Iimbalasane
Nangona ukutya okunotye kwi-lignans (umthombo we-phytoestrogen yokutya enesakhiwo esifana ne-estrogen) kunokuba nezinto ezisebenzayo ezinokuthi zincede ekunciphiseni umngcipheko weentlobo ezahlukeneyo zomhlaza, umanyano phakathi kwamanqanaba e-plasma enterolactone kunye nomngcipheko womhlaza awucaci. . Uphononongo lwakutsha nje lufumanise ukuba amanqanaba aphezulu e-enterolactone anokudityaniswa nomngcipheko omncinci wokufa komhlaza okhethekileyo phakathi kwabasetyhini kunye nengozi eyandayo yokufa kwamadoda. Olunye uphononongo oluvavanye ifuthe le-plasma enterolactone yoxinaniso kwisifuba, iprotate kunye nomhlaza we-endometrium awufumananga nhlangano okanye waphela uneziphumo eziphikisanayo. Ngenxa yoko, ukuza kuthi ga ngoku, abukho ubungqina obucacileyo obucebisa ukuba amanqanaba aphezulu ajikelezayo e-enterolactone anokubonelela ngeziphumo ezibalulekileyo zokukhusela umngcipheko wee-cancer ezinxulumene ne-hormone.
Yintoni iLignans?
I-Lignans zii-polyphenols kunye nomthombo wokutya oyintloko we-phytoestrogen (isityalo esine-estrogen), efumaneka kakhulu kukutya okutya okusekwe kwizityalo ezifana nembewu yeflakisi kunye nembewu yesesame kunye nezixa ezincinci kumandongomane, ukutya okuziinkozo, iziqhamo kunye imifuno. Oku kutya kutyebe nge-lignan kuhlala kusetyenziswa njengenxalenye yokutya okusempilweni. Ezinye zezinto zokuqala zeLignan ezichongiweyo kukutya okusekwe kwizityalo yi-secoisolariciresinol, pinoresinol, lariciresinol kunye ne-matairesinol.
Yintoni i-Enterolactone?
Iilignans zezityalo esizisebenzisayo ziguqulwa ngokwe-enzymatic ziintsholongwane zamathumbu ezikhokelela ekwakheni iikhompawundi ezibizwa ngokuba zii-Enterolignans. Oonobumba abaphambili abaphambili abajikeleza emzimbeni wethu zezi:
a. Enterodiol kunye
b. Ukungeniswa
I-Enterolactone yenye yezona zilwanyana zininzi zamamalia. I-Enterodiol inokuphinda iguqulwe ibe yi-enterolactone yi-bacteria yamathumbu. (UMeredith AJ Hullar okqhubekayo, iCancer Epidemiol Biomarkers Prev., 2015) Zombini i-enterodiol kunye ne-enterolactone, zaziwa ngokuba nomsebenzi obuthathaka we-estrogenic.
Ngaphandle kwenani lokutya kwe-lignans zezityalo, amanqanaba e-enterolactone kwi-serum kunye nomchamo unokubonisa umsebenzi webacteria yamathumbu. Ukusetyenziswa kwee-antibiotics kuye kwadibaniswa ne-serum enterolactone concentration.
Xa kuziwa kwi-phytoestrogen (indawo yokutyala enesakhiwo esifana ne-estrogen) -ukutya okunesityu, iisoflavones zesoya zihlala zibonakala, nangona kunjalo, iilignans zezona zinto ziphambili phytoestrogens ngakumbi kwizidlo zaseNtshona.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Ukujongwa kwePlasma Enterolactone kunye nomngcipheko womhlaza
Nangona ukutya okutyebileyo kwii-lignans (umthombo we-phytoestrogen yokutya enesakhiwo esifana ne-estrogen) kuthathwa njengesempilweni kwaye ineekhompawundi ezahlukeneyo ezisebenzayo ezinokunceda ekwehliseni umngcipheko weentlobo ezahlukeneyo zomhlaza, umanyano phakathi kwamanqanaba e-enterolactone kunye umngcipheko we i cancer Akucaci.
