Iimbalasane
Izifundo zonyango ezenziwa ngamaqela ophando ahlukeneyo ziphanda isiphumo sokutya ngomlomo izongezo ze-glutamine, i-amino acid engabalulekanga, kwizinga lezehlo i-esophagitis ebangelwa kukukhanya kwemitha okanye ukuginya ubunzima kunye nokuncipha kobunzima kwizigulane zoMhlaza weLung. Iziphumo zolu phando zibonise ukuba ukongezwa kwe-glutamine yomlomo kunokunceda imiphunga umhlaza izigulana ngokunciphisa izehlo zokudumba kommizo, ukuginya iingxaki/ubunzima kunye nokwehla kobunzima obunxulumeneyo.
I-Esophagitis kwizigulana ezinomhlaza wemiphunga
Umhlaza wamaphaphu ngoyena nobangela uphambili wokusweleka okunxulumene nomhlaza kumadoda nabasetyhini kwihlabathi liphela kwaye ubalelwa ngaphezulu kwe-18% yokusweleka komhlaza (GLOBOCAN, 2018). Ngenkqubela phambili yonyango lwamva nje, inani lemiphunga emitsha umhlaza iimeko ziye zancipha kule minyaka imbalwa idlulileyo (American Cancer Society, 2020). Ngokusekwe kuhlobo kunye nenqanaba lomhlaza, ukusebenza kwemiphunga kunye nempilo yonke yesigulana, unyango lwesigulane somhlaza wemiphunga lugqitywe kwiinketho ezahlukeneyo ezibandakanya iradiotherapy, ichemotherapy, i-immunotherapy, unyango olujoliswe kuyo kunye notyando. Nangona kunjalo, uninzi lolu nyango lunxulunyaniswa neziphumo ebezingalindelekanga ezininzi zexesha elide kunye nezexesha elifutshane. Esinye sezona ziphumo zixhaphakileyo, ezingemnandanga nezibuhlungu ezibonwa kwizigulana ezinomhlaza wemiphunga ezifumene unyango lwemitha kwindawo yesifuba yi-esophagitis.
I-Esophagitis kukudumba kwe-esophagus, ityhubhu yomsipha emgodini edibanisa umqala nesisu. Ngokubanzi, ukuqala kwe-esophagitis ebangelwa kukukhanya kwemitha (ARIE) kwenzeka kwisithuba seenyanga ezi-3 emva kwonyango lweradiotherapy kwaye kunokubangela iingxaki eziginya kakhulu. Yiyo loo nto kwenziwe uphando olunzulu lokujonga iindlela zokuthintela kunye nokulawula i-esophagitis ebangelwa yimitha kwizigulana ezinomhlaza. Izifundo ezininzi ezipapashwe kutsha nje ziveze ukusetyenziswa kwezongezo ezinje ngegutamine ukukhusela okanye ukulibazisa i-radiation esophagitis. I-L-Glutamine, ebizwa ngokuba yi-Glutamine yinto engabalulekanga e-amino acid eveliswa ngumzimba kwaye inokufumaneka kwizinto ezahlukeneyo zokutya ezibandakanya imithombo yezilwanyana njengobisi, iimveliso zobisi, amaqanda nenyama, kunye nemithombo yezityalo enjalo njengekhaphetshu, iimbotyi, isipinatshi, iparsley kunye nemifuno ye-beet. Nangona kunjalo, i-glutamine, eyenza i-60% yee-aminoacids ezikhoyo kwimisipha yethu yamathambo, ihlala iphele kakhulu kwizigulana ezinomhlaza ezikhokelela ekunciphiseni umzimba kunye nokudinwa.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izifundo ezinxulunyaniswa ne-Oral Glutamine Supplements & Radiation-Induction Swallowing Shree in Cancer Lung
Uphononongo lweSibhedlele seSikhumbuzo seMpuma Ekude, eTaiwan
Kuphononongo olusandula ukwenziwa olwenziwe ngabaphandi kwiSibhedlele i-Far Eastern Memorial, eTaiwan phakathi kukaSeptemba 2014 ukuya kuSeptemba 2015, idatha evela kwizigulana ezingama-60 ezingezizo ezincinane ezinomhlaza wemiphunga, kubandakanya amadoda angama-42 kunye nabasetyhini abali-18, abaneminyaka engama-60.3 ubudala. . (I-Chang SC okqhubekayo, amayeza (iBaltimore), 2019) Ezi zigulana zifumene iirejimeni ezisekwe kwiplatinam kunye nonyango lweradiyo ngaxeshanye, kunye okanye ngaphandle kongezo lomlomo lwe-glutamine unyaka we-1. Abaphandi bafumanise ukuba emva kwexesha elilandelelweyo lokulandela ixesha leenyanga ezingama-26.4, ukongezwa kwe-glutamine kunciphise imeko ye-grade 2/3 ye-radiation eshukumhagitis / i-esophagitis / ubunzima bokuginya ukuya kwi-6.7% xa kuthelekiswa ne-53.4% kwizigulana ezingafumani zongezelelo ze-glutamine. Kwaqwalaselwa kwakhona ukuba iqondo lokuhla kwesisindo lehle laya kwi-20% kwizigulana ezilawulwa yi-glutamine xa kuthelekiswa ne-73.3% kwizigulana ezingayifumaniyo i-glutamine. Unyango lweGlutamine luye lwalibazisa ukuqala kwe-esophagitis ebangelwa yimitha ebangelwa ziintsuku ezingama-5.8 (I-Chang SC okqhubekayo, iyeza (iBaltimore), 2019).
