Amaphuzu avelele
Ucwaningo lomtholampilo oluklanywe kahle lubonise ukuthi ukwelashwa/ukusetshenziswa kwenhlanganisela yemvelo ethathwe esitshalweni i-Berberine kubantu abaye basuswa i-colon adenomas (polyps) kuphephile ngaphandle kwemithelela emibi kakhulu futhi kusebenza ngempumelelo ekwehliseni ukuphindeka kwama-polyps. Ngakho-ke, ukusetshenziswa/ukwelashwa kwe-berberine ngethamo elifanele kungasiza ekwehliseni i-chemoprevention ye-colorectal adenoma (ukwakheka kwama-polyps kukholoni) kanye ne-colorectal. umdlavuza.
Ngokukhula kwenani labantu abagugayo, izigameko zomdlavuza ziyanda, futhi naphezu kwentuthuko nokusungulwa kokwelashwa komdlavuza, lesi sifo siyakwazi ukudlula zonke izindlela zokwelapha ngenani elikhulu leziguli. Izinketho zokwelapha ezinolaka nezihlosiwe ezisiza ngokulawula nokuqeda umdlavuza amaseli aphinde abangele imiphumela emibi eminingi enokhahlo, emibi futhi kwesinye isikhathi engalungiseki. Iziguli ezinomdlavuza kanye nabathandekayo bazo bahlale bebheke ukusebenzisa enye indlela yokwelapha yemvelo ukuze kudambise futhi kuvikelwe emiphumeleni engathandeki ye-chemotherapy, ukuqinisa amasosha omzimba kanye nokuphila kahle.
I-Berberine neCancer
Inhlanganisela yemvelo iBerberine, etholakala emithini eminingi efana neBarberry, Goldenseal neminye, isetshenzisiwe kuMuthi Wezokwelapha WesiShayina Wezakhiwo ngezindawo zayo eziningi ezizuzisayo. Okulandelayo ngezinye zezinzuzo zezempilo ze-berberine:
- Kungaba nemiphumela yokulwa nokuvuvukala
- Kungaba nezindawo ezilwa namagciwane
- Kungaba nezindawo ezithuthukisa izivikeli mzimba
- Kungasiza ekulawuleni ushukela wegazi
- Kungasiza ukunciphisa i-cholesterol embi
- Kungasiza ngezinkinga zokugaya ukudla nezomzimba
Kodwa-ke, kwabanye abantu, ukusetshenziswa ngokweqile kweBerberine kungaholela emiphumeleni ethile emibi njengokuphazamiseka kwesisu, isifo sohudo, ukuqunjelwa, ukuqunjelwa kanye nekhanda.
Impahla ye-Berberine yokulawula amazinga kashukela, umthombo oyinhloko kaphethiloli we- umdlavuza ukusinda kwamangqamuzana, kanye nezici zayo zokulwa nokuvuvukala kanye nezithuthukisa amasosha omzimba, kwenza lesi sithasiselo esithathwe esitshalweni sibe i-adjuvant yokulwa nomdlavuza. Kube nezifundo eziyishumi nambili emigqeni eminingi yamaseli omdlavuza namamodeli ezilwane eziqinisekise izinzuzo zokulwa nomdlavuza zeBerberine.
