Ndeipi kenza yaizobatsirwa nekubatanidza Curcumin mukudya kwavo?

Muchidimbu

Curcumin inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari pa genetic risk. Asi, kuchengetedzeka uye kushanda kweCurcumin yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, mamwe marapirwo, uye bundu genetics. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye kuisa chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Curcumin inogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab, asi zvingasava zvakanaka kune varwere vanogamuchira Ifosfamide yePrimary Round Cell Sarcoma. Uyezve, nepo Curcumin inogona kubatsira vanhu vane genetic risk factor "CDKN2A", inogona kunge isingafungidzirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pamusoro pekukodzera kweCurcumin kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Curcumin iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara ekusarudzwa kwekudya kwakakosha, kutarisa pamhedzisiro yezvese zvinoshanda zvinoringana muzvokudya / zvinowedzera seCurcumin panzvimbo yekuongorora chimwe nechimwe chinoshandiswa chinoshandiswa zvakasiyana kana kusazvidza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Curcumin mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Curcumin kana uine genetic predisposition kune cancer yakabatana neCDKN2A gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Curcumin mukudya kwako kana ukabatwa nePrimary Round Cell Sarcoma, kana kuti chirwere chako chiri Primary Mucinous colorectal adenocarcinoma? Uyezve, manwiro ako eCurcumin anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab kuenda kuIfosfamide? Izvo zvakakosha kuti uzive kuti zvirevo zvakareruka senge 'Curcumin ndeyechisikigo, saka zvinogara zvichibatsira' kana 'Curcumin inowedzera kusadzivirirwa' hazvina kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Curcumin mukudya kwako kana paine shanduko mukurapa kwako regimen. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seCurcumin mukudya kwako kune mabhenefiti ayo, iwe unofanirwa kufunga nezve yakazara biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma kana Primary Round Cell Sarcoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Curcumin. Ko genetic njodzi yegomarara kubva mukuchinjika muCDKN2A ine zvakafanana biochemical nzira nzira sekuchinja mune imwe gene? Kubva pakuona kwekudya, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inoenzana nePrimary Round Cell Sarcoma here? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuita Ifosfamide sevaya vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Curcumin - A Nutritional Supplement

Iyo yekuwedzera Curcumin inotenderedza huwandu hwezvinhu zvinoshanda, zvinosanganisira Curcumin, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya WNT Beta Catenin Signaling, DNA Repair, Ceramide Signaling uye PI3K-AKT-MTOR Signaling, iyo inogadzirisa zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iwo akakodzera ekuwedzera seCurcumin, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Kana uchifunga nezve kushandisa Curcumin yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweCurcumin haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Curcumin Supplements

Kutarisana nemubvunzo 'Ndirini pandinofanira kudzivirira Curcumin mumamiriro eCancer' inonetsa nekuti mhinduro yacho yakasarudzika - inongoti 'Inoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eCurcumin anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yekenza, genetic predispositions, genetic ngozi, marapirwo emazuva ano, zvimwe zvinowedzera kutorwa, mararamiro emararamiro, BMI, uye chero allergies zvese zvine basa mukuona kana Curcumin yakakodzera kana kudziviswa, ichisimbisa kukosha kwe fungidziro yemunhu pachake muzvisarudzo zvakadaro.

1. Ko Curcumin Supplements ichabatsira here Primary Round Cell Sarcoma Varwere vari kurapwa Ifosfamide?

Primary Round Cell Sarcoma inoratidzwa nekumwe kushanduka kwemajini, anoti CIC, ATM uye FBXW7, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya DNA Kugadziridza, Cell Cycle Checkpoints, Antigen Presentation uye Post Dudziro Kugadziriswa. Kubudirira kwekurapwa kwegomarara, senge Ifosfamide, zvinoenderana nemabatiro ayo ekuita pane idzi nzira. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Curcumin yekuwedzera, iyo inobata iyo DNA Kugadziriswa, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Round Cell Sarcoma paunenge uchienda kuIfosfamide. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Curcumin Supplements ichabatsira here Primary Mucinous colorectal adenocarcinoma Varwere vari kurapwa neCetuximab?

Primary Mucinous colorectal adenocarcinoma inotaridzwa neakananga genetic mutations, seTTN, APC uye KRAS, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya WNT Beta Catenin Signaling, Angiogenesis, G-protein-yakabatana Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Curcumin yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma iri pasi peCetuximab. Izvi zvinodaro nekuti Curcumin inokanganisa nzira dzakadai seWNT Beta Catenin Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

3. Ko Curcumin Supplements Yakachengeteka Kune Vane Utano Vanhu vane CDKN2A Mutation Associated Genetic Risk?

CDKN2A inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muCDKN2A inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints uye Cell Cycle, izvo zvinokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muCDKN2A yakabatana neGanda Regomarara, funga kuisa Curcumin yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePI3K-AKT-MTOR Kuratidzira, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CDKN2A shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seCurcumin, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Hukama hwehukama hwe curcumin derivatives inosunga kune BRCT domain yemunhu DNA polymerase lambda.
• Kuenzanisa kugadzirisa uye kushivirira kweDNA kukuvara kunokonzerwa nealkylating agents.
• Curcumin (diferuloylmethane) pasi-inogadzirisa kushandiswa kweiyo nyukliya-kappa B uye IkappaBalpha kinase mumasero evanhu akawanda myeloma, zvichiita kuti kudzvinyirirwa kwekuwedzera uye kuiswa kweapoptosis.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• cBioPortal yeCancer Genomics
• cBioPortal yeCancer Genomics
• lncRNA MIR100HG-yakatorwa miR-100 uye miR-125b inopindirana necetuximab kuramba kuburikidza neWnt / β-catenin kuisa chiratidzo.
• Curcumin inhibisa kukura kuburikidza neWnt / β-catenin nzira mune isiri-diki-sero kenza yemapapu maseru.