Muchidimbu
Liquid biopsy ndiyo bvunzo inoparadzanisa uye inoongorora kutenderera bundu DNA kubva muropa kana weti samples kuburikidza nekutevedzana, uye inogona kupa ruzivo rwezvingangoitika genetic shanduko uye aberrations akabatana ne kenza. Kunyange hunyanzvi uhu huine mabhenefiti ekutarisa zviri nyore chirwere, ine mukana wekunyepa uye parizvino haina kumira mushe mukuunganidza nekuongorora.
Kana munhu akaonekwa aine kenza, imwe yebvunzo ndeyetishu biopsy yemamota akasimba uye bhonzo biopsy yegomarara reropa, ese ari maviri maitiro anopinda anogona kuitwa kuburikidza netsono, endoscopy kana kuvhiyiwa, uye mune mamwe angave asina. zvinogoneka kana nzvimbo yebundu isingasvikike. Mhedzisiro yekuongorora maseru kubva kune aya mabiopsies inopa ruzivo rwemhando, nhanho uye kufungidzira kweiyo kenza. Munguva pfupi yapfuura uye nehunyanzvi hwekufambira mberi, masayendisiti akakwanisa kuona kutenderera bundu DNA (ctDNA) uye kutenderera bundu masero (CTCs) muropa, weti uye mate. A liquid biopsy saka sampuli yeropa remurwere kana mamwe masampuli ari nyore uye asingapindike ekuona, kufungidzira uye kuongorora.
Liquid biopsy yakavakirwa pafungidziro yekuti masero egomarara ari kukura mumuviri anoburitsa DNA yavo muropa. Pane matekiniki ekuona uye kubvisa minuscule uwandu hwectDNA kubva pakakwirira kumashure kweyakajairwa kutenderera DNA muropa kana weti. Kuongorora uye kuongorora iyi ctDNA kuburikidza neakasiyana bvunzo kusanganisira kutevedzana, inogona kupa ruzivo nezve genetic maitiro ebundu. Kuzivikanwa kwemajini ekuchinja senge kenza inoenderana nekuchinja kwemajini, kumwe kuchinjika kwechromosomal senge amplifications, kudzima, inversions, kutamiswa kwezvikamu zvinokanganisa genes regomarara, zvinopa nzwisiso yehunhu hwemamorekuru egomarara - ruzivo rwakakosha uye runogona kuitika rwemunhu werudzi uye nzira yekurapa (Elazezy naJoosse, Comput Struct Biotechnol J., 2018).
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Ndeapi mabhenefiti uye zvakashata zveLiquid Biopsy?
Kubatsira kweropa biopsy muCancer
Zvinyorwa pazasi ndezvimwe zvakakosha zvakakosha zvekuita mvura biopsy mukenza.
- Zvinogona kuitwa pamasampuli akadai seropa anowanikwa nyore nyore uye anowanzo shandiswa pakuedzwa kwerabhoritari. Izvo hazvitsamire pane zvinorwadza, zvinokanganisa uye zvinodhura maitiro sezvainodiwa kumatishu kana mapfupa emongo bhiopsy.
- Inotendera kuongorora kwekupindura kurapwa nekuongorora iwo mazinga eiyo ctDNA.
- Inobvumira kuongorora kudzokororazve kwechirwere nekuita ongororo nguva nenguva yematanho uye hunhu hwe ctDNA kana murwere apedza kurapwa uye ave mukuregererwa. Iyi yekutarisa inonziwo kuongororwa kweashoma masaridhi echirwere (MRD).
- Zvechirwere chemastastatic kana chinofambira mberi, iko kuongorora kuburikidza neiyo mvura biopsy yeiyo ctDNA ichapa nzwisiso yekuti mabundu akachinja sei kubva kune ayo ekutanga maitiro uye inogona kubatsira neshanduko mune ekurapa nzira yekurapa iyo inoshanduka uye ine hasha kenza.
Kukanganisa kweropa biopsy
Zvimwe zvekukanganisa kwemvura biopsy zvinosanganisira:
- Iyo inopararira bundu DNA (ctDNA) yevasungwa inogona kuve yakadzikira zvakanyanya mune yakakwira kumashure kweyakajairika kutenderera DNA uye nekudaro iyo yemvura biopsy nzira inogona kupotsa kubatika uye nekudaro inoshuma nhema mhedzisiro mhedzisiro.
- Nemahunyanzvi anoshandiswa emvura biopsy uko minuscule zviyero zvectDNA zvinowedzeredzwa kuti zviongororwe, mukana wekukanganisa uye zvigadzirwa zvinoguma nemhedzisiro yakanaka mhedzisiro zvakakwirira.
- Liquid biopsy matekiniki uye mafashama ekushambadzira nhasi anoshaya akaenzana mune yekuenzanisira kuunganidzwa uye muyedzo ongororo.
- Nekuda kwehuwandu hwakasiyana hwemuenzaniso pakati petishu biopsy uye mvura biopsy, ivo vanogona kupa isiri-inopindirana uye ruzivo rwakasiyana kune iye mumwe munhu izvo zvingavhiringidza sarudzo dzekurapa.
Ongororo yakaitwa neboka reBritish Columbia yakawana kuti ctDNA yakapa rumwe ruzivo runobatsira kune prostate biopsy muvarume vachangowanikwa vaine metastatic castration sensitive prostate. kenza, uye vakasimbisawo kuti pakanga paine kupindirana kwe80% mukuchinja pakati pectDNA neprostate tissue biopsy. Nzira yakakwana sekudzidza kwavo yakaratidza kushandiswa kwezvose zviri zviviri matishu uye yemvura biopsy sezvo pasina nzira yega yakatora zvese genetic ruzivo muvarwere vese.Vandekerkhove G, et al, Eur Urol, 2019). Chimwe chidzidzo kubva kuna MD Anderson, Texas, chakaratidzawo kushandiswa kwemvura biopsy uye ctDNA kuongorora mukenza yepancreatic (Bernard V, et al, Gastroenterol., 2019). Muchidimbu, mvura biopsy ine mukana wekupa ruzivo rwakakosha panguva dzakasiyana nhanho dzekurapwa kwegomarara uye yekutarisa panguva uye mushure mekurapa zvikamu.
Kune varwere vegomarara vanofarira kutsvaga mvura biopsy bvunzo, kune makambani mazhinji akamiswa mundima iyi. Iyo liquid biopsy bvunzo inosiyana zvichienderana neiyo kenza mhando uye runyoro rwemajini akafukidzwa, kudzika kwekutevedzana kwekuvhara kwemajini uye kunzwisiswa uye kujeka kweiyo assays. MuUS, makambani akadai seGuardant Health, Foundation Medicine, Genomic Health uye mamwe akawanda anopa akasiyana emvura biopsy bvunzo. Makambani akawanda muIndia anoitawo liquid biopsy bvunzo dzinosanganisira MedGenome, Dr Lal Path Labs, Strand Life Sciences, Datar Cancer Genetics, Redcliffe Life Sciences nevamwe. Liquid biopsy bvunzo kazhinji dziri kunze kwemari yemuhomwe yemurwere iyo isina kuvharwa neinishuwarenzi yehutano.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapwa kwekenza kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepamoyo wakanyanya wekenza uye kurapwa kwakanangana mhedzisiro.