Muchidimbu
Kune nzira dzakawanda umo genome / genomic kuteedzana kwevarwere 'cancer cancer inogona kubatsira, kusanganisira kufanotaura nezvenjodzi yegomarara, fungidziro yegomarara uye kuongororwa, uye kuziva munhu uye nemazvo kenza kurapwa. Kune makambani mazhinji anopa akasiyana genetic sequencing bvunzo dzegomarara uye bvunzo chaiyo inozoda kuzivikanwa zvichibva pane chaiyo mamiriro uye rudzi rwegomarara. Mamwe ma genetic test anopiwa nemakambani aya anovharwa neinishuwarenzi asi mazhinji anobva pakuzvibhadharira wega.
Kuongorora kuburikidza nekuongorora, zvinyorwa, mablog, mazano nezvimwewo kutumira chirwere chekenza kunogona kukuvadza. Kune ruzivo rwakawanda, mazwi matsva uye bvunzo dzakakurudzirwa idzo vazhinji vedu tisingazive nezvadzo. Tumor kuteedzana, gomarara / bundu profiling, inotevera-chizvarwa kuteedzera, zvakanangwa mapaneru, yakazara-exome kuteedzana, mamorekuru maitiro ekenza, ndiwo ese majaroni atinosangana nawo. Izvi zvinorevei uye izvi zvinobatsira sei?
Chii chinonzi Cancer Genome / Genomic Sequicing?
Ngatitangei nezvimwe zvekutanga zvecancer. Gomarara kukura kusingadzoreki kwemamwe maseru mumuviri wedu ayo ave asina kujairika nekuda kwekuunganidzwa kwemajini kuchinja mune yedu cellular DNA, inonzi mutations kana genomic aberrations. DNA inoumbwa nearufabheti nucleotides ina, kutevedzana kwacho kunoita majeni anopa mirairo yekugadzira mapuroteni anotyaira mashandiro emasero edu, nyama uye nhengo. Kuenzanisa ndiko kudhizaina kweiyo genomic zvemukati memasero. DNA kubva kumasero ekenza uye akajairwa asiri egomarara maseru anogona kusarudzika uye nekuda kwehunyanzvi uye kufambira mberi mune anotevera-chizvarwa kuteedzana matekinoroji, anogona kududzirwa padanho rekuteedzana kweiyo nucleotide. Kufananidza kwekenza uye kutonga kweDNA kuteedzana kunopa ruzivo pane izvo zvitsva uye zvakawanikwa shanduko izvo kana zvichiongororwa zvinopa ruzivo rwezvakakanganisika zviri kukonzera chirwere.
Mhando dzakasiyana dzeKuteedzana
Kuzivikanwa kwe genomic mutations uye abnormalities zvinogona kuitwa kuburikidza neakasiyana matekiniki uye bvunzo dzinosanganisira cytogenetic karyotyping, kukwidziridzwa kwenzvimbo dzakanangana dzeDNA kuburikidza nepolymerase chain reaction (PCR), kuzivikanwa kwehumwe hurema uye fusions uchishandisa fluorescence in situ hybridization (FISH), genomic sequencing ye pani yakanangwa yegomarara chairo genes, kana kuteedzana kweseti yakazara yemajini inonzi yakazara-exome sequencing (WES) kana iyo yese DNA yesero inogona kutevedzana sechikamu chese-genome sequencing (WGS). Yekushandisa kwekiriniki ye kenza profiling, iyo inosarudzirwa sarudzo inonangwa gene pane kutevedzana kwekenza chaiyo majini mumhando ye30 - 600 majini, nepo WES neWGS zvichishandiswa zvakanyanya munzvimbo yekutsvagisa. Zvakanakira zvekutevedzana zvakanangwa mutengo wakaderera, kudzika kwakadzama kwekutevedzana uye nekuongorora kwakadzama kwemamwe matunhu eDNA anogona kuve akakosha madhiraivha egomarara.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Cancer Genomic Sequicing Inobatsira - Ndeapi mabatsiro ayo?
Kune murwere wekenza, mumwe anofanirwa kutora iyo chaiyo bvunzo paneru kune yavo chaiyo kenza mhando. Kenza dzakasiyana dzinosanganisirwa neakasiyana maseru ekuchinja kwemajini uye akanangwa mapaneru kubva kumakambani akasiyana siyana anofukidza akasiyana maseru emajini. Kudzika kwepamusoro kwekufukidzwa kwenzvimbo dze genomic kurongedzwa kune zvakanakira pahupamhi hwekuvhara munhu anogona kuwana neWES asi inogona kupotsa zvimwe zvakakosha zvakawanikwa. Pachine kushomeka kweyemhando pese pakateedzana bvunzo uye musiyano mumhedzisiro kana uchiteedzera DNA kubva kune imwechete sampuro pamiyedzo yakasiyana, mune dzakawanda zviitiko. Iko kune zvakare mutsauko mukuteedzana kunoenderana nekuti chikamu chei bundu sampuro chakateedzana uye misiyano inoonekwa pakati pekuteedzana kweDNA kubva kune yakasimba bundu turu sampuro uye kutenderera bundu reDNA kubva kumurwere mumwe chete. Nekudaro, kunyangwe paine matambudziko akasiyana siyana, ruzivo rwunowanikwa kubva kugenomic kuteedzana kwegomarara runogona kubatsira zvakanyanya munzira dzakawanda sekuwongororwa nemasayendisiti kubva kuWelcome Sanger Institute kuUnited Kingdom (Nanglia naCampbell, Nyowani Engl J Med., 2019).
