Kodi ndizotheka kugwiritsa ntchito Soy Isoflavone Genistein limodzi ndi Chemotherapy ya Metastatic Colorectal Cancer?

Mfundo

Kafukufuku wamankhwala awonetsa kuti ndibwino kugwiritsa ntchito soya isoflavone Genistein supplement pamodzi ndi kuphatikiza chemotherapy FOLFOX pochiza odwala khansa ya m'matumbo. Kuphatikiza ma Genistein owonjezera kudya ndi chemotherapy kumatha kuthana ndi zotsatira za mankhwala a FOLFOX chemotherapy mwa odwala khansa yamatenda am'mimba.

Khansa Yam'mimba Yamtundu

Khansara ya Metastatic Colorectal (mCRC) ili ndi vuto losazindikira bwino lomwe ndipo kupulumuka kwa zaka ziwiri kumakhala kosakwana 2% ndipo kupulumuka kwazaka zisanu kumakhala kosakwana 40%, ngakhale pali njira zophatikizira kwambiri za mankhwala a chemotherapy. (AJCC Cancer Staging Handbook, 5th Edn).

Metastatic Colorectal Cancer Chemotherapy Regimens

Mitundu ya khansa ya Metastatic Colorectal imaphatikizapo 5-Fluorouracil pamodzi ndi mankhwala a platinamu Oxaliplatin, okhala ndi kapena opanda antiangiogenic (amaletsa mapangidwe a mitsempha yamagazi ku chotupa) wothandizira Bevacizumab (Avastin). Ma regimens atsopano kuphatikizapo FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) ndi FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan odwala matenda a irinotecan) awonetsanso zotsatira za m proCmisi.

Apa, tikambirana za machitidwe odziwika a mCRC omwe ali m'mayesero azachipatala ndipo amawonedwa kuti ndi othandiza motsutsana ndi Metastatic Colorectal Cancer (mCRC).

Kuchita bwino kwa FOLFOXIRI mu Metastatic Colorectal Cancer Odwala

Maphunziro angapo ayang'ana pamitundu yosiyanasiyana ya metastatic colorectal khansa regimens ndi mphamvu zawo mwa odwala mCRC. FOLFOXIRI ndi njira yoyamba yothandizira mCRC yomwe imaphatikizapo fluorouracil, oxaliplatin, leucovorin ndi irinotecan mankhwala osakaniza. Mu mayeso a TRIBE, omwe adasindikizidwa posachedwa mu 2020, kubwezeredwa kwa FOLFOXIRI yokhala ndi bevacizumab kudadzetsa zotulukapo zabwino kwambiri kuposa FOLFIRI kuphatikiza bevacizumab koma mwayi wokhala ndi kawopsedwe kwambiri chifukwa nthawi yayitali ya chemotherapy idafunikira ndipo zotsatira zoyipa zingapo zidawonedwa mwa odwala otere. (Glynne-Jones R, et al. Lancet Oncology, 2020). Njira iyi yophatikizira mankhwala othandiza koma a cytotoxic ndi antiangiogenic yadzetsa nkhawa kwa akatswiri a oncology pankhani yachitetezo ndi kawopsedwe. 

Tsatanetsatane wa Meta-analysis: XELOX vs. FOLFOX mu Metastatic Colorectal Cancer

Kafukufuku mu 2016 ndi Guo Y, et al. poyerekeza mphamvu ya capecitabine ndi fluorouracil, iliyonse yophatikizidwa ndi oxaliplatin, mwa odwala mCRC kuphatikiza ndi chemotherapy.Guo, Yu et al. Kafukufuku wa khansa, 2016).

• Mayesero asanu ndi atatu (RCTs) adagwiritsidwa ntchito pofufuza odwala 4,363 onse.
• Chomaliza chachikulu cha phunziroli chinali kuyesa chitetezo ndi mphamvu ya mankhwala a chemotherapy regimens XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (fluorouracil plus oxaliplatin) mu metastatic colorectal cancer odwala.
• Odwala okwana 2,194 adalandira chithandizo ndi mankhwala a XELOX pomwe odwala 2,169 adalandira chithandizo cha FOLFOX.

Zotsatira za Meta-analysis: XELOX vs. FOLFOX mu Metastatic Colorectal Cancer

• Gulu la XELOX linali ndi vuto lalikulu la matenda a phazi lamanja, kutsegula m'mimba ndi thrombocytopenia pamene gulu la FOLFOX linali ndi chiwerengero chapamwamba cha neutropenia yokha.
• Mafotokozedwe a kawopsedwe omwe adapezedwa pakuwunika kophatikizidwa kwamagulu onsewa anali osiyana koma kufufuza kwina pankhaniyi ndikofunikira.
• Kuchita bwino kwa XELOX kwa odwala mCRC ndikofanana ndi kuchita bwino kwa FOLFOX.

Zowonjezera za Genistein za Khansa

Genistein ndi isoflavone yomwe imapezeka mwachilengedwe muzakudya monga soya ndi soya. Genistein, PA imapezekanso mu mawonekedwe a zakudya zowonjezera zakudya ndipo amadziwika kuti ali ndi ubwino wambiri wathanzi chifukwa cha antioxidant, anti-inflammatory and anti-cancer properties. Zina mwazabwino zazaumoyo za genistein zowonjezera (kuphatikiza ndi anti-cancer properties) ndi monga:

• Zitha kuthandiza kuchepetsa kuchuluka kwa shuga m'magazi
• Zitha kuthandiza kuchepetsa kusamba kwa kusamba
• Zitha kuthandiza kukonza thanzi la mtima
• Timalimbikitsa thanzi la mafupa ndi ubongo

Mu blog iyi tikambirana ngati kugwiritsa ntchito kwa Genistein kuli ndi phindu mu metastatic colorectal khansa odwala.

