Kufunsira kwa Astragalus Extracts mu Cancer

Mfundo

Mayesero osiyanasiyana oyambira azachipatala, kafukufuku wowunikira komanso kuwunika kwa meta akuwonetsa kuti kuchotsa kwa Astragalus kumatha kukhala ndi thanzi labwino ndipo kungathandize kuchepetsa zotsatirapo zina zobwera chifukwa cha chemotherapy monga nseru, kusanza, kutsekula m'mimba, kuponderezana kwa mafupa, kusintha moyo wa odwala khansa yapamwamba; onjezerani kutopa kokhudzana ndi khansa ndi anorexia ndikulumikizana ndi ma chemotherapies ena ndikuwongolera magwiridwe antchito awo, makamaka mu khansa yosakhala yaying'ono ya m'mapapo. Komabe, kuchotsa kwa astragalus kumatha kuyanjana ndi mankhwala ena kuphatikiza ma chemotherapies khansa, zomwe zimayambitsa zovuta. Chifukwa chake, kugwiritsa ntchito mwachisawawa zowonjezera za Astragalus kuyenera kupewedwa.

Kodi Astragalus ndi chiyani?

Astragalus ndi therere lomwe lakhala likugwiritsidwa ntchito mu mankhwala achi China kwazaka mazana ambiri. Amadziwikanso kuti "vetch ya mkaka" kapena "huang qi" kutanthauza "mtsogoleri wachikaso", chifukwa muzu wake ndi wachikasu.

Kuchokera kwa Astragalus kumadziwika kuti kumakhala ndi mankhwala ndipo kumagwiritsidwa ntchito kuthandizira chitetezo cha mthupi. Pali mitundu yoposa 3000 ya Astragalus. Komabe, mitundu yomwe imagwiritsidwa ntchito kwambiri mu ma astragalus supplements ndi Astragalus membranaceus.

Ubwino Wathanzi la Astragalus Extract

Muzu ndi gawo la mankhwala la chomera cha Astragalus. Phindu la kuchotsedwa kwa Astragalus limapangidwa chifukwa cha mitundu yosiyanasiyana yogwira ntchito yomwe ilipo:

• Kuthamangitsidwa
• Saponins
• Flavonoids
• Linoleic acid
• Amino acid
• Ma alkaloids

Mwa izi, Astragalus polysaccharide imawonedwa ngati chinthu chofunikira kwambiri chokhala ndi zovuta zingapo zamankhwala.

Mu Traditional Chinese Medicine, chotsitsa cha Astragalus chagwiritsidwa ntchito chokha kapena chophatikiza ndi zitsamba zina zathanzi. Zotsatirazi ndi zina mwazabwino zaumoyo ndi mankhwala omwe amafunsidwa a Astragalus.

• Mutha kukhala ndi zida za antioxidant
• Mutha kukhala ndi maantimicrobial, antiviral ndi anti-inflammatory properties
• Atha kukhala ndi zoteteza mtima / kuthandizira kukonza mtima
• Itha kulimbikitsa chitetezo cha mthupi / kukhala ndi zotsatira zoteteza thupi lanu
• Zitha kuchepetsa kutopa kwakanthawi / kukulitsa mphamvu ndi mphamvu
• Titha kuteteza impso
• Zitha kuthandizira kuchepetsa magazi
• Mutha kukhala ndi zovuta zina za anticancer
• Itha kuchepetsa zovuta zina za chemotherapy
• Zitha kuthandizira kuchiza chimfine ndi ziwengo zina

Zotsatira zoyipa komanso kuyanjana kwa Astragalus ndi mankhwala ena

Ngakhale kuti astragalus amadziwika kuti ndi yotetezeka, imatha kusokoneza mankhwala ena ndipo imatha kubweretsa zovuta zina.

• Popeza Astragalus ili ndi chitetezo chamthupi, kugwiritsa ntchito kwake ndi mankhwala a immunosuppressant monga prednisone, cyclosporine ndi tacrolimus kumatha kuchepa kapena kulepheretsa mphamvu ya mankhwalawa omwe cholinga chake ndi kupondereza chitetezo chamthupi.

