Amaphuzu avelele
I-Silymarin ye-bioactive evela ku-herb- Milk Thistle, iyi-antioxidant futhi iboniswe ukuthi inezinzuzo ezithile umdlavuza iziguli ezifana nemiphumela ye-cardio-protective ngokunciphisa ukucindezeleka okwenziwe nge-oxidative. Ukusetshenziswa kwe-Milk Thistle esebenzayo i-Silymarin kanye ne-Doxorubicin kuzuzisa izingane ezine-leukemia ngokunciphisa i-cardiotoxicity eyenziwe yi-Doxorubicin njengoba kuboniswe ocwaningweni lomtholampilo lwezingane ezine-acute lymphoblastic leukemia.
I-Doxorubicin Chemotherapy ne-Cardiotoxicity ku-Leukemia
I-Doxorubicin isidakamizwa se-chemotherapy esivunyiwe ukuthi sisetshenziswe njengendlela yokwelapha yokunakekelwa ezinkomba eziningi zomdlavuza ezihlanganisa i-acute lymphoblastic leukemia (ALL), i-acute myeloblastic leukemia (AML), i-neuroblastoma, i-sarcomas, ibele, i-ovarian, isinye, i-thyroid, i-gastric nokuningi. eminye imidlavuza. I-Doxorubicin iyakwazi ukubulala ukukhula ngokushesha okungajwayelekile umdlavuza amaseli ngokubangela ukulimala kwe-DNA ngokweqile kanye nokwanda kwengcindezi ye-oxidative ebuye ibangele ukufa kwamangqamuzana. Kodwa-ke, lo mthelela we-Doxorubicin uholela ekulimaleni okuqinile kwamangqamuzana anempilo, ne-cardiotoxicity njengenye yemiphumela emibi kakhulu enethuba lokumelwa yinhliziyo ebulalayo, okungenzeka phakathi nokwelashwa noma izinyanga noma iminyaka ngemuva kokwelashwa. . Amathuba andayo okuba ne-cardiotoxicity, njengoba kuhlolwe izimpawu nezimpawu ezahlukahlukene, okuhlanganisa ukwehla kokusebenza kwenhliziyo noma ukuguquka kwamazinga ama-enzyme abalulekile ezimpawu ze-cardiotoxicity, ayanda ngokwandisa umthamo ophelele oqoqwayo we-Doxorubicin.
Lokhu kudidizela kokuqeda umdlavuza kuqhathaniswa nokubhekana nemiphumela emibi emibi futhi kwesinye isikhathi engalungiseki kuyinkinga eqhubekayo emphakathini womdlavuza. Ngakho-ke, kunemizamo eqhubekayo yokuthola izindlela ezingasiza ukunciphisa noma ukuvikela isiguli emiphumeleni emibi kakhulu. Abaphenyi bafundile ngomphumela wezithako ezahlukahlukene ezitholakala ezitshalweni zemvelo lapho zithathwa kanye neDoxorubicin emaphethelweni e-cardiotoxicity kumaseli womdlavuza nakumamodeli wezifo zezilwane, afana nalawo asetshenziswa kwinqubo yokwakhiwa kwezidakamizwa zemithi evunyelwe. Esinye isitshalo esinjalo sathola uSilymarin osebenzayo esihlahleni seMilk ubisi sihlolwe ezifundweni eziningi zokuhlola futhi sikhombise imiphumela yokuvikela enhliziyweni.
