o ka Naauao
Hāʻawi nui ʻia ka lāʻau Ascorbic Acid (Vitamin C) me ka chemotherapy hui ʻia e like me FOLFOX a me FOLFIRI, i loko o nā metectatic colorectal a i ʻole nā maʻi maʻi maʻi ʻōpū gastric, hiki ke lawelawe ʻia me ka palekana me ka ʻole o nā mea ʻona i hoʻohui ʻia. Lawe i ka lāʻau kiʻekiʻe C Vitamin C a i ʻole me ka hoʻopili ʻana i nā meaʻai momona ʻo Vitamin C ma ke ʻano he ʻāpana o ka maʻiʻai o nā maʻi ʻaʻai me ka chemotherapy hiki ke hoʻomaikaʻi i ka pane holoʻokoʻa a hoʻemi i nā hopena pili i ka chemotherapy i ka maʻi maʻi colorectal a i ʻole ka ʻōpū Ka maʻi 'aʻai.
ʻO ka Vitamin C / ʻAkika Ascorbic
ʻO ka ʻakika Ascorbic (Vitamin C) kahi mea antioxidant maʻamau a hoʻohana nui ʻia a me ka hoʻoikaika kino kūlohelohe. Eia naʻe, kona kuleana ma Ka maʻi 'aʻai Ua hoʻopaʻapaʻa ka pale a me ka mālama ʻana. ʻOiai ua hōʻike ʻia kekahi mau hōʻike anecdotal i ka ʻai ʻana i nā meaʻai waiwai ʻo Vitamin C i hōʻemi i ka pilikia o ka maʻi kanesa, ʻaʻole i hōʻike ʻia nā hōʻike mai ka interventional, randomized clinical trials me ka ascorbate waha. Akā, i nā haʻawina preclinical hou loa me ka nui loa o ka ascorbic acid hoʻolaha me ka intravenous infusion selectively pepehi maʻi 'aʻai maʻi 'aʻai, a hōʻike synergistic hopena me cytotoxic laau. Hiki ke hoʻokō ʻia ka nui kiʻekiʻe o ka waika ascorbic me ka infusion intravenous a ma kēia ʻano, hiki i ka waikawa ascorbic ke loaʻa i nā hopena pro-oxidant, e hoʻonui ai i ka pōʻino DNA, a laila hiki ke make i ka maʻi kanesa. Eia kekahi, aia nā hōʻike hōʻike mua e hōʻiliʻili ana e hōʻike ana e hiki ke hāʻawi maluhia ʻia ka waika ascorbic kiʻekiʻe me nā lāʻau cytotoxic e like me gemcitabine, paclitaxel a me carboplatin (ʻO Ma Y et al, ʻo Sci. Unuhi. Med., 2014; ʻO Welsh JL et al, Cancer Chemother Pharmacol, 2013)
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
Ke hoʻohana nei i ka Vitamin C / Ascorbic Acid me Chemotherapy ma Metastatic Colorectal a me Gastric Cancer
No ka loiloi i ka palekana a me ka maximal tolerated dose (MTD) o ka ascorbic acid/ Vitamin C i hiki ke hāʻawi ʻia me ka hui pū ʻana o ka cytotoxic chemotherapy regimens e like me FOLFOX a me FOLFIRI, nā mea noiʻi mai ka Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University ma Kina ua hana i kahi hoʻokolohua lapaʻau Phase 1 (NCT02969681) i loko o ka metastatic colorectal (mCRC) a i ʻole gastric Ka maʻi 'aʻai (mGC) nā maʻi. ʻO FOLFOX kahi lāʻau lapaʻau hui pū ʻia me 3 mau lāʻau: leucovorin (Folinic acid), Fluorouracil a me oxaliplatin. I loko o ka regimen FOLFIRI, ua hoʻohana ʻia nā lāʻau cytotoxic 4 - Folinic acid, Fluorouracil, Irinotecan a me Cetuximab. (Wang F et al, BMC maʻi ʻaʻai, 2019)
Ua hoʻāʻo ʻia nā mea maʻi 36 me ka hoʻonui ʻia ʻana o ka acid ascorbic intravenous mai ka 0.2-1.5 g / kg no kahi hoʻouluulu 3 hola, hoʻokahi manawa i kēlā me kēia lā, no nā lā 1-3, me FOLFOX aiʻole FOLFIRI i kahi pōʻai 14 mau lā, a hiki i ka hoʻokō ʻana o MTD. Mai nā maʻi he 36 i kākau inoa ʻia, 24 (23 me mCRC a me 1 me mGC) i loiloi ʻia no ka pane tumole. ʻO ka pane ʻoi loa ka hopena me kahi hapa pane i nā maʻi he ʻumikūmāhā (58.35%), maʻi kūpaʻa i ʻeiwa (37.5%), me ka nui o ka mālama ʻana i nā maʻi o 95.8%. Ua hōʻike nā kānaka noiʻi ʻaʻohe MTD i hiki a ʻaʻole lākou i ʻike i kahi lāʻau lāʻau palena palena palena ʻole i ʻike ʻia ma ka piʻi ʻana o ka lāʻau. ʻO nā hopena ʻaoʻao maʻamau e pili ana i ka waikawa ascorbic kiʻekiʻe me ka ʻeha o ke poʻo, ke poʻo māmā, ka waha maloʻo a me kekahi mea ʻona gastrointestinal ma muli o ka infraveous infusion. Ua hōʻike pū ʻia kēia noi i ka hoʻemi ʻana o ka momona iwi iwi a me nā ʻōpala gastrointestinal e pili ana i nā regimens chemotherapy ke hāʻawi ʻia ka lāʻau ascorbic acid kiʻekiʻe me ka chemotherapy.
Ua hōʻike ʻia nā hopena o kēia noi ʻana "ʻo ka ascorbic acid / Vitamin C ma 1.5 g / kg i hoʻokahi manawa i kēlā me kēia lā no ʻekolu mau lā ma hope ke hiki ke mālama pū ʻia me FOLFOX a i ʻole FOLFIRI chemotherapy i kahi pōʻaiapuni 14 mau lā." (Wang F et al, BMC maʻi ʻaʻai, 2019)
Panina
Hiki ke hoʻomaikaʻi i ka pane holoʻokoʻa a hoʻemi i nā hopena pili i ka chemotherapy i ka maʻi maʻi colorectal a i ʻole ka ʻōpū. Ka maʻi 'aʻai.
He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ke pale aku i ka kuhi hewa a me ke koho ʻole ʻia) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no Ka maʻi 'aʻai a me ka lāʻau pili i nā hopena ʻaoʻao.