Ntchito ya Genistein Supplement mu Colorectal Cancer

Kafukufuku wambiri wasonyeza kuyanjana kwa chiopsezo chochepa cha khansa yamitundumitundu kumadera akum'mawa kwa Asia omwe amadya zakudya zokhala ndi Soy. Pali maphunziro ambiri oyeserera omwe awonetsa kuti anti-khansa ya soy isoflavone Genistein, komanso kuthekera kwake kuchepetsa kuchepa kwa chemotherapy m'maselo a khansa. Chifukwa chake, ofufuza ku Icahn School of Medicine ku Mount Sinai, ku New York, adayesa chitetezo ndikugwiritsa ntchito soya isoflavone Genistein limodzi ndi muyezo wa chisamaliro chophatikizira chemotherapy pofufuza mwachipatala mwa odwala khansa yamatenda owoneka bwino. (NCT01985763) (Pintova S et al, Cancer Chemotherapy & Pharmacol., 2019)

Zambiri za Phunziro la Zachipatala pa ntchito ya Genistein Supplement mu Colorectal Cancer

• Panali odwala 13 omwe anali ndi mCRC opanda chithandizo choyambirira omwe adathandizidwa ndi FOLFOX ndi Genistein (N=10) ndi FOLFOX + Bevacizumab + Genistein (N=3).
• Mapeto oyambira a phunziroli anali kuwunika chitetezo ndi kulolerana kogwiritsa ntchito Genistein ndi kuphatikiza chemotherapy. Mapeto ake achiwiri anali kuwunika mayankho abwino kwambiri (BOR) pambuyo pa 6 chemotherapy.
• Genistein pamlingo wa 60 mg / tsiku, amapatsidwa pakamwa masiku 7 pamasabata awiri aliwonse, kuyambira masiku 2 isanafike chemo ndikupitilira masiku 4-1 a chemo kulowetsedwa. Izi zidapangitsa ofufuzawo kuwunika zoyipa zake ndi Genistein yekha komanso pamaso pa chemo.

Zotsatira za Phunziro lachipatala pa ntchito ya Genistein Supplement mu Colorectal Cancer

• Kuphatikiza kwa Genistein ndi chemotherapy kunapezeka kuti ndi kotetezeka komanso kosalolera.
• Zochitika zoyipa zomwe zimanenedwa ndi Genistein yekha zinali zofatsa kwambiri, monga kupweteka mutu, mseru komanso kuwotcha.
• Zochitika zovutitsa zomwe Genistein anapatsidwa limodzi ndi chemotherapy zinali zokhudzana ndi zovuta zamankhwala am'mimba, monga matenda amitsempha, kutopa, kutsegula m'mimba, komabe, palibe m'modzi mwa odwalawo adakumana ndi vuto lalikulu la 4.
• Panali kusintha kwamayankho abwino kwambiri (BOR) mwa odwala a mCRC omwe amatenga chemotherapy limodzi ndi Genistein, poyerekeza ndi omwe adanenedwa za mankhwala a chemotherapy okha m'maphunziro am'mbuyomu. BOR anali 61.5% mu kafukufukuyu motsutsana ndi 38-49% m'maphunziro am'mbuyomu ndimankhwala amodzimodzi a chemotherapy. (Saltz LB et al, J Clin Oncol, 2008)
• Ngakhale kuchuluka kwa kupulumuka kwaulere, komwe kumawonetsa kuchuluka kwa nthawi komwe chotupacho sichinapite patsogolo ndi chithandizocho, anali wazaka zapakati pa miyezi 11.5 ndi kuphatikiza kwa Genistein vs. miyezi 8 ya chemotherapy yokha potengera kafukufuku wam'mbuyomu. (Saltz LB et al, J Clin Oncol., 2008)

Kutsiliza

Kafukufukuyu, ngakhale ali odwala ochepa, akuwonetsa kugwiritsa ntchito soya isoflavone Genistein supplement pamodzi ndi kuphatikiza chemotherapy kunali kotetezeka ndipo sikunawonjezere poizoni wa chemotherapy mu Colorectal Cancer. Kuphatikiza apo, kugwiritsa ntchito Genistein kuphatikiza FOLFOX kumatha kupititsa patsogolo chithandizo chamankhwala ndipo mwina kumachepetsa zoyipa za chemotherapy. Zotsatira izi, ngakhale zili zolonjeza, zifunikira kuwunikidwa ndikutsimikiziridwa m'maphunziro akulu azachipatala.

Zakudya zomwe mumadya, ndi zowonjezera zomwe mumatenga ndi chisankho chomwe mumapanga. Lingaliro lanu liphatikizepo kulingalira za kusintha kwa chibadwa cha khansa, khansa, chithandizo chopitilira ndi zowonjezera, zowawa zilizonse, zokhudzana ndi moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera zakudya za khansa kuchokera ku addon sikuchokera pakusaka pa intaneti. Imasinthiratu zisankho zanu kutengera sayansi yamamolekyu yokhazikitsidwa ndi asayansi athu ndi akatswiri opanga mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa njira zomwe zimapangidwira kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa ndikofunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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