patsogolo chithandizo cha radiotherapy powonjezera chiwopsezo cha chotupa komanso kuchepetsa kuwonongeka kwa ma cell komwe kumachitika chifukwa cha kuwala.” (Ahire V. et al, Nutrition ndi Cancer, 2017)

Kutsiliza

Kuphatikiza pa mphamvu ya radiosensitization m'maselo a khansa, maphunziro ambiri asayansi awunikiranso zinthu zambiri zoteteza khansa za Ellagic Acid (yomwe imapezeka m'makangaza), kuti athe kuletsa kuchuluka kwa ma khansa, kuti athandizire Imfa ya khungu la khansa yotchedwa apoptosis, kupewa kufalikira kwa khansa poletsa kukula kwa mitsempha yatsopano yamagazi ndi kusamuka ndi kuwukiridwa kwa maselo a khansa kumadera ena a thupi (Ceci C et al, Zakudya zopatsa thanzi, 2018; Zhang H et al, Khansa Biol Med., 2014). Pali mayesero azachipatala omwe akupitilira zisonyezo zosiyanasiyana za khansa (khansa ya m'mawere (NCT03482401), khansa ya colorectal (NCT01916239), khansa ya prostate (NCT03535675) ndi ena) kuti atsimikizire phindu la chemopreventive ndi achire a Ellagic Acid mwa odwala khansa, monga tawonera mu zitsanzo zoyesera za khansa. Ngakhale kuti chowonjezera chachilengedwechi sichikhala chapoizoni komanso chotetezeka, Ellagic acid iyenera kugwiritsidwa ntchito pokambirana ndi akatswiri azachipatala, chifukwa imatha kuyanjana ndi mankhwala ena chifukwa choletsa ma enzyme omwe amasokoneza chiwindi. Komanso, kusankha mlingo woyenera wa Ellagic acid wowonjezera ndi kapangidwe kamene kamakhala ndi kusungunuka bwino komanso bioavailability ndikofunikira kuti mupeze chithandizo chake chonse.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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