Ubwino Wachipatala Wa Mkaka Waminga / Silymarin mu Khansa

Mfundo

Mkaka Thistle Extract/Silymarin ndi chigawo chake chachikulu Silibinin ali ndi zabwino zambiri zaumoyo chifukwa cha antioxidant, anti-inflammatory and anti-cancer properties. Maphunziro osiyanasiyana a in vitro/in vivo ndi nyama afufuza za thanzi la nthula ya mkaka komanso kuthekera kwake kuletsa mitundu yosiyanasiyana ya khansa ndikupeza zotsatira zabwino. Mayesero ochepa chabe a anthu adanenanso kuti nthula ya mkaka ndi zosakaniza zake zingakhale zothandiza kuchepetsa zotsatira zina zowopsa za chemotherapy ndi radiotherapy monga cardiotoxicity, hepatotoxicity ndi edema mu ubongo nthawi zina. khansa mitundu yothandizidwa ndi chemotherapy yeniyeni.

Kodi Milk Thistle ndi chiyani?

Mkaka wamkaka ndi chomera chamaluwa chomwe chakhala chikugwiritsidwa ntchito kwa zaka mazana ambiri ngati mankhwala achilengedwe kuchiza matenda a chiwindi ndi bile makamaka m'maiko aku Europe. Mkaka wamkaka umapezekanso ngati chowonjezera pazakudya. Dzina la nthula lamkaka linachokera ku madzi amkaka omwe amatuluka m'masamba akasweka. 

Zosakaniza Zofunika Kwambiri Mkaka Waminga

Zomwe zimakhudzidwa kwambiri ndi mbewu zouma zamkaka zamkaka ndi flavonolignans (phenols zachilengedwe zopangidwa ndi gawo la flavonoid ndi gawo lignan) zomwe zimaphatikizapo:

• Silibinin (silybin)
• Isosilybin
• Silychristin
• Silydianin.

Chisakanizo cha ma flavonolignans otengedwa kuchokera ku njere za nthula zamkaka amadziwika kuti Silymarin. Silibinin yomwe imadziwikanso kuti silybin, ndiye gawo lalikulu la silymarin. Silymarin ali ndi antioxidant, antiviral ndi anti-inflammatory properties. Mkaka Wamasamba / Silymarin amapezeka ngati chowonjezera pazakudya ndipo amagwiritsidwa ntchito kwambiri pothandiza kuthana ndi vuto la chiwindi. Zowonjezera zambiri zimakhazikikanso potengera zomwe zili ndi silibinin. Palinso mitundu ina yapadera ya silymarin kapena silibinin yomwe imatha kukulitsa kupezeka kwawo mwa kulumikizana ndi phosphatidylcholine.

Ubwino Wazambiri Zaumoyo wa Mkaka nthula

Maphunziro ambiri a nyama ndi maphunziro ochepa azachipatala achitika kuti awunikire ubwino wa nthula yamkaka. Zina mwazabwino zomwe zimaperekedwa pa thanzi la nthula ya mkaka ndi izi:

1. Angathandize pamavuto a Chiwindi monga cirrhosis, jaundice, hepatitis
2. Itha kuthandizira pamavuto a chikhodzodzo
3. Akamamwa pamodzi ndi mankhwala ochiritsira, amatha kusintha matenda ashuga
4. Zitha kuthandizira kukweza mafuta m'thupi mwa odwala matenda ashuga
5. Angakuthandizeni ndi kutentha pa chifuwa ndi kudzimbidwa
6. Itha kuthandizira kuletsa khansa

Ubwino wa Milk Thistle mu Cancer

Pazaka makumi awiri zapitazi, pakhala chidwi chochulukirapo pakumvetsetsa phindu lamankhwala a mkaka nthula mu khansa. Ena mwa maphunziro a in vitro/in vivo/anyama/anthu omwe amawunika ntchito/zotsatira za nthula ya mkaka mu khansa zafotokozedwa mwachidule pansipa:

