Tilmaamaha
Inkasta oo cuntooyinka hodanka ku ah lignans (ilaha phytoestrogen-ka ee leh qaab dhismeed la mid ah estrogen) ay lahaan karaan xeryahooda firfircoon ee muhiimka ah ee ka caawin kara yareynta halista noocyada kala duwan ee kansarrada, xiriirka ka dhexeeya heerarka plasma enterolactone iyo halista kansarku ma cadda . Daraasad dhowaan la sameeyay ayaa lagu ogaaday in heerarka sare ee 'enterolactone' laga yaabo inay la xiriiraan halista dhimista dhimashada kansarka ku dhaca mindhicirka ee u gaarka ah dumarka iyo halista dhimashada ragga. Daraasado kale oo lagu qiimeeyay saameynta isku-ururinta plasma enterolactone ee naasaha, qanjirka 'prostate' iyo kansarka endometrial ma helin wax xiriir ah ama waxay ku dhammaatay natiijooyin is khilaafsan. Sidaa awgeed, illaa iyo hadda, ma jirto caddayn cad oo soo jeedinaysa in heerarka wareegga sare ee enterolactone ay bixin karaan saameyn weyn oo ka hortag ah halista kansarka hormoonka la xiriira.
Waa maxay Lignans?
Lignans waa polyphenols iyo sidoo kale ilaha ugu weyn ee cuntada laga helo ee phytoestrogen (isku darka dhir leh qaab dhismeed la mid ah estrogen), waxaa si aad ah looga helaa cuntooyinka dhirta ku saleysan ee kala duwan sida miraha flax iyo sisinta iyo qaddarka yar ee lowska, miraha dhan, miraha iyo khudaarta. Cunnooyinkaan hodanka ku ah lignan waxaa badanaa loo isticmaalaa qayb ka mid ah cunno caafimaad leh. Qaar ka mid ah horudhacayaasha ugu caansan ee loo yaqaan 'lignan preursors' ee lagu aqoonsaday cuntooyinka dhirta ku saleysan waa secoisolariciresinol, pinoresinol, lariciresinol iyo matairesinol.
Waa maxay Enterolactone?
Lignans-ka dhirta ee aan cunno waxaa enzym ahaan loogu beddelaa bakteeriyada xiidmaha taasoo keenta sameynta iskudhafyo loo yaqaan Enterolignans Labada shirkadood ee ugu waawayn ee wareegaya jidhkeenu waa:
a. Enterodiol iyo
b. Enterolactone
Enterolactone waa mid ka mid ah lignans-yada naasleyda ugu badan. Enterodiol sidoo kale waxaa loo sii beddeli karaa enterolactone oo ay keento bakteeriyada xiidmaha. (Meredith AJ Hullar et al, Cancer Epidemiol Biomarkers Prev., 2015) enterodiol iyo enterolactone labadaba, waxaa lagu yaqaan inay leeyihiin firfircoonaan estrogenic ah.
Marka laga reebo qadarka qaadashada lignans-ka dhirta, heerarka enterolactone ee dhiigga iyo kaadida ayaa sidoo kale laga yaabaa inay ka tarjumaan waxqabadka bakteeriyada xiidmaha. Sidoo kale, isticmaalka antibiyootikada ayaa lala xiriiriyay isku-uruurinta serum enterolactone.
Marka laga hadlayo phytoestrogen (isku-darka dhirta oo leh qaab la mid ah estrogen) -cunnooyinka hodanka ah, soy isoflavones badanaa waxay ku yimaadaan muuqaal, si kastaba ha noqotee, lignans dhab ahaantii waa ilaha ugu muhiimsan ee phytoestrogens gaar ahaan cuntada reer galbeedka.
Cuntooyinka la Cuno Ka Dib Baaritaanka Kansarka!
Ma jiraan laba kansar oo isku mid ah. Ka gudub tilmaamaha guud ee nafaqada ee qof walba oo samee go'aanno shaqsiyeed oo ku saabsan cuntada iyo kaabayaasha si kalsooni leh.
