Izinzuzo Zomtholampilo Wobisi Thistle / Silymarin kuCancer

Amaphuzu avelele

I-Milk Thistle Extract/Silymarin kanye nengxenye yayo eyinhloko i-Silibinin inezinzuzo eziningi zezempilo ezihlaba umxhwele ngenxa yezakhiwo zayo zokulwa ne-antioxidant, anti-inflammatory kanye ne-anti-cancer. Izifundo ezihlukene ze-in vitro/in vivo kanye nezilwane ziye zaphenya ngezinzuzo zezempilo ze-milk thistle extract kanye nekhono layo lokuvimbela izinhlobo zomdlavuza futhi bathola imiphumela ethembisayo. Zimbalwa izivivinyo zabantu eziphinde zaphakamisa ukuthi i-milk thistle kanye nezithako zayo ezisebenzayo zingase zibe usizo ekwehliseni eminye yemiphumela emibi eyingozi ye-chemotherapy kanye ne-radiotherapy efana ne-cardiotoxicity, i-hepatotoxicity kanye ne-brain edema kwezinye izindawo. umdlavuza izinhlobo ezilashwa ngekhemo ethile.

Kuyini Ubisi Thistle?

Ubisi lwamakhambi isitshalo esinezimbali esisetshenziswe amakhulu eminyaka njengekhambi lemvelo lokwelapha ukuphazamiseka kwesibindi nenyongo ikakhulukazi emazweni aseYurophu. Ikhakhasi lobisi liyatholakala futhi njengesengezo sokudla. Ikhakhasi lobisi lithole igama lisuselwa obisini oluphuma emaqabungeni lapho ephukile. 

Izithako Eziyinhloko Ezisebenzayo Zobisi Lobisi

Izakhi ezisemqoka zezimbewu zomunga zobisi ezomisiwe yi-flavonolignans (ama-phenols emvelo akhiwa yingxenye ye-flavonoid nengxenye ye-lignan) afaka:

• I-Silibinin (silybin)
• I-Isosilybin
• USilychristin
• USilydianin.

Ingxube yalawa ma-flavonolignans akhishwe embewini yamakhakhasi obisi yaziwa ngokuhlanganyela njenge-Silymarin. I-Silibinin eyaziwa nangokuthi i-silybin, iyindawo enkulu esebenzayo ye-silymarin. I-Silymarin inezakhi ze-antioxidant, anti-virus kanye ne-anti-inflammatory. Ubisi Thistle / Silymarin luyatholakala njengesengezo sokudla futhi luvame ukusetshenziselwa izakhiwo zalo ezilusizo ekwelapheni ukuphazamiseka kwesibindi. Izithasiselo eziningi nazo zilinganisiwe ngokuya ngokuqukethwe kwazo kwe-silibinin. Kukhona futhi ukwakheka okukhethekile kwe-silymarin noma i-silibinin etholakalayo engakhuphula ukutholakala kwayo ngokuhlangana ne-phosphatidylcholine.

Izinzuzo Ezijwayelekile Zezempilo Zobisi Lobisi

Izifundo eziningi zezilwane kanye nezifundo ezimbalwa zokwelashwa zenziwe ukuze kuhlolwe izinzuzo zomunga wobisi. Ezinye zezinzuzo eziphakanyisiwe zezempilo zomuthi wobisi yilezi:

1. Kungasiza ezinkingeni zesibindi kufaka phakathi i-cirrhosis, jaundice, hepatitis
2. Kungasiza ezinkingeni zesisu se-Gall
3. Uma ithathwa ihambisana nokwelashwa okuvamile, kungasithuthukisa isifo sikashukela
4. Kungasiza ekuthuthukiseni amazinga e-cholesterol ezigulini ezinesifo sikashukela
5. Kwangathi kungakusiza ngesilungulela nokugaya ukudla
6. Kungasiza ngokuvimbela umdlavuza

Izinzuzo ze-Milk Thistle ku-Cancer

Kule minyaka engamashumi amabili edlule, kube nentshisekelo ekhulayo yokuqonda izinzuzo zomtholampilo ze-milk thistle kumdlavuza. Ezinye zezifundo ze-in vitro/in vivo/isilwane/zabantu ezihlole ukusetshenziswa/imithelela ye-milk thistle ku umdlavuza zifinyezwa ngezansi:

Ku-Vitro / In Vivo / Animal Study

1. Kwangathi Kungavimbela Ukukhula Komdlavuza We-Pancreatic futhi Kwehlise I-Cachexia / Ubuthakathaka Obubangelwa Umdlavuza We-Pancreatic