Mu Vitro/In Vivo/Animal Studies

1. Zitha Kuletsa Kukula kwa Khansa ya Pancreatic & Kuchepetsa Cachexia / Kufooka Kwambiri Chifukwa cha Khansa

Kafukufuku wa in vitro adawonetsa kuti nthula ya mkaka yogwira silibinin imatha kuletsa kukula kwa khansa ya kapamba motengera mlingo. Kafukufuku wina mu vivo akuwonetsanso kuti silibinin imachepetsa kukula kwa chotupa ndi kuchuluka kwa khansa ya kapamba ndipo ingathandize kupewa kuchepa kwa thupi ndi minofu. (Shukla SK et al, Oncotarget., 2015)

Mwachidule, maphunziro a in vitro ndi nyama akuwonetsa kuti nthula ya mkaka / silibinin ingapindule pochepetsa kukula kwa khansa ya kapamba ndi khansa ya pancreatic-Induced cachexia / kufooka. Mayesero azachipatala amafunikira kuti akhazikitse zomwezo mwa anthu. 

2. Akhoza Kuletsa Kukula kwa Khansa ya M'mawere

Kafukufuku wa in vitro adawonetsa kuti silibinin idaletsa kukula kwa maselo a khansa ya m'mawere ndikupangitsa kuti apoptosis / cell kufa m'maselo a khansa ya m'mawere. Zomwe zapeza kuchokera kumaphunziro osiyanasiyana zikuwonetsa kuti silibinin ili ndi zotsutsana ndi khansa ya m'mawere. (Tiwari P et al, Cancer Invest., 2011)

3. Angaletse Kukula kwa Khansa ya Prostate

Pakafukufuku wina, zotsatira zotsutsana ndi khansa za Silibinin zidawunikidwa pamankhwala ophatikiza pamodzi ndi DOX / Adriamycin. Phunziroli, maselo a prostate carcinoma amathandizidwa ndi silibinin ndi DOX kuphatikiza. Zomwe zapezazi zidawonetsa kuti kuphatikiza kwa silibinin-DOX kudapangitsa 62-69% yoletsa kukula m'maselo ochiritsidwa. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

4. Akhoza Kuletsa Khansa Yapakhungu

Kafukufuku wambiri adachitidwanso kuti awunikire zotsatira za Milk Thistle yogwira Silibinin pa khansa yapakhungu. Zotsatira za kafukufukuyu mu vitro zidawonetsa kuti mankhwala a Silibinin atha kukhala ndi zoteteza m'maselo a khansa yapakhungu la anthu. Kafukufuku wa vivo adapeza kuti Silibinin imathandizanso kupewa khansa yapakhungu yochokera ku UVB ndipo itha kuthandiza kukonzanso kuwonongeka kwa DNA kwa khungu la mbewa. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Maphunzirowa akulonjeza ndipo akuwonetsa kuti nthula ya mkaka / silibinin ikhoza kukhala yotetezeka komanso yopindulitsa khungu khansa.

5. Atha Kuletsa Khansa Yosasunthika

Ena mwa maphunziro a in vitro adawonetsa kuti Silibinin imatha kuyambitsa kufa kwa cell m'maselo a khansa yapakhungu. Kafukufuku wa in vitro adapezanso kuti chithandizo cha Silibinin kwa 24h chingachepetse kukula kwa maselo a khansa ndi 30-49%. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Ubwino wa Milk Thistle/Silibinin adawunikidwanso kuphatikiza ndi mankhwala ena monga histone-deacetylase(HDAC) inhibitors. Kuphatikizikako kunawonetsa zotsatira za synergistic m'ma cell colorectal.

6. Angaletse khansa ya m'mapapo

Kafukufuku wa mu vitro adawonetsa kuti Silibinin atha kukhala ndi zoteteza m'mizere ya khansa yamapapu yamunthu. Kafukufuku adawonetsanso kuti Silibinin kuphatikiza ndi DOX idaletsa kukula kwa khungu la khansa yam'mapapo mu vitro. Silibinin pamodzi ndi indole-3-carbinol zinayambitsanso mphamvu zolimbana ndi kupatsirana kuposa omwe amathandizira. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Zotsatirazi zikuwonetsa kuti Milk Thistle yogwira Silibinin itha kukhalanso ndi chithandizo chochizira khansa ya m'mapapo.