Plasma Enterolactone Uruurinta iyo Khatarta Kansarka
Inkasta oo cuntooyinka hodanka ku ah lignans ( isha laga helo phytoestrogen-ka cuntada ee qaab-dhismeedka la midka ah estrogen) loo tixgeliyo inay caafimaad qabaan oo ka kooban xeryahooda firfircoon ee kala duwan kuwaas oo gacan ka geysan kara yaraynta khatarta noocyada kala duwan ee kansarrada, xiriirka ka dhexeeya heerarka enterolactone iyo khatarta ah Kansarka ma cadda.
Plasma Enterolactone Feejignaanta iyo Dhimashada Kansarka Mindhicirka
Daraasad lagu daabacay 2019 oo ay sameeyeen cilmi-baarayaal ka socda Danmark, waxay qiimeeyeen xiriirka ka dhexeeya uruurinta plasma ee enterolactone (metabolite ugu weyn ee lignan) ka hor baaritaanka kansarka, iyo badbaadada ka dib mindhicirka. kansarka, iyadoo lagu salaynayo xogta 416 dumar ah iyo 537 rag ah oo laga helay kansarka mindhicirka, kuwaas oo ka qaybqaatay Daraasada Cunto, Kansarka iyo Caafimaadka Danishka. Intii lagu guda jiray muddada dabagalka, wadar ahaan 210 haween ah iyo 325 rag ah ayaa dhintay, kuwaas oo 170 dumar ah iyo 215 rag ah ay u dhinteen kansarka mindhicirka. (Cecilie Kyrø iyo al, Br J Nutr., 2019)
Natiijooyinka daraasadda waxay ahaayeen kuwo aad u xiiso badan. Daraasadu waxay ogaatay in uruurinta sare ee Enterolactone ay la xiriirto dhimashada u gaarka ah kansarka mindhicirka hoose ee dumarka, gaar ahaan kuwa aan isticmaalin antibiyootikada. Laablaabista kudhaca plasma enterolactone ee haweenka waxay laxirirtay 12% khatarta dhimashada ee ugu hooseysa kansarka malawadka. Sidoo kale, haweenka leh heerka sare ee plasma enterolactone waxay leeyihiin 37% heerka dhimashada ee u yar kansarka mindhicirka, marka la barbardhigo kuwa leh heerarka hoose ee plasma ee enterolactone. Si kastaba ha noqotee, ragga, uruurinta sare ee enterolactone waxay la xiriirtay dhimashooyinka gaarka ah ee kansarka mindhicirka. Xaqiiqdii, ragga, laba-jibbaarida isku-darka plasma enterolactone waxay la xiriirtay 10% khatarta sare ee dhimashada sababo la xiriira kansarka mindhicirka.
Tani waxay la jaanqaadeysaa daraasad hore oo muujisay in estrogen, hormoonka galmada dumarka, uu leeyahay xiriir qalloocan oo leh halista kansarka mindhicirka iyo dhimashada (Neil Murphy et al, J Natl Cancer Inst., 2015). Enterolactone waxaa loo tixgeliyaa inuu yahay phytoestrogen. Phytoestrogens waa isku-darka dhirta oo leh qaab dhismeed la mid ah estrogen, iyo cunnooyinka dhirta ku saleysan ee hodanka ku ah lignan ayaa ah ilaha ugu muhiimsan ee ay ka helaan cuntada.
Marka la soo koobo, cilmi-baarayaashu waxay soo gabagabeeyeen in heerarka sare ee enterolactone laga yaabo inay la xiriiraan halista dhimista dhimashada kansarka ku dhaca mindhicirka ee u gaarka ah dumarka iyo halista dhimashada ragga.
