Mfundo
Mbeu zakuda ndi mafuta akuda amatha kuchepetsa zotsatira za mankhwala a chemotherapy amitundu yosiyanasiyana ya khansa. Mbeu zakuda zimakhala ndi zakudya zosiyanasiyana monga Thymoquinone. Ubwino wa anticancer wa mbewu yakuda ndi Thymoquinone adayesedwa mwa odwala komanso maphunziro a labu. Zitsanzo zochepa za ubwino wa thymoquinone, monga momwe zasonyezedwera ndi maphunzirowa ndi monga kuchepa kwa kutentha thupi ndi matenda ochokera ku chiwerengero chochepa cha neutrophil mu khansa ya mu ubongo wa ana, kuchepa kwa methotrexate (chemotherapy) yokhudzana ndi zotsatira za poizoni mu khansa ya m'magazi ndi kuyankha bwino kwa odwala khansa ya m'mawere omwe amathandizidwa ndi tamoxifen. chithandizo. Chifukwa mafuta akuda akuda ndi owawa - nthawi zambiri amatengedwa ndi uchi. Kutengera zomwe khansa ndi chithandizo, zakudya zina ndi zakudya zowonjezera sizingakhale zotetezeka. Chifukwa chake, ngati wodwala khansa ya m'mawere akuthandizidwa ndi tamoxifen ndikudya mafuta ambewu yakuda - ndiye kuti ndikofunikira kupewa Parsley, Sipinachi ndi Tiyi Wobiriwira, ndi zakudya zowonjezera monga Quercetin. Chifukwa chake, ndikofunikira kwambiri kusintha zakudya zomwe zimagwirizana ndi khansa inayake komanso chithandizo kuti mupeze phindu pazakudya komanso kukhala otetezeka.
Ndiwo okhawo omwe amakumana ndi matenda osayembekezeka a khansa ndi okondedwa awo omwe amadziwa bwino momwe zimakhalira kuyesera kudziwa njira yomwe ikubwera, kupeza madokotala abwino kwambiri, njira zabwino zothandizira, ndi moyo wina uliwonse, zakudya ndi zina zowonjezera. angagwiritse ntchito, kuti apeze mwayi wolimbana nawo kuti asakhale ndi khansa. Komanso, ambiri amakhudzidwa ndi chithandizo chamankhwala chomwe amayenera kulandira ngakhale ali ndi zotsatirapo zoyipa kwambiri ndipo amafunafuna njira zowonjezera mankhwala awo achilengedwe a chemotherapy kuti achepetse zotsatira zake ndikuwongolera thanzi lawo. Chimodzi mwazowonjezera zachilengedwe zomwe zili ndi chidziwitso chokwanira cha preclinical khansa mizere maselo ndi zitsanzo nyama ndi wakuda mbewu mafuta.
Mafuta Akuda Akuda ndi Thymoquinone
Mafuta akuda amtunduwu amapezeka kuchokera ku mbewu zakuda, mbewu za chomera chotchedwa Nigella sativa chofiirira, maluwa abuluu kapena oyera, omwe amadziwika kuti maluwa a fennel. Mbeu zakuda zimagwiritsidwa ntchito kwambiri pachakudya cha ku Asia ndi Mediterranean. Mbeu zakuda zimadziwikanso kuti chitowe chakuda, kalonji, caraway wakuda ndi nthanga za anyezi wakuda.
Mbeu zakuda zakhala zikugwiritsidwa ntchito popanga mankhwala kwazaka zambiri. Chimodzi mwazinthu zazikulu zopangira mafuta akuda ndi antioxidant, anti-inflammatory ndi anti-cancer katundu ndi Thymoquinone.
Ubwino Wathanzi Wonse wa Black Black Mafuta / Thymoquinone
Chifukwa cha antioxidant komanso anti-inflammatory properties, Black seed mafuta / Thymoquinone amadziwika kuti ali ndi maubwino ambiri azaumoyo. Zina mwazomwe mafuta akuda akutha kugwira ntchito ndi awa:
- Mphumu: Mbewu yakuda imatha kuchepetsa kutsokomola, kupumira, ndi mapapo kwa anthu ena omwe ali ndi mphumu.
- shuga: Mbeu yakuda imatha kusintha shuga m'magazi komanso kuchuluka kwama cholesterol mwa anthu omwe ali ndi shuga.