• Astragalus imakhala ndi diuretic zotsatira. Chifukwa chake, kugwiritsa ntchito kwake limodzi ndi mankhwala ena okodzetsa kumatha kukulitsa zotsatira zake. Kuphatikiza apo, kutenga astragalus kumathandizanso momwe thupi limachotsera lithiamu, potero zimapangitsa kuchuluka kwa ma lithiamu ndi zovuta zina zoyanjana.

• Astragalus amathanso kukhala ndi kupopera magazi. Chifukwa chake, kugwiritsa ntchito kwake limodzi ndi mankhwala ena opha magazi kumachulukitsa chiopsezo chotaya magazi.

Kafukufuku Wogwiritsa Ntchito Astragalus mu Cancer 

1. Khansa Yapakhosi kapena Yam'mapapo

Zotsatira za Astragalus Polysaccharides limodzi ndi Concurrent Chemoradiotherapy pa Zochitika Zovuta ndi Moyo Wamoyo wa Odwala Khansa

Poyeserera kwaposachedwa, koyambirira, koyesa II kwachipatala kochitidwa ndi ofufuza a Yunivesite ya Chang Gung ku China, adaphunzira momwe mphamvu ya Asparagus polysaccharides jekeseni wothandizirana ndi chemoradiation therapy (CCRT) imakumana ndi zovuta kwa odwala omwe ali ndi khansa yapakhosi kapena laryngeal. Mankhwala a chemotherapy anali ndi cisplatin, tegafur-uracil ndi leucovorin. Odwala 17 adaphatikizidwa phunziroli. (Chia-Hsun Hsieh et al, J Cancer Res Chipatala Oncol., 2020)

Kafukufukuyu adapeza kuti zovuta zomwe zimakhudzana ndi chithandizo sizimachitika kawirikawiri pagulu la odwala khansa omwe amalandila astragalus polysaccharides ndi conorrent chemoradiation therapy (CCRT), poyerekeza ndi gulu lomwe limangolandira CCRT yokha. Kafukufukuyu adapezanso kusiyanasiyana kwamitundu mu astragalus kuphatikiza gulu la CCRT, poyerekeza ndi gulu lomwe limangolandira CCRT yokha. Kusiyanako kunali kofunikira pazinthu za QOL (mtundu wa moyo) kuphatikiza zopweteka, kusowa kwa njala, komanso kudya pagulu. 

Komabe, kafukufukuyu sanapeze zopindulitsa zina pakuyankha kwa chotupa, kupulumuka kwa matenda enieni komanso kupulumuka kwathunthu akamaperekedwa ndi Astragalus polysaccharides panthawi imodzi ya chemoradiotherapy mu pharyngeal kapena laryngeal. khansa odwala.

2. Khansa ya M'mapapo Yaying'ono

Ubwino wa jakisoni wa Astragalus kuphatikiza Platinum-based Chemotherapy mu Odwala Khansa

Pofufuza meta mu 2019 ndi ofufuza a Chipatala Chothandizira cha Nanjing University of Chinese Medicine, China, adawunika maubwino ogwiritsa ntchito astragalus kuphatikiza ndi platinamu yochokera ku chemotherapy kwa odwala omwe ali ndi khansa ya m'mapapo osakhala yaying'ono. Pakuwunika, adapeza zambiri pofufuza m'mabuku mu PubMed, EMBASE, China National Knowledge Infrastructure Database, Cochrane Library, Wanfang Database, China Biological Medicine Database, ndi Chinese Scientific Journal Database mpaka Julayi 2018. Kafukufukuyu adaphatikizira 19 onse osasankhidwa mayesero olamulidwa kuphatikiza odwala 1635. (Ailing Cao et al, Medicine (Baltimore)., 2019)

Kufufuza kwa meta kunapeza kuti kugwiritsa ntchito jakisoni wa astragalus kuphatikiza chemotherapy kumathandizira kuti mphamvu ya chemotherapy yochokera ku platinamu ipindule, ndikuwonjezera kupulumuka kwa chaka chimodzi, kumachepetsa kuchuluka kwa leukopenia (low cell cell count), poizoni wam'maplatelet, ndi kusanza. Komabe, mulingo wa umboni unali wotsika. Mayesero akulu azachipatala amafunikira kuti athe kupeza izi.

