Ndi khansa iti yomwe ingapindule ndikuphatikiza Curcumin muzakudya zawo?

Mfundo

Curcumin amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Curcumin kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Curcumin ikhoza kupindulitsa iwo omwe ali ndi Primary Mucinous colorectal adenocarcinoma omwe akudwala Cetuximab, koma sizingakhale zabwino kwa odwala omwe akulandira Ifosfamide ya Primary Round Cell Sarcoma. Kuphatikiza apo, ngakhale Curcumin imatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "CDKN2A", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana. Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Curcumin kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Curcumin ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse za zigawo zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Curcumin m'malo mowunika chilichonse chogwiritsira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza Curcumin muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Curcumin ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDKN2A? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini? Kodi ndizopindulitsa kuphatikiza Curcumin muzakudya zanu ngati mwapezeka ndi Primary Round Cell Sarcoma, kapena ngati matenda anu ndi Primary Mucinous colorectal adenocarcinoma? Komanso, momwe mumamwa Curcumin muyenera kusintha bwanji ngati mukulandira chithandizo cha Cetuximab kapena ngati dongosolo lanu lamankhwala likusintha kuchoka ku Cetuximab kupita ku Ifosfamide? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Curcumin ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Curcumin imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Curcumin muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Curcumin muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira momwe biochemical imakhudzira zosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso enieni omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Mucinous colorectal adenocarcinoma kapena Primary Round Cell Sarcoma, njira zochiritsira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthuyo, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enieni a khansa posankha zakudya, monga Curcumin. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDKN2A chimakhala ndi zotsatira zofananira ndi kusintha kwa jini ina? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Mucinous colorectal adenocarcinoma chikufanana ndi Primary Round Cell Sarcoma? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akudwala Ifosfamide monga omwe amalandira Cetuximab? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Curcumin - Chowonjezera Chakudya

Curcumin yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo Curcumin, iliyonse yomwe ilipo pamagulu osiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka WNT Beta Catenin Signaling, Kukonza DNA, Ceramide Signaling ndi PI3K-AKT-MTOR Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Curcumin, zokha kapena zophatikizana, zimakhala chisankho chofunikira pazakudya za khansa. Mukaganizira kugwiritsa ntchito Curcumin pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Curcumin si chisankho chapadziko lonse choyenera kwa makhansa onse koma chiyenera kukhala payekha.

Kusankha Zowonjezera za Curcumin

Kuyankha funso lakuti 'Ndiyenera kupewa liti Curcumin pa nkhani ya Khansa' ndizovuta chifukwa yankho ndilokhazikika payekha - limangokhala 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Curcumin zimasiyana malinga ndi zochitika zaumwini. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, kuopsa kwa majini, chithandizo chamakono, zowonjezera zowonjezera zomwe zimatengedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Curcumin ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunika kwa kuganiziridwa kwaumwini pazisankho zotere.

1. Kodi Curcumin Supplements ingapindule Odwala Odwala Odwala Sarcoma Omwe Akulandira chithandizo cha Ifosfamide?

Primary Round Cell Sarcoma imadziwika ndi kusintha kwa majini, komwe ndi CIC, ATM ndi FBXW7, zomwe zimabweretsa kusintha kwa njira zama biochemical, makamaka Kukonzanso kwa DNA, Ma cell Cycle Checkpoints, Antigen Presentation ndi Post Translation Modification. Kuchita bwino kwa chithandizo cha khansa, monga Ifosfamide, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Curcumin, chomwe chimakhudza Kukonzanso kwa DNA, sichingakhale chisankho choyenera pa nkhani ya Primary Round Cell Sarcoma pamene akukumana ndi Ifosfamide. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Curcumin Supplements idzapindulitsa Odwala a Primary Mucinous colorectal adenocarcinoma omwe akulandira chithandizo cha Cetuximab?

Primary Mucinous colorectal adenocarcinoma imadziwika ndi kusintha kwa majini, monga TTN, APC ndi KRAS, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka WNT Beta Catenin Signaling, Angiogenesis, G-protein-coupled Receptor Signaling ndi Growth Factor Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Cetuximab, kumatsimikiziridwa ndi kulumikizana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Curcumin ndi njira yabwino kwa iwo omwe ali ndi Primary Mucinous colorectal adenocarcinoma akukumana ndi Cetuximab. Izi ndichifukwa choti Curcumin imakhudza njira monga WNT Beta Catenin Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Mucinous colorectal adenocarcinoma kapena kupindulitsa mphamvu ya Cetuximab.

3. Kodi Zowonjezera za Curcumin Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi CDKN2A Mutation Associated Genetic Risk?

CDKN2A imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa ma CDKN2A kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints ndi Cell Cycle, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a CDKN2A okhudzana ndi Khansa Yapakhungu, lingalirani zophatikiza zowonjezera za Curcumin mu dongosolo lanu lazakudya. Zowonjezera izi zitha kulimbikitsa njira ngati PI3K-AKT-MTOR Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a CDKN2A ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikizapo chakudya ndi zowonjezera monga Curcumin, ndi chida chothandiza chomwe chingathe kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Ubale wamapangidwe a zotumphukira za curcumin zomwe zimamangiriza ku BRCT domain ya human DNA polymerase lambda.
• Kulinganiza kukonza ndi kulolerana kwa kuwonongeka kwa DNA komwe kumachitika ndi ma alkylating agents.
• Curcumin (diferuloylmethane) pansi-imayang'anira kuyambitsa kwa nyukiliya-kappa B ndi IkappaBalpha kinase m'maselo angapo a myeloma aumunthu, zomwe zimapangitsa kuti kuchuluke komanso kulowetsedwa kwa apoptosis.
• Pan-cancer kusanthula ma genomes onse.
• cBioPortal ya Cancer Genomics
• cBioPortal ya Cancer Genomics
• lncRNA MIR100HG yochokera ku miR-100 ndi miR-125b imayimira kukana kwa cetuximab kudzera pa Wnt/β-catenin signing.
• Curcumin imalepheretsa kukula kudzera njira ya Wnt/β-catenin m'maselo a khansa ya m'mapapo omwe si ang'onoang'ono.