- Kuthamanga kwa magazi: Kutenga mbewu zakuda kumachepetsa kuthamanga kwa magazi pang'ono.
- Kusabereka kwa amuna: Kutenga mafuta akuda kumachulukitsa umuna komanso kuti amayenda msanga bwanji mwa amuna osabereka.
- Kupweteka kwa m'mawere (mastalgia): Kupaka gel osakaniza ndi mafuta akuda m'mawere pakapita msambo kumachepetsa kupweteka kwa azimayi omwe ali ndi vuto la m'mawere.
Zotsatira zoyipa za Mbewu Yakuda Mafuta / Thymoquinone
Mukamadya pang'ono ngati zonunkhira, zakudya zakuda ndi mafuta akuda atha kukhala otetezeka kwa anthu ambiri. Komabe, kugwiritsa ntchito mafuta akuda kapena zowonjezera mu zinthu zotsatirazi zitha kukhala zosatetezeka.
- Mimba: Pewani kudya kwambiri mafuta akuda kapena zotulutsa panthawi yapakati chifukwa zingachedwetse chiberekero kuti chisatengeke.
- Kusokonezeka kwa Magazi: Kudya mafuta akuda wakuda kumatha kukhudza magazi ndikuwonjezera magazi. Chifukwa chake, pali kuthekera kwakuti kudya mbewu yakuda kumatha kukulitsa vuto lakukha magazi.
- Hypoglycemia: Popeza mafuta akuda amachepetsa shuga m'magazi, odwala matenda ashuga omwe akumwa mankhwala ayenera kuyang'anira zizindikiro za shuga wotsika magazi.
- Kuthamanga kwa magazi: Pewani mafuta akuda ngati muli ndi kuthamanga kwa magazi chifukwa mbewu yakuda imatha kuchepetsa kuthamanga kwa magazi.
Chifukwa cha zoopsa zomwe zingachitike komanso zotsatirapo zake, munthu ayenera kupewa kugwiritsa ntchito mafuta akuda ngati akufuna kuchitidwa opaleshoni.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Gwiritsani ntchito Mafuta a Thymoquinone / Mbewu Yakuda pokonzanso mphamvu ya Chemotherapy kapena Kuchepetsa zoyipa za khansa
Ndemanga zaposachedwa m'manyuzipepala asayansi adafotokozera mwachidule kuchuluka kwamaphunziro oyeserera pamaselo kapena mitundu yazinyama zama khansa osiyanasiyana zomwe zidawonetsa ma anticancer a Thymoquinone ochokera ku Black seed mafuta, kuphatikiza momwe angalimbikitsire zotupa ku mankhwala ena ochiritsira a chemotherapy ndi ma radiation (Mostafa AGM et al, Front Pharmacol, 2017; Khan MA et al, Oncotarget 2017).
Komabe, pali kafukufuku wochepa komanso maphunziro omwe amapezeka mwa anthu omwe amawunika zotsatira za thymoquinone kapena mafuta ambewu yakuda mosiyanasiyana. khansa pamene akuthandizidwa ndi kapena popanda mankhwala enaake a chemotherapy. Ndi khansa zambiri, chemotherapy kapena radiation therapy imaperekedwa pambuyo pa opaleshoni kuti athetse maselo a khansa omwe atsala. Koma mankhwala owonjezerawa sakhala opambana nthawi zonse ndipo amatha kusokoneza moyo wa wodwala. Mu blog iyi, tiwona maphunziro osiyanasiyana azachipatala amafuta akuda kapena thymoquinone mu khansa ndikuwona ngati kumwa kwake kuli kopindulitsa kwa odwala khansa ndipo angagwiritsidwe ntchito kukulitsa Zakudya za odwala khansa.
Mbewu Yakuda / Thymoquinone limodzi ndi Chemotherapy Zitha Kuchepetsa Zotsatira zoyipa za Febrile Neutropenia mwa Ana Omwe Ali Ndi Zotupa Za Ubongo
Kodi Febrile Neutropenia ndi chiyani?
Chimodzi mwazotsatira zoyipa za chemotherapy ndikubwezeretsa m'mafupa ndi ma cell amthupi. Febrile neutropenia ndimomwe chifukwa cha ma neutrophil ochepa kwambiri, mtundu wa maselo oyera amthupi, wodwalayo amatha kutenga matenda ndi malungo. Izi ndizotsatira zoyipa zomwe zimawonedwa mwa ana omwe ali ndi zotupa zamaubongo omwe amalandira mankhwala a chemotherapy.