Kusanthula kofananako komwe kudachitika zaka khumi m'mbuyomu, komwe kunaphatikizapo mayesero 65 azachipatala okhudzana ndi odwala 4751 adatinso zomwe zingachitike mukamapereka astragalus limodzi ndi chemotherapy yochokera ku platinamu. Komabe, ofufuzawo adanenapo zakufunika kotsimikizira zomwe apezazo m'mayesero azachipatala omwe adachitika bwino asanaperekedwe ndi malingaliro aliwonse. (Jean Jacques Dugoua et al, Khansa ya M'mapapo (Auckl)., 2010)

Ubwino Wothandizirana Kugwiritsa Ntchito Mankhwala Osakaniza a China a Astragalus ndi Radiotherapy mu Odwala Khansa

Pakuwunika mwadongosolo komwe kunachitika mu 2013 ndi ofufuza a Chipatala Chothandizira cha Nanjing University of Chinese Medicine ku China, adawunika maubwino ogwiritsa ntchito mankhwala azitsamba a ku China a Astragalus pamodzi ndi radiotherapy mwa omwe ali ochepa khansa ya m'mapapo odwala. Kuwunikaku kunaphatikiza maphunziro 29 oyenerera. (Hailang He et al, Evid Based Complement Alternat Med., 2013)

Kafukufukuyu adawona kuti kugwiritsa ntchito mankhwala azitsamba achi China a Astragalus ndi radiotherapy kutha kukhala kopindulitsa kwa odwala omwe ali ndi khansa ya m'mapapo yomwe siing'onoting'ono powonjezera kuthandizira ndikuchepetsa poizoni wa radiotherapy. Komabe, ofufuzawa adayesa mayesero akuluakulu azachipatala kuti atsimikizire izi. 

Zotsatira za jakisoni wa Astragalus polysaccharide kuphatikiza ndi Vinorelbine ndi Cisplatin paumoyo wamoyo ndi kupulumuka kwa Odwala Khansa

Ofufuza kuchokera ku Chipatala Chachitatu Chothandizana ndi Harbin Medical University, China adachita zoyeserera kuti awone ngati jakisoni wa Astragalus polysaccharide (APS) wophatikizidwa ndi vinorelbine ndi cisplatin (VC) watukula moyo wa odwala omwe ali ndi khansa yapakatikati yam'mapapo (NSCLC) ). Kafukufukuyu adawunikiranso momwe zimakhudzira kuyankha kwa chotupa, poyizoni, ndi zotsatira zakupulumuka kutengera chidziwitso cha odwala onse a 136 NSCLC omwe adalembetsa nawo kafukufukuyu kuyambira Meyi 2008 mpaka Marichi 2010. (Li Guo et al, Med Oncol., 2012)

Mulingo woyankha poyankha komanso nthawi yopulumuka yasintha pang'ono (42.64% ndi miyezi 10.7 motsatana) mwa odwala omwe adalandira jakisoni wa Astragalus polysaccharide (APS) kuphatikiza vinorelbine ndi cisplatin (VC) poyerekeza ndi omwe adalandira vinorelbine ndi cisplatin okha (36.76% ndi 10.2 miyezi motsatira).

Kafukufukuyu adapezanso kuti panali kusintha pamiyoyo yonse ya wodwala, thupi, kutopa, nseru ndi kusanza, kupweteka, komanso kusowa kwa njala kwa odwala a NSCLC omwe amathandizidwa ndi Astragalus polysaccharide ndi VC, poyerekeza ndi VC yokha.

