Muchidimbu
Curcumin ndiyo yakakosha inoshanda yezvinhu zvakajairika zvinonhuwira Turmeric. Piperine, chinhu chakakosha cheBlack pepper chinowanzo kuverengerwa muCurcumin mafomu ekuvandudza iyo bioavailability. Vazhinji varwere vegomarara repazamu vanorapwa neyakajairika kurapwa kwehomoni inonzi Tamoxifen. Pamwe pamwe nemhando dzakadai dzekurapwa, varwere vegomarara repazamu vanowanzo tarisa kune zvekusikwa zvinowedzerwa seCurcumin (kubva kuTurmeric) ine yakasimba-inorwisa-kuzvimba, antioxidant uye anti-kenza zvivakwa zvekuvandudza hutachiona, hutano hwekurapa, hupenyu hwehupenyu kana kuderedza kurapwa mhedzisiro. Nekudaro, zvimwe zvezvinowedzera izvi zvinogona kupedzisira zvichikuvadza kurapwa. Chidzidzo chekiriniki chakakurukurwa mune ino blog chakawana kusangana kusingadiwe pakati peTamoxifen mishonga yekurapa neCurcumin inobviswa muTurmeric. Kutora Curcumin yekuwedzera panguva yeTamoxifen kurapa kunogona kudzikisa iwo mwero weiyo inoshanda metabolite yeTamoxifen uye kupindira nekurapa kukanganisa kwechirwere mune varwere vegomarara repazamu. Nekudaro, munhu anofanirwa kudzivirira kusanganisira Curcumin zvinowedzera sechikamu chechipfuva kanzuru yevarwere chikafu kana uchirapwa neTamoxifen. Zvakare, zvakakosha kugadzirisa chikafu kune chakananga kenza uye kurapwa kuti uwane mabhenefiti akawanda kubva kune zvinovaka muviri uye uve wakachengeteka.
Tamoxifen YeCancer Yezamu
Gomarara repazamu ndiyo inonyanya kubatwa kenza uye chimwe chezvikonzero zvinotungamira zvekufa zvine chekuita nekenza mune vakadzi pasi rose. Imwe yeanowanzozivikanwa maseru ekenza yemazamu ndeyepabonde mahormone anoenderana, estrogen (ER) uye progesterone (PR) receptor yakanaka uye yevanhu epidermal yekukura factor 2 (ERBB2, inonziwo HER2) isina - (ER + / PR + / HER2- subtype) . Iyo hormone yakanaka subtype yekenza yemazamu ine fungidziro yakanaka ine yakanyanya kwazvo makore mashanu ekupona mwero we5-94% (Waks uye Winer, JAMA, 2019) Varwere vakaonekwa vaine mahomoni akanaka egomarara rezamu vanorapwa neendocrine therapy senge Tamoxifen yekudzivirira kenza yemazamu uye kudzokazve, mushure mekuvhiyiwa kwavo uye chemo-radiation kurapwa. Tamoxifen inoshanda seyakasarudzika estrogen receptor modulator (SERM), iyo inovharira mahormone receptors mugomarara remazamu kuti aderedze kupona. kenza masero uye kuderedza njodzi yekudzoka zvakare.
Curcumin- Iyo Inoshanda Ingredient yeTurmeric
Chirwere chegomarara chinounza shanduko huru yemararamiro muvanhu kusanganisira maitiro ekushandisa zviwanikwa-zvinowedzerwa zvinomera izvo zvinozivikanwa kuti zvine anti-kenza zvivakwa, zvinowedzera hutachiona uye hutano hwakanaka. Mhedzisiro yedzidzo dzichangoburwa yakaratidza kuti anopfuura makumi masere muzana evarwere vegomarara vanoshandisa zvinowedzera zvinosanganisira zvinowedzerana uye imwe nzira yekurapa (Richardson MA et al, J Clin Oncol., 80). Curcumin, chinhu chinoshanda kubva ku curry spice turmeric, ndeimwe yakadaro yekuwedzera yekuwedzera iyo inozivikanwa pakati pevarwere vegomarara uye vakapona anti-gomarara uye Anti-inflammatory zvivakwa. Naizvozvo, mukana wevarwere vegomarara repazamu vanotora maCurcumin ekuwedzera (akatorwa kubva kuTurmeric) vachiri paTamoxifen kurapa kwakakwira. Curcumin inozivikanwa kuva nehurombo husina kunyura mumuviri uye nekudaro inowanzo shandiswa mukuumbwa ne piperine, chinhu chepepuru nhema, iyo inobatsira kuwedzera yayo bioavailability zvakanyanya (Shoba G et al, Planta Med, 1998).
