Mfundo
Curcumin ndiye chinthu chofunikira kwambiri pa zonunkhira wamba za Turmeric. Piperine, chinthu chofunikira kwambiri cha tsabola wakuda nthawi zambiri chimaphatikizidwamo mumapangidwe a Curcumin kuti athandizire kupezeka kwa bioavailability. Odwala ambiri omwe ali ndi khansa ya m'mawere amathandizidwa ndi mankhwala amtundu wotchedwa Tamoxifen. Kuphatikiza pa chithandizo chamankhwala chotere, odwala khansa ya m'mawere nthawi zambiri amayang'ana zowonjezera zowonjezera zachilengedwe monga Curcumin (yochokera ku Turmeric) yokhala ndi mphamvu zotsutsana ndi zotupa, antioxidant ndi anti-khansa kuti ateteze chitetezo chawo, kuthandizira chithandizo, moyo wabwino kapena kuchepetsa zotsatira zoyipa zamankhwala. Komabe, zina mwazowonjezera izi zimatha kuvulaza chithandizo. Kafukufuku wamankhwala omwe afotokozedwa mu blog iyi adapeza kulumikizana kosafunikira pakati pa mankhwala a Tamoxifen ndi Curcumin omwe amachokera ku Turmeric. Kutenga chowonjezera cha Curcumin mukamamwa mankhwala a Tamoxifen kumatha kuchepetsa kuchuluka kwa metabolism yogwira ya Tamoxifen ndikulepheretsa kuthandizira kwa mankhwala kwa odwala khansa ya m'mawere. Chifukwa chake, munthu ayenera kupewa kuphatikiza zowonjezera za Curcumin ngati gawo la bere Zakudya za odwala khansa ngati akulandira chithandizo cha Tamoxifen. Komanso, ndikofunikira kusintha zakudya kuti zikhale zenizeni khansa ndi chithandizo kuti mupeze phindu lalikulu kuchokera ku zakudya ndikukhala otetezeka.
Tamoxifen Ya Khansa Ya M'mawere
Khansa ya m'mawere ndi khansa yomwe imapezeka kwambiri ndipo ndi imodzi mwazomwe zimayambitsa kufa kwa amayi omwe ali ndi khansa padziko lonse lapansi. Chimodzi mwazinthu zodziwika bwino kwambiri za khansa ya m'mawere ndimadalira mahomoni ogonana, estrogen (ER) ndi progesterone (PR) cholandilira ndi chotupa cha anthu chotulutsa khungu 2 (ERBB2, chotchedwanso HER2) cholakwika - (ER + / PR + / HER2- subtype) . Hormone positive subtype ya khansa ya m'mawere ili ndi chiwonetsero chabwino chokhala ndi zaka 5 zapakati pa 94-99% (Waks ndi Winer, JAMA, 2019). Odwala omwe ali ndi khansa ya m'mawere ya mahomoni amathandizidwa ndi endocrine therapy monga Tamoxifen pofuna kupewa khansa ya m'mawere ndi kuyambiranso, pambuyo pa opaleshoni yawo ndi mankhwala a chemo-radiation. Tamoxifen imagwira ntchito ngati chosankha cha estrogen receptor modulator (SERM), komwe imalepheretsa zolandilira mahomoni mu minofu ya khansa ya m'mawere kuti achepetse kupulumuka kwa khansa ya m'mawere. khansa ma cell ndikuchepetsa chiopsezo choyambiranso.
Curcumin- Chowonjezera Chowonjezera cha Turmeric
Matenda a khansa amachititsa kusintha kwakukulu kwa moyo wa anthu kuphatikizapo chizoloŵezi chogwiritsa ntchito zowonjezera zowonjezera zachilengedwe zomwe zimadziwika kuti zili ndi anti-khansa, zimalimbikitsa chitetezo cha mthupi komanso thanzi labwino. Zotsatira za kafukufuku waposachedwa zawonetsa kuti oposa 80% a odwala khansa amagwiritsa ntchito zowonjezera kuphatikiza mankhwala othandizira ndi othandizira (Richardson MA et al, J Clin Oncol., 2000). Curcumin, chinthu chogwiritsidwa ntchito kuchokera ku curry spice turmeric, ndichimodzi mwazowonjezera zachilengedwe zomwe ndizodziwika pakati pa odwala khansa ndi opulumuka chifukwa cha anti-khansa ndi Anti-yotupa katundu. Chifukwa chake, mwayi woti odwala khansa ya m'mawere amatenga ma curcumin supplements (otengedwa ku Turmeric) pomwe ali pa Tamoxifen therapy ndi okwera. Curcumin imadziwika kuti imakhala yopanda mphamvu mthupi ndipo chifukwa chake imagwiritsidwa ntchito popanga ndi piperine, gawo la tsabola wakuda, yomwe imathandizira kukulitsa kupezeka kwake (XNUMX)Shoba G et al, Planta Med, 1998).
