Iimbalasane
Uphononongo oluyilwe kakuhle lwezonyango lubonise ukuba unyango/ukusetyenziswa kwekhompawundi yendalo ephuma kwisityalo iBerberine kubantu abaye basuswa icolon adenomas (polyps) ikhuselekile ngaphandle kweziphumo ebezingalindelekanga ezimandundu kwaye iyasebenza ekwehliseni ukuphinda kwecolon polyps. Ke, ukusetyenziswa kwe-berberine / unyango kwidosi efanelekileyo kunokunceda kwi-chemoprevention ye-colorectal adenoma (ukwenziwa kweepolyps kwikholoni) kunye ne-colorectal. umhlaza.
Ngokukhula kwabantu abagugayo, iziganeko zomhlaza zikhula, kwaye nangona ukuqhubela phambili kunye nokutsha kunyango lomhlaza, esi sifo siyakwazi ukugqithisa zonke iindlela zonyango kwinani elikhulu lezigulane. Iinketho zonyango ezindlongondlongo nezijoliswe kuzo ezinceda ekulawuleni nasekupheliseni umhlaza iiseli zikwabangela uninzi lweziphumo ebezingalindelekanga ezininzi ezirhabaxa, ezingalunganga kwaye ngamanye amaxesha ezingenakuguqulwa. Izigulana zomhlaza kunye nabo babathandayo bahlala bejonge ukusebenzisa olunye unyango lwendalo ukunciphisa kunye nokukhusela kwiziphumo ebezingalindelekanga zechemotherapy, ukomeleza ukhuseleko kunye nokuba sempilweni.
IBerberine kunye neCancer
Ikhompawundi yendalo iBerberine, efumaneka kwizityalo ezininzi ezinje ngeBarberry, iGoldenseal kunye nezinye, sele isetyenzisiwe kuNyango lwesiTshayina lwesiNtu kwiipropathi zayo eziluncedo. Oku kulandelayo zezinye zezibonelelo zempilo zeberberine:
- Ngamana unokuba neziphumo ezichasayo
- Ngaba unokuba neepropathi ezichasene ne-bacteria
- Ngamana unokufumana iipropati zokuphucula amajoni omzimba
- Ngamana unokunceda ukulawula iswekile yegazi
- Ngamana unokunceda ukunciphisa i-cholesterol embi
- Ngamana unokunceda kwimicimbi yokugaya ukutya kunye namathumbu
Nangona kunjalo, kwabanye abantu, ukusebenzisa kakhulu i-Berberine kunokukhokelela kwiziphumo ebezingalindelekanga ezinje ngesisu, isisu esihambisayo, ukuqunjelwa, ukuqhina, kunye nentloko.
Ipropathi yeBerberine yokulawula amanqanaba eswekile, umthombo ongundoqo wamafutha a umhlaza ukusinda kweseli, kunye ne-anti-ukudumba kunye nepropathi yokuphucula i-immune, yenza esi sityalo-ephuma kwisityalo esongezelelweyo sibe sisixhobo esichasene nomhlaza. Kubekho izifundo ezingapheliyo kwimigca yeeseli zomhlaza ezahlukeneyo kunye neemodeli zezilwanyana eziye zaqinisekisa izibonelelo ezichasene nomhlaza zeBerberine.
