Kuwonjezeka Kwangozi Kwa Osteoporosis mu Opulumuka Khansa

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Odwala khansa ndi opulumuka omwe adalandira chithandizo monga aromatase inhibitors, chemotherapy, mankhwala a mahomoni monga Tamoxifen kapena kuphatikiza kwa izi, ali pachiwopsezo chowonjezeka cha osteoporosis, chikhalidwe chomwe chimachepetsa kuchulukira kwa mafupa, ndikupangitsa kuti ikhale yosalimba. Chifukwa chake, kupanga dongosolo lathunthu lamankhwala kuphatikiza kasamalidwe koyenera ka thanzi lachigoba la odwala khansa ndizosapeweka.

Kupita patsogolo kwaposachedwa pa kafukufuku wa khansa kwathandiza kuchulukitsa chiwerengero cha odwala khansa padziko lonse lapansi. Komabe, ngakhale kupita patsogolo kwamankhwala a khansa, ambiri opulumuka khansa amatha kuthana ndi zotsatirapo zosiyanasiyana za mankhwalawa. Osteoporosis ndi imodzi mwazotsatira zanthawi yayitali zomwe zimawonedwa mwa odwala khansa ndi omwe adapulumuka omwe adalandira chithandizo monga chemotherapy ndi mahomoni. Osteoporosis ndi chikhalidwe chachipatala chomwe chimapangitsa kuti fupa likhale lofooka komanso lolimba. Kafukufuku wambiri akuwonetsa kuti odwala ndi opulumuka amitundu ya khansa monga khansa ya m'mawere, khansa ya prostate ndi lymphoma ali pachiwopsezo chowonjezeka cha osteoporosis.

Kafukufuku wowonetsa Kuopsa kwa Osteoporosis mwa Opulumuka Khansa

Pakafukufuku wotsogozedwa ndi ofufuza ochokera ku Johns Hopkins Bloomberg School of Public Health, Baltimore, United States, adawunika kuchuluka kwa matenda a osteoporosis ndi matenda ena otaya mafupa otchedwa osteopenia mwa opulumuka 211 omwe adapezeka ndi khansa ya m'mawere omwe adapezeka ndi khansa. amatanthauza zaka 47, ndikuyerekeza zomwe zili ndi amayi 567 opanda khansa. (Cody Ramin et al, Kafukufuku wa Khansa ya M'mawere, 2018) Zomwe zimagwiritsidwa ntchito pofufuza izi zinapezedwa kuchokera ku BOSS Study (Breast and Ovarian Surveillance Service study) ndipo zinaphatikizapo deta ya amayi omwe anali ndi chidziwitso pa mayesero a mafupa. 66% ya opulumuka khansa ya m'mawere ndi 53% ya amayi omwe alibe khansa adayesedwa kuti awonongeke mafupa panthawi yotsatila zaka za 5.8 ndipo chiwerengero cha 112 cha osteopenia ndi / kapena osteoporosis chinanenedwa. Ofufuzawo adapeza kuti panali chiopsezo chachikulu cha 68% cha kuwonongeka kwa mafupa mwa omwe adapulumuka khansa ya m'mawere poyerekeza ndi amayi omwe alibe khansa. Kuphatikiza apo, ochita kafukufuku adawonetsanso zotsatirazi zazikulu za kafukufukuyu:

• Opulumuka khansa ya m'mawere omwe adapezeka ali ndi zaka ≤ zaka 50 anali ndi 1.98 folds yowonjezera chiopsezo cha osteopenia ndi osteoporosis poyerekeza ndi amayi opanda khansa.
• Azimayi omwe ali ndi zotupa za ER-positive (estrogen receptor positive) anali ndi zopindika 2.1 zomwe zimawonjezera chiopsezo cha kuwonongeka kwa mafupa poyerekeza ndi amayi opanda khansa.
• Omwe adapulumuka khansa ya m'mawere amathandizidwa ndi kuphatikiza kophatikizana kwa mankhwala a chemotherapy ndi mankhwala a mahomoni anali ndi mikwingwirima 2.7 yochulukitsa chiopsezo cha osteopenia ndi osteoporosis poyerekeza ndi azimayi opanda khansa.
• Azimayi omwe anapezeka ndi khansa ya m'mawere ndi kuthandizidwa ndi mankhwala osakaniza a chemotherapy ndi tamoxifen, mankhwala omwe amagwiritsidwa ntchito kwambiri ndi khansa ya m'mawere, anali ndi mikwingwirima 2.48 yowonjezera chiopsezo cha kuwonongeka kwa mafupa poyerekeza ndi amayi omwe alibe khansa.
• Opulumuka khansa ya m'mawere amathandizidwa ndi aromatase inhibitors omwe amachepetsa kupanga kwa estrogen, anali ndi 2.72 ndi 3.83 folds yowonjezera chiopsezo cha osteopenia ndi osteoporosis pamene amachiritsidwa okha kapena kuphatikiza ndi chemotherapy, motero, poyerekeza ndi amayi opanda khansa.

Mwachidule, kafukufukuyu adatsimikiza kuti panali chiwopsezo chowonjezereka cha kuwonongeka kwa mafupa mwa opulumuka khansa ya m'mawere omwe anali achichepere, omwe anali ndi zotupa zabwino za ER (estrogen receptor), amathandizidwa ndi aromatase inhibitors okha, kapena kuphatikiza kwa chemotherapy ndi aromatase inhibitors. kapena tamoxifen. (Cody Ramin et al, Kafukufuku wa Khansa ya M'mawere, 2018)

Mu kafukufuku wina wachipatala, deta yochokera kwa odwala 2589 aku Danish, omwe adapezeka ndi B-cell lymphoma kapena follicular lymphoma, omwe nthawi zambiri amachiritsidwa ndi ma steroids monga prednisolone, pakati pa 2000 ndi 2012 ndi 12,945 olamulira adawunikidwa chifukwa cha zochitika za kuwonongeka kwa mafupa. Zotsatira zinawonetsa kuti odwala lymphoma anali ndi chiopsezo chowonjezeka cha kuwonongeka kwa mafupa poyerekeza ndi kulamulira, ndi zaka 5 ndi zaka 10 zoopsa zowonjezera zomwe zimanenedwa kuti ndi 10.0% ndi 16.3% kwa odwala lymphoma poyerekeza ndi 6.8% ndi 13.5% kuti aziwongolera. (Baech J et al, Leuk Lymphoma., 2020)

Maphunziro onsewa amathandizira kuti pali chiwopsezo chowonjezereka cha matenda a osteoporosis mwa odwala khansa ndi opulumuka omwe amatsatira chithandizo chamankhwala osiyanasiyana. Thandizo la khansa nthawi zambiri limasankhidwa ndi cholinga chofuna kupititsa patsogolo kupulumuka, osapereka kufunikira kwa zomwe zingawononge thanzi la chigoba. Chofunikira ndichakuti, musanayambe chithandizo, ndikofunikira kuphunzitsa odwala khansa za zovuta zomwe zingachitike chifukwa chamankhwalawa pa thanzi lawo lachigoba ndikuphatikizanso dongosolo lamankhwala la khansa lomwe limakhudzanso kasamalidwe kabwino ka thanzi la mafupa a mafupa. khansa odwala.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kulosera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe khansa ndi zotsatira zake zokhudzana ndi chithandizo.

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• Opulumuka Khansa Yaubwana Amathandizidwa ndi Chemotherapy Ali Ndi Chiwopsezo Chambiri Chotsatira Khansa
• Kuwonjezeka Kowopsa Kwa Matenda a Mtima Omwe Amapulumuka Khansa Ya m'mawere
• Ubwino wa Co-Q10 / Ubiquinol wogwiritsa ntchito khansa ya m'mawere