7. Angaletse khansa ya chikhodzodzo

Kafukufuku wa in vitro adawonetsa kuti Silibinin adayambitsa apoptosis / kufa kwa maselo a khansa ya chikhodzodzo. Kafukufuku adawonetsanso kuti Silibinin imathanso kupondereza kusamuka komanso kufalikira kwa maselo a khansa ya chikhodzodzo. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

8. Akhoza kuletsa Khansa ya Ovarian

Kafukufuku wa mu vitro adawonetsa kuti silibinin imatha kuletsa kukula kwa ma cell a khansa yamchiberekero chaumunthu, komanso kupangitsa apoptosis / cell kufa. Kafukufuku adawonanso kuti Silibinin imathandizira kutulutsa chidwi cha maselo a khansa yamchiberekero ku PTX (Onxal). Silibinin ikagwiritsidwa ntchito limodzi ndi PTX (Onxal) imathandizanso kuti apoptosis / cell afe. (Prabha Tiwari ndi Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Zomwe zapezazi zikuwonetsa kuti silibinin itha kugwiritsidwa ntchito ngati gawo lamankhwala ophatikizika motsutsana ndi khansa ya ovarian.

9. Itha kuletsa Khansa ya M'chiberekero

Kafukufuku akuwonetsa kuti Silibinin imatha kuletsa kuchuluka kwa maselo amtundu wamunthu. Kuphatikiza apo, silibinin limodzi ndi MET, odziwika bwino odana ndi matenda ashuga, akuwonetsa zoyanjana pakuletsa kwa khansa ya khomo lachiberekero ndi kufa kwa cell. Chifukwa chake, silibinin itha kukhala yothandiza ngati mankhwala opewera khansa ya pachibelekero. Maphunziro ena akuyenera kuwunika momwe angapangire njira zabwino zochiritsira khansa ya pachibelekero.

Maphunziro a Zachipatala mu Anthu

Tiyeni tiwone maphunziro osiyanasiyana azachipatala kuti timvetsetse ngati kuphatikiza nthula yamkaka ngati gawo la Zakudya za odwala khansa ndi yopindulitsa kapena ayi.

1. Ubwino wa Milk Thistle pochepetsa Kuopsa kwa Cardiotoxicity mu Acute Lymphoblastic Leukemia Ana Othandizidwa ndi DOX(Adriamycin)

Silymarin, chimodzi mwazinthu zofunikira kwambiri mkaka wa nthula, awonetsedwa poyesa kukhala ndi zotsatira zamatenda amthupi mukapatsidwa limodzi ndi DOX. Silymarin amatha kuchepetsa kupsinjika kwa oxidative, komwe kumayambitsa matenda a cardiotoxicity. Ndi antioxidant ndipo imatha kuchepetsa kuwonongeka kwa nembanemba ndi mapuloteni amtundu wambiri, omwe amapangidwa ngati gawo la njira ya DOX, popewa kuwonongeka kwa makina amtundu wa antioxidant a maselo athanzi. (Roskovic A et al, Mamolekyu a 2011)

Kafukufuku wamankhwala ochokera ku Yunivesite ya Tanta ku Egypt adawunika momwe Silymarin wochokera ku Milk Thistle amathandizira ana omwe ali ndi Acute Lymphoblastic Leukemia (ALL), omwe amathandizidwa ndi DOX. Kafukufukuyu adagwiritsa ntchito chidziwitso kuchokera kwa ana 80 omwe ali ndi ZONSE, pomwe odwala 40 amathandizidwa ndi DOX limodzi ndi Silymarin pa 420 mg / tsiku ndipo 40 otsala amathandizidwa ndi DOX (placebo group) yokha. Kafukufukuyu adapeza kuti pagulu la Silymarin, panali 'kuchepa koyambirira kwa DOX-komwe kumapangitsa ma ventricular systolic function kusokonekera' pagulu la placebo. Kafukufuku wamankhwala uyu, ngakhale ali ndi ana ochepa ONSE, amapereka chitsimikiziro chazovuta za mtima wa Silymarin monga momwe zimawonedwera pamitundu yoyesera yamatenda. (Adel A Hagag et al, Infect Disord Drug Target., 2019)

