Kugwiritsa Ntchito Zotulutsa za Burdock mu Khansa ya Pancreatic

Mfundo

Phunziro lotseguka, la bungwe limodzi, la gawo loyamba lopangidwa ndi ofufuza ochokera ku Japan linanena kuti mlingo wa tsiku ndi tsiku wa 12 g wa GBS-01, womwe uli ndi pafupifupi 4g burdock zipatso zokhala ndi arctigenin, ukhoza kukhala wotetezeka kuchipatala ndipo ukhoza kukhala ndi phindu odwala omwe ali ndi pancreatic yapamwamba khansa kukana chithandizo cha Gemcitabine. Komabe, mayesero odziwika bwino amafunikira kuti atsimikizire izi.

Burdock ndi Makampani Ake Ogwira Ntchito

Arctium lappa, yomwe imadziwika kuti burdock, ndi chomera chosatha ku Asia ndi Europe. Burdock tsopano ndiwotchuka padziko lonse lapansi ndipo amalimidwa ndikugwiritsidwa ntchito ngati masamba m'malo ambiri padziko lapansi. Mizu, masamba, ndi mbewu za chomerachi zimagwiritsidwa ntchito ngati mankhwala achikhalidwe achi China ngati njira yothetsera matenda osiyanasiyana. Mizu ya Burdock yodzaza ndi ma antioxidants ndipo amawonedwanso kuti ali ndi zovuta zotsutsana ndi khansa.

Kafukufuku wosiyanasiyana wamankhwala am'mbuyomu adanenanso kuti burdock ikhoza kukhala ndi anti-inflammatory, antibacterial, antidiabetic, antiulcerogenic, hepatoprotective, ndi anticancer. Makina ofunikira a zotulutsa za burdock ndi monga caffeoylquinic acid zotengera, lignans ndi ma flavonoids osiyanasiyana.

Masamba a burdock makamaka amakhala ndi mitundu iwiri ya lignans:

• Arctiin 
• Arctigenin

Kupatula izi, phenolic acid, quercetin, quercitrin ndi luteolin amathanso kupezeka m'masamba a burdock. 

Mbeu za Burdock zimakhala ndi phenolic acid monga Caffeic acid, Chlorogenic acid ndi Cynarin.

Makina omwe amagwiritsidwa ntchito kwambiri mumizu ya Burdock ndi Arctiin, Luteolin ndi Quercetin rhamnoside omwe angapangitse kuti azitha kuyambitsa khansa.

Zogwiritsidwa Ntchito Zotulutsidwa za Burdock

Burdock yakhala ikugwiritsidwa ntchito kwambiri ku Traditional Chinese Medicine pazifukwa zotsatirazi, ngakhale kulibe umboni wazachipatala wotsimikizira kugwiritsa ntchito kwake pazambiri izi:

• Kuyeretsa magazi
• Kuchepetsa matenda oopsa
• Kuchepetsa gout
• Kuchepetsa matenda a chiwindi
• Kuchepetsa matenda opatsirana
• Kuchepetsa shuga m'magazi mwa odwala matenda ashuga
• Kuchiza zovuta zamakhungu monga eczema ndi psoriasis
• Kuchepetsa makwinya
• Kuchiza zovuta zotupa
• Kuchiza Edzi
• Kuchiza Khansa
• Monga diuretic
• Monga tiyi ya antipyretic yothandizira malungo

Kodi Burdock Extracts Ipindulira Odwala Khansa ya Pancreatic otsutsa Gemcitabine?

Malinga ndi American Cancer Society, khansa ya pancreatic ndi yachisanu ndi chinayi yofala kwambiri khansa mwa amayi ndi khansa ya khumi yofala kwambiri mwa amuna ndipo imachititsa 7% ya imfa zonse za khansa.

Ndichachinayi chomwe chimayambitsa matenda a khansa mwa abambo ndi amai. 

Gemcitabine ndi mzere woyamba wa chemotherapeutic wothandizira khansa ya kapamba. Komabe, khansa ya pancreatic microenvelo imadziwika kuti imadziwika ndi hypoxia yayikulu, vuto lomwe thupi limasowa mpweya wokwanira pamisinkhu, komanso kuchepa kwa michere, makamaka shuga. Hypoxia imathandizira kukana kutsutsana ndi gemcitabine, potero kumachepetsa phindu la chemotherapy iyi. 

