Ukufakwa Kwe-Iron Nutrient kanye Nengozi Yomdlavuza

Amaphuzu avelele

Okutholwe ocwaningweni oluhlukene kuphakamise ukuthi ukudla okusansimbi/i-heme iron okweqile kube yingozi kumdlavuza onjengoCancer Webele kanye Nomdlavuza Wendlala; Nokho, ukuthathwa kwe-iron okuphelele noma ukungena kwe-non-heme iron kungase kube nomthelela wokuvikela kumdlavuza we-colorectal kanye ne-esophageal. Ngokusekelwe ezifundweni ezihlolwe kule bhulogi, ku zomdlavuza njengomdlavuza wamaphaphu nomdlavuza wendlala yesinye, azikho izinhlangano ezibalulekile ezitholakele. Kudingeka izifundo eziningi ezichazwe kahle ukuze kutholakale lokhu okutholakele. Ukuthathwa kwezithako ze-iron nama-Erythropoiesis-stimulating agents for cancer chemotherapy-induced anemia (amazinga aphansi e-hemoglobin) angase abe nezinzuzo ezithile. Nakuba ukuthathwa kwenani elifanele le-iron kubalulekile ekusebenzeni kahle komzimba wethu, ukuthatha kwayo ngokweqile kungase kuholele emiphumeleni engemihle futhi kungase kubulale izingane. Ngakho-ke, thintana nodokotela ngaphambi kokuthatha izithako zokudla okusansimbi.

Insimbi - Umsoco Obalulekile

I-ayoni iyiminerali ebalulekile ebalulekile ekusebenzeni kahle kwe-hemoglobin, iphrotheni edingekayo ukuhambisa umoya-mpilo egazini, kanye nokukhula nentuthuko. Njengomsoco obalulekile, i-iron idinga ukutholakala ekudleni kwethu. Iphinde ibambe iqhaza elibalulekile kwezinye izinqubo ezahlukahlukene njengokudala i-serotonin, ukusebenza kwemisipha, ukukhiqizwa kwamandla, izinqubo zesisu, ukulawulwa kokushisa komzimba, i-DNA synthesis kanye nokukhulisa amasosha omzimba. 

Insimbi igcinwa kakhulu esibindini nasemnkantsheni njenge-ferritin noma i-hemosiderin. Kungabuye kugcinwe emthonjeni, e-duodenum nasemisipha yamathambo. 

Imithombo Yokudla Yensimbi

Ezinye zezibonelo zemithombo yokudla yensimbi zifaka:

• Inyama ebomvu 
• Isibindi
• Ubhontshisi
• Nuts
• Izithelo ezomile njengezinsuku ezomisiwe nama-apricot
• Ubhontshisi weSoy

Izinhlobo Zensimbi Yezokudla

Insimbi yokudla ikhona ngezindlela ezimbili:

• Insimbi ye-Heme
• Insimbi engeyona i-heme

I-Heme iron iqukethe cishe i-55-70% yensimbi ephelele evela kumikhiqizo yezilwane efana nenyama ebomvu, izinkukhu nezinhlanzi futhi inokusebenza kahle kokumunca. 

I-non-heme iron iqukethe insimbi esele kanye nensimbi ekhona ekudleni okususelwa ezitshalweni ezinjengembotyi nezinhlamvu, nezithako zensimbi. Kunzima ukumunca i-ayoni ekudleni okutshalwe ezitshalweni. Sicela wazi ukuthi ukusebenzisa i-Vitamin C kuzosiza ekutholeni i-Iron.

Ukushoda Kwensimbi

Ukushoda kwensimbi, okubizwa nge-anemia, yisimo lapho ukuntuleka kwensimbi emzimbeni kuholela kwinani elincane lamaseli abomvu anempilo angathwala umoya-mpilo aye ezicutshini. 

Isabelo sansuku zonke se-Iron esinconywayo siyehluka ngeminyaka nobulili:

• I-8.7mg ngosuku yamadoda angaphezu kwe-18
• 14.8mg ngosuku kwabesifazane abaneminyaka engu-19 kuya kwengu-50
• 8.7mg ngosuku kwabesifazane abaneminyaka engaphezu kwengu-50

Lezi zimali zivame ukutholakala ekudleni kwethu.

Ukushoda kwe-Iron yikona ukuntuleka kwezakhi zomzimba okuvame kakhulu emhlabeni. Ngakho-ke, phambilini ukugxila okuhlobene nensimbi yokudla bekuqonde kakhulu ekushodeni kwensimbi. Kodwa-ke, esikhathini esedlule, abacwaningi bebelokhu behlola nemithelela yensimbi eyeqile emzimbeni. Kule bhulogi, sizogxila kwezinye zezifundo ezihlolisise ukuhlangana phakathi kwensimbi nobungozi bezinhlobo ezahlukahlukene zomdlavuza.