2. Ubwino wa Milk Thistle pochepetsa Kuopsa kwa Chiwindi mu Acute Lymphoblastic Leukemia Ana Othandizidwa ndi Chemotherapy

Chithandizo cha ana omwe ali ndi khansa ya m'magazi (ALL) yogwiritsa ntchito mankhwala a chemotherapy nthawi zambiri imasokonekera chifukwa cha chiwindi cha hepatotoxicity / chiwindi chomwe chimayambitsa mankhwala a chemotherapy. Izi zothetsa khansa pogwiritsa ntchito mankhwala a chemotherapy motsutsana ndi kuthana ndi zovuta zoyipa zomwe nthawi zina sizingasinthe za mankhwalawa ndizovuta zomwe zimachitika mgulu la khansa. Chifukwa chake, pali kuyesayesa kosalekeza kopeza njira zomwe zitha kuthandiza kuchepetsa kapena kuteteza wodwalayo ku zovuta zoyipa.

Mu kafukufuku wamankhwala, ana omwe ali ndi vuto la leukemia (ALL) omwe ali ndi poyizoni wowopsa amathandizidwa ndi chemotherapy yokha (placebo) kapena kapisozi wa mkaka waminga wamkaka wokhala ndi 80 mg ya silibinin limodzi ndi chemotherapy (MTX / 6-MP / VCR) pakamwa ( Mkaka Waminga Gulu) masiku 28. Ana 50 adalembetsa kuyambira Meyi 2002 mpaka Ogasiti 2005 pa kafukufukuyu, ndi maphunziro 26 mgulu la placebo ndi 24 mu Gulu la Milk Thistle. 49 mwa ana 50 adayesedwa pa kafukufukuyu. Chiwindi cha chiwindi chimayang'aniridwa nthawi yonse yakuchipatala. (EJ Ladas et al, Cancer., 2010)

Zotsatira za kafukufukuyu zikusonyeza kuti kutenga Mkaka Waminga pamodzi ndi chemotherapy ndi odwala ONSE kumatha kuphatikizidwa ndi kuchepa kwa chiwindi cha chiwindi. Kafukufukuyu sanapeze poizoni wosayembekezereka, kufunika kochepetsa kuchepa kwa mankhwala a chemotherapy, kapena kuchedwa kulikonse kwamankhwala panthawi yothandizidwa ndi nthula yamkaka. Kafukufukuyu adawonetsanso kuti nthula yamkaka siyinakhudze mphamvu ya ma chemotherapy omwe amagwiritsidwa ntchito pochiza ONSE. 

Ofufuzawa adapereka lingaliro la kafukufuku wamtsogolo kuti apeze mlingo wothandiza kwambiri wa Milk Thistle ndi zotsatira zake pa hepatotoxicity / chiwindi kawopsedwe komanso kupulumuka kwa leukemia.

3. Ubwino wa Milk Thistle yogwira Silibinin pochepetsa edema ya muubongo mu Odwala khansa ya m'mapapo omwe ali ndi Brain Metastasis.

Kafukufuku akusonyeza kuti kugwiritsa ntchito mkaka nthula yogwira ntchito silibinin-based nutraceutical yotchedwa Legasil® ikhoza kupititsa patsogolo Brain Metastasis kuchokera kwa odwala khansa ya m'mapapo ya NSCLC/mapapo omwe adapita patsogolo polandira chithandizo ndi radiotherapy ndi chemotherapy. Zotsatira za maphunzirowa zimasonyezanso kuti kayendetsedwe ka silibinin kungachepetse kwambiri edema ya ubongo. Komabe, zolepheretsa izi za silibinin pa metastasis yaubongo sizingakhudze chotupa choyambirira m'mapapo. khansa odwala. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Ubwino wa Thistle wa Mkaka pochepetsa Kuopsa kwa Chiwindi kwa Wodwala Khansa ya M'mawere

