Mfundo
Curcumin, yotengedwa muzu wa turmeric, yawerengedwa mozama chifukwa cha zotsutsana ndi khansa ndi chidziwitso pamakina am'manja a momwe angathandizire kugwirizanitsa ndi mankhwala enaake a chemotherapy. Curcumin yochokera ku turmeric idathandizira kuyankha kwa chithandizo cha FOLFOX chemotherapy mwa odwala khansa ya colorectal monga momwe zidawonetsedwera ndi kuyesa kwachipatala kwa gawo lachiwiri. Komabe, khansa odwala ayenera kutenga Curcumin supplements (concentrate curcumin yotengedwa kuchokera ku turmeric) pokhapokha motsogoleredwa ndi dokotala momwe angagwirizanitse ndi mankhwala ena monga Tamoxifen.
Zokometsera za Turmeric
Turmeric ndi zonunkhira zomwe zakhala zikugwiritsidwa ntchito kwazaka mazana ambiri ku Asia osati monga chinthu chofunikira pachakudya cha ku India koma pachikhalidwe chachi China komanso mankhwala achi Indian Ayurvedic, kuti athetse mavuto osiyanasiyana azaumoyo. Posachedwa pakhala kafukufuku wambiri pamankhwala olimbana ndi khansa pazofunikira za Curcumin, zomwe zili mu turmeric (curcuma longa). Curcumin imachokera m'mizu ya Turmeric ndipo imadziwika ndi chikasu cha lalanje. Pali maphunziro ochulukirapo komanso zowunikira zomwe zidasindikizidwa m'manyuzipepala azaka masauzande ambiri pazithandizo za Curcumin.
Curcumin yochokera ku zonunkhira za Turmeric ndi phytochemical yomwe imakhudza zochitika zambiri zamagetsi, njira, mapuloteni ndi majini kuphatikiza kinases, cytokines, enzymes ndi zinthu zolembera. Chifukwa chake Curcumin ili ndi zinthu zambiri zodzitchinjiriza kuphatikiza antioxidant, anti-cancer, anti-inflammatory, antimicrobial, immunomodulatory, neuroprotective, komanso chitetezo chokwanira ku ziwalo zambiri ndi ziwalo zamagulu kuphatikiza chiwindi, impso, khungu etc. (Kocaadam B et al, Crit. Rev. Food Sci. Nutriti., 2015)
Mu blog iyi tifotokozera mwachidule umboni woyeserera komanso wazachipatala wazam'madzi zoteteza ku Curcumin, chinsinsi cha Spice Turmeric. Ndizofikirika mosavuta, zotsika mtengo komanso poizoni wotsika, masoka achilengedwe, osankhidwa ngati chimodzi mwazinthu zabwino zomwe zingayesedwe m'mayesero azachipatala ndi US National Cancer Institute.
Ngakhale umboni woyeserera komanso umunthu wamankhwala wokhudzana ndi mankhwala a Curcumin omwe ali ndi khansa, uli ndi zovuta zakusavomerezeka komanso kupezeka kochepa m'thupi, mwachilengedwe. Izi zitha kuthetsedwa kudzera pama form omwe amalimbikitsa kupezeka kwa bioavailability yake. Kuphatikiza apo, kudzera mu kulumikizana kwake ndi ma enzyme omwe amagwiritsira ntchito mankhwala osokoneza bongo komanso omwe amatumiza mankhwala osokoneza bongo, amatha kuchita bwino ndi mankhwala ena. Chifukwa chake, pakufunika maphunziro owongoleredwa bwino azachipatala kuti afotokozere momwe zinthu zilili komanso kuphatikiza komwe Curcumin ingagwiritsidwe ntchito. (Unlu A Et al, JBUON, 2016)
Katundu Wopewera Kutupa wa Curcumin / Turmeric Amapereka Zabwino Zotsutsana ndi Khansa
Makhalidwe ofunikira a khansa ya Curcumin / Turmeric ndi chifukwa cha anti-inflammatory and immunomodulatory properties.