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Curcumin (kuchokera ku Turmeric) & Tamoxifen Kuyanjana kwa Mankhwala mu Khansa ya m'mawere
Mankhwala amkamwa a Tamoxifen amasinthidwa mthupi mthupi mwa ma metabolism omwe amagwiritsidwa ntchito ndi mankhwala kudzera mu michere ya cytochrome P450 m'chiwindi. Endoxifen ndi metabolite yogwira ya Tamoxifen, ndiye mkhalapakati wofunikira wa mankhwala a tamoxifen (Del Re M et al, Pharmacol Res., 2016). Kafukufuku wina wakale yemwe wachitika pa makoswe adawonetsa kuti pali kulumikizana kwa mankhwala osokoneza bongo pakati pa Curcumin (kuchokera ku Turmeric) ndi Tamoxifen chifukwa Curcumin idaletsa cytochrome P450 mediated metabolism ya tamoxifen kutembenukira ku mawonekedwe ake (Cho YA et al, Pharmazie, 2012). Kafukufuku yemwe angachitike posachedwa (EudraCT 2016-004008-71 / NTR6149) ochokera ku Erasmus MC Cancer Institute ku Netherlands, adayesa kulumikizana uku pakati pa Curcumin ndi Tamoxifen mwa odwala khansa ya m'mawere (Hussaarts KGAM et al, Khansa (Basel), 2019).
Mu phunziro ili adayesa zotsatira za Curcumin yekha ndi Curcumin ndi Piperine yake yowonjezera bio pamene adatengedwa nthawi imodzi ndi Tamoxifen mu mawere 16 oyesedwa. khansa odwala. Odwala anapatsidwa Tamoxifen kwa masiku 28 asanayambe phunzirolo kuti atsimikizire kuti Tamoxifen yakhazikika m'mitu yonse. Odwala adapatsidwa maulendo a 3 m'magulu a 2 osankhidwa mwachisawawa ndi machitidwe osiyanasiyana. Tamoxifen anapatsidwa mlingo wokhazikika wa 20-30 mg pa nthawi ya 3. Mipikisano ya 3 inaphatikizapo Tamoxifen yokha, Tamoxifen ndi 1200 mg Curcumin yotengedwa katatu tsiku lililonse, kapena Tamoxifen ndi 1200 mg Curcumin ndi 10 mg Piperine yotengedwa katatu tsiku lililonse. Miyezo ya Tamoxifen ndi Endoxifen inafaniziridwa ndi popanda Curcumin yokha komanso ndi kuwonjezera kwa bio-enhancer Piperine.
Kafukufukuyu akuwonetsa kuti kuchuluka kwa metabolite yogwira Endoxifen kunachepa ndi Curcumin ndikupitilira kuchepa ndi Curcumin ndi Piperine atagwirizanitsidwa. Kutsika uku mu Endoxifen kunali kofunika kwambiri.
Kutsiliza
Mwachidule, ngati wowonjezera wa Curcumin atengedwa limodzi ndi mankhwala a Tamoxifen, amatha kuchepetsa kuchuluka kwa mankhwala omwe ali pansi pake kuti agwire bwino ntchito ndipo atha kusokoneza kukhudzidwa kwa mankhwalawa. Kafukufuku wonga ameneyu sanganyalanyazidwe, ngakhale ndi ochepa mwa odwala khansa ya m'mawere, ndipo amachenjeza azimayi omwe amatenga tamoxifen kuti asankhe mankhwala omwe amamwa mosamala, omwe samasokoneza mphamvu ya khansa (chithandizo chazithandizo) zilizonse njira. Kutengera ndi umboniwu, Curcumin sikuwoneka ngati chowonjezera choyenera kutengedwa limodzi ndi Tamoxifen chifukwa zimasokoneza mphamvu yothandizira.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.