Amaphuzu avelele
Noma ukudla okunothe ngama-lignans (umthombo we-phytoestrogen yokudla enesakhiwo esifana ne-estrogen) kungahle kube nezakhi ezibalulekile ezisebenzayo ezingasiza ekwehliseni ubungozi bezinhlobo ezahlukahlukene zomdlavuza, ukuhlangana phakathi kwamazinga e-plasma enterolactone kanye nengozi yomdlavuza akucaci . Ucwaningo lwakamuva luthole ukuthi amazinga aphezulu we-enterolactone angahle ahlotshaniswe nengozi encishisiwe yokufa okuqondile komdlavuza oqondile phakathi kwabesifazane kanye nengozi eyengeziwe yokufa kwabantu besilisa. Ezinye izifundo ezihlolisise umthelela wokuhlushwa kwe-plasma enterolactone kumdlavuza webele, we-prostate nowe-endometrial azitholanga nhlangano noma zagcina zinemiphumela ephikisanayo. Ngakho-ke, kuze kube manje, abukho ubufakazi obucacile obukhombisa ukuthi amazinga aphakeme ajikelezayo we-enterolactone anganikela ngemiphumela ebalulekile yokuvikela engcupheni yama-cancer ahlobene ne-hormone.
Yini amaLignans?
AmaLignans angama-polyphenol kanye nomthombo oyinhloko wokudla we-phytoestrogen (isakhi sezitshalo esinesakhiwo esifana ne-estrogen), esitholakala kakhulu ekudleni okuhlukahlukene okutshalwe ezitshalweni njengembewu yefilakisi nembewu yesesame futhi ngamanani amancane kumantongomane, okusanhlamvu okuphelele, izithelo kanye imifino. Lokhu kudla okunothe nge-lignan kuvame ukusetshenziswa njengengxenye yokudla okunempilo. Ezinye zezandulela ze-lignan ezivame kakhulu ezikhonjwe ekudleni okususelwa ezitshalweni yi-secoisolariciresinol, i-pinoresinol, i-lariciresinol ne-matairesinol.
Kuyini i-Enterolactone?
Ama-lignans esitshalo esiwadlayo aguqulwa nge-enzymatic amagciwane wamathumbu aholela ekwakhiweni kwamakhemikhali abizwa nge-Enterolignans. Ama-enterolignans amabili amakhulu ajikeleza emzimbeni wethu yile:
a. Enterodiol futhi
b. I-Enterolactone
I-Enterolactone ingenye yama-lignans amaningi kakhulu asemammalia. I-Enterodiol nayo ingaphinde iguqulwe ibe yi-enterolactone ngamagciwane emathunjini. (UMeredith AJ Hullar et al, Cancer Epidemiol Biomarkers Prev., 2015) Kokubili i-enterodiol ne-enterolactone, kuyaziwa ukuthi zinomsebenzi obuthakathaka we-estrogenic.
Ngaphandle kwenani lokutholwa kwama-lignans ezitshalo, amazinga we-enterolactone ku-serum nomchamo nawo angakhombisa ukusebenza kwamagciwane emathunjini. Futhi, ukusetshenziswa kwama-antibiotic kuhlotshaniswe nokuhlushwa kwe-serum enterolactone ephansi.
Uma kukhulunywa nge-phytoestrogen (inhlanganisela yezitshalo enesakhiwo esifana ne-estrogen) -ukudla okunothile, ama-soy isoflavones avame ukugqama, kepha ama-lignans empeleni ayimithombo eyinhloko yama-phytoestrogens ikakhulukazi ekudleni kwaseNtshonalanga.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ukugxila kwePlasma Enterolactone kanye nengozi yomdlavuza
Ngisho noma ukudla okunothe ngama-lignans (umthombo we-phytoestrogen yokudla enesakhiwo esifana ne-estrogen) kuthathwa njengokunempilo futhi kuqukethe izinhlanganisela ezibalulekile ezisebenzayo ezingasiza ekwehliseni ubungozi bezinhlobo ezahlukene zomdlavuza, ukuhlangana phakathi kwamazinga e-enterolactone kanye ingozi ye zomdlavuza akucaci.