Khansa imachitika maselo athu akasinthidwa chifukwa chosintha komanso zolakwika zomwe zimayambitsidwa pazifukwa zosiyanasiyana monga moyo, kadyedwe, kupsinjika, chilengedwe komanso zomwe zimayambitsa chibadwa. Matupi athu adapangidwa ndi alonda ndi njira zodzitetezera pamawonekedwe amachitidwe. Chitetezo chathu chimapangidwa kuti chizindikiritse chilichonse chachilendo (kachilombo ka bakiteriya kapena kachilombo ka HIV) kapena china chilichonse m'thupi chomwe chili chachilendo, ndipo chimakhala ndi njira komanso mayendedwe achilengedwe kuti athetse vutoli. Ngakhale pamlingo wama cell momwe magawano amakula, kukonzanso, kupoletsa mabala ndi magwiridwe antchito ena amthupi, timayang'anitsitsa mulingo uliwonse kuyambira ndikuwunika kulondola kwa uthenga wabwino mu genome yathu, DNA. Pali DNA yowonongeka komanso yokonza makina omwe akugwira ntchito nthawi zonse.
Khansa ikachitika, kafukufukuyu atsimikizira kuti pali cholakwika pama cell ndi makina okonza DNA omwe amawononga kuwonongeka kwa ma cell ndi zina zachilendo, komanso kuwonongeka kwa chitetezo cha mthupi chomwe chanyalanyaza ndipo sichinathe kuzindikira ndikuchotsa zachilendo. Chifukwa chake maselo osazolowereka amaloledwa kupulumuka ndipo maselo amtunduwu amalanda kachitidwe kameneka ndikukula ndikukula ngati matendawa akupita.
Kutupa ndi njira yomwe thupi limazindikira kuti ili ndi vuto kapena labwinobwino ndikugwiritsa ntchito chitetezo cha mthupi kuti athane ndi vutoli. Makamaka, zovuta zonse kuphatikiza zovuta zama autoimmune, zovuta zowononga ngakhale khansa zimachitika chifukwa cha kusowa kwa chitetezo chamthupi. Pankhani ya khansa, chitetezo cha mthupi chimabedwa kuti chisazindikire koma chimathandizira ma cell osazolowereka ndikuwathandiza kukula.
Pali maphunziro ambiri omwe atsimikizira njira zamagetsi zotsutsana ndi zotupa za Curcumin zochokera ku Turmeric zomwe zimapindulitsa kwambiri polimbana ndi khansa. Curcumin imakhala ndi zinthu zotsutsana ndi zotupa kudzera pakulumikizana ndi oyimira pakati angapo monga kuletsa kutulutsa zotupa monga Nuclear factor kappa B (NFKB), kumalepheretsa zotupa zotupa, chemokines, prostaglandins komanso mitundu yama oxygen (ROS). Ambiri mwa otetezerawa amatenga nawo mbali pama cell angapo ophatikizira omwe amapezeka ndimatenda a khansa monga kuchuluka kwa khansa (kuchuluka), kuchepa kwamaselo (apoptosis), kuphuka kwambiri kwa mitsempha yatsopano yamagazi (angiogenesis) ndikuthandizira kufalikira kwa ma cell osadziwika a khansa ku ziwalo zina za thupi (metastasis). Katemera wa ma curcumin samangobwera chifukwa chokhazikitsa ma cell a cell komanso amatha kusinthitsa bwino ma cell a chitetezo monga macrophages, cell dendritic, T-cell ndi B-lymphocyte, chitetezo chamthupi. (Giordano A ndi Tommonaro G, Nutrients, 2019)
Kafukufuku Woyeserera Pazotsatira Zotsutsana ndi khansa za Turmeric / Curcumin In Cancer
Zotsatira zotsutsana ndi khansa za Curcumin / Turmeric zafufuzidwa m'mizere yambiri ya khansa ndi mitundu yazinyama. Curcumin yawonetsa zopindulitsa pochepetsa kukula kwa maselo a khansa pamitundu ya khansa ya prostate, khansa ya m'mawere kuphatikiza khansa ya m'mawere yopanda katatu, khansa yam'mutu ndi khosi, khansa yam'mapapo ndi ena ambiri. (Unlu A Et al, JBUON, 2016)
Kuphatikiza apo, pakhala maphunziro owunika ngati Curcumin itha kukulitsa chidwi cha mankhwala a chemotherapy ndi mankhwala a radiation.