Plasma Enterolactone Feejignaanta iyo Khatarta Kansarka Endometrial
Isku-uruurinta Enterolactone iyo Khatarta Kansarka Endometrial ee Haweenka Danmark
Daraasad ay daabacday cilmibaareyaasha Xarunta Cilmibaarista Bulshada Kansarka ee Danmark, waxay qiimeeyeen xiriirka ka dhexeeya heerarka plasma enterolactone iyo dhacdooyinka kansarka endometrial, iyadoo lagu saleynayo xogta laga helay 173 kiisaska endometrial iyo 149 si aan kala sooc lahayn loo xushay haweenka deenishka ee ka diiwaangashan ' Daraasada kooxeed ee Cunnada, Kansarka iyo Caafimaadka inta udhaxaysay 1993 iyo 1997 waxayna da'doodu udhaxaysay 50 ilaa 64 sano. (Julie Aarestrup et al, Br J Nutr., 2013)
Daraasadu waxay ogaatay in dumarka leh 20 nmol / l ka badan heerka plasma ee enterolactone laga yaabo inay la xiriiraan halista dhimista kansarka endometrial. Si kastaba ha noqotee, dhimistu ma ahayn mid muhiim ah. Daraasadu waxay sidoo kale qiimeysay ururka ka dib markii laga reebay xogta dumarka leh xoogsashada enterolactone sababtoo ah isticmaalka antibiyootigga waxayna ogaadeen in ururku xoogaa ka xoog yaraaday, hase yeeshe, weli wuxuu ahaa mid aan muhiim ahayn. Daraasadu sidoo kale ma helin kala duwanaansho ku saabsan xiriirka sababtoo ah xaaladda menopausal, daaweynta beddelka hoormoonka ama BMI.
Cilmi baarayaashu waxay soo gabagabeeyeen in heerka sare ee plasma enterolactone ay yareyn karto halista kansarka endometrial, laakiin saameyntu waxay noqon kartaa mid aan muhiim aheyn.
Isku-uruurinta Enterolactone iyo Khatarta Kansarka Endometrial ee haweenka Mareykanka
Cilmi-baarayaal ka socda Iskuulka Caafimaadka ee Jaamacadda New York ee dalka Mareykanka ayaa horey u sameeyay daraasad tan la mid ah oo lagu qiimeeyay xiriirka ka dhexeeya kansarka endometrial iyo heerarka wareega ee enterolactone. Xogta daraasaddan waxaa laga helay 3 daraasadood oo koox koox ah oo ka kala dhacay magaalooyinka New York, Sweden iyo Talyaaniga. Kadib dabagal celcelis ahaan 5.3 sano, wadarta kiisaska 153 ayaa la ogaaday, kuwaas oo lagu daray daraasadda oo ay weheliyaan 271 kontaroolo isku aaddan. Daraasadu ma helin kaalin difaac ah oo ku wareegaya enterolactone oo ka dhan ah kansarka endometrial ee haweenka premenopausal ama postmenopausal. (Anne Zeleniuch-Jacquotte et al, Int J Kansarka., 2006)
Daraasadahaani ma bixiyaan wax caddeyn ah in enterolactone uu kahortagayo kansarka endometrial.
Plasma Enterolactone Uruurinta iyo Dhimashada Kansarka Prostate
Daraasad lagu daabacay 2017 oo ay sameeyeen cilmi-baarayaal ka kala socda Denmark iyo Sweden, waxay qiimeeyeen xiriirka ka dhexeeya uruurinta enterolactone prediagnostic iyo dhimashada ragga Danishka ee qaba qanjirka 'prostate'. kansarka. Daraasadda waxaa ku jiray xog laga helay 1390 rag ah oo laga helay kansarka qanjirka 'prostate' kuwaas oo ka diiwaangashan Daraasadda Cunnada Danishka, Kansarka iyo Caafimaadka. (AK Eriksen iyo al, Eur J Clin Nutr., 2017)
Daraasadu ma helin xiriir muhiim ah oo udhaxeeya 20 nmol / l ka sareeya heerka plasma ee enterolactone iyo dhimashada ragga deenishka ah ee qaba kansarka qanjirka 'prostate'. Daraasadu sidoo kale ma helin kala duwanaansho ku saabsan ururka sababo ay ka mid yihiin sigaar cabista, qiyaasta jirka ama isboortiga, iyo sidoo kale dagaalka kansarka qanjirka 'prostate'.
