Muchidimbu
Immunotherapy imhando yekurapa cancer inomutsa uye inoshandisa immune system yemuviri kurwisa cancer. Kofi, chimwe chezvinwiwa zvinonyanya kufarirwa pasirese, ine mukana wekusimudzira anti-cancer kusadzivirirwa uye kuzadzisa nzira dzakasiyana siyana dziri kubuda dzepharmacological immunotherapy. Kofi inowedzera anti-cancer kusadzivirirwa uye inozadzisa immunotherapy nekudzoreredza immune system padyo nebundu rinokura, kuderedza kuumbwa kwetsinga yeropa uye kudzivirira bundu kuti risapinda mukugadzirisa kana rikakuvadzwa. kenza kurapwa.
Kofi ndechimwe chezvinwiwa zvinozivikanwa muUnited States uye nepasi rose. Chinhu chakakosha chekofi ndeye psychostimulant caffeine, inovawo chikamu chakakosha muzvinwiwa zvine caffeine, masodha, simba rekusimudzira uye zvimwe zvinwiwa zvehutano. Kunze kwekakineine, kofi zvakare ine akati wandei zvimwe phytochemical zvinoriumba zvine anti-kupisa uye antioxidant zvivakwa. Kune zvidzidzo zvinopfuura zviuru gumi nezvishanu zvakaongorora hutano hwekunwa kofi uye zvakawonekwa kuti zvine hutano kupfuura zvinokuvadza, kana zvisina kushandiswa zvakawandisa.
Kofi yakaratidzirwa kuve iine hutano hwakawanda mabhenefiti senge kudzora maburi, kusimudzira mutambo wemitambo, kugadzirisa mamoods, uye kudzora kutemwa nemusoro. Mhedzisiro yekofi yakaratidzirwawo kudzikisa njodzi yezvirwere zvakasiyana-siyana zvisingaperi uye zvakakomba senge rudzi rwechipiri chirwere cheshuga, gomarara rekoloni, gomarara rechiropa, nduru, cirrhosis yechiropa uye Chirwere chaParkinson. (Hong et al, Nutrients, 2; Contaldo et al, Curr Opin Clin Nutriti Metab Kuchengeta, 2020; Kolb H et al, Nutrients, 2019)
Mune ino blog, isu tichaongorora nzira idzo kofi inogona kusimudzira kurwisa-gomarara hutachiona uye nekutsigira dzakasiyana siyana dziri kubuda dzemakemikari nzira yemunotherapy nzira. Ticharondedzera muchidimbu kuti kenza inobatanidza sei immune system kuti ifambise kukura kwayo uye kurarama uye zvakare ipe pfupiso pakubuda kwechinangwa chitsva pakushandisa immune system yedu kubata uye kudzora gomarara kuburikidza nekufambira mberi kwenzira dzakasiyana dzekuzvidzivirira, kuitira kuti uburitse zvinokonzeresa zvekofi.
Kenza Immunology 101
Sezvinozivikanwa, gomarara mamiriro anokonzerwa nekukura kusingadzorwe uye nekupararira kwemamwe maseru mumuviri wedu ayo ave asina kujairika uye aenda haywire. Kune zvikonzero zvakawanda zvegomarara zvinosiyana kubva pakuva nemajini ekufungisisa uye nenjodzi yemhuri, kune mararamiro uye zvikonzero zvezvakatipoteredza. Kukwegura, kufutisa uye zvimwe zvinokurudzira kuzvimba pamwe nemamiriro ezvinhu zvinowedzerawo njodzi yekenza.
Miviri yedu yakashongedzwa neyedu pachedu yekuzvidzivirira inova iyo immune system. Inosanganisira akawanda maseru emhando dzakasiyana anosanganisira macrophage, T maseru, B maseru, dendritic maseru, chaiwo maseru anouraya, neutrophils uye mamwe anotarisana nekudzivirira muviri kubva kuzvirwere nekukuvara. Ma immune immune mumunhu ane hutano ane chekuita chekucherechedza kuti aone chero chinhu chiri chekunze, senge microbial bacteria uye mavairasi, kana kukuvara, nekuda kwekukuvara kana nekuda kwemamwe maseru mukati memuviri wedu ayo ave nekenza, uye kuadzima. Isu tese takabaiwa jekiseni sevana kuzvirwere zvakasiyana siyana zvakadai seporiyo, chibhokisi, gwirikwiti, mamota uye vamwe kuti vatange immune system kuti vazive hutachiona hunokuvadza uye vagadzirire kurwa navo pazvinenge zvichidikanwa.