Kuphunzira ndi Kupeza Kiyi
Pakafukufuku wamankhwala, wopangidwa ku Yunivesite ya Alexandria ku Egypt, ofufuzawo adawunika momwe angatengere mbewu zakuda ndi chemotherapy, pazotsatira za febrile neutropenia mwa ana omwe ali ndi zotupa zamaubongo. Ana a 80 azaka zapakati pa 2-18 azaka zotupa zamaubongo, omwe amalandira chemotherapy, adapatsidwa magulu awiri. Gulu limodzi la ana 40 limalandira 5 g ya njere zakuda tsiku lililonse m'mankhwala awo a chemotherapy pomwe gulu lina la ana a 40 limangolandira chemotherapy. (Mousa HFM et al, Child's Nervous Syst., 2017).
Zotsatira za kafukufukuyu zikuwonetsa kuti 2.2% yokha ya ana mgululi omwe amatenga mbewu zakuda anali ndi febrile neutropenia ali mgululi, 19.2% ana anali ndi zoyipa za febrile neutropenia. Izi zikutanthauza kuti kudya mbewu yakuda limodzi ndi chemotherapy kumachepetsa kuchuluka kwa magawo a febrile neutropenia ndi 88% poyerekeza ndi gulu lolamulira.
Mafuta a Black Black / Thymoquinone atha Kuchepetsa Methotrexate Chemotherapy-Yoyipa Yoyipa ya Chiwindi / Hepato-kawopsedwe mwa ana omwe ali ndi Leukemia
Khansa ya m'magazi yotchedwa lymphoblastic leukemia ndi imodzi mwa khansa yodziwika bwino kwambiri ya ana. Methotrexate ndi mankhwala wamba omwe amagwiritsidwa ntchito kuonjezera kupulumuka kwa ana omwe ali ndi khansa ya m'magazi. Komabe, mankhwala a methotrexate atha kubweretsa zotsatira zoyipa za mankhwala a hepatotoxicity kapena chiwindi cha chiwindi, potero amachepetsa zovuta zake.
Phunziro & Kupeza Kiyi
A kuyesedwa kosasinthika kochitidwa ndi ofufuza ochokera ku Yunivesite ya Tanta ku Egypt adawunika momwe mafuta akuda amathandizira pa methotrexate yomwe imayambitsa hepatotoxicity mwa ana 40 aku Egypt omwe amapezeka ndi khansa ya m'magazi ya lymphoblastic. Hafu ya odwala adalandira mankhwala a methotrexate ndi mafuta akuda akuda ndipo theka lopuma adathandizidwa ndi methotrexate therapy ndi placebo (chinthu chopanda chithandizo). Kafukufukuyu anaphatikizanso ana 20 athanzi lofanana ndi msinkhu komanso kugonana ndipo adagwiritsidwa ntchito ngati gulu lolamulira. (Adel A Hagag et al, Infect Disord Drug Target., 2015)
Kafukufukuyu adapeza kuti mafuta akuda / thymoquinone amachepetsa methotrexate chemotherapy yomwe imayambitsa zotsatira za hepatotoxicity ndikuwonjezera kuchuluka kwa odwala omwe amakhululukidwa pafupifupi 30%, amachepetsa kubwereranso ndi pafupifupi 33%, ndikuthandizira kupulumuka kopanda matenda pafupifupi 60% Poyerekeza placebo ana ndi pachimake lymphoblastic khansa ya m'magazi; komabe, panalibe kusintha kwakukulu pakupulumuka konse. Ofufuzawo adazindikira kuti mafuta akuda / thymoquinone atha kulimbikitsidwa ngati mankhwala othandizira ana omwe ali ndi khansa ya m'magazi omwe amalandira mankhwala a methotrexate.
Kutenga Thymoquinone limodzi ndi Tamoxifen kumatha kukweza magwiridwe antchito ake mwa Odwala Khansa ya M'mawere
Khansara ya m'mawere ndi imodzi mwa zofala kwambiri khansa mwa akazi padziko lonse lapansi. Tamoxifen ndi muyezo wa chisamaliro chamankhwala a mahomoni omwe amagwiritsidwa ntchito mu khansa ya m'mawere ya estrogen receptor positive (ER+ve). Komabe, kukula kwa tamoxifen kukana ndi chimodzi mwazovuta zazikulu. Thymoquinone, chinthu chofunikira kwambiri chamafuta ambewu yakuda, adapezeka kuti ndi cytotoxic mumitundu ingapo ya mizere yama cell a khansa yamunthu.
