Wepamusoro 3 Zvikonzero zvekuita Genomic Sequicing yeCancer

Muchidimbu

Cancer genome / DNA kuteedzana kunogona kubatsira neyakajeka cancer kuongororwa, kufungidzira kuri nani kufanotaura uye kuzivikanwa kweakasarudzika ekurapa sarudzo zvichienderana nekenza genomic maitiro. Nekudaro, kunyangwe iri kuwedzera kukurumbira uye hype nezve mabhenefiti uye kushandiswa kwekenza genomic kuteedzana, pane chete chidimbu chevarwere icho parizvino chinobatsirwa neichi.

Kune munhu achangobva kubatwa nechirwere ichi kenza uye kubata nekuvhunduka kwekuongororwa uku, kune mibvunzo yakawanda yekuti sei, chii, sei uye matanho anotevera. Ivo vakaremerwa neakawanda ma buzzwords uye jargon, imwe yacho iri cancer genomic sequencing uye yemunhu kurapwa.

Chii chinonzi Tumor Genomic Sequicing?

Tumor genomic kuteedzana inzira yekuwana rudzi rwemamolecular scan yeDNA yakatorwa kubva kumabundu masero akawanikwa kubva mubiopsy specimen kana kubva muropa kana mwongo wemurwere. Ruzivo urwu runopa ruzivo rwekuti ndeapi matunhu ebundu DNA akasiyana kubva kune asiri-tumor cell DNA uye dudziro yeiyo genomic sequencing data inopa nzwisiso kune akakosha majini uye madhiraivha eiyo kenza. Pakave nekufambira mberi kunoshamisa mumatekinoroji ekuteedzera izvo zvakagonesa kuwana ruzivo rwe genomic yebundu rakachipa uye rinowanikwa nyore kushandiswa kwekiriniki. Mapurojekiti akawanda ekutsvagisa anotsigirwa nehurumende dzakasiyana pasirese ari kuunganidza dhata pamusoro pebundu genomic kutevedzana kwehuwandu hukuru hwevarwere vegomarara, pamwe nenhoroondo yavo yekiriniki, ruzivo rwekurapa uye mhedzisiro yekiriniki, izvo zvakawanikwa kuti zviongororwe munharaunda yeruzhinji mumapurojekiti. zvakadai se: The Cancer Genome Atlas (TCGA), Genomic England, cBIOPortal nevamwe vakawanda. Kuenderera mberi kwekuongorora kweaya makuru egomarara dhatasets kwakapa ruzivo rwakakosha rwuri kushandura mamiriro ekurapa cancer pasi rose:

1. Cancers ehumwe matissue matangi senge kenza dzese dzemazamu kana kenza dzese dzemapapu, idzo dzaimbofungidzirwa kunge dzakafanana uye dzakarapwa zvakafanana, nhasi dzinozivikanwa kunge dzakasiyana zvakasiyana uye dzakakamurwa kuita akasarudzika mamorekuru zvidimbu zvinoda kurapwa zvakasiyana.
2. Kunyangwe mukati memakemikoro subclass yeiyo chaiyo kenza chiratidzo, chega chega munhu 'tumor genomic chimiro chakasiyana uye chakasarudzika.
3. Iyo genomic ongororo yekenza DNA inopa ruzivo pamusoro peiyo huru geni zvisizvo (shanduko) izvo zvine basa rekutyaira chirwere uye mazhinji eaya ane chaiwo madhiragi akagadzirirwa kudzivirira zviito zvavo.
4. Kujairika kwekenza DNA kuri kubatsira kuti unzwisise zvirinani mashandiro anoita kenza yesero kukura kwayo nekukurumidza uye nekukurumidza uye kupararira, uye izvi zviri kubatsira nekuwanikwa kwemishonga mitsva uye yakanangwa.

Naizvozvo, kana zvasvika kuchirwere senge kenza, icho chinosanganisirwa nemhedzisiro inouraya uye inouraya, chidimbu cheruzivo chinobatsira nekunzwisisa hunhu hwekenza yemunhu hunobatsira.

