Mfundo
DIM kapena diindolylmethane, chowonjezera chomwe chimagwiritsidwa ntchito kwambiri, ndi metabolite ya I3C (indole-3-carbinol), yomwe imapezeka kwambiri mumasamba athanzi monga broccoli, kabichi, kolifulawa ndi kale. Odwala khansa nthawi zambiri amayesa kuphatikizira zakudya zopatsa thanzi komanso machiritso omwe amapitilira khansa kuti apititse patsogolo moyo wawo kapena chithandizo chamankhwala, poganiza kuti kumwa mankhwala aliwonse achilengedwe kapena zomera pamodzi ndi machiritso omwe amapitilira nthawi zonse kumakhala kotetezeka ndipo sikungabweretse vuto lililonse. Izi sizowona nthawi zonse. Kutengera ndi mtundu wa khansa ndi chithandizo chake, zotsatira za mankhwalawa zimatha kusiyanasiyana ndipo zimatha kusokoneza chithandizo chamankhwala chapadera. Mu blog iyi, tikukambirana pa kafukufuku wina wachipatala woterewu womwe unapeza kuti DIM (diindolylmethane) ikhoza kusokoneza Tamoxifen, muyezo wa chithandizo cha khansa ya m'mawere, ndi kuchepetsa milingo ya metabolite yogwira ya Tamoxifen. Kuyanjana kwa DIM-tamoxifen kumatha kukhudza mphamvu zakuchiritsa za Tamoxifen ndipo ndibwino kuti musaphatikizepo zowonjezera za DIM ngati gawo la bere. Zakudya za odwala khansa pamene akulandira chithandizo cha Tamoxifen. Izi zikuwonetsa kufunikira kwa dongosolo lazakudya lokhazikika lomwe lili ndi zakudya zoyenera komanso zowonjezera kuti zithandizire zenizeni khansa chithandizo ndikupeza phindu ndikukhala otetezeka.
Kugwiritsa ntchito DIM (diindolylmethane) mu Khansa ya M'mawere
Pali anthu ambiri omwe apulumuka khansa ya m'mawere omwe amadzipangira okha zakudya zopatsa thanzi zomwe zimapangidwa ndi bioactive ndicholinga choletsa. khansa kubwereza ndikupeza mapindu opulumuka. Kusankha kwamankhwala omwe amamwa kumangochitika mwachisawawa potengera zomwe abwenzi kapena abale, kapena kutengera zomwe amafufuza pa intaneti komanso zambiri pa intaneti.
Chowonjezera chomwe chimagwiritsidwa ntchito kwambiri ndi DIM (diindolylmethane), metabolite ya I3C (indole-3-carbinol), yomwe imapezeka mumasamba a cruciferous monga broccoli, kolifulawa, kale, kabichi, Brussels zikumera. Kugwiritsiridwa ntchito kofala kwa DIM pakati pa odwala khansa ya m'mawere kumatha kutengera zomwe zapezedwa kuchokera ku maphunziro azachipatala owunikira kuphatikiza kafukufuku wa Women's Healthy Eating and Living (WHEL) wa odwala khansa ya m'mawere opitilira 3000 omwe adapeza mgwirizano wa kuchepa kwa chiwopsezo cha kuyambiranso kwa khansa ya m'mawere mwa amayi omwe akutenga. Mankhwala a Tamoxifen, omwe adadyanso masamba a cruciferous monga gawo lazakudya zawo. Mgwirizanowu malinga ndi ofufuzawo ukhoza kulumikizidwa ndi ntchito za phytochemicals monga DIM mumasamba a cruciferous omwe ali ndi anti-cancer ndi anti-inflammatory properties (Thomson CA, Breast Cancer Res Treat., 2011). Kuwunika kwina kwaposachedwa kwaposachedwa kwa maphunziro 13 owongolera milandu komanso omwe akuyembekezeka kuphatikiziranso kafukufuku wapagulu adawonetsanso kuti kudya kwambiri masamba a cruciferous (olemera mu indole-3-carbinol) monga broccoli, kale, kabichi, kolifulawa ndi sipinachi muzakudya zimalumikizidwa kwambiri. ndi 15% chiopsezo chochepa cha khansa ya m'mawere (Liu X et al, Breast, 2013).
