Hoʻonui i ka makaʻu o ka Osteoporosis i nā mea pakele maʻi ʻaʻai

o ka Naauao

ʻO nā mea maʻi maʻi ʻaʻai a me nā mea ola i loaʻa i nā mālama e like me nā mea kāohi aromatase, chemotherapy, hormone therapy e like me Tamoxifen a i ʻole ka hui pū ʻana o kēia mau mea, aia i ka nui o ka maka o ka osteoporosis, kahi ʻano e hōʻemi ana i ka iwi iwi, a palupalu. No laila, ke hoʻolālā nei i kahi hoʻolālā lapaʻau ākea e like me ka mālama optimum o ke olakino kino o nā mea maʻi maʻi maʻi hiki ʻole ke hiki.

Ua kōkua nā holomua o ka noiʻi ʻana i ka maʻi ʻaʻai i ka hoʻonui ʻana i ka nui o nā mea ola i ka maʻi ʻaʻai ma ka honua holoʻokoʻa. Eia nō naʻe, ʻoiai nā holomua a pau i nā maʻi ʻaukā, ʻo ka hapa nui o nā mea ola o ka maʻi ʻaʻai ke hoʻopau ʻana me nā hopena ʻokoʻa o kēia mau ʻano hana. ʻO ka Osteoporosis kahi hopena lōʻihi lōʻihi i ʻike ʻia i nā mea maʻi ʻaʻai a me nā mea ola i loaʻa i nā lāʻau e like me chemotherapy a me ka hormone therapy. ʻO Osteoporosis ke ʻano olakino kahi i hoʻemi ʻia ai ka iwi iwi, a nāwaliwali ka iwi a palupalu. Hōʻike nā noiʻi he nui nā mea maʻi a me nā mea ola o nā ʻano maʻi ʻaʻai e like me ka maʻi ʻaʻai umauma, maʻi ʻaʻai prostate a me ka lymphoma i ka nui o ka maka o ka osteoporosis.

Ke hōʻike nei i nā noiʻi e hōʻike ana i ka makaʻu o ka Osteoporosis i ke ola ʻana o ka maʻi ʻaʻai

I loko o kahi noiʻi i alakaʻi ʻia e nā kānaka noiʻi mai Johns Hopkins Bloomberg School of Public Health, Baltimore, United States, ua loiloi lākou i ke alapine o ka loaʻa ʻana o ka osteoporosis a me kahi kūlana pohō ʻē aʻe i kapa ʻia he osteopenia ma 211 poʻe i loaʻa i ka maʻi ʻaʻai umauma i ʻike ʻia me ka maʻi ʻaʻai ma a mean mau makahiki o 47 mau makahiki, a hoʻohālikelike i ka ʻike me 567 mau wahine ʻaʻohe maʻi ʻaʻai. (ʻO Cody Ramin et al, ʻImi ʻana i ka maʻi ʻaʻai umauma, 2018) Loaʻa ka ʻikepili i hoʻohana ʻia no kēia kālailai mai ka hoʻopaʻa ʻana ʻo BOSS Study (Breast and Ovarian Surveillance Service study) a me nā ʻikepili o nā wahine i loaʻa ka ʻike e pili ana i nā hoʻāʻo pohō iwi. 66% o ka poʻe i koe i ka maʻi ʻaʻai umauma a me 53% o nā wahine ʻaʻohe maʻi ʻaʻai i hoʻokolohua i ka hoʻoneʻe iwi ʻana i ka wā i ukali ʻia he 5.8 mau makahiki a he 112 mau hanana o ka osteopenia a me / a i ʻole osteoporosis i hōʻike ʻia. Ua ʻike nā kānaka noiʻi aia he 68% ʻoi aku ka nui o ka hopena o ka nalowale iwi i nā mea ola i ka maʻi ʻaʻa umauma i ka hoʻohālikelike ʻia me nā wahine maʻi ʻole. Hoʻohui ʻia, ua hōʻike pū kekahi nā kānaka noiʻi i nā hopena nui i loaʻa o ka hoʻopaʻa ʻana:

• Ua ʻike ʻia nā mea ola i ka maʻi ʻaʻai umauma ma ka makahiki ≤ 50 mau makahiki i hoʻonui ʻia ka 1.98 mau pelu o ka osteopenia a me nā osteoporosis me nā wahine maʻi ʻole.
• ʻO nā wahine me ka maʻi ER-positive (estrogen receptor positive) ua loaʻa he 2.1 pālua i ka nui o ka hopena o ka iwi-nalowale ke hoʻohālikelike ʻia me nā wahine maʻi ʻole.
• ʻO nā mea ola i ka maʻi ʻaʻai umauma i mālama ʻia me ka hui maʻamau o chemotherapy a me ka hormone therapy i loaʻa he 2.7 mau pā i hoʻonui i ka maka o ka osteopenia a me ka osteoporosis i hoʻohālikelike ʻia me nā wahine kū ʻole i ka maʻi ʻaʻai.
• ʻO nā wahine i ʻike ʻia me ka maʻi ʻaʻai umauma a mālama ʻia me ka hui pū ʻana o chemotherapy a me tamoxifen, kahi therapy hormonone i hoʻohana nui ʻia no ka maʻi ʻaʻai umauma, ua hoʻonui ʻia ka 2.48 mau pā o nā kūlana pohō iwi inā hoʻohālikelike ʻia me nā wahine maʻi ʻole.
• Mālama ʻia nā mea pakele o ka maʻi ʻaʻai me nā mea kāohi aromatase e hoʻemi ana i ka hana estrogen, ua hoʻonui ʻia ka 2.72 a me ka 3.83 mau pelu o ka osteopenia a me ka osteoporosis ke mālama wale ʻia a i ʻole me ka chemotherapy, hoʻohālikelike ʻia me nā wahine ʻaʻohe maʻi ʻaʻai.

I ka pōkole, ua hoʻoholo ka hoʻopaʻa ʻana ua hoʻonui ʻia ka makaʻu o nā kūlana pohō o ka iwi i nā poʻe i loaʻa i ka maʻi ʻaʻa umauma ʻoi aku ka ʻōpio, loaʻa iā ER (estrogen receptor) - nā tumors hopena, mālama ʻia me nā mea kāohi aromatase wale nō, a i ʻole ka hui pū ʻana o nā chemotherapy a me nā aromatase inhibitors aiʻole tamoxifen. (ʻO Cody Ramin et al, ʻImi ʻana i ka maʻi ʻaʻai umauma, 2018)

Ma kahi noiʻi hoʻokolohua ʻē aʻe, ua kālailai ʻia ka ʻikepili mai 2589 mau mea maʻi Denemaka, me nā lymphoma B-cell diffuse nui a i ʻole follicular lymphoma, i mālama pinepine ʻia me nā steroid e like me prednisolone, ma waena o 2000 a me 2012 a me 12,945 mau kumuhana hoʻokele no nā hanana o ka pohō iwi. Ua hōʻike ʻia nā hopena i loaʻa i nā mea maʻi lymphoma ka nui o ka hopena o nā hanana pohō o ka iwi ke hoʻohālikelike ʻia me ka kaohi, me nā makahiki ʻelima a me 5 mau makahiki i hōʻike ʻia he 10% a me 10.0% no nā mea maʻi lymphoma i hoʻohālikelike ʻia me 16.3% a me 6.8% no ka kaohi. (Baech J et al, Leuk Lymphoma., 2020)

Ke kākoʻo nei kēia mau haʻawina āpau i ka ʻoiaʻiʻo e piʻi aʻe ka pilikia o ka osteoporosis i nā maʻi maʻi maʻi a me nā mea ola ma hope o nā lāʻau lapaʻau like ʻole. Hoʻohana pinepine ʻia nā lāʻau lapaʻau maʻi maʻi me ka manaʻo e hoʻomaikaʻi i nā helu ola, me ka ʻole o ka hāʻawi ʻana i ka mea nui i kā lākou hopena maikaʻi i ke olakino iwi. ʻO ka laina lalo, ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, he mea nui ia e aʻo i ka poʻe maʻi maʻi maʻi e pili ana i nā hopena maikaʻi ʻole o kēia mau lāʻau i ko lākou olakino iwi a hoʻokomo i kahi hoʻolālā lapaʻau maʻi maʻi āpau e uhi pū ana i ka hoʻokele maikaʻi loa o ke olakino iwi. Ka maʻi 'aʻai maʻi.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ke pale aku i ka kuhi hewa a me ke koho ʻole ʻia) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no Ka maʻi 'aʻai a me ka lāʻau pili i nā hopena ʻaoʻao.

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