- Curcumin adawonetsedwa kuti akuwonjezera chidwi cha 5-fluorouracil m'mizere yoyera yamatenda a khansa. (Shakibaei M et al, PLoS One, 2014)
- Curcumin yotengedwa ku Turmeric idayesa kuchita bwino kwa cisplatin m'mutu ndi m'khosi ndi khansa yamchiberekero. (Kumar B et al, PLoS One, 2014; Selvendiran K et al, Cancer Biol. Ther., 2011)
- Curcumin akuti akuwonjezera mphamvu ya paclitaxel m'maselo a khansa ya pachibelekero. (Sreekanth CN et al, Oncogene, 2011)
- Mu lymphoma, Curcumin adawonetsedwa kuti apititse patsogolo mphamvu ya radiation. (Qiao Q et al, Mankhwala a Anticancer, 2012)
- M'maselo a khansa ya m'mapapo ya squamous, Curcumin wochokera ku Turmeric akuti amagwirizana ndi chemotherapy mankhwala vinorelbine. (Sen S et al, Biochem Biophys Res. Mgwirizano., 2005)
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Zofufuza Zachipatala Pazotsatira za Curcumin mu Cancer
Curcumin ikufufuzidwabe m'maphunziro ambiri azachipatala, monga monotherapy komanso kuphatikiza mankhwala ena.
- Pakafukufuku wamatenda a khansa yoyipa, mawonekedwe amlomo a curcumin adayesedwa. Panalibe poizoni ndi Curcumin, pomwe 2 mwa odwala 15 adawonetsa matenda osakhazikika pakatha miyezi iwiri yothandizidwa ndi Curcumin. (Sharma RA et al, Clin Cancer Res., 2) Mu gawo lina lachiwiri la odwala 2004 omwe ali ndi zotupa za khansa ya m'matumbo, kugwiritsa ntchito Curcumin masiku 44 kunanenedwa kuti kumachepetsa zilonda ndi 30%. (Carroll RE et al, Cancer Prev. Res. (Phila), 40)
- Poyeserera gawo lachiwiri la kapangidwe kamlomo ka Curcumin mwa 25 odwala khansa ya kapamba, odwala awiri adawonetsa zochitika zamankhwala ndi wodwala m'modzi akuti ali ndi matenda okhazikika kwa> miyezi 18 ndipo wina ali ndi chifuwa chachidule koma chachikulu. (Dhillon N et al, Clin Cancer Res., 2008)
- Kafukufuku wamankhwala odwala matenda a myeloid leukemia (CML), zotsatira zochiritsira kuphatikiza kwa Curcumin pamodzi ndi Imatinib (muyezo wa mankhwala osamalira CML) adayesedwa. Kuphatikizaku kunawonetsa kuyendetsa bwino kuposa Imatinib yekha. (Ghalaut VS et al, J Oncol. Pharm Pract., 2012)
- Odwala khansa ya m'mawere, Curcumin akufufuzidwa mu monotherapy (NCT03980509) komanso kuphatikiza paclitaxel (NCT03072992). Ikuwunikidwanso m'maphunziro ena azachipatala a khansa ya prostate yomwe ili pachiwopsezo chochepa, khansa ya pachibelekero, khansa ya endometrial, uterine sarcoma ndi ena. (Giordano A ndi Tommonaro G, Nutrients, 2019)
- Kafukufuku waposachedwa wa II wothandizira odwala omwe ali ndi khansa ya m'matumbo (NCT01490996) poyerekeza kupulumuka konse kwa odwala omwe amalandila kuphatikiza chemotherapy FOLFOX (folinic acid / 5-fluorouracil / oxaliplatin chithandizo) ndi popanda Curcumin zowonjezera (kuchokera ku Turmeric). Kuphatikiza kwa Curcumin kupita ku FOLFOX kunapezeka kuti kuli kotetezeka komanso kosalekerera odwala khansa yamitundumitundu ndipo sikunakulitse zovuta za chemo. Ponena za kuchuluka kwa mayankho, gulu la Curcumin + FOLFOX linali ndi zotsatira zabwino zopulumuka ndikupita patsogolo kwaulere kukhala masiku 120 kuposa gulu la FOLFOX ndipo kupulumuka konse kukuwonjezeka kawiri. (Howells LM et al, J Nutr, 2019) Kuphatikiza ndi Curcumin ngati gawo limodzi lokongola Zakudya za odwala khansa mukamamwa mankhwala a FOLFOX chemotherapy atha kukhala opindulitsa.