Ukuhlushwa kwePlasma Enterolactone kanye nokufa komdlavuza weColorectal
Ocwaningweni olwanyatheliswa ngo-2019 ngabacwaningi abavela eDenmark, bahlola ukuhlangana phakathi kokugxilwa kwe-plasma kwe-enterolactone (i-lignan metabolite eyinhloko) ngaphambi kokuxilongwa komdlavuza, kanye nokusinda ngemuva kwe-colorectal. umdlavuza, ngokusekelwe kudatha evela kwabesifazane abangu-416 kanye namadoda angu-537 atholakala enomdlavuza we-colorectal, ababambe iqhaza ku-Danish Diet, Cancer and Health cohort Study. Ngesikhathi sokulandelela, kwashona abesifazane abangu-210 namadoda angu-325, phakathi kwabo abesifazane abangu-170 namadoda angu-215 bashona ngenxa yomdlavuza wesikhumba. (UCecilie Kyrø et al, Br J Nutriti., 2019)
Okutholakele ocwaningweni bekuthakazelisa impela. Ucwaningo luthole ukuthi ukugxila okuphezulu kwe-Enterolactone kuhlotshaniswa nokufa okuningana komdlavuza ophakathi kwabantu besifazane, ikakhulukazi kulabo abangawasebenzisi ama-antibiotic. Ukuphindwa kabili kokuhlushwa kwe-plasma enterolactone kwabesifazane kuhlotshaniswa nengozi ephansi engu-12% yokufa ngenxa yomdlavuza obala. Futhi, abesifazane abanokuhlushwa okuphezulu kakhulu kwe-plasma enterolactone babenezinga eliphansi labangu-37% lokufa ngenxa yomdlavuza obala, uma kuqhathaniswa nalabo abanamazinga aphansi e-plasma we-enterolactone. Kodwa-ke, emadodeni, ukugxila okuphezulu kwe-enterolactone kwakuhlotshaniswa nokufa okuphezulu okuphathelene nomdlavuza. Eqinisweni, emadodeni, ukuphindeka kabili kwe-plasma enterolactone okuhlushwa kwakuhlotshaniswa nengozi ephezulu ye-10% yokufa ngenxa yomdlavuza obala.
Lokhu kuhambisana nesifundo sangaphambilini esikhombise ukuthi i-estrogen, i-hormone yabesifazane besifazane, inobudlelwano obuphambene nobungozi bomdlavuza obumbala nokufa (UNeil Murphy et al, J Natl Cancer Inst., 2015). I-Enterolactone ibhekwa njenge-phytoestrogen. Ama-phytoestrogens ayizinhlanganisela zezitshalo ezinesakhiwo esifana ne-estrogen, futhi ukudla okunothile okususelwa ezitshalweni i-lignan kungumthombo wazo oyinhloko wokudla.
Ngamafuphi, abacwaningi baphetha ngokuthi amazinga aphezulu e-enterolactone angahle ahlotshaniswe nengozi encishisiwe yokufa okuqondile komdlavuza phakathi kwabesifazane kanye nengozi eyengeziwe yokufa kwabantu besilisa.
Ukuhlushwa kwe-Plasma Enterolactone kanye ne-Endometrial Cancer Risk
Ukungena kwe-Enterolactone Concentration kanye ne-Endometrial Cancer Risk Kwabesifazane BaseDenmark
Ocwaningweni olushicilelwe ngabaphenyi beDanish Cancer Society Research Center eDenmark, bahlole ukuhlangana phakathi kwamazinga e-plasma enterolactone kanye nesifo somdlavuza we-endometrium, ngokususelwa kwimininingwane evela emacaleni e-endometrial ayi-173 kanye nabesifazane abangama-149 abakhethwe ngokungahleliwe ababhalisile Isifundo sabantu abadlayo, esinomdlavuza nesempilo phakathi kuka-1993 no-1997 futhi bebeneminyaka ephakathi kuka-50 no-64. (UJulie Aarestrup et al, Br J Nutr., 2013)
Ucwaningo luthole ukuthi abesifazane abane-plasma nmol / l ephakeme ye-plasma ye-enterolactone ingahle ihlotshaniswe nengozi encishisiwe yomdlavuza we-endometrium. Kodwa-ke, ukuncishiswa akubalulekanga kangako. Ucwaningo luphinde lwahlola le nhlangano ngemuva kokukhipha imininingwane evela kubantu besifazane abanokugxila okuphansi kwe-enterolactone ngenxa yokusebenzisa ama-antibiotic futhi bathola ukuthi inhlangano yaqina kancane, noma kunjalo, yahlala ingabalulekile. Ucwaningo alutholanga nokwehluka enhlanganweni ngenxa yesimo sokuya esikhathini, ukwelashwa kwamahomoni noma i-BMI.
Abaphenyi baphetha ngokuthi ukuhlushwa okuphezulu kwe-plasma enterolactone kunganciphisa ingozi yomdlavuza we-endometrial, kepha umthelela kungenzeka ungabaluleki.