Masoja ekudzivirira muviri akanyatsoenzana. Kana yakanyanyiswa, inogona kurwisa 'wega' uye inoguma ne autoimmune kusagadzikana senge rheumatoid arthritis, multiple sclerosis nevamwe. Kana masoja ekudzivirira masoja akaderedzwa, zvinoguma nezvirwere zvakaita segomarara uye zvimwe zvirwere zvinotapukira zvakanyanya. Hutano hwemuviri hunodzivirirwa nehupenyu hwedu hwekunetseka, kudya kwedu kusinganake, pamwe nehurongwa hwekukwegura hunoderedza masimba ekurwa e immune system.
Nekudaro maseru ekenza anogona kukura uye kubudirira kana apunyuka kuongororwa kwe immune. Uye zvakare, gomarara rinobatanidza immune system kuti isangoidzivirira chete, asi inoshandisa michina yekudzivirira kufambisa kufambira mberi kwechirwere kuburikidza nekukura kwayo nesimba uye nekupararira nemuviri. Cancer masero zvakare anokwanisa kudzikisira hutachiona hwekutarisa munzvimbo yayo (microenvelo) uye vanokura munzvimbo isina kudzvinyirirwa.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Immunotherapy Basics
Zvichibva pakutsvaga kwakawanda kwesainzi uye nekunzwisisa iro rakakosha basa rema immune system mukutsigira gomarara, pane kutsva kutariswa munzira dzakasiyana dzemishonga kukurudzira uye kushandisa immune system kurwisa gomarara. (Waldman AD et al, Nature Ongororo Immunology, 2020) Iyi fomu yekurapa kenza iyo inoshandisa immune system yemuviri kurapa gomarara inonzi immunotherapy. Kune nzira dzakasiyana dzekuzvidzivirira panyama dzakanangana nekudzikisa kudzivirirwa kwekuzvidzivirira kwemuviri mune bundu microenvironment nekusimudzira hutachiona hwekuongorora uye mashandiro emasero emumuviri. Izvi zvinosanganisira:
- Kurapa nemaimmune mediators (cytokines) kuita kuti masero emuviri arwise kenza.
- Inhibiting the inherent sign (checkpoint inhibitors) aripo ekudzivirira maseru ekudzivirira muviri kubva kuzvirwisa, ayo akasarudzwa nekenza kudzivirira kutaridzika seasina kujairika uye kuparadzwa.
- Kushandisa yemurwere masero ezvirwere zvemuviri izvo zvakatorwa kubva mumiviri yavo uye zvakagadzirirwa kunze kuti vazive nekurwisa maseru egomarara munzira inonzi yekugamuchira sero kurapwa. CAR T (Chimeric antigen receptor T masero) yakaratidza kubudirira pakurapa B maseru malignancies.
- Mishonga yekudzivirira gomarara ndeimwe nzira iri kuongororwa.
Nzira idzo Kenza Maseru Dzinodzivirira Kuzivikanwa Kwemuviri
- Iyo isina kujairika gomarara maseru inogadzira iyo microenvelo yakatenderedza pachega iyo iri immunosuppressive uye inotitisa iyo activation uye mashandiro emasero ezvirwere.
- Sezvo gomarara rinokura, masero asina kujairika anodzidza kurarama pane yakaderera oxygen. Ichi chiitiko chinonzi hypoxia. Hypoxia mumasero ekenza inokonzeresa shanduko dzinowedzera kuwedzera kupona. Hypoxia inokonzeresa kugadzirwa kwakanyanya kwevarevereri kunowedzera kuwedzerwa kweropa kugomarara nekudaro kuchipa zvakawanda zvinovaka muviri, uye zvakare kunogadzira vamwe vayananisi vakaita seadenosine, iyo inobatsira mukugadzira kudzvinyirira immune munzvimbo yayo.
- Cancer maseru anowedzerawo kugadzirwa kweakananga blocker kune ekuisa chiratidzo maseru ekudzivirira (immune checkpoints) ayo anodzivirira maseru ekudzivirira kubva pakuparadza akajairika maseru ekenza.
Kofi Inobatsira Sei nekusimudzira Kudzivirira Kenza-Kudzivirirwa?
Zvinotaurwa pazasi ndedzimwe nzira idzo kofi inogona kusimudzira anti-cancer immune immune.
Kofi inomutsidzira immune system padyo nebundu riri kukura
Iyo hypoxia nharaunda yakagadzirwa nekenza nekuda kwekushayikwa kweokisijeni inogumira kuwanikwa kwesimba masosi uye inokonzeresa kuunganidzwa kwesimba repakati rinodaidzwa kuti adenosine kuti riunganidzike kunze mukenza microenvelo. Adenosine inobatsira mumasero esimba kuchinjisa nekugadzira iyo molekyuru yesimba ATP. Ichowo chiratidzo chemurevereri uye chinoshanda seanodzivirira neurotransmitter muuropi.