Isifundo esenziwe yiNecmettin Erbakan University Meram Medicine School, Turkey
Kwesinye isifundo seklinikhi esiqhutywe ngabaphandi baseNecmettin Erbakan University Meram Medicine School, eTurkey, phakathi kwe-2010 kunye ne-2014, idatha evela kwi-122 Stage 3 non-small cell lung umhlaza izigulane zahlalutywa (UKanyilmaz Gul okqhubekayo, uKlinikhi yeNutr., 2017). Ezi zigulana zifumene i-chemotherapy efanayo (kunye neCisplatin / carboplatin + pactitaxel okanye iCisplatin + Etoposide, okanye iCisplatin + Vinorelbine) kunye ne-radiotherapy, kunye okanye ngaphandle kokongezwa komlomo kwe-glutamine. Zizonke izigulana ezingama-56 (46%) zongezwa nge-glutamine yomlomo. Abaphandi bafumanise ukuba emva kwexesha lokulandela eliphakathi leenyanga ezili-13.14, ukuxhaswa kwe-glutamine kunciphise imeko ye-2-3 ye-radiation etsala i-esophagitis / ubunzima bokuginya ukuya kwi-30% xa kuthelekiswa ne-70% kwabo bangakhange bafumane izongezo ze-glutamine. Bakwaphawule ukuba izinga lokuhla kwesisindo lehle laya kwi-53% kwizigulana ezilawulwa yi-glutamine xa kuthelekiswa ne-86% kwizigulana ezingayifumananga i-glutamine. Isifundo sikwabonakalise ukuba ukongezwa kwe-glutamine akunampembelelo imbi kulawulo lwethumba nakwiziphumo zokusinda (UKanyilmaz Gul okqhubekayo, Iklinikhi yeNutr., 2017).
Ngaba ukuncedisa ngomlomo ngeGlutamine kunganciphisa i-Esophagitis okanye ukuGwinya uBunzima kwizigulana ezinomhlaza wemiphunga?
Isishwankathelo, olu phononongo lubonisa ukuba ukuthatha izongezo ze-glutamine zomlomo kunokunceda izigulana ezinomhlaza wemiphunga ezingezizo ezincinci ngokunciphisa izehlo ze-radiation-induced esophagitis/ukuginya ubunzima kunye nokuncipha kobunzima, ngaloo ndlela bephucula umgangatho wobomi babo. Nangona kunjalo, ekubeni izifundo zangaphambili ze-in vitro zicebise ukuba i-glutamine inokuxhasa ukukhula kweeseli zomhlaza, i-oncologists yayihlala ithandabuza ukulawula i-glutamine umhlaza izigulana ukwenzela ukuphepha naziphi na iingxaki (Kanyilmaz Gul et al, Asian Pacific Journal of Cancer Prevention, 2015), nangona izifundo zeklinikhi zakutsha nje zibonise impembelelo embi kulawulo lwethumba kunye neziphumo zokusinda kunye ne-glutamine supplementation. (Kanyilmaz Gul et al, Clin Nutr., 2017) Ke ngoko, ngelixa izifundo ezishwankathelweyo kule bhlog ziqaqambisa izibonelelo ze-glutamine kumhlaza wemiphunga, izigulane kufuneka zihlale zixoxa nogqirha wazo ngaphambi kokuba zithathe naziphi na izongezo zomhlaza wazo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.