Ingozi Yokuhlushwa Komdlavuza we-Enterolactone kanye ne-Endometrial Cancer kubantu besifazane base-US
Abaphenyi baseNew York University School of Medicine e-US phambilini babenze ucwaningo olufanayo olwaluhlola ubudlelwane obuphakathi komdlavuza we-endometrium namazinga ajikelezayo e-enterolactone. Imininingwane yocwaningo itholwe ezifundweni ze-3 cohort eNew York, Sweden nase-Italy. Ngemuva kokulandelwa okucacile kweminyaka engu-5.3, kwatholakala inani lamacala ayi-153, afakiwe ocwaningweni kanye nezilawuli ezingama-271 ezifanayo. Ucwaningo alutholanga ndima evikelayo yokusabalalisa i-enterolactone kumdlavuza we-endometrial kwabesifazane be-premenopausal noma postmenopausal. (U-Anne Zeleniuch-Jacquotte et al, I-Int J Cancer., 2006)
Lezi zifundo azinikezi bufakazi bokuthi i-enterolactone iyazivikela kumdlavuza we-endometrium.
Ukugxila kwePlasma Enterolactone kanye nokufa komdlavuza wesibeletho
Ocwaningweni olwanyatheliswa ngo-2017 ngabacwaningi abavela eDenmark naseSweden, bahlola ukuhlangana phakathi kokugxila kwe-enterolactone kwangaphambili nokufa phakathi kwamadoda aseDenmark ane-prostate. umdlavuza. Ucwaningo lwaluhlanganisa idatha evela kumadoda angu-1390 atholakala enomdlavuza wendlala yesinye abhaliswe kuDanish Diet, Cancer and Health cohort Study. (AK Eriksen et al, Eur J Clin Nutr., 2017)
Ucwaningo alutholanga ukuhlangana okuphawulekayo phakathi kwe-20 nmol / l ephakeme ye-plasma ye-enterolactone nokufa kwamadoda aseDenmark anomdlavuza we-prostate. Ucwaningo alutholanga nokwehluka kusoseshini ngenxa yezinto ezifana nokubhema, inkomba yomzimba noma ezemidlalo, kanye nokuba nolaka komdlavuza wendlala yabesilisa.
Ngamafuphi, ucwaningo alutholanga ukuhlangana phakathi kokugxila kwe-enterolactone nokufa phakathi kwamadoda aseDenmark atholakale enomdlavuza wendlala yesinye.
Ngokuya ngemininingwane elinganiselwe, abukho ubufakazi obusekela ukuhlangana okuphambene phakathi kwe-lignan (umthombo we-phytoestrogen yokudla enesakhiwo esifana ne-estrogen) -ukudla okunothile, ukugxila kwe-serum enterolactone kanye nengozi yomdlavuza we-prostate.
Ukugxila kwePlasma Enterolactone kanye nomdlavuza webele
Ukuhlushwa kwe-Enterolactone kanye ne-Cancer Breast Prognosis kumaDanish Postmenopausal Women
Ocwaningweni olushicilelwe ngo-2018 ngabaphenyi beDanish Cancer Society Research Center ne-Aarhus University eDenmark, bahlole ubudlelwano phakathi kokugxilwa kwe-plasma kwangaphambi kokuxilongwa kwe-enterolactone nomdlavuza webele kubantu besifazane abasesimeni sokuya esikhathini njengokuphindaphinda, ukufa komdlavuza othile webele nazo zonke izimbangela zokufa. Ucwaningo lubandakanya imininingwane evela emacaleni omdlavuza webele we-1457 avela eDenmark Diet, Cancer kanye ne-Health cohort Study. Ngesikhathi esilandelwayo seminyaka eyi-9, bangu-404 abesifazane abashonile, okuyilapho abangu-250 babulawa ngumdlavuza webele, kwathi abangu-267 baphindelela. (UCecilie Kyrø et al, Umtholampilo Wezempilo., 2018)
Ucwaningo luthole ukuthi i-plasma enterolactone ephezulu ibinokuhlangana okuncane kuphela nokufa okuqondile okuqondene nomdlavuza webele kwabesifazane abangemva kokuya esikhathini, futhi akukho ukuzihlanganisa nokufa kwabantu nokuvela njalo ngemuva kokubheka izinto ezinjengokubhema, ukufunda isikole, i-BMI, ukuzivocavoca umzimba kanye ukusetshenziswa kwama-hormone wokuya esikhathini. Imiphumela ayizange ishintshe ngemuva kokufaka izinto ezinjengezici zokwelashwa nokwelashwa.
Ucwaningo luphethe ngokuthi abukho ubudlelwano obucacile phakathi kokugxilwa kwe-plasma kwangaphambi kokuxilongwa kwe-enterolactone kanye nomdlavuza webele ukubikezelwa kwabesifazane abangemva kokuya esikhathini.