Adenosine inosunga kune Adenosine receptors ane akasiyana mhedzisiro pane akasiyana maseru marudzi. Adenosine inodzivisa kumisikidza kweT-maseru, B-maseru, macrophage uye dendritic maseru asi inogona kumisikidza inodzora subset yeT-maseru, ichigadzira iyo immunosuppressive nharaunda yakatenderedza bundu.
Caffeine iripo mukofi inosungawo kune mamwe maasher receptors seadenosine uye inokwikwidza nayo, nekudaro ichipokana neadenosine chiito. Nenzira iyi, caffeine inogona kupindira uye kudzivirira adenosine kubva mukudzivirira maseru ezvirwere anodiwa kuti azive uye abvise chisina kujairika bundu sero. (Merighi S et al, Mol. Pharmacol, 2007; Tej GNVC et al, Int. Immunopharmacol., 2019; Jacobson KA et al, Br. J Pharmacol, 2020)
Kofi inoderedza kugadzirwa patsva kweropa
Adenosine iripo mune bundu microenvelo inowedzera kugadzirwa kwevarevereri senge interleukin 8 (IL8) uye vascular endothelial kukura chinhu (VEGF) inosimudzira kuumbwa kwemidzi mitsva yeropa munzira inonzi angiogenesis. Izvi zvinobatsira maseru egomarara kuti atore zvimwe zvekudya zvinovaka kukura kwavo uye kurarama.
Kofi, nekupindira uye nekupokana neadenosine chiito, inogona kudzivirira chiitiko ichi chebundu angiogenesis. (Gullanki Naga Venkata Charan Tej , Biomed Pharmacother., 2018)
Kofi inodzivirira bundu kuti risaende mukugadzirisa modhi kana rikakuvadzwa nekenza kurapwa senge chemotherapy uye radiation radiation
Cancer kurapwa senge chemotherapy uye radiation radiation inopindirana nezviito zvavo nekukonzeresa kukuvara kweDNA kumaseru egomarara, nokudaro zvichikonzera maseru kufa. Kufa kwemasero ekenza kunogona zvakare kuita kuti immune system idikanwe kujekesa masero akafa. Cancer maseru anozvigadzirisazve pachavo kuti vararame uye kana zvikaitika kukuvara, gadzirisa michina yekugadzirisa kuburikidza nekuwedzera kugadzirwa kwemajini ekugadzirisa akadai seATM neATR.
Caffeine inogona kutadzisa mapuroteni eATM uye ATR uye kudzivirira kugadziriswa kwekenza DNA kukuvara, nokudaro ichiita kuti sero rekenza rive munjodzi yekuuraiwa nemamwe marapirwo ekenza. (Li N et al., Biomed Res Int., 2018Nekudzivirira maseru ekugadzirisa michina mumasero ekenza, caffeine inobatsira pamwe nekukonzeresa zvinokonzeresa zvemakemikari uye kurapwa nemwaranzi zvakare, pamwe nezviito zvadzo pakuderedza kudzvinyirira immune mune bundu microenvelo.
pfupiso
Zvakawanda zvinobatsira zvekofi zvakasimbiswa zvichibva mukutsvagisa kwesainzi. Pane kubuda kwekutarisa pane dzakasiyana pharmacological immunotherapy nzira, tichishandisa isu pachedu kudzivirira kwemuviri kurwisa kenza, uye nekunzwisisa kuti sei immune system yakadzvanywa uye isingakwanise kuziva masero egomarara asina kujairika ari mumuviri. Izvi zvakasimudzira kutsvaga kwechisikigo uye akachengeteka adjuvants anogona kuderedza kudzivirira kwekudzivirira uye kuwedzera kudzivirira kwekudzivirira. Iwo immune modulating mhedzisiro yekofi, kuburikidza nekupikisa adenosine mune tumor microenvironment uye nekudaro kuderedza kudzvanywa kwekudzivirira, inogona kubatsira uye kuzadzisa immunotherapy yekudzora cancer. Nekudaro, kunyangwe paine mabhenefiti angangoita ekofi mukusimudzira anti-cancer kusadzivirirwa uye kuzadzisa immunotherapy, yakawandisa dosing ye caffeine inogona kuuraya. Kofi ndeye psychostimulant uye inofanirwa kutorwa mune inodzorwa uye ine mwero huwandu kuti ishandise yayo inobatsira.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.