Iindlela zeemolekyuli ezilawulwa yiBerberine zibandakanya uxinzelelo lwe-oxidative, ukutyikitywa kwe-TGFB, ukulungiswa kwe-DNA, i-angiogenesis kunye ne-noncoding RNA signaling. Ezi ndlela zeselfowuni ngokuthe ngqo okanye ngokungathanga ngqo zilawula umhlaza othile wokuphela kwemolekyuli njengokukhula, ukusasazeka kunye nokufa. Ngenxa yalo mmiselo webhayoloji- kwisondlo somhlaza, ukhetho oluchanekileyo lwezincedisi ezinje ngeBerberine ngokukodwa okanye ngokudibeneyo sisigqibo esibalulekileyo ekufuneka senziwe. Xa usenza izigqibo malunga nokusetyenziswa kweBerberine yomhlaza- ziqwalasele zonke ezi zinto kunye nengcaciso. Kungenxa yokuba inyani kunyango lomhlaza- ukusetyenziswa kweBerberine akunakuba sisigqibo esilinganayo kuzo zonke iintlobo zomhlaza.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Unyango lweBerberine / Ukusetyenziswa kweColorectal Adenoma Ukuphindaphindeka (iiPolyps eColon - Abanduleli beCancer Colon)
Uphononongo lwamva nje lweklinikhi oluxhaswa ngemali yiNational Natural Science Foundation yaseTshayina luvavanye ngokubonakalayo ukusetyenziswa kweBerberine kwichemoprevention of colorectal adenoma (ukwenziwa kweepolyps kwikholoni) kunye ne-colorectal. umhlaza. Olu lingo lungenamkhethe, olungaboniyo, olulawulwa yi-placebo lwenziwa kumaziko esibhedlele esi-7 kumaphondo angama-6 eTshayina. (NCT02226185) Abantu abaqeshwe kwesi sifundo baye basuswa kwiipolyps ezininzi kwikholoni kwiinyanga ze-6 ngaphambi kokuqala isifundo. Baye babelwa ngokwamaqela amabini, kunye nabantu abangama-553 abafumana iBerberine (0.3 grams, kabini yonke imihla) kunye nama-555 abantu abafumana ithebhulethi ye-placebo. Abathathi-nxaxheba kwafuneka balandele i-colonoscopy yokulandela kwi-1-year kunye ne-2-year timepoints post registration. Isiphelo esiphambili sophononongo luvavanyo lokuphindaphinda kweepolyps kwikholoni kuyo nayiphi na i-colonoscopy yokulandelwa. (U-Chen YX okqhubekayo, iLancet gastroenterology kunye neHepatology, 2020)
Iziphumo eziphambili
Ukufunyanwa kolu phononongo yayikukuba i-155 yabantu (i-36%) kwiqela le-Berberine lalinee-polyps eziphindaphindayo ngelixa kwiqela le-placebo eli nani laliphezulu kakhulu nge-216 (47%) yabantu abanee-polyps eziphindaphindiweyo (adenoma). Akukho mhlaza womhlaza ufunyanisiweyo ngexesha lokulandela. Esona siganeko siqhelekileyo esibuhlungu yayikukuqunjelwa kubonwe kwi-1% yezigulana kwiqela le-Berberine kunye ne-0.5% kwiqela le-placebo. Akukho ziganeko zibi zichazwe ngokusetyenziswa kweBerberine.
Isitshixo esisusa kolu phononongo lweklinikhi kukuba i-0.3 gram ye-Berberine ethathwe kabini yonke imihla yafunyanwa ikhuselekile kwaye isebenza ngokukuko ekunciphiseni umngcipheko wokuphindeka kwe-colorectal adenomas (polyps). Kuba bekungekho ziphumo ebezingalindelekanga ezibi ezifunyenwe kuphononongo xa kuthathwe iidosi ezichanekileyo, ukusetyenziswa kweBerberine kunokuba yinto enokuthintela umhlaza kubantu abane-polypectomy (ukususwa kweepolyps kwikholoni).
Ukuququmbela
Ukusebenzisa i-Berberine kubantu abaye basuswa i-colon adenoma kunokukhuseleka ngaphandle kwemiphumo emibi xa ithathwa kwidosi efanelekileyo kwaye inokuba luncedo ekunciphiseni ukuphindaphinda kwe-colon polyps kunye namathuba okuba ne-colorectal. umhlaza. Nangona kunjalo, ukusetyenziswa ngokungakhethiyo kwezongezo ze-berberine ngabaguli abanomhlaza kufuneka kuphetshwe. Izigulana ezinomhlaza kufuneka zidibane neengcali zezempilo phambi kokuba zithathe izongezo zokutya ngaphandle kwenkxaso yenzululwazi, njengoko ezi zinokusebenzisana nonyango oluqhubekayo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.