Mfundo
Mannitol, mankhwala achilengedwe, amagwiritsidwa ntchito ngati diuretic kuti iwonjezere mkodzo mwa anthu omwe ali ndi impso zoyipa (zotsatira zoyipa za chemo). Kafukufuku wamankhwala awonetsa kuti kugwiritsa ntchito mannitol limodzi ndi Cisplatin chemotherapy kumachepetsa kuvulala kwa impso kwa Cisplatin, zotsatira zoyipa zomwe zimawonedwa ndi gawo limodzi mwa atatu mwa odwala omwe amathandizidwa ndi Cisplatin. Kugwiritsa ntchito Mannitol limodzi ndi Cisplatin kumatha kukhala nephroprotective.
Cisplatin Chemotherapy zoyipa
Cisplatin ndi chemotherapy yomwe imagwiritsidwa ntchito pochiza zotupa zambiri zolimba komanso muyezo wosamalira khansa ya chikhodzodzo, mutu ndi khosi, cell yaying'ono komanso mapapo omwe si ang'onoang'ono. khansa, khansa yamchiberekero, khomo pachibelekero ndi ma testicular ndi ena ambiri. Cisplatin imathandizira kuthetsa ma cell a khansa poyambitsa kupsinjika kwa okosijeni komanso kuwonongeka kwa DNA, motero kumayambitsa kufa kwa maselo a khansa. Komabe, kugwiritsidwa ntchito kwa Cisplatin kumalumikizidwanso ndi zotsatirapo zambiri zosafunikira kuphatikiza matupi awo sagwirizana, chitetezo chamthupi chochepa, matenda am'mimba, matenda amtima komanso mavuto akulu a impso. Gawo limodzi mwa magawo atatu a odwala omwe amathandizidwa ndi Cisplatin amakumana ndi kuwonongeka kwa impso atalandira chithandizo choyambirira (Yao X, et al, Am J Med. Sci., 2007). Kuwonongeka kwa impso kapena nephrotoxicity chifukwa cha Cisplatin chadziwika ngati chochitika choyipa kwambiri (O, Gi-Su, et al. Electrolyte Blood Press, 2014). Chimodzi mwa zifukwa zazikulu za nephrotoxicity yapamwamba ndi Cisplatin ndi chifukwa chakuti mankhwalawa amapezeka kwambiri mu impso motero amawononga impso.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Mannitol ndi chiyani?
Mannitol, yemwenso amadziwika kuti sugar alcohol, amapezeka m'malo ambiri achilengedwe monga bowa, strawberries, udzu winawake, anyezi, maungu ndi algae. Imadziwikanso kuti ndi chinthu chosungika ndi FDA (Food and Drug Administration), ndipo ndi chinthu chogwiritsidwa ntchito kwambiri popanga mankhwala.
Ubwino / Kugwiritsa Ntchito Zowonjezera za Mannitol
Zotsatirazi ndi zina mwazomwe anthu amagwiritsa ntchito mannitol:
- Mannitol amagwiritsidwa ntchito ngati diuretic kuonjezera mkodzo mwa anthu omwe ali ndi vuto la impso.
- Mannitol imagwiritsidwanso ntchito popanga mankhwala kuti muchepetse kuthamanga komanso kutupa muubongo.
- Mannitol itha kuthandizira kusintha kwamwazi wamagazi
Zotsatira zoyipa za Mannitol Supplements
Zotsatirazi ndi zina zoyipa zomwe zimachitika ndi mannitol supplements:
- Kukodza Pafupipafupi
- Kuwonjezeka kwa mtima
- litsipa
- chizungulire
- madzi m'thupi
Mannitol wa Cisplatin Chemo Side Effect- Kuvulala kwa Impso
Njira imodzi yochepetsera mavuto a chemo monga nephrotoxicity, akamathandizidwa ndi Cisplatin, omwe adayesedwa kuchipatala akugwiritsa ntchito Mannitol limodzi ndi Cisplatin chemotherapy.
Pakhala pali maphunziro angapo pomwe awunika momwe Mannitol amagwiritsira ntchito limodzi ndi Cisplatin chemotherapy pa nephrotoxicity (chemo side-effect) monga seramu creatinine milingo:
- Kafukufuku wobwereza kuchokera ku University of Minnesota Health-Fairview system adasanthula odwala 313 omwe amathandizidwa ndi Cisplatin (95 adalandira mankhwala a mannitol ndi 218 opanda), adapeza kuti gulu lomwe linagwiritsa ntchito Mannitol linali ndi kuchuluka kwapakati kwa seramu creatinine kuposa gulu lomwe silinagwiritse ntchito. Mannitol. Nephrotoxicity inachitika mocheperapo mwa odwala omwe adalandira Mannitol kuposa omwe sanalandire - 6-8% ndi Mannitol vs. 17-23% popanda Mannitol.Williams RP Jr et al, J Oncol Pharm Pract., 2017).
- Kafukufuku wina wochokera ku Emory University adakonzanso kuwunika kwa odwala onse omwe amalandira cisplatin yokhala ndi radiation ya squamous cell carcinoma ya mutu ndi khosi. Kusanthula kwa data kuchokera kwa odwala 139 (88 yokhala ndi Mannitol ndi 51 yokhala ndi mchere wokha) kunawonetsa kuti gulu la Mannitol linali ndi chiwonjezeko chotsika cha serum creatinine chosonyeza kuchepa kwa nephrotoxicity (McKibbin T et al, Cancer Yothandizira Care, 2016).
- Kafukufuku wapakati pachipatala cha Rigshospitalet ndi Herlev, Denmark, adatsimikiziranso zotsatira za nephroprotective za kugwiritsa ntchito Mannitol pamutu ndi pakhosi. khansa odwala omwe amalandira chithandizo cha cisplatin pagulu la odwala 78 (Hagerstrom E, et al, Clin Med Kuzindikira Oncol., 2019).
Kutsiliza
Umboni wachipatala womwe uli pamwambawu umagwirizana ndi kugwiritsa ntchito zinthu zotetezeka, zachilengedwe monga mannitol, kuchepetsa zotsatira za nephrotoxicity chifukwa cha cisplatin. khansa odwala.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.