Inhlangano phakathi kwe-Iron ne-Breast Cancer Risk

I-Serum and Tumor Tissue Tissue Ingozi Yomdlavuza Webele

Ukuhlaziywa kwe-meta okwenziwe ngabaphenyi baseGolestan University of Medical Sciences, Ilam University of Medical Sciences, iShahid Beheshti University of Medical Sciences kanye neBirjand University of Medical Sciences kuhlolisise ubudlelwane obuphakathi kwengozi yomdlavuza wensimbi nobele. Ukuhlaziywa kufaka izindatshana ezingama-20 (ezibandakanya abantu abayi-4,110 abaneziguli ezinomdlavuza webele eziyi-1,624 kanye nezilawuli ezingama-2,486) ezashicilelwa phakathi kuka-1984 no-2017 futhi zatholakala ngokuseshwa kwezincwadi ePubMed, Scopus, Embase, Web of Science, naseCochrane Library. (U-Akram Sanagoo et al, uCaspian J Intern Med., Ubusika 2020)

Ukuhlaziywa kwathola ingozi enkulu yomdlavuza webele ngokugxilisa insimbi ephezulu emaqenjini lapho i-iron ikalwa khona ezicutshini zamabele. Kodwa-ke, abatholanga ukuhlobana phakathi kokugxilwa kwensimbi nebele umdlavuza ingozi emaqenjini lapho insimbi ikalwa khona ezinweleni zekhanda. 

Ukutholwa kwe-Iron, isimo sensimbi yomzimba, kanye Nengozi Yomdlavuza Webele

Abaphenyi abavela eNyuvesi yaseToronto naseCancer Care Ontario, eCanada benze ukuhlaziywa kwe-meta ukuhlola izinhlangano eziphakathi kokudla insimbi nesimo sensimbi yomzimba kanye nengozi yomdlavuza webele. Izifundo ze-23 zifakiwe ekucwaningweni kokucwaninga kokuthunyelwa kwezincwadi ku-MEDLINE, EMBASE, CINAHL, naku-Scopus yolwazi kuze kube nguDisemba 2018. (UVicky C Chang et al, BMC Cancer., 2019)

Bathola ukuthi uma kuqhathaniswa nalabo abane-heme iron ephansi kakhulu, kube nokwanda okungu-12% kwengozi yomdlavuza webele kulabo abane-heme iron. Kodwa-ke, abatholanga ubudlelwane obubalulekile phakathi kokudla, okokwengeza noma ukudla okuphelele kwensimbi kanye nengozi yomdlavuza webele. Izifundo ezengeziwe ezichazwe kahle zomtholampilo ziyadingeka ukuze kucaciswe kangcono ukuhlangana phakathi kwengozi yomdlavuza wensimbi nomdlavuza webele.

Umthelela we-Antioxidant Supplementation ebudlelwaneni obuphakathi kokudla kwe-Dietary iron ne-Breast Cancer Risk

Ucwaningo olwenziwe ngabaphenyi eFrance ngo-2016 luhlolisise ukuhlangana phakathi kokudla insimbi okudliwayo kanye nengozi yomdlavuza webele, kanye nokushintshashintsha kwayo okungenzeka nge-antioxidant supplementation kanye nokudla kwe-lipid kwabesifazane abangama-4646 abavela ocwaningweni lweSU.VI.MAX Ngesikhathi sokulandelwa okusho kweminyaka eyi-12.6, kwabikwa amacala omdlavuza webele angu-188. (Abou Diallo et al, Oncotarget., 2016)

Ucwaningo luthole ukuthi ukudla i-ayoni okudliwayo kuhlotshaniswa nobungozi obandayo bomdlavuza webele, ikakhulukazi kwabesifazane abadle ama-lipids amaningi, kepha-ke, le nhlangano itholakale kuphela kulabo abangazange bangezelelwe ngama-antioxidants ngesikhathi sokuhlolwa. Ucwaningo luphethe ngokuthi ingozi yomdlavuza webele kungenzeka ukuthi inyuswe yi-lipid peroxidation eyenziwe yensimbi.