Dzimwe dzenzira idzo kenza genome / genomic kuteedzana inogona kubatsira pakuongorora, kusarudza kurapwa uye kuongorora gomarara zvakanyorwa pazasi:
- Kanzira-njodzi yekufanotaura mune mumwe munhu ane hutano anogona kunge aine nhoroondo yemhuri yekenza. Kuenzanisira kweDNA kubva muropa sampuro yemunhu ane hutano kunogona kupa ruzivo pane aripo majemusi shanduko anogona kunge aripo uye anogona kuwedzera ramangwana kenza njodzi. Semuenzaniso. kuvapo kwekenza-dhizaini geni shanduko muBRCA, APC kana VHL.
- Pharmacogenomics - germline genomics inogona kuona imwechete nucleotide polymorphisms (SNPs) muzvinodhaka zvinogadzirisa enzymes izvo zvinogona kushandiswa kuzivisa varwere vari panjodzi yehuturu hunokanganisa chemotherapy.
- Epidemiology uye Ruzhinji Hutano - genomic kuenzanisira kwemamota kubva kumatunhu uko kune kwakanyanya kuitika kwechimwe chirwere chegomarara kunogona kubatsira mukuziva zvakatipoteredza, chikafu kana kumwe kuburitswa kunogona kukonzera kukonzeresa kwakanyanya kwegomarara.
- Kuenzanisira kwezvipembenene zvekutanga kunogona kubatsira pakusarudza kufungidzira kwechirwere uye kuda kwekupindira. Genomics ine huwandu hwakawanda hweshanduko / shanduko uye mhando yeshanduko, inogona kuzivikanwa seiya inoda kwekutanga uye zvine hukasha kupindira.
- Cancer kuongororwa nekuzivikanwa kwekuchinja mutyairi senge BCR_ABL, KRAS, TP53 uye nevamwe vanogona kusimbisa gomarara iri pasi.
- Kuzivikanwa kwetishu yekwakabva kenza yeprimary isingazivikanwe. Kuchinja kwakasiyana kunobatanidzwa nemhando dzegomarara chairo.
- Kurongeka kwemamota kunogona kuitwa pahwaro hwekuumbwa kwekuchinja kwemutyairi uye kwakabatana nechirwere chebiology icho chinogona kurapwa pamwe neakanangwa marapirwo.
- Kufanotaurira mhedzisiro yevarwere uye kupa zviri nani kufungidzira kunoenderana nekiriniki uye genomic dhata. Semuenzaniso. Mamota ane TP53 shanduko ane zvakanyanya kufungidzira.
- Genome kuteedzana kunobatsira ne Precision cancer kurapwa- Varwere veCancer vane zvakawanda zveshanduko uye mukwanisi wekuchinja kwakasarudzika kune wese murwere wekenza. Nekudaro, yakasarudzika yakasarudzika uye yakasarudzika yekubatanidza kurapwa kuzivikanwa iyo inogona kugadzirisa kukanganiswa kweese kusakanganiswa kungave iyo tsvene grail yekurapa kenza.
- Kuziva nzira dzekumirisana nekuteedzera kwecancer iyo isina kupindura kurapwa kwakatemwa.
- Kenza yekutarisisa kuburikidza nemvura biopsy yekuparadzira bundu reDNA kana kutenderera tumarara maseru kunogona kubatsira kuona kudzokororazve kwechirwere kana kudzokazve pasina inopinda biopsy kana kuvhiyiwa.
Nokudaro, sezvakarongwa, kune nzira dzakawanda dzokuita nadzo kenza genomic/genome sequencing inogona kubatsira kusanganisira kufanotaura njodzi yegomarara, fungidziro yegomarara uye kuongororwa, uye kuona kurapa kwegomarara kwemunhu uye kwakaringana, kunyangwe zvisiri zvakanyanya mumaitiro mazhinji eoncology.
Ndekupi kwaungawana iyo Genetic Sequicing Bvunzo yeCancer yakaitwa?
Kune makambani akati wandei anopa genomic / genetisheni yekuteedzera bvunzo zvichibva pamate kana masampuli eropa ane hunyanzvi hwakasiyana sezvataurwa pamusoro apa zvinoda kuzivikanwa zvichibva pane zvakatarwa, gomarara rudzi uye chinangwa. Kune mashoma mageneral test ekenza anopihwa nemakambani aya ayo ave kubhadharwa nezvirongwa zvehurumende zvakaita seMedicare kana NHS asi munyika zhinji dzakaita seIndia neChina, bvunzo idzi dzinobhadharwa nevarwere. Ndokumbira kuti ubvunze nevehutano hwako uye vanopa inishuwarenzi kuti uwane iyo ruzivo pane iyo genetiki bvunzo yekenza yakafukidzwa muchirongwa chako. Iwe unogona zvakare kutarisa peji rino kuti uwane a Pamazita yemakemikari anogamuchirwa ekenza njodzi.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapwa kwekenza kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepamoyo wakanyanya wekenza uye kurapwa kwakanangana mhedzisiro.