Marka la soo koobo, daraasadda laguma helin wax xiriir ah oo u dhexeeya uruurinta enterolactone iyo dhimashada ragga deenishka ah ee laga helay kansarka qanjirka 'prostate'.
Iyada oo ku saleysan xogta xaddidan, ma jirto wax caddeyn ah oo lagu taageerayo isku-duwidda is-daba-marinta ee udhaxeysa lignan (ilaha cuntada phytoestrogen ee leh qaab dhismeed la mid ah estrogen)-cunno qaadasho hodan ah, uruurinta serum enterolactone iyo halista kansarka qanjirka 'prostate'.
Plasma Enterolactone Fiirsashada iyo Kansarka Naasaha
Isku-uruurinta Enterolactone iyo Saadaalinta Kansarka Naasaha ee Dumarka Dheeniga ah ee Dumarka Kadib
Daraasad lagu daabacay 2018 cilmi-baareyaasha Xarunta Cilmi-baarista Kansarka ee Danmark iyo Jaamacadda Aarhus ee Danmark, waxay qiimeeyeen xiriirka ka dhexeeya isku-darka ka-hortagga plasma ee enterolactone iyo saadaalinta kansarka naasaha ee haweenka postmenopausal sida soo noqnoqda, dhimashada kansarka naasaha-gaar ah iyo sababaha oo dhan. Daraasadda waxaa ku jiray xog laga helay kiisaska kansarka naasaha ee 1457 oo ka yimid Daraasadda Cunnada ee Danmark, Kansarka iyo Daraasadda wadaagga caafimaadka. Intii lagu jiray muddada dabagalka celceliska ee 9 sano, wadar ahaan 404 haween ah ayaa dhimatay, kuwaas oo 250 ka mid ah ay u dhinteen kansarka naasaha, iyo 267 soo noqnoqday. (Cecilie Kyrø et al, Clin Nutr., 2018)
Daraasadu waxay ogaatay in plasma sare ee enterolactone kaliya xiriir yar lala yeesho dhimashada u gaarka ah kansarka naasaha ee gaarka u ah dumarka dhalmada kadib, isla markaana aysan jirin wax xiriir ah oo la leh dhimashada oo dhan iyo soo noqoshada ka dib markii la tixgeliyo waxyaabaha ay ka mid yihiin sigaar cabista, iskuulka, BMI, dhaqdhaqaaqa jirka iyo isticmaalka hoormoonka dhalmo-dayska. Natiijooyinka isma beddelin kadib markii lagu daro arrimo sida astaamaha caafimaad iyo daaweynta.
Daraasadu waxay soo gabagabeysay inaysan jirin xiriir cad oo udhaxeeya isku-darka ka-hortagga plasma ee enterolactone iyo saadaalinta kansarka naasaha ee haweenka postmenopausal.
Khatarta kansarka naasaha ee Enterolactone iyo Postmenopausal ee estrogen, progesterone iyo herceptin 2 heerka soo dhaweynta
Falanqeyn meta ah oo ay sameeyeen baarayaasha Xarunta Cilmibaarista Kansarka Jarmalka, Heidelberg, Jarmalka, waxay qiimeeyeen xiriirka ka dhexeeya serum enterolactone iyo halista kansarka naasaha ee postmenopausal. Xogta falanqaynta waxaa laga helay 1,250 kiisaska kansarka naasaha iyo 2,164 kontaroolo daraasad ballaaran oo ku saleysan dadweynaha. (Aida Karina Zaineddin et al, Int J Cancer., 2012)
Daraasadu waxay ogaatay in heerarka serum enterolactone ee la kordhiyay ay la xiriirto hoos u dhaca halista kansarka naasaha ee dhalmada kadib. Daraasadu waxay sidoo kale muujisay in ururku muhiimad weyn u lahaa kansarka naasaha Estrogen (ER) -ve / Progesterone Receptor (PR) - marka la barbar dhigo kansarka naasaha ee ER + ve / PR + ve. Dheeraad ah, muujinta HER2 wax saameyn ah kuma yeelan ururka.
