Chithandizo Chotheka cha Quercetin mu Khansa

Mfundo

Quercetin ndi flavonoid yachilengedwe yomwe imapezeka muzakudya zosiyanasiyana monga zipatso zamitundu ndi ndiwo zamasamba ndipo imakhala ndi thanzi labwino chifukwa champhamvu ya antioxidant, anti-cancer, anti-inflammatory, antiviral and antibacterial properties. Kafukufuku wosiyanasiyana woyesera ndi nyama wawonetsa mapindu ochiritsira a quercetin (omwe amapezeka kudzera muzakudya / zowonjezera) mumitundu ina ya khansa monga kapamba, bere, ovarian, chiwindi, glioblastoma, khansa ya prostate ndi m'mapapo, komanso pakuwongolera magwiridwe antchito amankhwala enaake komanso zina khansa mankhwala. Mayesero akuluakulu azachipatala akuyenera kuchitidwa kuti atsimikizire zopindulitsa izi mwa anthu. Komanso, kugwiritsidwa ntchito mopitirira muyeso kwa quercetin kungayambitse zotsatira zina monga kuwonongeka kwa chithokomiro.

Kodi Quercetin ndi chiyani?

Quercetin ndi flavonoid yachilengedwe yomwe imapezeka kwambiri muzakudya zingapo zophatikizika kuphatikizapo: 

• Zipatso Zachikuda monga maapulo, mphesa ndi zipatso
• Anyezi Ofiira
• Tiyi
• Zipatso
• Vinyo wofiyira
• Leafy amadyera
• tomato
• Burokoli

Ili ndi mphamvu ya antioxidant, anti-inflammatory, antiviral ndi antibacterial.

Ubwino Wathanzi la Quercetin

Kukhala wamphamvu antioxidant, quercetin ndi zakudya zopatsa thanzi za quercetin zimawerengedwa kuti zili ndi zabwino zambiri. Zina mwazabwino za quercetin ndi monga:

• Zitha kuchepetsa matenda amtima
• Zitha kuchepetsa kutupa
• Zingachepetse zizindikiro za ukalamba
• Zitha kuchepetsa chiopsezo cha matenda opatsirana komanso m'mimba
• Mutha kuchepetsa kuthamanga kwa magazi
• Zitha kuchepetsa ziwengo

Zotsatira zoyipa za Quercetin

Zotsatirazi ndi zina zoyipa za quercetin mukamamwa pakamwa:

• Dzanzi m'manja ndi m'miyendo
• mutu

Kulowetsa mkati mwa mankhwala okwera kwambiri a quercetin kumatha kukhala ndi zovuta zina mwa anthu ena monga:

• Kutuluka thukuta ndi thukuta
• Mseru ndi kusanza
• Kupuma movutikira
• Kuwonongeka kwa impso

Zina zomwe zingachitike chifukwa chodya kwambiri mankhwala a quercetin ndikuti amatha kusokoneza chithokomiro. Kupatula pazotsatira zoyipa monga vuto la chithokomiro, kumwa quercetin kumathandizanso kukulitsa zovuta kwa omwe ali ndi vuto la impso.

Katundu Wotsutsa Khansa wa Quercetin

Flavonoid quercetin ikuwoneka kuti ndi yodalirika yolimbana ndi khansa potengera zomwe apeza kuchokera kuma labotore angapo ndi mitundu yazinyama zamankhwala komanso maphunziro ochepa azachipatala ndi owunikira. M'munsimu muli zitsanzo za ena mwa maphunzirowa omwe akuwonetsa zabwino zomwe zingagwiritsidwe ntchito polimbana ndi khansa ya quercetin.

Mphamvu yogwiritsira ntchito Quercetin limodzi ndi zowonjezera zina kapena mankhwala a khansa

Quercetin limodzi ndi Curcumin atha Kuchepetsa Adenomas mwa Odwala Odziwika ndi Adenomatous Polyposis - Clinical Study

Kafukufuku wocheperako wochitidwa ndi ofufuza ochokera ku Cleveland Clinic ku Florida, United States adawunika momwe kuphatikizira kwa zakudya zowonjezera mavitamini a curcumin ndi quercetin kumachepetsa adenomas mwa odwala 5 omwe ali ndi Familial adenomatous polyposis, mkhalidwe wobadwa nawo pomwe ma polyp ambiri mu colon kapena rectum, potero kuwonjezera mwayi wa khansa colorectal. Kafukufukuyu adawona kuti kuchuluka ndi kukula kwa ma polyps kunachepa mwa odwala onse omwe ali ndi kuchepa kwa 60.4% ndi 50.9%, motsatana, atatha miyezi isanu ndi umodzi yothandizidwa ndi curcumin ndi quercetin. (Marcia Cruz-Correa et al, Clin Gastroenterol Hepatol., 6)

Quercetin Itha Kukweza Kugwira Ntchito kwa Temozolomide Poletsa Maselo a Glioblastoma- Kafukufuku Woyesera