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
DIM (diindolylmethane) ndi Tamoxifen Interactions mu Breast Cancer
Odwala khansa ya m'mawere omwe ali ndi khansa ya m'mawere (Estrogen Receptor ER+) amathandizidwa ndi adjuvant Tamoxifen endocrine therapy kwa nthawi yotalikirapo ya zaka 5-10 pambuyo pa opaleshoni yawo ndi mankhwala a chemo-radiation. Tamoxifen ndi yosankha estrogen receptor modulator (SERM) yomwe imachita mwa kupikisana ndi hormone ya estrogen kuti imangirire ku ER mu minofu ya m'mawere, motero imalepheretsa zotsatira za khansa ya estrogen. Tamoxifen, mankhwala apakamwa, amapangidwa ndi ma cytochrome P450 michere m'chiwindi kukhala ma metabolites ake a bioactive omwe ndi amkhalapakati ofunikira a tamoxifen. Pali zina wamba chomera linachokera zowonjezera kuti akhoza kusokoneza kagayidwe Tamoxifen ndipo potero kuchepetsa ndende ya mankhwala pansi pachimake achire. Mmodzi mwachisawawa, wakhungu, wakhungu, wakhungu, woyendetsedwa ndi placebo wogwiritsa ntchito DIM supplement, metabolite ya indole-3-carbinol compound kuchokera ku masamba a cruciferous, pamodzi ndi Tamoxifen, odwala khansa ya m'mawere, awonetsa mchitidwe wowopsya wa kuchepetsa tamoxifen metabolite. , kuti odwala khansa ya m'mawere pa DIM supplement ayenera kudziwa.
Tsatanetsatane wa Phunziroli
Tsatanetsatane wa mayeso osasinthika, oyendetsedwa ndi placebo kuti awunike bere lomwe akufuna khansa Chemopreventive ntchito ya DIM mu odwala khansa ya m'mawere omwe amatenga mankhwala a Tamoxifen akufotokozedwa mwachidule pansipa (NCT01391689) (Ref: Thomson CA, Breast Cancer Res. Treat., 2017).
- Panali amayi 130 omwe adapatsidwa Tamoxifen, omwe adagawidwa mwachisawawa m'magulu awiri: gulu lomwe linalandira kwa miyezi 12 kapena DIM supplement pa 150 mg, kawiri pa tsiku, kapena placebo. Amayi 98 adamaliza kafukufukuyu (gulu la placebo 51, gulu la DIM 47).
- Chomaliza chachikulu cha phunziroli chinali kuyesa kusintha kwa mikodzo ya metabolites ya estrogen hormone 2/16-hydroxyestrone, ndiye anti-tumorigenic metabolite. Mapeto ena achiwiri adayesedwanso kuphatikiza ma serum estrogens, kuchuluka kwa mabere pogwiritsa ntchito mammography kapena MRI, komanso milingo ya tamoxifen metabolites.
- DIM idakulitsa mulingo wa anti-tumorigenic estrogen metabolite poyerekeza ndi placebo, zomwe ndi zotsatira zabwino za chemopreventive.
- Panalibe kusintha komwe kunapezeka mu kachulukidwe ka bere pakati pa magulu awiriwa.
- Chodabwitsa ndichakuti panali kuchepa kwa plasma ya metabolites yogwira ntchito ya tamoxifen (endoxifen, 4-hydroxy tamoxifen, ndi N-desmethyl tamoxifen). Mu gulu la DIM, panali kuchepa kwakukulu kwa chiwerengero cha plasma ya metabolites yogwira ntchito ya tamoxifen, ndi zotsatira za kuchepa kumeneku zimawonekera pa masabata a 6 ndikukhazikika pakapita nthawi. Miyezo yogwira ntchito ya tamoxifen metabolites kwa amayi mu gulu la DIM idawonedwa kuti ili pansi pazipata zochiritsira za tamoxifen.
Kutsiliza
Ngakhale kuti kuchepa kwa ma tamoxifen kumasonyeza kusokoneza kapena kuyanjana pakati pa DIM ndi Tamoxifen metabolism, ofufuza a kafukufukuyu akuwonetsa kafukufuku wowonjezereka kuti adziwe ngati kuchepa kwa ma metabolites a tamoxifen kungachepetse kwambiri phindu lachipatala la tamoxifen. Komabe, popeza deta yachipatala ikuwonetsa mayendedwe apakati pa DIM (metabolite ya indole-3-carbinol) ndi tamoxifen, zingakhale bwino kwa bere. khansa odwala pa mankhwala a tamoxifen kuti atembenukire kumbali yosamala ndikupewa kutenga DIM pamene akugwiritsa ntchito mankhwala a Tamoxifen. Zakudya zochokera ku zomera kuphatikizapo masamba a cruciferous omwe ali ndi indole-3-carbinol angapereke phindu lofunika potenga DIM zakudya zowonjezera pamene mukumwa mankhwala a mahomoni a khansa ya m'mawere.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.