Ukudla kwe-NIH-AARP kanye ne-Health Study

Kokunye ukuhlaziywa kwedatha yokudla okuvela kwabesifazane abangu-193,742 be-postmenopausal ababeyingxenye ye-NIH-AARP Diet and Health Study, lapho kwatholakala khona umdlavuza webele wezigameko ezingama-9,305 (1995-2006), kwatholakala ukuthi ukudla i-heme iron iron okuphezulu kwakuhlotshaniswa ingozi eyengeziwe yomdlavuza webele, isiyonke futhi kuzo zonke izigaba zomdlavuza. (UMaki Inoue-Choi et al, I-Int J Cancer., 2016)

Inhlangano phakathi kwe-Iron ne-Colorectal Cancer Risk

Ukufakwa kwe-Iron, ama-Serum Iron Indices nobungozi bama-Colorectal Adenomas

Abaphenyi besibhedlela i-Zhejiang Provincial People's Hospital kanye ne-The First People's Hospital yesifunda i-Fuyang e-China, bahlolisise ukuhlangana phakathi kokudla i-iron, izinkomba zensimbi ye-serum kanye nobungozi be-colorectal adenoma, besebenzisa imininingwane evela kuzindatshana eziyishumi, ezibandakanya amacala angama-10 e-colorectal adenoma, atholakala ngezincwadi sesha ku-MEDLINE naku-EMBASE kuze kube ngumhlaka 3318 Mashi 31. (H Cao et al, Eur J Cancer Care (Engl)., 2015)

Ucwaningo luthole ukuthi ukwanda kokudla kwe-heme iron kuhlotshaniswa nobungozi obukhuphuke kakhulu be-colorectal adenoma, kanti ukutholwa kwe-non-heme noma i-supplemental iron kunciphise ubungozi be-colorectal adenomas. Ngokuya ngemininingwane elinganiselwe etholakalayo, bezingekho izinhlangano phakathi kwama-indices iron indices kanye ne-colorectal adenoma risk.

Ukungeniswa kwe-heme iron ne-zinc kanye ne-colorectal cancer incidence

Ucwaningo olwenziwe abacwaningi baseSibhedlela i-Shengjing sase-China Medical University e-China bahlole ukuhlobana phakathi kokusetshenziswa kwe-heme iron ne-zinc kanye ne-colorectal. umdlavuza isigameko. Izifundo eziyisishiyagalombili mayelana ne-heme iron entake kanye nezifundo eziyisithupha zokuthatha i-zinc zisetshenziswe ekuhlaziyweni okutholwe ngokusesha izincwadi ku-PubMed ne-EMBASE database kuze kube ngu-December 2012. (Lei Qiao et al, Cancer Causes Control., 2013)

Lokhu kuhlaziywa kwe-meta kuthole ukwanda okuphawulekayo engozini yomdlavuza obala ngokunyuka kwe-heme iron kanye nokwehla okuphawulekayo engozini yomdlavuza obala ngokunyuka kwezinc.

Ukuhlangana phakathi kwengozi yomdlavuza we-Iron ne-Esophageal

Abaphenyi baseZhengzhou University naseZhejiang University School of Medicine eChina benze ucwaningo lwe-meta oluhlelekile ukuhlola ubudlelwane phakathi kokutholwa kwensimbi kanye ne-zinc kanye nensimbi ye-heme ephansi kanye nobungozi be-Esophageal Cancer. Imininingwane yokuhlaziywa itholakale ezihlokweni ezingama-20 ezinamacala angama-4855 avela kubahlanganyeli abayi-1387482, atholwe kusesho lwezincwadi e-Embase, PubMed, nakuWebhu yeSayensi yolwazi ngo-Ephreli 2018. (UJifei Ma e al, Nutr Res., 2018)

Ucwaningo luthole ukuthi njalo ukwanda kwe-5 mg / ngosuku kokudla okuphelele kwensimbi kuhlotshaniswa nengozi encishisiwe ye-15% ye-Esophageal Cancer. Ukuncishiswa kwengozi kwatholakala ikakhulukazi kubantu base-Asia. Ngakolunye uhlangothi, njalo ukwanda kwe-1 mg / ngosuku kokutholwa kwe-heme iron kwakuhlotshaniswa nokwanda okungama-21% kwengozi yomdlavuza we-Esophageal. 

Inhlangano phakathi kwe-Iron ne-Pancreatic Cancer Risk

Ucwaningo olushicilelwe ngo-2016 lwahlola inhlangano yokudla inyama, izindlela zokupheka inyama kanye nokunikela kanye ne-heme iron kanye nokudla kwe-mutagen nomdlavuza we-pancreatic ku-NIH-AARP Diet and Health Study cohort ehilela ababambiqhaza abangu-322,846 lapho abangu-187,265 kwakungamadoda kanti i-135,581 kwakungabesifazane. Ngemuva kokulandelela okulinganiselwe kweminyaka engu-9.2, ama-pancreatic 1,417 umdlavuza amacala abikwa. (Pulkit Taunk et al, Int J Cancer., 2016)

Ucwaningo luthole ukuthi ingozi yomdlavuza wepancreatic inyuke kakhulu ngokudla inyama isiyonke, inyama ebomvu, inyama ephekwe okushisa okuphezulu, inyama eyosiwe / eyosiwe, inyama eyenziwe kahle / eyenziwe kahle kanye nensimbi ye-heme evela enyameni ebomvu. Abaphenyi baphakamise izifundo ezichazwe kahle kakhulu ukuqinisekisa ukutholakele kwabo.