Ukujongwa kwePlasma Enterolactone kunye nokufa komhlaza weColorectal
Kuphononongo olupapashwe ngo-2019 ngabaphandi abavela eDenmark, bavavanya umanyano phakathi kokugxilwa kweplasma ye-enterolactone (eyona nto iphambili ye-lignan metabolite) ngaphambi kokuxilongwa ngumhlaza, kunye nokusinda emva komhlaza. umhlaza, Ngokusekelwe kwidatha evela kubafazi be-416 kunye namadoda angama-537 afunyanwe ngumhlaza we-colorectal, owathatha inxaxheba kwi-Danish Diet, iCancer kunye ne-Health cohort Study. Ngexesha lokulandelela, i-210 yabasetyhini kunye namadoda angama-325 bafa, apho abafazi be-170 kunye namadoda angama-215 bafa ngenxa yomhlaza wesisu. (UCecilie Kyrø okqhubekayo, Br J Nutriti., 2019)
Iziphumo zophando zazinomdla kakhulu. Uphononongo lufumanise ukuba ukugxila okuphezulu kwe-Enterolactone kunxulunyaniswa nokusweleka okuthe ngqo kumhlaza phakathi kwabafazi, ngakumbi kwabo bangasebenzisi zintsholongwane. Ukuphindaphinda i-plasma enterolactone yoxinzelelo koomama kunxulunyaniswa nomngcipheko ophantsi we-12% wokufa ngenxa yomhlaza ongalunganga. Kwakhona, abasetyhini abane-plasma ephezulu kakhulu yokufakwa kwe-enterolactone babene-37% yenqanaba lokufa elisezantsi ngenxa yomhlaza wecolorectal cancer, xa kuthelekiswa nalawo anezinga eliphantsi le-plasma ye-enterolactone. Nangona kunjalo, emadodeni, ukugxila okuphezulu kwe-enterolactone kwakudityaniswa nokufa okuphezulu komhlaza okhethekileyo. Ngapha koko, emadodeni, ukuphindaphinda kwe-plasma enterolactone concentration kwakudityaniswa ne-10% ephezulu yokufa ngenxa yomhlaza ongalunganga.
Oku kungqinelana nesifundo sangaphambili esibonise ukuba i-estrogen, ihomoni yesini yabasetyhini, inonxibelelwano olwahlukileyo lomngcipheko womhlaza kunye nokufa kwabantu (UNeil Murphy okqhubekayo, J Natl Cancer Inst., 2015). I-Enterolactone ithathwa njenge-phytoestrogen. I-Phytoestrogens yimixube yezityalo ezinesakhiwo esifana ne-estrogen, kunye nokutya okutyebileyo okutyebileyo okutyala kwizityalo kukutya kwabo okuyintloko.
Ngamafutshane, abaphandi bagqiba kwelokuba amanqanaba aphezulu e-enterolactone anokuhambelana nomngcipheko omncinci wokufa komhlaza okhethekileyo phakathi kwabasetyhini kunye nengozi eyandayo yokufa phakathi kwamadoda.
Ukujongwa kwePlasma Enterolactone kunye nomngcipheko womhlaza we-Endometrial
Ukugxininiswa kwe-Enterolactone kunye nomngcipheko womhlaza we-Endometrial kumabhinqa aseDanish
Kuphononongo olupapashwe ngabaphandi beDanish Cancer Society Research Centre eDenmark, bavavanya umbutho phakathi kwamanqanaba eplasma enterolactone kunye neziganeko zomhlaza we-endometrium, esekwe kwidatha evela kumatyala e-endometriya ayi-173 kunye nabasetyhini abangama-149 abakhethwe ngokungenamkhethe ababhalise ' Ukutya, umhlaza kunye neMpilo 'isifundo seqela phakathi kwe-1993 kunye ne-1997 kwaye babeneminyaka ephakathi kwama-50 nama-64 eminyaka. (UJulie Aarestrup okqhubekayo, Br J Nutriti., 2013)
Uphononongo lufumanise ukuba abasetyhini abane-20 nmol / l ephezulu ye-plasma ye-enterolactone inokunxulunyaniswa nomngcipheko omncinci womhlaza we-endometrium. Nangona kunjalo, ukuncitshiswa akubalulekanga kangako. Olu phononongo luvavanye umbutho emva kokungafakwanga idatha kubafazi abanee-enterolactone ezisezantsi ngenxa yokusetyenziswa kwe-antibiotiki kwaye bafumanisa ukuba umbutho womelele kancinci, nangona kunjalo, uhlala ungabalulekanga. Isifundo asifumananga mahluko kumbutho ngenxa yemeko yokuyeka ukuya exesheni, unyango lwehomoni okanye iBMI.
Abaphandi bagqiba kwelokuba uxinzelelo oluphezulu lwe-plasma enterolactone lunokunciphisa umngcipheko womhlaza we-endometrium, kodwa ifuthe linokubaluleka.