Kafukufuku wina adasindikizidwa pa wodwala khansa ya m'mawere yemwe amalandila mankhwala azithandizo zisanu zamankhwala am'mene amathandizira chiwindi. Ripotilo linanena kuti zotsatira za kuyesa kwa chiwindi zafika pangozi mpaka kuwopsa kwa moyo patatha magawo anayi amathandizidwe a chemotherapy. Wodwalayo adawonjezeredwa ndi mankhwala osakanikirana ndi Silibinin otchedwa Legasil® positi pomwe kuwunika kwamankhwala ndi chiwindi kudawonedwa, komwe kumathandiza wodwalayo kupitiliza chemotherapy. (Bosch-Barrera J et al, Anticancer Res., 5)

Kafukufukuyu adawonetsa phindu lachipatala la silibinin pochepetsa chiwopsezo cha chiwindi mwa odwala khansa ya m'mawere omwe amathandizidwa ndi chemotherapy.

5. Ubwino wa nthula ya Mkaka Pakupititsa patsogolo Zotsatira za Kupulumuka mu Odwala a Metastatic mu Ubongo Omwe Anathandizidwa ndi Radiotherapy

Kafukufuku akuwonetsa kuti nthula yamkaka imatha kupindulitsa odwala metastatic omwe amalandira radiotherapy. Kafukufuku wamankhwala anaphatikiza zambiri kuchokera kwa odwala omwe ali ndi ma metastases aubongo omwe amathandizidwa ndi radiotherapy yokha kapena radiotherapy limodzi ndi omega 3 fatty acids ndi silymarin. Kafukufukuyu anapeza kuti odwala omwe amatenga omega 3 fatty acids ndi silymarin anali ndi nthawi yopulumuka komanso radionecrosis yochepetsedwa. (Gramaglia A et al, Anticancer Res., 1999)

Kutsiliza

Mkaka wa Nthula / Silymarin ndi gawo lake lofunikira Silibinin lili ndi maubwino ambiri azaumoyo chifukwa cha antioxidant, anti-inflammatory and anti-cancer. Kutulutsa mkaka wa mkaka / Silymarin nthawi zambiri samakhala ndi zovuta zambiri akamamwa pakamwa moyenera. Komabe, mwa anthu ena, kutenga mkaka wa nthula kumatha kuyambitsa kutsekula m'mimba, nseru, mpweya wam'mimba, kuphulika, kudzaza kapena kupweteka, komanso kusowa chilakolako. Komanso, popeza kuti nthula ya mkaka imatha kutsitsa shuga m'magazi mwa anthu omwe ali ndi matenda ashuga, mayeza a matenda ashuga amayenera kusintha. Kutulutsa nthula yamkaka kumathanso kukhala ndi zotsatira za estrogenic zomwe zitha kukulitsa mavuto okhudzana ndi mahomoni, kuphatikiza mitundu ina ya khansa ya m'mawere.

Maphunziro osiyanasiyana a invitro/invivo ndi nyama afufuza za thanzi la nthula ya mkaka komanso kuthekera kwake kuletsa mitundu yosiyanasiyana ya khansa. Zotsatira zabwino zanenedwa ndi ambiri mwa maphunzirowa omwe akuwonetsa chitetezo cha mkaka nthula mu mitundu ina ya khansa. Mayesero ochepa aumunthu amathandizanso kuti nthula ya mkaka ndi zosakaniza zake zogwira ntchito zingakhale zopindulitsa kuchepetsa zotsatira zina zoopsa za mankhwala amphamvu a chemotherapy ndi radiotherapy monga cardiotoxicity, hepatotoxicity ndi edema ya ubongo mu mitundu ina ya khansa yomwe imachiritsidwa ndi chemo yeniyeni. Komabe, kutenga zowonjezera zachilengedwe monga nthula zamkaka zimachotsa mwachisawawa ndi chemotherapy iliyonse khansa Sitikulimbikitsidwa chifukwa zingayambitse kusagwirizana kwa mankhwala ndi zitsamba. Chifukwa chake, nthawi zonse munthu ayenera kukaonana ndi dokotala asanayambe kumwa mankhwala aliwonse achilengedwe pamodzi ndi chemotherapy.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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