Kafukufuku wopangidwa ndi akatswiri ofufuza amapanga Changshu Traditional Chinese Medical Hospital ndi Second Affiliated Hospital of Soochow University ku China adapeza kuti kugwiritsa ntchito quercetin limodzi ndi temozolomide, mankhwala ochiritsira a zotupa muubongo, adathandizira kwambiri mphamvu ya Temozolomide yoletsa maselo a khansa ya glioblastoma / ubongo ndikuletsa kupulumuka kwa khungu la glioblastoma. (Dong-Ping Sang et al, Acta Pharmacol Sin., 2014)

Quercetin Itha Kukweza Zotsutsana ndi khansa za Doxorubicin m'maselo a Khansa ya Chiwindi - Kafukufuku Woyesera

Kafukufuku wina wopangidwa ndi akatswiri ofufuza kuchokera ku Yunivesite ya Zhejiang ku China adanenanso kuti kugwiritsa ntchito quercetin kumathandizira kuthana ndi khansa ya doxorubicin chemotherapy pamaselo a khansa ya chiwindi ndikuteteza maselo abwinobwino a chiwindi. (Guanyu Wang et al, PLoS One., 2012)

Quercetin limodzi ndi Cisplatin Chemotherapy atha Kukulitsa Apoptosis / Cell Imfa ya Maselo a Khansa Yam'kamwa - Kafukufuku Woyesera

Pakafukufuku omwe adachitika ndi ofufuza ochokera ku Guangdong Provincial Center for Control and Prevention, Yunivesite ya Sun Yat-sen ndi South China Institute of Environmental Science - Guangzhou ku China, adawunika momwe kugwiritsa ntchito quercetin pamodzi ndi Cisplatin chemotherapy mu Oral Squamous Ma Cell Cellcinoma Cell lines (OSCCs) komanso mbewa zomwe zimayambitsa khansa yapakamwa. Kafukufukuyu adawonetsa kuti kuphatikiza kwa quercetin ndi cisplatin kumathandizira kufa kwa cell / apoptosis m'maselo am'magazi amkamwa komanso kuletsa kukula kwa khansa mbewa, ndikuwonetsa kuthekera kwa kuchiritsa kwa quercetin ndi kuphatikiza kwa cisplatin mu Oral Cancer. (Xin Li et al, J Khansa., 2019)

Kugwiritsa ntchito Quercetin mu Ovarian Cancer Refractory ku Cisplatin Chemotherapy kungakhale kopindulitsa - Clinical Study

Mu gawo laling'ono lachipatala la 1 lomwe ofufuza a University of Birmingham, UK, wodwala khansa ya ovarian yemwe sanayankhe chithandizo cha cisplatin anapatsidwa maphunziro awiri a quercetin, positi yomwe kuchuluka kwa mapuloteni CA 125.khansa antigen 125 - yogwiritsidwa ntchito ngati chizindikiro cha khansa ya ovari) m'magazi amachepetsa kwambiri kuchokera ku 295 mpaka 55 units / ml. (DR Ferry et al, Clin Cancer Res. 1996)

Quercetin Supplement limodzi ndi Resveratrol atha kupindula poyang'anira Prostate Cancer ndi Colon Cancer - Preclinical Study

Kafukufuku wopangidwa ndi ofufuza ochokera ku University of Wisconsin ndi a William S. Middleton VA Medical Center ku Wisconsin ku United States mu mbewa (transgenic adenocarcinoma of the mouse prostate -TRAMP) yomwe imafanana kwambiri ndi matenda a kansa ya prostate ya anthu, yapezeka kuti kuphatikiza kwa quercetin ndi resveratrol zowonjezerapo, ma antioxidants awiri omwe amapezeka kwambiri mu mphesa, anali ndi ma anti-khansa mumtundu wa khansa ya prostate. (Chandra K Singh et al, Khansa (Basel)., 2020)

Kafukufuku wina yemwe adachita ndi ofufuza ochokera ku Texas A&M University, ku United States adapeza kuti kuphatikiza kwa Resveratrol ndipo quercetin imatha kukhala ndi zochita za anticancer m'maselo a khansa yam'matumbo. (Armando Del Follo-Martinez et al, Khansa ya Nutriti., 2013)

Quercetin itha kupititsa patsogolo mphamvu yothandizirayi ya mankhwala a Fluorouracil mu Khansa ya Chiwindi - Kafukufuku Woyesera

Kafukufuku wa labotale wochitidwa ndi Yunivesite ya Kurume, ku Japan adapeza kuti kuphatikiza kwa quercetin ndi fluorouracil (5-FU) kumatha kubweretsa zina kapena mphamvu zolepheretsa kufalikira kwa khansa ya chiwindi. (Toru Hisaka et al, Anticancer Res. 2020)

Kugwiritsa Ntchito Quercetin ndi Kuopsa kwa Khansa

Kudya kwa Quercetin Kungachepetse Kuopsa kwa Khansa Yosakhala Ya Cardia Gastric

Ochita kafukufuku ochokera ku Karolinska Institutet ku Sweden adasanthula kafukufuku wina wofufuza anthu ambiri aku Sweden okhudzana ndi matenda a khansa ya m'mimba 505 ndikuwongolera kwa 1116 kuwunika kuyanjana pakati pa quercetin ndi chiwopsezo mitundu ingapo ya khansa ya m'mimba monga Cardia ndi non-cardia subtypes ya khansa ya m'mimba . Kafukufukuyu adawonetsa kuti kudya kwamagulu ambiri a quercetin kumachepetsa kwambiri chiopsezo cha noncardia chapamimba adenocarcinoma, makamaka mwa omwe amasuta fodya. (AM Ekström et al, Ann Oncol., 2011)

Kutenga zakudya zowonjezera za quercetin kungakhale kopindulitsa pochepetsa chiopsezo cha khansa monga khansa ya m'mimba.