Inhlangano phakathi kwe-Iron ne-Prostate Cancer Risk

Ocwaningweni olushicilelwe ngabaphenyi be-EpidStat Institutes eMichigan naseWashington e-US, bahlole ubudlelwane phakathi kwezindlela zokupheka inyama, i-heme iron, nomdlavuza we-heterocyclic amine (HCA) nomdlavuza wendlala yesinye ngokususelwa ezincwadini ezingama-26 ezivela ezifundweni ezahlukahlukene ezingama-19 . (ULauren C Bylsma et al, uNutr J., 2015)

Ukuhlaziywa kwabo abakutholanga ukuhlangana phakathi kwenyama ebomvu noma okusetshenzisiwe kwenyama kanye nomdlavuza wendlala; kodwa-ke, bathole ukwanda okuncane engcupheni yokusetshenziswa kwenyama esetshenzisiwe.

Inhlangano phakathi kwamazinga eSerum Iron kanye neengozi yomdlavuza wamaphaphu

Ucwaningo olwenziwe ngabaphenyi baseZhejiang Rongjun Hospital, Zhejiang Cancer Hospital, eFujian Medical University Cancer Hospital naseLishui Hospital yaseZhejiang University eChina luhlolisise ukuhlangana phakathi kwamazinga e-serum iron kanye nengozi yomdlavuza wamaphaphu. Imininingwane yokuhlaziywa itholwe kulwazi lwePubMed, WanFang, CNKI, kanye neSinoMed kuze kube uMar 1, 2018. Ucwaningo luthole ukuthi amazinga e-serum iron awanabo ubudlelwano obubalulekile nobungozi bomdlavuza wamaphaphu. (UHua-Fei Chen et al, Cell Mol Biol (Noisy-le-grand)., 2018)

Ukusetshenziswa kwe-Iron Supplements ku-Management of Chemotherapy-induced Anemia (amazinga aphansi e-hemoglobin) ezigulini zeCancer

Ucwaningo olwenziwe yiCentre for Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA luhlolisise izinzuzo nokulimala okuhlobene nokusetshenziswa kwezithako zensimbi kanye nama-Erythropoiesis-stimulating agents (ESAs), asetshenziswa kakhulu ukwelapha i-anemia ebangelwa umdlavuza ngamakhemikhali (amazinga aphansi e-hemoglobin) - i-CIA, ne-Cochrane Database Syst iron kuphela uma kuqhathaniswa ne-ESA kuphela ekuphathweni kwe-CIA. (URahul Mhaskar et al, Rev., 2016) Ucwaningo luthole ukuthi kufaka phakathi izithako zensimbi kanye nama-ESA womdlavuza owenziwe ngamakhemikhali kungaholela ekuphenduleni okuphezulu kwe-hematopoietic, kunciphise ubungozi bokumpontshelwa kweRed Blood Cell, futhi kuthuthukise amazinga aphansi e-hemoglobin.

Ngakho-ke, ukufaka i-iron supplement kungaba nemiphumela ezuzisayo ezigulini ezinomdlavuza ezine-chemotherapy-induced anemia (amazinga aphansi e-hemoglobin).

Isiphetho

Lezi zifundo ziphakamise imiphumela ehlukahlukene ye-iron ehlukene zomdlavuza. Insimbi eyeqile yatholakala iyingozi kumdlavuza onjengoCancer Webele kanye noCancer Pancreatic, mhlawumbe ngenxa yomsebenzi wayo we-pro-oxidant ongaholela ekulimaleni kwe-DNA oxidative; noma kunjalo, ukuthathwa kwensimbi okuphelele kanye ne-non-heme iron intake, kwatholakala ukuthi kunemiphumela yokuzivikela kumdlavuza we-colorectal kanye ne-esophageal. Emidlavuza enjengomdlavuza wamaphaphu nomdlavuza wendlala yesinye, azikho izinhlangano ezibalulekile ezibikiwe. Izithako ze-ayoni kanye nama-ESA e-anemia ebangelwa umdlavuza ngenxa yamakhemikhali (amazinga aphansi e-hemoglobin) angase abe yinzuzo. Nakuba ukuthathwa kwenani elifanele lensimbi kubalulekile ekusebenzeni kahle kwemizimba yethu, ukudla kwayo ngokweqile ngokusebenzisa izithasiselo kungase kuholele emiphumeleni engemihle njengokuqunjelwa kanye nobuhlungu besisu futhi kungabulala nezingane. Ngakho-ke, thintana nodokotela ngaphambi kokuthatha izithasiselo zensimbi. Amanani ensimbi adingekayo angatholakala ekudleni. 

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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