Ingozi yomdlavuza webele i-Enterolactone ne-Postmenopausal nge-estrogen, progesterone kanye ne-herceptin 2 status receptor
Ekuhlaziyweni kwe-meta okwenziwe ngabaphenyi beGerman Cancer Research Center, eHeidelberg, eJalimane, bahlole ubudlelwane phakathi kwe-serum enterolactone ne-postmenopausal yomdlavuza webele. Imininingwane yokuhlaziywa itholakele emacaleni omdlavuza webele we-1,250 kanye nezilawuli ze-2,164 ezivela ocwaningweni olukhulu olususelwa kubantu. (U-Aida Karina Zaineddin et al, I-Int J Cancer., 2012)
Ucwaningo luthole ukuthi ukwanda kwamazinga e-serum enterolactone kuhlotshaniswa nokwehla kwengozi yomdlavuza webele we-postmenopausal. Ucwaningo luphinde lwagqamisa ukuthi le nhlangano ibaluleke kakhulu kumdlavuza webele we-Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) uma kuqhathaniswa nomdlavuza webele we-ER + ve / PR + ve. Ngaphezu kwalokho, ukubonakaliswa kwe-HER2 akubanga nomthelela enhlanganweni.
Lolu cwaningo luphakamise ukuthi amazinga aphezulu we-serum enterolactone angahle ahlotshaniswe nengozi enciphisiwe yomdlavuza webele we-postmenopausal, ikakhulukazi e-Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) - umdlavuza webele.
Ukungena kwe-Enterolactone kanye nobungozi bomdlavuza webele ku-French Postmenopausal Women
Ucwaningo lwangaphambilini olushicilelwe ngo-2007 ngabaphenyi be-Institut Gustave-Roussy, eFrance luphinde lwahlola izinhlangano eziphakathi kwengozi yomdlavuza webele we-postmenopausal kanye nokufakwa kokudla kwezitshalo ezine ze-lignans -pinoresinol, i-lariciresinol, i-secoisolariciresinol, ne-matairesinol, nokuvezwa kwama-enterolignans amabili - i-enterodiol ne-enterolactone. Ucwaningo lusebenzise idatha evela kwimibuzo yemibuzo yokudla ezilawulwayo evela kwabesifazane abangama-58,049 base-postmenopausal baseFrance ababengathathi izithako ze-soy isoflavone. Ngesikhathi sokulandelwa okusho kweminyaka engu-7.7, kwatholakala inani lamacala angu-1469 womdlavuza webele. (UMarina S Touillaud et al, J Natl Cancer Inst., 2007)
Ucwaningo luthole ukuthi uma kuqhathaniswa nabesifazane abane-lignans ephansi kunazo zonke, labo abanokudla okuphezulu kakhulu kwe-lignan okuhambelana> 1395 microg / day, babe nengozi encishisiwe yomdlavuza webele. Ucwaningo luye lwathola nokuthi izinhlangano eziphambene phakathi kokufakwa kwe-phytoestrogen kanye nengozi yomdlavuza webele we-postmenopausal zikhawulelwe ku-Estrogen Receptor (ER) ne-Progesterone Receptor (PR) - umdlavuza webele omuhle.
Ukususwa Kokhiye: Kuze kube manje, kunemiphumela engqubuzanayo ngakho-ke, asikwazi ukuphetha ngokuthi ngabe i-lignan ephezulu (umthombo we-phytoestrogen yokudla enesakhiwo esifana ne-estrogen) -ukudla okunothile nokuxinana kwe-plasma kwe-enterolactone kunemiphumela yokuvikela umdlavuza webele.
Isiphetho
Ngisho noma ukudla okucebile ngama-lignans (umthombo we-phytoestrogen yokudla enesakhiwo esifana ne-estrogen) kunempilo futhi kungase kube nezinhlanganisela ezibalulekile ezingasiza ekwehliseni ubungozi bezinhlobo ezahlukene zomdlavuza, ukuhlobana phakathi kwamazinga e-plasma enterolactone kanye nobungozi. yomdlavuza ehlukene akukacaci. Olunye ucwaningo lwakamuva luphakamise indima yokuvikela ye-enterolactone ekufeni komdlavuza we-colorectal kwabesifazane, noma kunjalo, izinhlangano zaziphambene uma kwenzeka kubesilisa. Olunye ucwaningo oluhlole umthelela wokugxilwa kwe-enterolactone ku-plasma kumdlavuza ohambisana nama-hormone njengomdlavuza webele, umdlavuza wendlala yesinye kanye nomdlavuza we-endometrial alutholanga ukuhlangana noma lwagcina lunemiphumela engqubuzanayo. Ngakho-ke, okwamanje, abukho ubufakazi obucacile obuphakamisa ukuthi amazinga aphezulu okujikeleza kwe-enterolactone anganikeza imiphumela ebalulekile yokuvikela engcupheni ye-hormone ehlobene. zomdlavuza.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.