Ukugxininiswa kwe-Enterolactone kunye nomngcipheko womhlaza we-Endometrial kubantu base-US
Abaphandi abavela kwiYunivesithi yaseNew York yeSikolo sezoNyango e-US babekhe baqhuba isifundo esifanayo esivavanya umanyano phakathi komhlaza we-endometrium kunye namanqanaba ajikelezayo e-enterolactone. Idatha yesifundo yafunyanwa kwizifundo ze-3 cohort eNew York, eSweden nase-Itali. Emva kokulandelwa kweminyaka emi-5.3, kwafunyaniswa iimeko eziyi-153, ezibandakanyiweyo kuphononongo kunye nolawulo oluhambelana ne-271. Olu phononongo alufumananga ndima ikhuselayo yokujikeleza i-enterolactone ngokuchasene nomhlaza we-endometrium kubasetyhini be-premenopausal okanye postmenopausal. (U-Anne Zeleniuch-Jacquotte okqhubekayo, Umhlaza we-Int J., 2006)
Olu phononongo alunikezeli nabuphi na ubungqina bokuba i-enterolactone iyakhusela kumhlaza we-endometrium.
Ukujongwa kwePlasma Enterolactone kunye nokufa komhlaza webele leProstate
Kuphononongo olupapashwe ngo-2017 ngabaphandi abavela eDenmark naseSweden, bavavanya umanyano phakathi kokugxilwa kwe-enterolactone kwangaphambili kunye nokufa phakathi kwamadoda aseDenmark ane-prostate. umhlaza. Uphononongo lubandakanya idatha evela kumadoda angama-1390 afunyaniswa ukuba anomdlavuza we-prostate abhaliswe kwi-Danish Diet, iCancer kunye ne-Health cohort Study. (AK Eriksen et al, Eur J Clin Nutr., 2017)
Uphononongo alufumananga unxibelelwano olubalulekileyo phakathi kwe-20 nmol / l ephezulu ye-plasma ye-enterolactone kunye nokufa kwamadoda aseDenmark anomhlaza wesibeletho. Isifundo asifumananga mahluko kumbutho ngenxa yezinto ezifana nokutshaya, isalathiso sobunzima bomzimba okanye umdlalo, kunye nomhlaza webala lobudoda.
Ngamafutshane, uphononongo alufumananga ntlangano phakathi kokugxininiswa kwe-enterolactone kunye nokufa phakathi kwamadoda aseDenmark afunyenwe enomhlaza wesibeletho.
Ngokusekwe kwidatha encinci, abukho bungqina bokuxhasa umanyano oluphambeneyo phakathi kwe-lignan (umthombo we-phytoestrogen yokutya enesakhiwo esifana ne-estrogen) -ukutya ukutya okunesityebi, ukugxila kwe-serum enterolactone kunye nomngcipheko womhlaza webele.
Ukujongwa kwePlasma Enterolactone kunye noMhlaza webele
Ukugxininiswa kwe-Enterolactone kunye nokuCaciswa komhlaza webele kwiDanish Postmenopausal Women
Kwisifundo esapapashwa ngo-2018 ngabaphandi beDanish Cancer Society Research Centre kunye neYunivesithi yase-Aarhus eDenmark, bavavanya umanyano phakathi koxinzelelo lweplasma lwangaphambi kokuqonda isifo se-enterolactone kunye nokuxelwa komhlaza webele kubantu basetyhini abasemva kwemini njengokuphindaphinda, ukubulawa ngumhlaza othile webele. kwaye zonke-unobangela wokufa. Uphononongo lubandakanya idatha evela kumatyala omhlaza webele angama-1457 asuka kwiDanish Diet, iCancer kunye neQela lezeMpilo lokuFunda. Ngexesha lokulandelwa kweminyaka eli-9, inani labasetyhini abangama-404 basweleka, apho abangama-250 babulawa ngumhlaza wamabele, kwaye abangama-267 bafumana ukuphindaphinda. (UCecilie Kyrø et al, uKlinikhi yeNutriti., 2018)
Uphononongo lufumanise ukuba i-plasma ephezulu ye-enterolactone yayinomanyano nje oluncinci kunye nokufa okuthe ngqo komhlaza wamabele kwabasetyhini abasemva kokuya exesheni, kwaye akukho ntlangano yokufa kunye nokuphindaphinda emva kokuthathela ingqalelo izinto ezinjengokutshaya, ukuya esikolweni, iBMI, ukwenza umthambo kunye Ukusetyenziswa kwehomoni yokuya exesheni. Iziphumo azitshintshanga emva kokubandakanya izinto ezinje ngeempawu zonyango kunye nonyango.
Uphononongo luphelile ukuba kwakungekho nxu lumano oluphakathi kokuxilongwa kwangaphambili kwe-plasma ye-enterolactone kunye nokuxilongwa komhlaza wesifuba kubafazi be-postmenopausal.
