Amaphuzu avelele
Imikhiqizo etholwe yizitshalo efana ne-Curcumin esebenzayo, ekhishwe empandeni ye-spice turmeric, icwaningwe kabanzi ngezindawo zayo zokulwa nomdlavuza ngokuqonda ngezindlela zamaselula zokuthi ingasiza kanjani ukusebenzisana namakhemikhali athile ukuthuthukisa impendulo ezigulini zomdlavuza. ICurcumin, omunye wemikhiqizo yemvelo enezinzuzo ezahlukahlukene zezempilo, ikhonjisiwe ukuthi ithuthukisa ukusebenza ngempumelelo kwemithi ethile yokwelapha umdlavuza / i-chemotherapy kanye nokunciphisa imiphumela emibi.
I-Cancer, Chemotherapy kanye nokuthandwa kwezithasiselo zemvelo njengeCurcumin
Noma kunjalo umdlavuza amaseli ayizinguqulo eziguquliwe zamaseli avamile, izivikelo zamaselula zisenamandla ngendlela emangalisayo futhi ziyakwazi ukumelana nokuhlasela okunobuthi kwe-chemotherapy ukuze ziqhubeke ziphila futhi zikhule. Eqinisweni, kumdlavuza we-metastatic (umdlavuza osusakazeke ezingxenyeni eziningi zomzimba), i-chemoresistance ibalelwa ku-90% wakho konke ukwehluleka kwezidakamizwa (U-Alimbetov D et al, Int J Mol Sci. 2018).
Empeleni, kunezindlela eziningana lapho amangqamuzana omdlavuza akwazi ukuqeda ubuthi be-chemo - enye yezindlela ezibaluleke kakhulu ukusebenzisa iphrotheni elithumela ngaphandle izidakamizwa elaziwa nge-P-glycoprotein (PGP). Amaseli womdlavuza ajwayele ukuqukethe inani eliphakeme lale phrotheni ezingxenyeni zawo zamangqamuzana futhi le PGP ikhipha ngenkuthalo ama-cytotoxic chemo agents avela kumaseli, ngaleyo ndlela yehlisa ukusebenza kwezidakamizwa nokusiza amangqamuzana omdlavuza aphile isikhathi eside. Enye indlela umzimba osebenzelana ngayo nezinto ezinobuthi ukuzicubungula ngokusebenzisa izitho ezithile ukuze uzihlukanise zibe izinhlanganisela ezincane ezingasebenzi, okwenza into yokuqala eyi-cytotoxic ingasebenzi. Futhi ekugcineni amangqamuzana omdlavuza angajwayelekile kakhulu ayakwazi ukuvika ukuhlaselwa ngamakhemikhali ngokwenza izindlela zokuzivikela ezifanayo ezisiza ukusinda kwawo lapho kukhona isidakamizwa futhi lapho umuthi ususwa, lawa maseli afanayo azochuma ngokubuyela emuva.
Ngakho-ke, izinga lokuphendula elijwayelekile le-chemotherapy liyi-50-60%, kuyindlela esekelwe ebufakazini, eqhutshwa yiziqondiso, ilingana nosayizi owodwa futhi ku-subset yeziguli ukuthi ayisebenzi, banokuphindwe kabili. i-whammy yokubhekana nomdlavuza ongazweli kanye nemiphumela emibi kakhulu. Ngakho-ke iningi umdlavuza iziguli kanye nabathandekayo bazo bahlale befuna izinto ezengeziwe ezingakwazi ukuzenza ukuze bathuthukise amathuba abo okuphumelela, njengamakhambi emvelo omdlavuza. Umkhiqizo wemvelo othola ukuduma emhlabeni wonke ngenxa yezakhiwo zawo zokulwa nomdlavuza yi-Curcumin esebenzayo evela ku-spice turmeric.
Izinzuzo Ezijwayelekile Zezempilo zeTurmeric Spice- Curcumin
Okulandelayo ngezinye zezinzuzo zezempilo zeCurcumin:
- Inezakhi ezinamandla zokulwa ne-antioxidant
- Inezinto eziqinile zokulwa nokuvuvukala
- Kungasiza ukunciphisa izimpawu ezihlobene nesifo samathambo
- Kungaba nezindawo zokulwa nokuguga
- Inemiphumela elwa namagciwane
- Kungasiza ukunciphisa ingozi yezifo zenhliziyo
- Kungasiza iziguli ezinesifo i-Alzheimer's
- Kungasiza ukunciphisa ukucindezeleka
- Inezinto ezilwa nomdlavuza
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Imiphumela Emelene Nomdlavuza yeCurcumin / Turmeric
I-Curcumin ikhonjisiwe ukuthi ivimba iprotheni ye-PGP ekusunduzeni umuthi we-chemo ngaphandle kweseli nokunciphisa amazinga we-PGP expression kumaseli womdlavuza ngokuvimbela umlamuleli wayo wezinkulumo (into yokubhala ebizwa nge-NFKB) (U-Anuchapreeda S et al, uBiochem Pharmacol. 2002; USingh S et al, J Biol Chem. 1995; AmaBentires-Alj M et al, Oncogene. 2003). ICurcumin ingasiza ekwenzeni imvelo emincane ibe nobutha kakhulu ukuthi iseli lomdlavuza lisinde ngokuvimbela ukucindezelwa kwe-oxidative kanye nokuhluma kokuphakelwa kwegazi okusha ukondla isimila. Empeleni, ocwaningweni olwenziwe ngokusebenza kahle kwenhlanganisela ye-curcumin nezidakamizwa ezithile ze-chemo ezinhlobonhlobo zemigqa yamangqamuzana omdlavuza kanye namamodeli ezinwele zezilwane, abacwaningi bathole ukuthi i-curcumin ithuthukise imiphumela ye-cytotoxic ye-chemo ngokusebenzisa izindlela eziningi zamangqamuzana ezibhekise kuzo zonke izigaba ukukhula kwesimila (UTan BL et al, amaMolekyuli. 2019).
Ukutholakala kweCurcumin
Naphezu kwezakhiwo ezicwaningwe kahle zokulwa nomdlavuza ze-Curcumin, kuyaziwa ukuthi ine-bioavailability embi kakhulu kanye nokumuncwa emzimbeni. Inhlanganisela ye-Curcumin ne-black pepper extract isiza ukuthuthukisa i-bioavailability yayo. Abacwaningi futhi basebenzela ukuthuthukisa ukwakheka kwe-Curcumin kusuka ku-turmeric ukuze amangqamuzana akwazi ukumunca amaphesenti amakhulu ayo ukuze asebenze kahle ekusebenzisaneni nemithi ethile ye-chemotherapy ukulawula nokuqeda ukuvuvukala. umdlavuza. Ngakho-ke nakuba kusobala ukuthi imikhiqizo yemvelo efana ne-curcumin iyakwazi ukukhombisa izinto ezihlukahlukene zokulwa nomdlavuza, indlela efanele yokuletha le mikhiqizo yemvelo emzimbeni kanye nenhlanganisela efanele yezidakamizwa ze-chemo isaphikisana kakhulu.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.