Ucwaningo lwe-in vitro lukhombisile ukuthi ubisi lwameva asebenzayo i-silibinin lunamandla okuvimbela ukukhula kwesifo somdlavuza we-pancreatic ngendlela encike kumthamo. Okunye kwizifundo ze-vivo kuphakamisa nokuthi i-silibinin inciphisa ukukhula kwesimila nokwanda komdlavuza we-pancreatic futhi ingasiza ekuvimbeleni ukwehla kwesisindo somzimba kanye nemisipha. (UShukla SK et al, Oncotarget., 2015)

Ngamafuphi, izifundo ze-in vitro nezilwane ziphakamisa ukuthi ubisi lwameva / i-silibinin lungazuza ekwehliseni ukukhula komdlavuza we-pancreatic kanye nomdlavuza wepancreatic-i-cachexia / ubuthakathaka obenziwe. Ukuhlolwa komtholampilo kuyadingeka ukusungula okufanayo kubantu. 

2. Kungavimbela Ukukhula Komdlavuza Webele

Ucwaningo lwe-in vitro lubonise ukuthi i-silibinin evimbela ukukhula komdlavuza webele futhi yakhuthaza ukufa kwe-apoptosis / cell kumaseli womdlavuza webele. Okutholakele ezifundweni ezahlukahlukene kuphakamisa ukuthi i-silibinin inezakhiwo zomdlavuza ezilwa nesifuba eziphumelelayo. (Tiwari P et al, Cancer Invest., 2011)

3. Kwangathi Kungavimbela Ukukhula Komdlavuza Wendlala Yesinye

Kwesinye isifundo, imiphumela elwa nomdlavuza kaSilibinin yahlolwa ekwelashweni okuhlanganisiwe kanye ne-DOX / Adriamycin. Kulolu cwaningo, amaseli e-prostate carcinoma aphathwa nge-silibinin ne-DOX ngokuhlangana.Okutholakele kukhombisile ukuthi inhlanganisela ye-silibinin-DOX iholele ekuvinjelweni kokukhula kwamaseli aphathwayo. (Prabha Tiwari noKaushala Prasad Mishra, Imingcele Yokucwaninga Ngomdlavuza., 62)

4. Kungavimbela Umdlavuza Wesikhumba

Ucwaningo oluningi luye lwenziwa ukuhlola imiphumela ye-Milk Thistle Silibinin esebenzayo kumdlavuza wesikhumba. Okutholakele kulezi zifundo ze-in vitro kukhombisile ukuthi ukwelashwa kweSilibinin kungaba nemiphumela yokuvimbela kumaseli womdlavuza wesikhumba womuntu. Ucwaningo lwe-in vivo luthole ukuthi uSilibinin angavikela nomdlavuza wesikhumba obangelwa yimisebe ye-UVB futhi angasiza ekulungiseni ukulimala kwe-DNA okubangelwa i-DNA esikhunjeni segundane. (Prabha Tiwari noKaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Lezi zifundo ziyethembisa futhi ziphakamisa ukuthi i-milk thistle/silibinin ingase iphephe futhi izuzise isikhumba umdlavuza.

5. Kungavimbela I-Colorectal Cancer

Olunye ucwaningo lwe-in vitro lukhombise ukuthi uSilibinin angadala ukufa kweseli kumaseli womdlavuza wobuntu. Ucwaningo lwe-in vitro luphinde lwathola ukuthi ukwelashwa kweSilibinin kwe-24h kunganciphisa ukukhula kwamangqamuzana omdlavuza ngo-30-49%. (Prabha Tiwari noKaushala Prasad Mishra, Imingcele Yokucwaninga Ngomdlavuza., 2015)

Izinzuzo zeMilk Thistle / Silibinin nazo zahlolwa ngokuhlanganiswa nezinye izindlela zokwelapha ezifana ne-histone-deacetylase (HDAC) inhibitors. Inhlanganisela ikhombise imiphumela yokuhlangana kumaseli abumbala.

6. Kungavimbela umdlavuza wamaphaphu

Ucwaningo lwe-in vitro lukhombise ukuthi uSilibinin angaba nemiphumela yokuvimbela emigqeni yeseli yomdlavuza womuntu. Ucwaningo luphinde lwabonisa ukuthi iSilibinin ngokuhlangana ne-DOX evimbela ukukhula komdlavuza wamaphaphu kumaseli. I-Silibinin kanye ne-indole-3-carbinol nayo idale imiphumela enamandla ye-antiproliferative kunama-ejenti ngamanye. (Prabha Tiwari noKaushala Prasad Mishra, Imingcele Yokucwaninga Ngomdlavuza., 2015)

Lokhu okutholakele kuphakamisa ukuthi i-Milk Thistle esebenzayo i-Silibinin nayo ingaba nenzuzo yokwelapha emdlavuza wamaphaphu.