Umngcipheko womhlaza webele we-Enterolactone kunye ne-Postmenopausal yi-estrogen, iprogesterone kunye ne-herceptin 2 status status
Kuhlalutyo lweemeta olwenziwe ngabaphandi beziko laseJamani loPhando ngomhlaza, eHeidelberg, eJamani, bavavanya umanyano phakathi kwe-serum enterolactone kunye ne-postmenopausal yomhlaza webele. Idatha yohlalutyo yafunyanwa kwi-1,250 yezehlo zomhlaza wamabele kunye nolawulo lwe-2,164 ukusuka kuphando olukhulu olusekwe kubemi. (UAida Karina Zaineddin okqhubekayo, Int J Cancer., 2012)
Uphononongo lufumanise ukuba ukonyuka kwamanqanaba e-serum enterolactone kwakudityaniswa nomngcipheko womhlaza webele we-postmenopausal. Uphononongo luye lwaqaqambisa ukuba umbutho ubaluleke kakhulu kwi-Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) -umhlaza webele xa kuthelekiswa nomhlaza webele we-ER + ve / PR + ve. Ngapha koko, ukubonakaliswa kwe-HER2 akunampembelelo kumbutho.
Olu phononongo lucebise ukuba amanqanaba aphezulu e-serum enterolactone angadibaniswa nokwehliswa komngcipheko wesifo somhlaza wamabele se-postmenopausal, ngakumbi kwi-Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) -umhlaza webele.
Ukugxininiswa kwe-Enterolactone kunye nomngcipheko womhlaza webele kwi-French Postmenopausal Women
Uphononongo lwangaphambili olwapapashwa ngo-2007 ngabaphandi be-Institut Gustave-Roussy, e-France baphinde bavavanya imibutho phakathi komngcipheko wesifo somhlaza wamabele we-postmenopausal kunye nokutya okutyayo kwizityalo ezine ze-lignans -pinoresinol, lariciresinol, secoisolariciresinol, kunye ne-matairesinol, kunye nokuvezwa koosomashishini ababini - enterodiol kunye ne-enterolactone. Uphononongo lusebenzise idatha evela kwiphepha lemibuzo lokutya elizimeleyo elivela kwi-58,049 yabasetyhini baseFrance abasemva abangathathi zongezo ze-soy isoflavone. Ngexesha lokulandelwa kweminyaka esi-7.7, kwafunyaniswa iimeko ezingama-1469 zomhlaza wamabele. (Marina S Touillaud okqhubekayo, J Natl Cancer Inst., 2007)
Uphononongo lufumanise ukuba xa kuthelekiswa nabasetyhini abaneyona lignans iphantsi, abo bane-lignan ephezulu yokutya ehambelana> 1395 microg / ngosuku, babenomngcipheko omncinci womhlaza webele. Uphononongo lufumanise ukuba imibutho eguqukayo phakathi kokungeniswa kwe-phytoestrogen kunye ne-postmenopausal yomhlaza webele ibekelwe umda kwi-Estrogen Receptor (ER) kunye neProgesterone Receptor (PR) -imhlaza yomhlaza webele.
Ukususwa okungundoqo: Ukuza kuthi ga ngoku, kukho iziphumo ezingqubanayo kwaye ke, asinakugqiba ukuba i-lignan ephezulu (umthombo we-phytoestrogen yokutya enesakhiwo esifana ne-estrogen) -ukutya ukutya okuninzi kunye ne-plasma ye-enterolactone ineziphumo ezikhuselayo kumhlaza webele.
isiphelo
Nangona ukuthathwa kokutya okutyebileyo kwii-lignans (umthombo we-phytoestrogen yokutya enesakhiwo esifana ne-estrogen) isempilweni kwaye inokuba neekhompawundi eziphambili ezisebenzayo ezinokunceda ekunciphiseni umngcipheko weentlobo ezahlukeneyo zomhlaza, umanyano phakathi kwamanqanaba e-plasma enterolactone kunye nomngcipheko. zomhlaza ezahlukeneyo akukacaci. Olunye lwezifundo zamva nje lucebise indima ekhuselayo ye-enterolactone ngokuchasene nokufa komhlaza we-colorectal kwabasetyhini, nangona kunjalo, imibutho yayichasene kwimeko yamadoda. Olunye uphononongo oluvavanye impembelelo yoxinzelelo lwe-plasma ye-enterolactone kumhlaza onxulumene nehomoni njengomhlaza webele, umhlaza wedlala lesinyi kunye nomhlaza we-endometrial awufumananga nxulumano okanye uphele uneziphumo eziphikisanayo. Ke, okwangoku, akukho bungqina bucacileyo obubonisa ukuba amanqanaba aphezulu okujikeleza kwe-enterolactone anokubonelela ngeziphumo ezikhuselayo kumngcipheko wehomoni ehambelanayo. i cancer.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.