Kuyanjana kwa Curcumin ndi Mankhwala Ena
Curcumin, ngakhale imadziwika kuti ndi yotetezeka kwambiri ndi FDA (Food and Drug Administration), ili ndi umboni wosonyeza kuti imakhudza ma enzymes a cytochrome P450 a metabolizing. Chifukwa chake, imatha kuyanjana ndi mankhwala ena ndikusokoneza mphamvu ya mankhwalawa. Pali maphunziro pakuchita kwake ndi mankhwala kuphatikiza antiplatelet mankhwala, ndi zina khansa ndi mankhwala amphamvu a chemotherapy kuphatikizapo Tamoxifen, doxorubicin, cyclophosphamide, tacrolimus ndi ena. (Unlu A et al, JBUON, 2016)
Katundu wa Curcumin antiplatelet angapangitse mwayi wotuluka magazi akagwiritsidwa ntchito ndi ma anticoagulants. Katundu wake wa antioxidant amatha kusokoneza mawonekedwe a mankhwala a chemotherapy monga cyclophosphamide ndi doxorubicin. (Yeung KS et al, Oncology J, Kuphatikiza Oncol., 2018)
Curcumin wochokera ku Turmeric amalumikizana ndi chithandizo cha Tamoxifen, Standard of Care for Hormone Positive Breast Cancer
Mankhwala amkamwa a Tamoxifen amasinthidwa mthupi mthupi mwa ma metabolism omwe amagwiritsidwa ntchito ndi mankhwala kudzera mu michere ya cytochrome P450 m'chiwindi. Endoxifen ndi metabolite yogwira ya Tamoxifen, ndiye mkhalapakati wofunikira wa mankhwala a tamoxifen (Del Re M et al, Pharmacol Res., 2016). Kafukufuku wina wakale yemwe wachitika pa makoswe adawonetsa kuti pali kulumikizana kwa mankhwala osokoneza bongo pakati pa Curcumin ndi Tamoxifen. Curcumin adaletsa cytochrome P450 mediated metabolism ya tamoxifen kutembenuka kukhala mawonekedwe ake (Cho YA et al, Pharmazie, 2012). Kafukufuku waposachedwa wazachipatala (EudraCT 2016-004008-71 / NTR6149) ochokera ku Erasmus MC Cancer Institute ku Netherlands, adayesa kulumikizana uku pakati pa Curcumin ndi Turmeric (wopanda piperine) ndi chithandizo cha Tamoxifen mwa odwala khansa ya m'mawere (Hussaarts KGAM et al, Khansa (Basel), 2019). Ofufuzawo adawunika kuchuluka kwa Tamoxifen ndi Endoxifen pamaso pa Curcumin.
Zotsatira zake zidawonetsa kuti kuchuluka kwa metabolism yogwira ya Endoxifen yatsika ndi Curcumin. Kutsika uku mu Endoxifen kunali kofunika kwambiri. Chifukwa chake, ngati Curcumin supplement (yochokera ku Turmeric) itatengedwa limodzi ndi mankhwala a Tamoxifen a khansa ya m'mawere, imatha kutsitsa kuchuluka kwa mankhwala omwe ali pansi pake kuti agwire bwino ntchito ndipo atha kusokoneza kukhudzidwa kwa mankhwalawa.