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Curcumin (kubva kuTurmeric) & Tamoxifen Kudyidzana Kwezvinodhaka muCancer yeCancer
Mushonga wemumuromo Tamoxifen inogadziriswa mumuviri mune ayo pharmacologically anoshanda metabolites kuburikidza ne cytochrome P450 enzymes muchiropa. Endoxifen ndiyo kiriniki inoshanda yeTamoxifen, ndiyo muyananisi wakakosha wekubudirira kwetamoxifen therapy (Del Re M et al, Pharmacol Res., 2016). Zvimwe zvekare zvidzidzo zvakaitwa pamakonzo zvainge zvaratidza kuti kune kudyidzana kwezvinodhaka-zvinodhaka pakati peCurcumin (kubva kuTurmeric) neTamoxifen nekuti Curcumin yakavhiringidza iyo cytochrome P450 yakagadziriswa metabolism yetamoxifen kutendeukira kune yayo inoshanda fomu (Sarudzo YA et al, Pharmazie, 2012). Chichangobva kuburitswa chinotarisirwa kiriniki yekudzidza (EudraCT 2016-004008-71 / NTR6149) kubva kuErasmus MC Cancer Institute muNetherlands, yakaedza kubatana uku pakati peCurcumin naTamoxifen mune varwere vegomarara repazamu (Hussaarts KGAM et al, Cancers (Basel), 2019).
Muchidzidzo ichi vakaedza mashandiro eCurcumin chete uye Curcumin ine bio-enhancer Piperine payakatorwa panguva imwe chete neTamoxifen mune gumi nematanhatu mazamu anoyera. kenza varwere. Varwere vakapiwa Tamoxifen kwemazuva 28 vasati vadzidza kuti vave nechokwadi chetamoxifen yakadzikama mune zvidzidzo zvose. Varwere vakabva vapiwa 3 cycles mu2 mapoka akasiyana-siyana ane maitiro akasiyana-siyana ekutenderera. Tamoxifen yakapiwa pachiyero chenguva dzose che 20-30 mg panguva yemitambo ye3. Mitambo ye3 yaisanganisira Tamoxifen chete, Tamoxifen ine 1200 mg Curcumin inotorwa katatu zuva nezuva, kana Tamoxifen ine 1200 mg Curcumin uye 10 mg Piperine inotorwa katatu zuva nezuva. Mazinga eTamoxifen uye Endoxifen akaenzaniswa uye asina Curcumin chete uye nekuwedzera kwebio-enhancer Piperine.
Chidzidzo ichi chakaratidza kuti kusangana kweiyo inoshanda metabolite Endoxifen yakaderera neCurcumin uye ikaramba ichiderera neCurcumin naPiperine yakatorwa pamwechete. Uku kuderera muEndoxifen kwaive kwakakosha.
mhedziso
Mukupfupisa, kana Curcumin yekuwedzera ichitorwa pamwe chete neTamoxifen therapy, inogona kudzikisa kuwanda kwemushonga unoshanda pazasi pechikumbaridzo chekubudirira uye inogona kukanganisa kurapa kwechirwere. Zvidzidzo zvakaita seizvi hazvigone kufuratirwa, kunyangwe mune vashoma varwere vegomarara repazamu, uye vopa yambiro kuvakadzi vanotora tamoxifen kusarudza zvinowedzerwa zvepanyama zvavanotora nemazvo, izvo hazvipindire nekenza zvinodhaka zvinodhaka (therapeutic impact) mune chero nzira. Zvichienderana nehuchapupu uhu, Curcumin inoita senge iri chaiyo yekuwedzera inofanirwa kutorwa pamwe neTamoxifen sezvo ichikanganisa nehutano hwekurapa.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.