Zotsatira zamankhwala azitsamba a Astragalus pamankhwala a pharmacokinetics a Docetaxel 

Ofufuza kuchokera ku Memorial Sloan-Kettering Cancer Center, New York, US adachita kafukufuku kuti awone momwe mankhwala azitsamba a Astragalus amathandizira pa pharmacokinetics ya docetaxel mwa odwala NSCLC. Zotsatira za phunziroli zidawonetsa kuti kugwiritsa ntchito mankhwala azitsamba a Astragalus sikunasinthe pharmacokinetics a docetaxel kapena kuthandizira kupulumuka kwa odwala khansa yamapapo. (Barrie R Cassileth et al, Cancer Chemother Pharmacol., 2009)

Zomwe zimakhudza kuponderezedwa kwa mafupa pambuyo pa Chemotherapy

Pakafukufuku yemwe ZHENG Zhao-peng et al. mu 2013, adayesa momwe angatengere jakisoni wa astragalus polysaccharide pamafupa oponderezedwa omwe amachititsidwa ndi chemotherapy mwa odwala khansa yamapapo. Kafukufukuyu adaphatikizira odwala 61 omwe ali ndi khansa yaying'ono yaying'ono yamapapo yam'mapapo. (ZHENG Zhao-peng et al, Chin. Herbal Med., 2013)

Kafukufukuyu anapeza kuti kuchuluka kwa kupsinjika kwa mafupa kwa odwala omwe adalandira jakisoni wa astragalus polysaccharide pamodzi ndi chemotherapy anali 31.3%, omwe anali otsika kwambiri kuposa 58.6% mwa omwe adalandira chemotherapy okha. 

Ofufuzawo adazindikira kuti jakisoni wa Astragalus polysaccharide amathanso kuchepetsa kuperewera kwa mafupa pambuyo pa chemotherapy.

3. Khansa Yabwino Kwambiri

Pakafukufuku wa meta wa 2019 omwe ochita kafukufuku ku China adachita, adawunika momwe ntchito yogwiritsira ntchito mankhwala achi China yaku Astragalus imagwirira ntchito limodzi ndi chemotherapy poyerekeza ndi chemotherapy yokhayo yothandizira khansa yoyipa. Kafukufuku wowerengeka wa 22 wokhudza odwala 1,409 adapezeka pofufuza m'mabuku mu PubMed, EMBASE, Ovid, Web of Science, Cochrane Library, Chinese Science and Technology Journals (CQVIP), China Academic Journals (CNKI), ndi mabuku a Chinese Biomedical Literature.

Kufufuza kwa meta kunapeza kuti kuphatikiza kwa mankhwala achi China ochokera ku Astragalus ndi chemotherapy kumatha kusintha kuchuluka kwa zotupa m'matenda a khansa ya Colorectal, kusintha moyo wawo ndikuchepetsa zovuta monga neutropenia (ma neutrophils otsika -mtundu wa magazi oyera cell) m'magazi, kuchepa magazi m'thupi, thrombocytopenia (kuchuluka kwamagazi), nseru ndi kusanza, kutsegula m'mimba, ndi neurotoxicity. Komabe, mayesero akuluakulu azachipatala amafunikira kuti athe kupeza izi (Shuang Lin et al, Front Oncol. 2019)

Kafukufuku wina wopangidwa ndi ofufuza ku China adawunikiranso zotsatira za kuphatikiza komwe kumaphatikizapo Astragalus membranaceus ndi Jiaozhe, pazotchinga m'matumbo za odwala omwe ali ndi khansa yapakatikati. Kafukufukuyu adapeza kuti kuphatikizaku kunali ndi zoteteza pakusokonekera kwamatumbo am'mimba mu postoperative colorectal. khansa odwala. (Qian-zhu Wang et al, Zhongguo Zhong Xi Yi Jie He Za Zhi., 2015)

4. Astragalus polysaccharide imakulitsa Moyo Wodwala wa Metastatic Cancer Odwala

Pakufufuza kwaposachedwa kochitidwa ndi ofufuza ochokera ku Taipei, Taiwan, adawunika zovuta za Astragalus polysaccharides (PG2) pazizindikiro zotupa zokhudzana ndi khansa ndi Quality of Life.