Kutsiliza
Turmeric, zonunkhira zachikaso chachikaso, yakhala ikugwiritsidwa ntchito kwazaka zambiri, ngakhale Curcumin yake isanadziwike, chifukwa chazithandizo zake zambiri. Amagwiritsidwa ntchito ngati anti-yotupa ndipo amagwiritsidwanso ntchito molunjika pamabala kuti athandize kuchira kwa bala. Tizilombo tating'onoting'ono tokhala ndi mkaka wotentha ndi mankhwala okhalitsa a antibacterial komanso chitetezo chamthupi chomwe chimagwiritsidwa ntchito m'mabanja masiku ano, malinga ndi nzeru zachikhalidwe. Ndi pophika ufa wophika ndipo amagwiritsidwa ntchito mozama ngati gawo la zakudya zaku India ndi ku Asia. Msuzi wa supuni yaiwisi ndi grated turmeric mizu limodzi ndi tsabola wakuda ndi mandimu ndichinthu china chodziwika bwino chomwe chimagwiritsidwa ntchito pafupipafupi pothana ndi matenda ashuga, odana ndi nyamakazi, komanso chitetezo chamthupi. Chifukwa chake monga chakudya chachilengedwe ndi zonunkhira, turmeric imagwiritsidwa ntchito kwambiri.
Masiku ano, pali mitundu yonse yazotulutsa zam'madzi ndi ma Curcumin, mapiritsi, makapisozi, ndi mitundu yosiyanasiyana yogulitsidwa pamsika, yokwera pazabwino zodziwika bwino. Komabe, Curcumin amadziwika kuti ali ndi mayamwidwe oyipa komanso kupezeka kwa thupi m'thupi. Mukakhala limodzi ndi tsabola wakuda kapena piperine kapena bioperine, zimapangitsa kuti bioavailability ipitirire. Zogulitsa za Curcumin zimawerengedwa ngati zitsamba ndi botanicals zomwe sizimayendetsedwa molingana ndi mankhwala. Chifukwa chake, ngakhale kuchuluka kwa zinthu za Curcumin pamsika, munthu ayenera kudziwa kusankha mankhwalawo ndi malembedwe oyenera ndikuwonjezera zilembo zoyenerera kuchokera ku USP, NSF ndi zina, kuti atsimikizire mtundu wabwino wa malonda.
Monga momwe zalembedwera mu blog, pali maphunziro ambiri oyeserera m'maselo osiyanasiyana a khansa ndi mitundu yazinyama zomwe zikuwonetsa momwe Curcumin silingaletsere kukula kwa khansa ndi malekezero ena a khansa, komanso adasekanso malingaliridwe abodza a momwe Curcumin amagwirira ntchito ikugwira ntchito popereka ma anti-cancer. Pali maphunziro ena azachipatala omwe awonetsa phindu lochepa ndipo awonetsa kusintha kwa mankhwala othandiza ena a khansa kuphatikiza chemotherapy ndi radiation, kuphatikiza ndi Curcumin (wochokera ku Turmeric).
Komabe, mosiyana ndi zofunikira zokhwima za maphunziro a mankhwala achipatala, kugwiritsa ntchito Curcumin formulations ndi kuika kwake sikunakhale kofanana komanso kovomerezeka m'maphunziro ambiri azachipatala. Kuonjezera apo, chifukwa chodziwika bwino cha bioavailability ya Curcumin yachilengedwe, zotsatira za maphunziro a zachipatala sizinali zochititsa chidwi komanso zokhutiritsa. Komanso pali zambiri zokhudzana ndi kuyanjana kwa Curcumin ndi mankhwala ena omwe angakhudze mphamvu ya mankhwalawa. Chifukwa chake pazifukwa zonse zomwe tafotokozazi, kuphatikiza kugwiritsa ntchito turmeric muzakudya ndi zakudya zathu komanso mwina kupangidwa koyenera kwa curcumin chifukwa cha mphamvu zake zolimbitsa thupi, kugwiritsa ntchito Curcumin ndi khansa odwala sakulimbikitsidwa pokhapokha motsogoleredwa ndi dokotala.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.