Izindlela zamangqamuzana ezilawulwa yiBerberine zifaka i-Oxidative Stress, i-TGFB Signaling, i-DNA Repair, i-Angiogenesis ne-Noncoding RNA Signaling. Lezi zindlela zeselula ziqondisa ngqo noma ngokungaqondile imigqa ethile yamangqamuzana omdlavuza njengokukhula, ukusabalala nokufa. Ngenxa yalomthethonqubo webhayoloji - wokudla komdlavuza, ukukhetha okulungile kwezithako ezinjengeBerberine ngawodwana noma ngokuhlangana kuyisinqumo esibalulekile okufanele senziwe. Lapho wenza izinqumo ngokusetshenziswa kwe-Berberine yokwengeza umdlavuza - cabanga ngazo zonke lezi zinto kanye nencazelo. Ngoba njengoba kunjalo nokwelashwa komdlavuza - ukusetshenziswa kweBerberine akukwazi ukuba yisinqumo esilingana nazo zonke izinhlobo zomdlavuza.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ukwelashwa kwe-Berberine / Ukusetshenziselwa ukuphindaphinda kwe-Colorectal Adenoma (Ama-polyps eColon - Precursors of Colon Cancer)
Ucwaningo lwakamuva lomtholampilo oluxhaswe yiNational Natural Science Foundation yaseChina luhlole ukusetshenziswa kwe-Berberine ekwelapheni i-colorectal adenoma (ukwakheka kwama-polyps kukholoni) kanye ne-colorectal. umdlavuza. Lokhu kuhlolwa okungahleliwe, okungaboni, nokulawulwa yi-placebo kwenziwa ezikhungweni zezibhedlela ezingu-7 ezifundazweni ezingu-6 eChina. (NCT02226185) Abantu abaqashelwe lolu cwaningo baye basuswa ama-polyps amaningi kukholoni phakathi nezinyanga ezingu-6 ngaphambi kokuqala isifundo. Babelwa ngamaqembu amabili ngokungahleliwe, nabantu abangu-553 abathola i-Berberine (0.3 amagremu, kabili ngosuku) kanye nabantu abangu-555 abathola ithebhulethi ye-placebo. Ababambiqhaza kwakudingeka benze i-colonoscopy yokulandelela ngonyaka ongu-1 kanye nezikhathi zesikhathi zeminyaka emi-2 zokubhaliswa kokuthunyelwe. Isiphetho esiyinhloko socwaningo kwakuwukuhlolwa kokuphindaphinda kwama-polyps kukholoni kunoma iyiphi i-colonoscopy yokulandela. (UChen YX et al, I-Lancet gastroenterology & Hepatology, 2020)
Ukutholwa Okusemqoka
Ukutholakala kwalolu cwaningo bekungukuthi abantu abayi-155 (36%) eqenjini laseBerberine babenezilwanyane eziphindaphindayo ngenkathi eqenjini le-placebo le nombolo yayiphakeme kakhulu nabantu abangama-216 (47%) abanezinhlayiya eziphindaphindayo (adenoma). Awekho umdlavuza onobuhle otholakele ngesikhathi sokulandelwa. Umcimbi omubi kakhulu obekungukuqunjelwa kubonakale ku-1% weziguli eziseqenjini le-Berberine kanye no-0.5% eqenjini le-placebo. Azikho izehlakalo ezimbi ezimbi ezibikwe ngokusetshenziswa kweBerberine.
Okusemqoka okususwayo kulolu cwaningo lomtholampilo ukuthi u-0.3 gram we-Berberine othathwe kabili nsuku zonke kutholakale ukuthi uphephile futhi usebenza ngempumelelo ekunciphiseni ubungozi bokuphindeka kwe-colorectal adenomas (polyps). Njengoba ibingekho imiphumela emibi ebucayi etholakale ocwaningweni lapho ithathwa ngemithamo elungile, ukusetshenziswa kweBerberine kungaba yindlela yokuvimbela umdlavuza kubantu abane-polypectomy (ukususwa kwama-polyps kukholoni).
Ekuphetheni
Ukusebenzisa i-Berberine kubantu abaye basuswa i-colon adenoma kungase kuphephe ngaphandle kwemiphumela emibi kakhulu uma kuthathwa ngesilinganiso esifanele futhi kungase kubazuzise ekwehliseni ukuphindaphinda kwama-polyps kanye namathuba okuba ne-colorectal. umdlavuza. Kodwa-ke, ukusetshenziswa okungahleliwe kwezithako ze-berberine yiziguli ezinomdlavuza kufanele kugwenywe. Iziguli ezinomdlavuza kufanele zithintane nochwepheshe bazo bezempilo ngaphambi kokuthatha izithasiselo zokudla ngaphandle kokusekelwa kwesayensi, njengoba lokhu kungase kuhlanganyele nokwelashwa okuqhubekayo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.