Kafukufukuyu adaphatikiza odwala 23 omwe ali ndi khansa ya metastatic ndipo apeza kuti kugwiritsa ntchito Astragalus polysaccharides kumatha kuchepetsa kupweteka, mseru, kusanza ndi kutopa, komanso kupititsa patsogolo njala komanso kugona. Kafukufukuyu adapezanso kuti Astragalus amathanso kuchepetsa zolembera zosiyanasiyana zotupa. (Wen-Chien Huang et al, Khansa (Basel)., 2019)

Kafukufukuyu adapereka umboni woyamba woyanjana pakati pa Astragalus polysaccharides ndi moyo wabwino kwa odwala omwe ali ndi khansa yapitayi. Komabe, pamafunika mayesero akulu azachipatala kuti zitsimikizire izi

5. Zokhudza Kutopa Kokhudzana ndi Khansa kwa Odwala Osamalira Palliative

Ofufuza kuchokera ku Chipatala cha Mackay Memorial ku Taipei, ku Taiwan adafufuza momwe zingagwiritsire ntchito mankhwala a Astragalus pamankhwala ochepetsa kuthana ndi kutopa kokhudzana ndi khansa. Kafukufukuyu anapeza kuti Astragalus polysaccharides atha kukhala njira yothandiza komanso yotetezeka yochotsera kutopa kokhudzana ndi khansa pakati pa odwala khansa yothandizira. (Hong-Wen Chen et al, Clin Invest Med. 2012)

6. Zomwe zimachitika chifukwa chodana ndi khansa chifukwa cha odwala omwe ali ndi khansa yayikulu

Pa gawo lachiwiri lakuyesa kwamankhwala kochitidwa mu 2010 ndi ofufuza a East-West NeoMedical Center, Kyung Hee University ku Seoul, Korea, adayesa mphamvu ndi chitetezo cha mankhwala azitsamba omwe Astragalus amachotsa odwala khansa omwe ali ndi anorexia. (Jae Jin Lee et al, Integrated Cancer Ther., 2010)

Odwala onse 11 omwe ali ndi zaka zapakati pa 59.8 omwe adalembedwa pakati pa Januware, 2007 mpaka Januware, 2009 adaphatikizidwa nawo phunziroli. Kafukufukuyu adapeza kuti kugwiritsa ntchito Astragalus decoction kumathandizira njala komanso kulemera kwa odwala omwe ali ndi khansa yayikulu.

Ofufuzawo adazindikira kuti mankhwala azitsamba omwe amachotsedwa ndi Astragalus atha kukhala ndi mwayi wothandizira anorexia wokhudzana ndi khansa.

Kutsiliza

Mayesero ambiri oyambilira achipatala, kafukufuku wa anthu ndi kusanthula kwa meta amasonyeza kuti kuchotsa kwa Astragalus kungakhale ndi mphamvu yochepetsera zotsatira za mankhwala a chemotherapy monga nseru, kusanza, kutsekula m'mimba, kuponderezedwa kwa mafupa kumapangitsa kuti moyo wa odwala khansa apite patsogolo; kuchepetsa kutopa kwa khansa ndi anorexia; ndikulumikizana ndi ma chemotherapies ena ndikuwongolera bwino pakuchiritsa, makamaka m'mapapo omwe si ang'onoang'ono khansa. Komabe, astragalus imatha kuyanjana ndi mankhwala ena omwe amatsogolera kuzinthu zoyipa. Chifukwa chake, kugwiritsa ntchito mwachisawawa kwa Astragalus kuyenera kupewedwa. Lankhulani ndi wothandizira zaumoyo wanu komanso katswiri wazakudya ndikupeza upangiri pazakudya zanu musanatenge zowonjezera za Astragalus za khansa ya m'mapapo.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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