Chifukwa chake, ofufuza ochokera ku National Cancer Center Hospital East, Meiji Pharmaceutical University, National Cancer Center, Kracie Pharma, Ltd. ku Toyama, ndi Tokyo University of Science, Japan adasanthula mankhwala osiyanasiyana omwe angalepheretse kulolerana kwa ma cell a khansa kukhala ndi njala ya glucose ndi hypoxia, ndikudziwika arctigenin, cholumikizira chofunikira kwambiri chomwe chimapezeka muzotulutsa za Burdock, ngati gawo loyenera kwambiri loyeserera kuchipatala, chifukwa chazinthu zomwe zimachitika m'matenda ambiri a khansa komanso mbiri yotetezedwa yokwanira ikaperekedwa pamlingo wambiri mpaka 100 tsiku lililonse Mlingo woyenera kuchitapo kanthu pamagulu. (Masafumi Ikeda et al, Cancer Sci., 2016)

Ofufuzawa adagwiritsa ntchito mankhwala apakamwa a GBS-01, omwe amachokera ku chipatso cha Burdock, cholemera mu arctigenin, mwa odwala 15 omwe ali ndi kapamba. khansa kukana kwa gemcitabine. Mumlanduwu, adafufuza kuchuluka kwa GBS-01 kololedwa ndikuyang'ana poizoni wochepetsa Mlingo. Dose-limiting toxicities (DLTs) imatanthawuza kuoneka kwa grade 4 hematological/magazi kawopsedwe ndi grade 3 kapena 4 non-hematological/magazi kawopsedwe m'masiku 28 oyamba a chithandizo.

Mkafukufukuyu, adapeza kuti palibe zisonyezo za poizoni wamagazi a grade 4 komanso grade 3 kapena 4 yopanda magazi mwa odwala aliwonse omwe adalembetsa, pamlingo uliwonse womwe wagwiritsidwa ntchito (tsiku lililonse 3.0 g, 7.5 g kapena 12.0 g) . Komabe, poizoni wofatsa adawonedwa monga kuchuluka kwa seramu ‐ ‐ glutamyl transpeptidase, kuchuluka kwa magazi m'magazi, komanso kuchuluka kwa seramu yathunthu bilirubin. 

Kafukufukuyu adatsimikiza kuti GBS-01, yomwe imatulutsa arctigenin yochokera ku Burdock, ikhale 12.0 g tsiku lililonse, chifukwa palibe ma DLTs omwe adawonedwa pamlingo uliwonse wa milingo itatu. Mlingo watsiku ndi tsiku wa 12.0 g GBS-01 unali pafupifupi wofanana ndi 4.0 g wa zipatso za burdock.

Mwa odwala omwe amadya chotulutsa cha Burdock, odwala 4 anali ndi matenda okhazikika ndipo 1 adawonetsa kuyankha pang'ono panthawi yowonera. Kunena zowona, kuchuluka kwa omwe amayankha anali 6.7% ndipo kuchuluka kwa matenda anali 33.3%. Kafukufukuyu adapezanso kuti kupitirira kwaulere komanso kupulumuka kwa odwala kunali miyezi 1.1 ndi miyezi 5.7, motsatana. 

Kutsiliza

Mafuta a Burdock ndi mizu amaonedwa kuti ali ndi anti-yotupa, antibacterial, antidiabetic, antiulcerogenic, hepatoprotective, ndi anti-cancer properties. Kafukufuku wachipatala wa 2016 Phase I wochitidwa ndi ofufuza ochokera ku Japan adati mlingo watsiku ndi tsiku wa 12 g wa GBS-01 (wokhala ndi pafupifupi 4.0 g burdock zipatso zokhala ndi arctigenin) ukhoza kukhala wotetezeka kuchipatala ndipo ungakhale ndi phindu kwa odwala omwe ali ndi kapamba. khansa kukana chithandizo cha Gemcitabine. Komabe, kuyesa kwakukulu kodziwika bwino ndikofunikira kuti tipeze izi, tisanavomereze kugwiritsidwa ntchito kwa arctigenin kwa odwala khansa ya kapamba.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

• Kodi Therapy Target ndiyabwino kuposa Chemotherapy ya Relapsed FLT3-Mutated Acute Myeloid Leukemia?
• Kodi High Dose Ascorbic Acid (Vitamini C) ingaperekedwe bwino limodzi ndi Cytotoxic Chemotherapy?
• Kodi Neem Amachotsa Thandizo Pokulitsa Kuyankha kwa Chemotherapy mu Khansa ya Amayi?
• Kugwiritsa Ntchito Mbatata ndi Kuopsa kwa Khansa
• Kodi ndizotheka kugwiritsa ntchito Soy Isoflavone Genistein limodzi ndi Chemotherapy ya Metastatic Colorectal Cancer?