Daraasadani waxay soo jeedisay in heerarka sare ee serum enterolactone laga yaabo inay la xiriiraan khatarta kansarka naasaha ee postmenopausal, gaar ahaan kansarka naasaha ee Estrogen Receptor (ER) -ve / Progesterone Receptor (PR).
Isku-uruurinta 'Enterolactone' iyo Khatarta Kansarka Naasaha ee Dumarka Faransiiska Kadib
Daraasad hore oo la daabacay 2007 oo ay sameeyeen cilmi-baareyaasha Institut Gustave-Roussy, France ayaa sidoo kale qiimeysay ururada u dhexeeya halista kansarka naasaha ee dhalmada kadib iyo qaadashada cuntada ee afar lignans -pinoresinol, lariciresinol, secoisolariciresinol, iyo matairesinol, iyo soo-gaadhista laba enterolignans - enterodiol iyo enterolactone. Daraasadu waxay isticmaashay xogta ka timid su'aalaha taariikhda cuntada ee iskeed loo maamulo ee 58,049 haweenka uurka leh ee postmenopausal ee aan qaadanayn soy isoflavone supplements. Intii lagu jiray dabagalka celceliska 7.7 sano, wadar ahaan 1469 xaaladood oo kansarka naasaha ah ayaa laga helay. (Marina S Touillaud et al, J Natl Cancer Inst., 2007)
Daraasadu waxay ogaatay in marka la barbardhigo haweenka leh qaadashada ugu hooseysa ee lignans, kuwa leh wadarta guud ee ugu badan ee lignan u dhiganta> 1395 microg / day, ay leeyihiin khatarta dhimista kansarka naasaha. Daraasadda ayaa sidoo kale lagu ogaaday in ururada qalloocan ee u dhexeeya qaadashada phytoestrogen iyo halista kansarka naasaha ee postmenopausal ay ku xaddidan yihiin Estrogen Receptor (ER) iyo Progesterone Receptor (PR) - kansarrada naasaha ee ku habboon.
Furaha Furaha: Illaa iyo hadda, waxaa jira natiijooyin is khilaafsan oo sidaas awgeed, ma soo gabagabeyn karno haddii lignan sare (ilaha phytoestrogen-ka ee leh qaab dhismeed la mid ah estrogen) -cunitaanka cunnada iyo uruurinta plasma ee enterolactone ay leedahay saameyn kahortag kansarka naasaha.
Ugu Dambeyn
Inkasta oo qaadashada cuntooyinka hodanka ku ah lignans ( isha laga helo phytoestrogen-ka cuntada ee qaab-dhismeedka la mid ah estrogen) ay caafimaad qabaan oo laga yaabo inay yeeshaan xeryahooda firfircoon ee muhiimka ah kuwaas oo gacan ka geysan kara yareynta khatarta noocyada kala duwan ee kansarrada, xiriirka ka dhexeeya heerarka enterolactone plasma iyo khatarta Kansarrada kala duwan weli ma cadda. Mid ka mid ah daraasadihii ugu dambeeyay ayaa soo jeediyay doorka ilaalinta enterolactone ee ka dhanka ah dhimashada kansarka mindhicirka ee haweenka, si kastaba ha ahaatee, ururadu waxay ka soo horjeedaan kiiska ragga. Daraasado kale oo lagu qiimeeyay saamaynta plasma enterolactone fiirsashada kansarka hormoonnada la xidhiidha sida kansarka naasaha, kansarka qanjirka 'prostate' iyo kansarka endometrial ma helin wax urur ah ama waxay ku dhammaadeen natiijooyin is khilaafsan. Sidaa darteed, hadda, ma jirto caddayn cad oo soo jeedinaysa in heerarka wareegga wareegga sare ee enterolactone uu bixin karo saameyn muhiim ah oo ka hortag ah khatarta hormoonnada la xidhiidha. Kansarka.
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