Mfundo
Cisplatin, mankhwala omwe amagwiritsidwa ntchito kwambiri popanga zotupa zolimba amatha kuyambitsa zotsatira zoyipa za kumva kwa odwala, zomwe zitha kukhala zamuyaya. Kafukufuku waposachedwa adayesa kuyanjana kwa Cisplatin chemotherapy ndi kumwa khofi mu mtundu wa makoswe ndipo adapeza kuti kugwiritsa ntchito caffeine panthawi ya chithandizo cha Cisplatin kumapangitsa kuti Cisplatin ayambe kumva. Cancer odwala omwe ali ndi Cisplatin chemotherapy ayenera kuchenjezedwa za kugwiritsa ntchito caffeine.
Cisplatin Chemotherapy
Cisplatin ndi mankhwala othandiza kwambiri, omwe amagwiritsidwa ntchito kwambiri pochiza zotupa zolimba. Komabe, Cisplatin chemotherapy mwatsoka imabweretsanso zovuta zoyipa kuphatikiza kumva komanso kuwonongeka kwa impso. Mosiyana ndi zotsatirapo zina zomwe zimasintha ngati chithandizo chayimitsidwa, kumva kumva kumatha kukhala kosatha ndipo kumatha kukhudza kwambiri moyo wa wodwalayo. khansa wopulumuka. Tisanamvetsetse momwe Cisplatin imayambitsa kutayika kwa makutu (ototoxicity), tiyenera kumvetsetsa momwe khutu limapangidwira.
Mbali za khutu zomwe anthu ambiri amazidziwa ndi khutu lakunja ndi khutu koma mbali zina zazikuluzikulu zimaphatikizapo ma ossicles pakati pakhutu, cochlea, ndi nembanemba ya basilar, gawo la khutu lamkati. Kwenikweni, mawu amangopangidwa ndi kunjenjemera kwa zinthu ndipo izi zimatulutsidwa ndi ng'oma yamakutu kuchokera mlengalenga kupita ku ossicles ndi cochlea mkati khutu. Cochlea ndi yomwe imayambitsa kuphwanya minda yonse yomwe imapanga mawu ndipo imachita izi kudzera mu membrane wa basilar womwe umakhala mkati mwa cochlea. Chifukwa chake mamvekedwe atsopano akamatuluka mu ng'oma ya khutu, maselo amtundu wa basilar nembanemba amayamba kugwedezeka kutengera mafupipafupi awo omwe amatsogolera pakuyambitsa kwa ma sign a neural opita kuubongo. Chifukwa chake, anthu ovala zothandizira kumva amangokweza mawu akumka khutu koma sangathe kulowa m'malo mwa maselo omwe awonongeka mkati mwa cochlea.
Cisplatin imatha kulowa m'maselo a cochlea ndipo imasungidwa momwemo kwa miyezi ndi zaka. Cisplatin imatha kuwononga ma cell mu membrane ya basilar ndikuyambitsa kutupa ndi kufa kwa ma cell atsitsi, zomwe zimapangitsa kuti makutu amve kosatha. (Rybak LP et al, Semin Hear., 2019) Ma cell aku Cochlea ali ndi ma adenosine receptors omwe akayatsidwa, amatha kuteteza ku kuwonongeka kwa ma cellwa komanso kutayika kwakumva komwe kumayendera. Pakafukufuku waposachedwa mu 2019, asayansi apeza kuti zinthu zomwe zimagwiritsidwa ntchito kwambiri monga caffeine, zomwe zimapezeka khofi ndi zakumwa zosiyanasiyana zamphamvu ndi kaboni, zomwe zimatha kuletsa zolandilira adenosine, zikadyedwa pa Cisplatin chemotherapy chithandizo, zimatha kukulitsa vuto lakumva.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Caffeine & Cisplatin chemotherapy-yomwe imapangitsa kumva Kumva
Pakafukufukuyu wochitidwa ndi ofufuza ochokera ku Yunivesite ya Southern Illinois ku United States, adayesa lingaliro loti caffeine imatha kukulitsa zovuta zomwe Cisplatin idakumana nazo kwa odwala omwe amayamba kutaya khutu chifukwa chamankhwalawa. Lingaliro limeneli adayesa mtundu wamakoswe a cisplatin ototoxicity omwe amapatsa caffeine pakamwa. Adapeza kuti kumwa kamodzi kokha komwe kumapangitsa kuti cisplatin ichulukitse chidwi chakumva popanda kuwonongeka kwa khungu lakunja koma kumawonjezera kutupa kwamakutu kwamkati. Koma kumwa mankhwala angapo a caffeine kunayambitsanso kuwonongeka kwa maselo atsitsi mu cochlea kupatula kuyambitsa kutupa. Kuchita kwa caffeine komwe adatsimikiza kunali chifukwa choletsa adenosine receptors m'maselo a cochlea. (Sheth S et al, Sci Rep. 2019)
Kutsiliza
Pomaliza, zomwe zapeza kuchokera ku kafukufukuyu zikuwonetsa zotheka kuyanjana kwamankhwala pakati pa caffeine ndi cisplatin-induced kumva kumva. Chifukwa chake, khansa Odwala omwe ali ndi cisplatin omwe ali ndi mankhwala a chemotherapy ayenera kuchenjezedwa za kugwiritsa ntchito khofi ndi zakumwa zina za caffeine. Kupewa caffeine panthawi ya Cisplatin chemotherapy sikungaimitse kapena kubweza kutayika kwakumva komwe kukubwera, koma sikungapitirire kuipiraipira ndikufulumizitsa njirayi. Odwala omwe ali ndi Cisplatin therapy omwe ayamba kumva kumva kuti ali ndi vuto lakumva ayenera kudziwitsa madokotala awo nthawi yomweyo kuti adziwe njira zochepetsera mlingo ndikupewa mitundu yonse ya caffeine..
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo komanso kuyang'ana njira zina zochiritsira khansa chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kulosera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe khansa ndi zotsatira zake zokhudzana ndi chithandizo.