Kafukufuku Woyeserera pa Khansa Yotsutsana ndi Khansa ya Quercetin

Kafukufuku wambiri wa labotale achitidwa ndi ofufuza ochokera kumadera osiyanasiyana padziko lapansi kuti adziwe ngati zakudya / zowonjezera za quercetin zimakhala ndi zotsutsana ndi khansa pamitundu yosiyanasiyana ya khansa. Pansipa pali zitsanzo za kafukufuku waposachedwa wa labotale kapena maphunziro a preclinical omwe adawunikira kuthekera kothana ndi khansa kwa Quercetin.

Khansa ya Chiwindi: Kafukufuku wopangidwa ndi ofufuza ochokera ku Yunivesite ya Kurume ku Japan adawonetsa kuti quercetin imatha kuletsa kuchuluka kwa maselo a khansa ya chiwindi poyambitsa apoptosis / cell death komanso cell cell kumangidwa. (Toru Hisaka et al, Anticancer Res., 2020)

Khansa Yam'mapapo: Kafukufuku wopangidwa ndi Hubei University of Medicine, China adawonetsa kuti quercetin itha kulepheretsa kufalikira ndi kufalikira kwa khansa m'mizere ya anthu omwe si a Cell Cell Lung Cancer. (Yan Dong et al, Med Sci Monit ,. 2020)

Khansa ya Prostate: Kafukufuku wochitidwa ndi ofufuza ochokera ku University of Madras ku India ndi Pukyong National University ku South Korea adapeza kuti quercetin imatha kuchepetsa kupulumuka kwa maselo a khansa ya prostate mumitundu yazinyama, komanso ingalepheretse mapuloteni ochulukitsa komanso odana ndi apoptotic, kuwonetsa phindu ya quercetin yowonjezeretsa kupewa chiopsezo cha khansa ya prostate. (G Sharmila et al, Zakudya Zamankhwala., 2014)

Khansa Yamchiberekero: Kafukufuku wopangidwa ndi ofufuza ochokera ku Yunivesite ya Madras, India adawonetsa kuti Quercetin imatha kuletsa kukula kwa khansa ya m'mimba ya khansa ya m'mimba. (Dhanaraj Teekaraman et al, Chem Biol Kuyanjana., 2019)

Khansa ya m'mawere: Pakafukufuku omwe adachitika ndi akatswiri ochokera ku University of Madras ku India, adanenanso kuti kugwiritsa ntchito Quercetin kungathandize kuyambitsa Apoptosis kapena Cell kufa m'maselo a khansa ya m'mawere. (Santhalakshmi Ranganathan et al, PLoS One., 2015)

Khansa ya Pancreatic: Ofufuza kuchokera ku David Geffen School of Medicine ku UCLA, US adasanthula momwe kugwirira ntchito pakamwa kwa quercetin mu khansa ya kapamba ya khansa ndipo adapeza kuti quercetin imatha kuletsa kukula kwa zotupa za kapamba muntchito ya mbewa. (Eliane Angst et al, Pancreas., 2013)

Kutsiliza

Maphunziro osiyanasiyana a preclinical ndi labotale awonetsa zabwino / zotheka zazakudya zokhala ndi quercetin ndi zowonjezera pakuchiza kwapadera. khansa mitundu monga pancreatic, m'mawere, ovarian, chiwindi, glioblastoma, khansa ya prostate ndi m'mapapo, komanso kupititsa patsogolo mphamvu zamachiritso amankhwala enaake ndi mankhwala ena a khansa. Mayesero akuluakulu azachipatala akuyenera kuchitidwa kuti atsimikizire zopindulitsa zotsutsana ndi khansa za quercetin mwa anthu.

Quercetin ali ndi antioxidant wamphamvu, anti-khansa, anti-inflammatory, antiviral ndi antibacterial properties. Mitundu yambiri ya quercetin imatha kupezeka pophatikiza zakudya zosiyanasiyana monga zipatso ndi ndiwo zamasamba zodzaza ndi michere monga gawo la zakudya. Mankhwala a Quercetin nthawi zambiri amaphatikizidwa ndi mankhwala ena monga Vitamini C kapena Bromelain kuti athetse mphamvu yake. Komabe, kudya kwambiri quercetin kumatha kubweretsa zovuta zambiri kuphatikiza kusokonezedwa ndi chithokomiro choyenera. Pewani kumwa mankhwala a quercetin popanda malangizo kwa othandizira azaumoyo kuti mupewe mavuto obwera chifukwa chokhala ndi vuto la chithokomiro komanso kuyanjana ndi chithandizo chamankhwala.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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