Ubisi Thistle kanye noSilymarin walo osebenzayo
Ikhakhasi lobisi isitshalo esisetshenziswe amakhulu eminyaka ukwelashwa kokuphazamiseka kwesibindi nenyongo eYurophu. Itholakala futhi njengesengezo sokudla. Ikhakhasi lobisi lithola igama lisuselwa obisini oluphuma lapho kuphuka amaqabunga. Izithako ezibalulekile ze-Milk Thistle zihlanganisa uSilibinin (silybin), Isosilybin, Silychristin kanye noSilydianin owaziwa ngokuhlanganyela njengoSilymarin.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ukusetshenziswa kwe-Milk Thistle esebenzayo uSilymarin we-Doxorubicin-eyenzelwe i-Cardiotoxicity ku-Leukemia
USilymarin ukhonjiswe ngokuzama ukuthi abe nemiphumela yokuvikela inhliziyo lapho enikezwa kanye neDoxorubicin (ukunciphisa i-cardiotoxicity eyenziwe ngeDoxorubicin). USilymarin uyakwazi ukunciphisa ukucindezeleka okwenziwe nge-oxidative, okuyimbangela ye-cardiotoxicity. I-antioxidant futhi iyakwazi ukunciphisa ukulimala kolwelwesi namaprotheni yizinhlobo ezisebenzayo, ezidalwe njengengxenye yendlela yokusebenza yeDoxorubicin, ngokuvimbela ukuncipha kwemishini ye-antioxidant yamaseli aphilile (iRoskovic A et al, amaMolekyuli 2011) .
Ucwaningo Lwemitholampilo Ekusebenziseni kweSilymarin & ne-Cardiotoxicity eyenziwe nge-Doxorubicin
Ucwaningo lomtholampilo oluvela e-Tanta University eGibhithe luhlolisise izinzuzo / imiphumela yokuvikela i-cardio-Silymarin evela ku-Milk Thistle ezinganeni ezine-acute lymphoblastic leukemia (BONKE), eziphathwa nge-Doxorubicin (UHagag AA et al, Ukuthekelwa Kwezidakamizwa Zokutheleleka Kokungenelela Kwezifo. 2019). Kulolu cwaningo ezinganeni ezingama-80 ezinazo ZONKE, ezingama-40 zazo zelashwa nge-Doxorubicin kanye noSilymarin ngo-420 mg / ngosuku (Iqembu loku-I lokuhlola) kanti ezisele ezingama-40 zelashwa kuphela ngeDoxorubicin ngaphandle kweSilymarin (Iqembu 2 - i-placebo). Ukuhlolwa kokusebenza kwenhliziyo kulezi zingane kwenziwa ngezindlela ezijwayelekile ze-echo-Doppler zenhliziyo systolic kanye ne-diastolic function. Bathola ukuthi eqenjini likaSilymarin, 'kwehle ukuphazamiseka kokuqala kwe-Doxorubicin-induced ventricular systolic function (cardiotoxicity)' eqenjini le-placebo.
Isiphetho
Ucwaningo lubonisa ukuthi i-Milk Thistle esebenzayo i-Silymarin ingaba nezinzuzo ezigulini ezinomdlavuza njengokuncipha kwe-Doxorubicin-induced Cardiotoxicity Ezinganeni ezinomdlavuza wegazi. Lolu cwaningo lomtholampilo, nakuba lunenani elincane lezingane ze-leukemia, lunikeza isiqinisekiso esithile semiphumela ye-cardioprotective (izinzuzo) ye-Milk thistle esebenzayo i-Silymarin njengoba kubonakala kumamodeli wezifo zokuhlola. Naphezu komthelela onenzuzo wezithako zemvelo ezisekelwe ezifundweni zokuhlolwa nezincane zomtholampilo, iziguli ezinomdlavuza kufanele ziqaphele lapho zithatha lezi zithako kanye nezithako zazo. umdlavuza ukwelashwa. Lezi zithako zemvelo azizange zidlule ekuhlolweni okubanzi nokugunyazwa ngokomthetho futhi azihloselwe ukwelapha, ukuvimbela noma ukwelapha lesi sifo. Futhi, kukhona amathuba okungezelela izitshalo nokusebenzisana kwezidakamizwa okungaphazamisa ukwelashwa futhi kungaba yingozi kwezinye izimo. Ngakho-ke, iziguli ezinomdlavuza kufanele zihlale zithintana nodokotela wazo ngaphambi kokusebenzisa noma yisiphi isithasiselo semvelo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.