Nei varwere veCancer vachifanira kufunga Tumor Genomic Sequicing?

Zvakanyorwa pazasi ndizvo zvikonzero zvitatu zvepamusoro nei varwere vachifanira kufunga kuteedzana kwavo DNA uye nekubvunza nyanzvi nezvavanowana:

Genome Sequencing yeCancer helps neKururamisa Kwakajeka

Muzviitiko zvakawanda, saiti uye chikonzero chegomarara rekutanga hachinyatso kujeka uye genome kuteedzana kweiyo bundu DNA kunogona kubatsira nekuziva zvirinani iyo yekutanga bundu saiti uye yakakosha kenza majini, nokudaro ichipa kuongororwa kwakanyatsojeka. Kune akadai makenza asina kujairika kana gomarara akaonekwa kuti anonoka uye akapararira kuburikidza nenhengo dzakasiyana, kunzwisisa gomarara hunhu kunogona kubatsira nekusarudza nzira dzakakodzera dzekurapa.

Genomic Sequcing yeCancer helps pamwe Zvirinani kufungidzira

Kubva pane yekuteedzera data imwe inotora iyo genomic mbiri ye kenza DNA. Zvichienderana nekuongororwa kwekenza yehuwandu hwekutevedzana data, mapatani eakasiyana akasiyana akave akabatana nekuoma kwechirwere uye mhinduro yekurapa. Eg. Kusavapo kweGMT gene kunofanotaura mhinduro iri nani neTMZ (Temodal) kune varwere vane kenza yeuropi glioblastoma multiforme. (Hegi ME et al, New Engl J Med, 2005Kuvapo kweTET2 gene mutation kunowedzera mukana wekupindura kune imwe kirasi yemishonga inonzi hypomethylating vamiririri muvarwere veleukemia. (Bejar R, Ropa, 2014) Ruzivo urwu saka runopa ruzivo mukuomarara uye hunhu hwechirwere uye nekubatsira nekusarudza kurapwa kwakaomarara kana kwakanyanya.

Genomic Sequcing yeCancer helps neKutsvaga Yakasarudzika Kurapa Sarudzo

Kune vazhinji kenza varwere vasingadaire kune mwero wekutarisira chemotherapy marapirwo, kuteedzera bundu kunobatsira mukuona zvirinani kusakosha kwakakosha kunogona kurapwa nemishonga inonangwa yakagadziriswa nguva pfupi yadarika uye inogona kungoshandiswa mune dzakanangana zviitiko zvine zvinodiwa. hunhu. Mumazhinji eakasindimara, akadzokera kumashure uye asingarambiri kenza, genomic profiling yebundu DNA inofambisa kupinda uye kunyoresa mumiedzo yekiriniki yekuyedza mishonga mitsva uye yakanangana nemishonga kana kutsvaga yakasarudzika uye yakasarudzika mishonga yemishonga (kurapa) zvichienderana nehunhu hwegomarara.

mhedziso

Chinonyanya kukosha ndechekuti genome sequencing iri kuramba ichiwedzera kune varwere vanoonekwa vaine kenza nhasi. Kufanana neakatsanangurwa eblue-prints anogadzirwa nemuvaki asati atanga chirongwa chekuvaka, genomic data iblue-print yegomarara remurwere uye inogona kubatsira murapi nekuita kurapa kunoenderana nehunhu hwegomarara uye nekudaro zvinotarisirwa kubatsira cancer. kurapwa. Kuongorora kwechokwadi nezve chimiro uye zvinoshamisa zvekutevedzana kwebundu uye profiling yegomarara zvakatsanangurwa zvakanaka mune imwe nyaya ichangoburwa naDavid H. Freedmen mu 'The Newsweek' pa7/16/19. Anoyambira kuti kunyangwe nebudiriro yekunanga bundu remurwere wega wega kuburikidza nemushonga chaiwo, pane chikamu chidiki chevarwere chiri kubatsirwa kubva pane izvi. (https://www.newsweek.com/2019/07/26/targeting-each-patients-unique-tumor-precision-medicine-crushing-once-untreatable-cancers-1449287.html)

Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.

Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.

Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.

Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.

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