7. Kungavimbela umdlavuza wesinye

Izifundo ze-in vitro zikhombisile ukuthi uSilibinin ubangele ukufa kwe-apoptosis / cell kwamangqamuzana omdlavuza wesinye somuntu. Ucwaningo luphinde lwabonisa ukuthi uSilibinin angaphinde acindezele ukufuduka nokusabalala kwamangqamuzana omdlavuza wesinye. (Prabha Tiwari noKaushala Prasad Mishra, Imingcele Yokucwaninga Ngomdlavuza., 2015)

8. Kungavimbela umdlavuza we-Ovarian

Izifundo ze-in vitro zikhombisile ukuthi i-silibinin ingavimbela ukukhula kwamangqamuzana omdlavuza we-ovarian womuntu, futhi yenze nokufa kwe-apoptosis / cell. Izifundo zaphinde zathola ukuthi iSilibinin ingakhulisa ukuzwela kwamangqamuzana omdlavuza we-ovari ku-PTX (Onxal). I-Silibinin lapho isetshenziswa ngokuhlangana ne-PTX (Onxal) nayo ingakhuphula ukufa kwe-apoptosis / cell. (Prabha Tiwari noKaushala Prasad Mishra, Imingcele Yokucwaninga Ngomdlavuza., 2015)

Lokhu okutholakele kusikisela ukuthi i-silibinin ingasetshenziswa njengengxenye yokwelashwa okuhlanganisayo komdlavuza we-ovari.

9. Ingavimbela umdlavuza wesibeletho

Ucwaningo lukhombisa ukuthi uSilibinin angavimbela ukwanda kwamaseli womlomo wesibeletho womuntu. Ngaphezu kwalokho, i-silibinin kanye ne-MET, i-ejenti eyaziwayo elwa nesifo sikashukela, ikhombisa imiphumela ehambisanayo ekuvimbeleni amaseli omdlavuza womlomo wesibeletho kanye nokufa kwamaseli. Ngakho-ke, i-silibinin ingahle isebenze njenge-ejenti yokuvikela izifo yomdlavuza womlomo wesibeletho. Izifundo ezengeziwe kufanele zihlolisise amathuba okusungula amasu angcono okwelapha alwa nomdlavuza womlomo wesibeletho.

Izifundo Zemitholampilo Kubantu

Ake sibheke izifundo ezehlukene zokwelashwa ukuze siqonde ukuthi kufaka phakathi ubisi thistle njengengxenye ye- Ukudla kweziguli ezinomdlavuza kuyazuzisa noma cha.

1. Izinzuzo Zobisi Ekunciphiseni I-Cardiotoxicity ku-Acute Lymphoblastic Leukemia Izingane Ezelashwa nge-DOX (Adriamycin)

USilymarin, esinye sezithako ezibalulekile zomuthi wobisi, ukhonjisiwe ngokuzama ukuba nemiphumela yokuvikela inhliziyo uma unikezwa kanye ne-DOX. USilymarin anganciphisa ukucindezeleka okwenziwe nge-oxidative, okuyimbangela ye-cardiotoxicity. I-antioxidant futhi inganciphisa ukulimala kolwelwesi namaprotheni yizinhlobo ezisebenzayo, ezidalwe njengengxenye yesenzo se-DOX, ngokuvimbela ukuncipha kwemishini ye-antioxidant yemvelo yamaseli aphilile. (URoskovic A et al, amaMolekyuli 2011)

Ucwaningo lomtholampilo oluvela eNyuvesi yaseTanta eGibhithe luye lwahlola umphumela kaSilymarin ovela eMilk Thistle ezinganeni ezine-Acute Lymphoblastic Leukemia (BONKE), abelashwa nge-DOX. Ucwaningo lusebenzise idatha evela ezinganeni ezingama-80 ezineZONKE, lapho iziguli ezingama-40 zelashwa nge-DOX kanye noSilymarin ngo-420 mg / ngosuku kwathi ezingama-40 ezisele zaphathwa kuphela nge-DOX (iqembu le-placebo). Ucwaningo luthole ukuthi eqenjini likaSilymarin, kube 'nokuphazamiseka kokuqala kwe-DOX okubangelwe ukuphazamiseka kokusebenza kwe-ventricular systolic' ngaphezulu kweqembu le-placebo. Lolu cwaningo lomtholampilo, noma lunenani elincane LONKE lezingane, lunikeza isiqinisekiso semiphumela yokuvikela inhliziyo kaSilymarin njengoba kubonakala kumamodeli wezifo zokuhlola. (Adel A Hagag et al, Infect Disord Drug Target., 2019)