Kuphunzira ndi Kupeza Kiyi
Pakafukufuku omwe adachitika ndi ofufuza ochokera ku Central University of Gujarat ku India, Tanta University ku Egypt, University ya Taif ku Saudi Arabia ndi University of Benha ku Egypt, adawunika momwe kugwiritsa ntchito thymoquinone (chinthu chofunikira kwambiri cha mafuta akuda wakuda) limodzi ndi tamoxifen mwa odwala khansa ya m'mawere. Kafukufukuyu adaphatikiza azimayi okwana 80 omwe ali ndi khansa ya m'mawere omwe sanalandire chithandizo, amathandizidwa ndi tamoxifen okha, amathandizidwa ndi thymoquinone (kuchokera ku mbewu yakuda) okha kapena amathandizidwa ndi thymoquinone ndi tamoxifen. (Ahmed M Kabel et al, J Can Sci Res., 2016)
Kafukufukuyu anapeza kuti kumwa thymoquinone pamodzi ndi Tamoxifen kunali ndi zotsatira zabwino kuposa mankhwalawa aliwonse mwa odwala khansa ya m'mawere. Ofufuzawo adazindikira kuti kuwonjezera kwa thymoquinone (kuchokera ku mafuta akuda akuda) kupita ku tamoxifen kumatha kuyimira njira yatsopano yochizira khansa ya m'mawere.
Thymoquinone itha kukhala yotetezeka kwa Odwala omwe ali ndi Khansa Yapamwamba Yotsutsa, koma sangakhale ndi Therapeutic Impact
Kuphunzira ndi Kupeza Kiyi
Mu gawo lomwe ndinaphunzira mu 2009, ndi ofufuza a King Fahd Hospital of the University ndi King Faisal University ku Saudi Arabia, adawunika chitetezo, poizoni ndi chithandizo cha thymoquinone mwa odwala khansa yayikulu yomwe palibe mankhwala ochiritsira. kapena njira zochepetsera. Phunziroli, odwala achikulire a 21 omwe ali ndi zotupa zolimba kapena ma hematological malignancies omwe adalephera kapena kubwereranso kuchipatala adapatsidwa thymoquinone pakamwa pamlingo woyambira wa 3, 7, kapena 10mg / kg / tsiku. Pambuyo pakatha masabata a 3.71, palibe zovuta zomwe zidanenedwapo. Komabe, palibe zotsutsana ndi khansa zomwe zidawonedwanso phunziroli. Potengera kafukufukuyu ofufuzawo adazindikira kuti thymoquinone idaloledwa bwino pamlingo woyambira 75mg / tsiku mpaka 2600mg / tsiku popanda zoopsa kapena mayankho azithandizo omwe adanenedwa. (Ali M. Al-Amri ndi Abdullah O. Bamosa, Shiraz E-Med J., 2009)
Kutsiliza
Maphunziro ambiri a preclinical pamizere yama cell ndi osiyanasiyana khansa machitidwe azitsanzo adapezapo kale zinthu zambiri zoletsa khansa ya Thymoquinone kuchokera kumafuta ambewu yakuda. Maphunziro angapo azachipatala adawonetsanso kuti kudya mafuta akuda / thymoquinone kungachepetse chemotherapy yomwe imayambitsa zotsatira zoyipa za febrile neutropenia mwa ana omwe ali ndi zotupa muubongo, Methotrexate imayambitsa chiwopsezo cha chiwindi mwa ana omwe ali ndi khansa ya m'magazi ndipo imatha kuwongolera kuyankha kwa tamoxifen kwa odwala khansa ya m'mawere. . Komabe, mafuta owonjezera ambewu yakuda kapena mankhwala a thymoquinone ayenera kutengedwa ngati gawo la zakudya pokhapokha mutakambirana ndi wothandizira zaumoyo wanu kuti mupewe kusagwirizana kulikonse ndi mankhwala omwe akupitilira komanso zotsatira zake chifukwa cha matenda ena.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.