2.Izinzuzo Zobisi Lobisi ekwehliseni Isibindi Sobuthi ku-Acute Lymphoblastic Leukemia Izingane Zelashwa Nge-Chemotherapy

Ukwelashwa kwezingane ezine-acute lymphoblastic leukemia (ZONKE) zisebenzisa imishanguzo ye-chemotherapy kuvame ukuphazamiseka ngenxa ye-hepatotoxicity / isibindi sobuthi esibangelwa yimithi yokwelapha ngamakhemikhali. Lokhu kudidizela kokuqeda umdlavuza usebenzisa imishanguzo yamakhemikhali kuqhathaniswa nokubhekana nemiphumela emibi futhi kwesinye isikhathi engalungiseki yale mithi kuyinkinga eqhubekayo emphakathini womdlavuza. Ngakho-ke, kunemizamo eqhubekayo yokuthola izindlela ezingasiza ukunciphisa noma ukuvikela isiguli emiphumeleni emibi kakhulu.

Esifundweni somtholampilo, izingane ezine-acute lymphoblastic leukemia (ZONKE) ezine-toxicatic hepatic zelashwa nge-chemotherapy kuphela (i-placebo) noma inhlanganisela yephilisi lobisi lomunga eliqukethe u-80 mg we-silibinin kanye ne-chemotherapy (MTX / 6-MP / VCR) ngomlomo ( Milk Thistle Group) izinsuku ezingama-28. Izingane ezingama-50 zabhaliswa kusukela ngoMeyi 2002 kuya ku-Agasti 2005 zalolu cwaningo, ngezifundo ezingama-26 eqenjini le-placebo kwathi ezingama-24 zaba seQenjini leMilk Thistle. Izingane ezingama-49 kwezingu-50 zivivinyelwe lolu cwaningo. Ubuthi besibindi babhekwa ngaso sonke isikhathi sokwelashwa. (U-EJ Ladas et al, Umdlavuza., 2010)

Okutholakele ocwaningweni kuphakamisa ukuthi ukuthatha i-Milk Thistle kanye ne-chemotherapy yizo ZONKE iziguli kungahle kuhlotshaniswe nokwehliswa okukhulu kobuthi besibindi. Ucwaningo alutholanga ubuthi obungalindelekile, isidingo sokwehlisa imithamo ye-chemotherapy, nanoma ikuphi ukubambezeleka ekwelashweni ngesikhathi sokwengezelwa kwamakhakhasi obisi. Lezi zifundo zikhombise nokuthi ubumbano lwamabele aluzange lube nomthelela ekusebenzeni kwama-chemotherapy agents asetshenziselwa KONKE ukwelashwa. 

Abaphenyi nokho baphakamise izifundo zesikhathi esizayo ukuthola umthamo ophumelela kakhulu weMilk Thistle nomphumela wawo ku-hepatotoxicity / isibindi ubuthi nokusinda okungenayo i-leukemia.

3. Izinzuzo ze-Milk Thistle esebenzayo i-Silibinin yokwehlisa i-edema yobuchopho ezigulini zomdlavuza wamaphaphu ezine-Brain Metastasis

Ucwaningo luphakamisa ukuthi ukusetshenziswa kwe-milk thistle active-silibinin-based nutraceutical ebizwa ngokuthi iLeasil® kungase kuthuthukise i-Brain Metastasis evela ezigulini ezinomdlavuza wamaphaphu we-NSCLC/wamaphaphu okuqhubekisele phambili ukwelashwa ngemva kokwelashwa nge-radiotherapy kanye ne-chemotherapy. Okutholwe kwalezi zifundo kuphinde kuphakamise ukuthi ukuphathwa kwe-silibinin kunganciphisa kakhulu i-edema yobuchopho. Kodwa-ke, le miphumela evimbelayo ye-silibinin ku-metastasis yobuchopho ingase ingathinti ukuphuma kwesimila esiyinhloko emaphashini. umdlavuza iziguli. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Izinzuzo ze-Milk Thistle ekwehliseni ubuthi besibindi esigulini somdlavuza webele

Ucwaningo lwamacala lushicilelwe esigulini somdlavuza webele owelashwa ngemithi ehlukene emihlanu yokwelashwa ngamakhemikhali futhi waba nokuhluleka kwesibindi okuqhubekayo. Lo mbiko uveze ukuthi imiphumela yokuhlolwa kwesibindi yehle yaya emazingeni asongela impilo ngemuva kwemijikelezo emine yokwelashwa ngamakhemikhali. Isiguli sabe sesisizwa nge-nutraceutical esekwe eSilibinin egama linguLegasil® post okwakubonwa ukuthuthukiswa komtholampilo nesibindi, okusize isiguli ukuthi siqhubeke nokwelashwa ngamakhemikhali okuphulukisa. (UBosch-Barrera J et al, i-Anticancer Res., 5)

Lolu cwaningo luveze ukuthi kungenzeka kube khona usizo lomtholampilo lwe-silibinin ekwehliseni ubuthi besibindi ezigulini zomdlavuza webele eziphathwe ngamakhemikhali.

5. Izinzuzo Zobisi Lobisi Ekuthuthukiseni Imiphumela Yokusinda Ezigulini Ze-Brain Metastatic Zilashwa Nge-Radiotherapy

Ucwaningo lukhombisa ukuthi ubisi lwameva lungazuzisa iziguli ze-metastatic brain ezithola i-radiotherapy. Isifundo somtholampilo sifaka imininingwane evela ezigulini ezinama-metastases obuchopho abaphathwa nge-radiotherapy kuphela noma nge-radiotherapy kanye ne-omega 3 fatty acids kanye ne-silymarin. Ucwaningo luthole ukuthi iziguli ezazithatha i-omega 3 fatty acids ne-silymarin zinezikhathi ezinde zokuphila kanye ne-radionecrosis encishisiwe. (I-Gramaglia A et al, i-Anticancer Res., 1999)

Isiphetho

I-Milk Thistle Extract / i-Silymarin nengxenye yayo esemqoka i-Silibinin inezinzuzo eziningi zezempilo ngenxa yezakhi zayo zokulwa ne-antioxidant, anti-inflammatory kanye ne-anti-cancer. Ubisi lwekhakhasi / iSilymarin imvamisa ayinayo imiphumela emibi eminingi lapho ithathwa ngomlomo ngobuningi obufanele. Kodwa-ke, kwabanye abantu, ukuthatha ubisi lwameva kungaholela kuhudo, isicanucanu, igesi emathunjini, ukuqunjelwa, ukugcwala noma ubuhlungu, nokulahlekelwa isifiso sokudla. Futhi, njengoba ukukhishwa kwe-thistle yobisi kungehlisa izinga likashukela egazini kubantu abanesifo sikashukela, imithamo yemithi yesifo sikashukela kungadingeka ilungiswe kabusha. Ukukhishwa kwe-thistle yobisi nakho kungaba nemiphumela ye-estrogenic engase ibe nzima kakhulu izimo ezizwela i-hormone, kufaka phakathi izinhlobo ezithile zomdlavuza webele.

Izifundo ezihlukene ze-invitro/invivo kanye nezilwane ziphenye izinzuzo zezempilo ze-milk thistle extract kanye nekhono layo lokuvimbela izinhlobo zomdlavuza. Imiphumela ethembisayo ibikwe yiziningi zalezi zifundo eziphakamisa imiphumela yokuvikela ye-milk thistle ezinhlotsheni ezithile zomdlavuza. Zimbalwa izivivinyo zabantu futhi ezisekela ukuthi thistle ubisi kanye nezithako zalo ezisebenzayo kungase kube yinzuzo ekunciphiseni eminye yemiphumela emibi eyingozi yokwelapha ngamakhemikhali kanye ne-radiotherapy njenge-cardiotoxicity, i-hepatotoxicity kanye ne-edema yobuchopho ezinhlotsheni ezithile zomdlavuza ezilashwa nge-chemo ethile. Kodwa-ke, ukuthatha isengezo semvelo esifana nekhava lobisi kukhishwa ngokungahleliwe nganoma iyiphi i-chemotherapy yanoma iyiphi umdlavuza akunconywa ngoba kungabangela ukusebenzisana okubi kwemithi yemifino. Ngakho-ke, umuntu kufanele ahlale ebonana nodokotela wabo ngaphambi kokuthatha noma yisiphi isithasiselo semvelo kanye ne-chemotherapy.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

• I-Milk Thistle esebenzayo uSilymarin inciphisa i-Cardiotoxicity eyenziwe yi-Doxorubicin ezinganeni ezine-leukemia
• Ubisi, Imikhiqizo Yobisi kanye Nengozi Yomdlavuza
• Ukudla / izithasiselo zemvelo kuhlangana kanjani neChemotherapy kuCancer?
• Inhlangano edidayo yokusebenzisa iVithamin E Supplement kanye neBrain Cancers
• I-Lacto-Ovo Ukudla Kwemifino kanye Nengozi Yomdlavuza